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A/PROF Marie BOGOYEVITCH

Positions

  • Cardiac disease: changes to heart structure and function (heart failure, cardiac hypertrophy, infarction)
  • Cell death mechanisms: drivers of cardiac and neurodegenerative diseases (apoptosis, necrosis, autophagy)
  • Peptides: new tools for biological research and novel drug leads (random sequence, protein-based, gene fragment libraries, inhibitors, probes)
  • Protein Kinase Inhibitors: peptides and small molecules as new drug leads (ATP competitive, non-competitive or allosteric inhibitors)
  • Protein phosphorylation: post-translational regulatory mechanisms in intracellular control (protein kinase substrate specificity, consensus motifs)
  • Signal transduction: the biochemical processes of intracellular communication (protein kinases, transcription factors)
  • Signalling complexes: interacting partners controlling intracellular communication networks (adaptors, scaffolds, enzymes)
  • c-Jun N-terminal kinases: therapeutic targets (stroke, cardiovascular disease, diabetes, inflammatory disease)

Overview

OverviewText1

  • Marie A Bogoyevitch is an Associate Professor in Biochemistry and Molecular Biology at the University of Melbourne and the Bio21 Molecular Science and Biotechnology Institute. Marie~s current research explores molecular mechanisms in eukaryotic signal transduction with an emphasis on the discovery of new molecules to block protein kinase-substrate interactions and the exploration of how subtle differences in signal transduction proteins can have major effects on cellular events. A major challenge arising from this research area is to translate these interests in the area of rational drug design, thereby generating new approaches to therapeutic inhibition of these signaling interactions in disease. Her interests in these areas were initiated during postdoctoral work in London with Peter Sudgen (National Heart and Lung Institute) and Chris Marshall FRS (Institute for Cancer Research) and then were expanded upon during her appointments at the University of Western Australia (Lecturer, Senior Lecturer, Associate Professor; 1997-2006). Marie is an Editorial Board Member of the Biochemical Journal and the International Journal for Biochemistry and Molecular Biology. She is an Executive member of the Australian Society for Biochemistry and Molecular Biology (ASBMB) in her role as national Secretary, having previously been on the Editorial Board of the Society~s magazine ~The Australian Biochemist~ and has acted as the Western Australian state representative. She is an International Advisory Board Member for the International Workshops on Protein Kinase Inhibitors that are organized biannually in Warsaw, Poland. She is a Scientific Advisory Board Member of Phylogica Ltd. Marie has also participated in the grant peer review process by reviewing grants for agencies including the Australian Research Council and Wellcome Trust (UK). She has acted on the Regional Grant Interview Committees for the National Heart Foundation (NHF) as well as the Grant Review Panels for the Nationa   

Affiliation

Member of

  • Australian and New Zealand Society for Cell and Developmental Biology. Member, former WA representative 1997 -
  • Australian Society for Biochemistry and Molecular Biology. Honorary Secretary and Executive Member 1996 -
  • British Biochemical Society. Member and Editorial Board Member of Biochemical Journal 1990 -

Publications

Selected publications

Research

Investigator on

Awards

Education and training

  • PhD, The University of Queensland 1990
  • BSc (Hons), The University of Queensland 1987
  • BSc, The University of Queensland 1986

Awards and honors

  • Excellence in Teaching Award - Honours Supervision, The University of Western Australia, 2000
  • University of Queensland Medal for Outstanding Academic Achievement, The University of Queensland, 1986

Linkages

Supervision

Available for supervision

  • Y