Paediatric and Perinatal Thrombosis and Haemostasis
Platelet function and Platelet proteome
The age-specific effect of anticoagulants
I lead a highly productive, internationally competitive research laboratory in the field of paediatric thrombosis and haemostasis (aka kids blood). My team is acknowledged as being at the forefront of paediatric haemostasis research internationally, as well as being the only team focusing on this field nationally. I have strong collaborations with other national and international cross-disciplinary teams. In addition, my research experience has benefited significantly, through my role as student supervisor and mentor. I pioneered the world-first studies of the effect, pharmacokinetics and strategies for monitoring of anticoagulants in children. I established the first age-specific reference ranges for coagulation proteins in Australian neonates and children. This data was converted into 5000 cards distributed to haematology laboratories worldwide and clinical guidelines adopted nationally and internationally. Other studies have resulted in the incorporation of point-of-care monitors into home monitoring of Warfarin therapy at the Royal Children's Hospital (RCH). I am the co-chair of the International Thrombosis and Haemostasis (ISTH) Plasma Coagulation Inhibitors Scientific Committee and serve as an editor for journals Thrombosis and Haemostasis and Thrombosis Research. My research efforts include the use of proteomic studies in the paediatric setting, where I established for the first time the concept of “ageing of the plasma proteome”, and subsequently the concept of Developmental Proteomics. I am a co-founder and Chair of the Pediatric Proteome (PediOme) initiative established to support and facilitate studies of proteomics in the paediatric setting, a part of the Human Proteome Organisation (HUPO) and co-chair of the Plasma Proteome Project HUPO initiative. I am an advocate for diversity, inclusion and gender equality, specifically as a member of the Women in Science Parkville Precinct (WiSPP) committee.
2012-13 Murdoch Childrens Research Institute: How platelet proteins change with age: differences in the platelet proteome between children and adults. $24,000 2011-12 NHMRC Project Grant (CIC): The role of proteoglycans in contributing to placental thrombosis and fetal growth restriction. $356,518 2010-11 Murdoch Childrens Research Institute: Does the ratio of native to latent Antithrombin change with age? $6,000 Murdoch Childrens Research Institute: Determining age-related changes in glycosylation pattern of the plasma proteome in children with type 1 diabetes compared to healthy age-matched controls. $20,000 NHMRC Project Grant (CIC): Identification of a plasma-borne factor of remote ischemic preconditioning and its effect on the proteome after heart surgery $375,250 2009 Bayer: Rivaroxaban Paediatric Study. $113,000 2008 NHMRC/RAGS Equipment Grants: Investigating adverse pregnancy outcomes. $20,000 Murdoch Childrens Research Institute: Age-specific proteomic map of human plasma. $20,000 2007 Inner Wheel Australia: Improving the isolation and culturing of cord blood derived stem cells. $60,000 Murdoch Childrens Research Institute: Age-related structural and functional differences in haemostatic proteins. $25,000 Medical Research Grant: Gradient PCR machine purchase. $20,000 2007-9 NHMRC Project Grant (CIB): The impact of developmental haemostasis on the pharmacokinetics and pharmacodynamics of heparin in children. $273,000 2005-6 RAGS and NHMRC Equipment Grants: Gel Documentation and Analysis system (Syngene G:BOX). $61,475 Roche Diagnostics: CoaguChek XS study. $26,796 Murdoch Childrens Research Institute: Thrombin generation to assess bleeding and clotting risk in children. $43,000 Haemophilia Foundation Australia: Thrombin generation, the role of hyperfibrinolysis (levels of Thrombin Activatable Fibrinolysis Inhibitor; TAFI) an
Education and training
Monash University 2000
Monash University 1996
Awards and honors
Australian Academy of Science - Scientific visits to Europe award,
Young Investigator Award - International Society on Thrombosis and Haemostasis,
Sanofi Aventis/ISTH Research Fellowship,
Royal Children's Hospital Travelling Scholarship,
HSANZ - Travelling Grant,
Travelling Fellowship - Paediatric Research Society of Australia and New Zealand.,
I contribute greatly to research training, particularly via the supervision of higher degree research students (PhD, MD, BSc. Honours) and regularly incorporate student projects as part of my funded projects, ensuring that the student projects are of the highest quality.