PROF Peter Colman

PROF Peter Colman

Positions

  • Molecular interplay within the BCL2 protein family and its manipulation with organic ligands

Overview

OverviewText1

  • www.wehi.edu.au/people/peter-colman

    My laboratory studies the molecular events that prevent or permit cell death. This process is crucial for maintaining good health. Failure of the cell death program is a common hallmark of cancer.

    We visualise the three dimensional shapes of cell death proteins to better understanding their function in cell death. This is aiding the discovery of drugs that can kill certain types of tumour cells.   

Publications

Selected publications

Research

Awards

Education and training

  • PhD, Adelaide University
  • BSc, Adelaide University

Awards and honors

  • Fellow of the Australian Academy of Science, 1989

Supervision

Available for supervision

  • Y

Supervision Statement

  • Research interest

    We use structural biology to study the intrinsic pathway to cell death, controlled by the Bcl-2 family of proteins. We are seeking to better understand the molecular events that lead to the pro-apoptotic Bcl-2 family proteins Bax and Bak becoming active.

    We are exploiting this information to discover new drugs that interfere with the apoptotic pathway.