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PROF Helen Thomas

Positions

Honorary, Medicine - St Vincent's Hospital

Publications

Selected publications

2018
- Journal Articles Refereed
  - Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells. Pancreas. 47. 2018
  - Expression of miR-206 in human islets and its role in glucokinase regulation. American Journal of Physiology - Endocrinology and Metabolism. 315. 2018
  - Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice. Cell Death & Differentiation. 25. 2018
  - Proinsulin C-peptide is an autoantigen in people with type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 115. 2018
2017
- Journal Articles Refereed
  - Differential regulation of pro-inflammatory cytokine signalling by protein tyrosine phosphatases in pancreatic β-cells. Journal of Molecular Endocrinology. 59. 2017
  - Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility. Molecular Immunology. 82. 2017
  - Inhibition of Y1 receptor signaling improves islet transplant outcome. Nature Communications. 8. 2017
  - JNK activation of BIM promotes hepatic oxidative stress, steatosis, and insulin resistance in obesity. Diabetes. 66. 2017
  - Non-invasive, in vitro analysis of islet insulin production enabled by an optical porous silicon biosensor. Biosensors and Bioelectronics. 91. 2017
  - Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice. Diabetes. 66. 2017
  - Transplantation sites for human and murine islets. Diabetologia. 60. 2017
2016
- Journal Articles
  - The JAK/STAT pathway in obesity and diabetes. The FEBS Journal. 2016
- Journal Articles Refereed
  - Genetic strategies to bring islet xenotransplantation to the clinic. Current Opinion in Organ Transplantation. 21. 2016
  - Human islet cells are killed by BID-independent mechanisms in response to FAS ligand. Apoptosis. 21. 2016
  - Perforin facilitates beta cell killing and regulates autoreactive CD8(+) T-cell responses to antigen in mouse models of type 1 diabetes. Immunology and Cell Biology. 94. 2016
  - Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes 2016
  - p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.. Scientific Reports. 6. 2016
- Journal Articles Unrefereed Letters or Notes
  - How to Make Mice Tell the Truth. Diabetes. 65. 2016
2015
- Research Book Chapters
  - Measuring Death of Pancreatic Beta Cells in Response to Stress and Cytotoxic T Cells. Methods in Molecular Biology. Humana Press. 2015
- Journal Articles
  - Pancreatic Alpha Cells Hold the Key to Survival. EBioMedicine. 2. 2015
- Journal Articles Refereed
  - Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes. Diabetologia. 58. 2015
  - BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells. Diabetes. 64. 2015
  - Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets. Diabetes. 64. 2015
  - Lipotoxic Stress Induces Pancreatic beta-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System. Journal of Diabetes Research. 2015
2014
- Journal Articles
  - Linking obesity with type 2 diabetes: The role of T-bet. Diabetes, Metabolic Syndrome and Obesity: targets and therapy. 7. 2014
- Journal Articles Refereed
  - Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets. PLoS One. 9. 2014
  - Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice. Diabetes. 63. 2014
  - Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes. Journal of Immunology. 192. 2014
  - Functional cytotoxic T lymphocytes against IGRP(206-214) predict diabetes in the non-obese diabetic mouse. Immunology and Cell Biology. 92. 2014
  - Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine. 20. 2014
  - The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity. Cell Death & Disease. 5. 2014
2013
- Journal Articles Refereed
  - Proinflammatory cytokines contribute to development and function of regulatory T cells in type 1 diabetes. Annals of The New York Academy of Sciences. 1283. 2013
  - The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin Induced Diabetes in Mice. Diabetes. 62. 2013
2012
- Journal Articles Refereed
  - An indirect role for NK cells in a CD4(+) T-cell-dependent mouse model of type I diabetes. Immunology and Cell Biology. 90. 2012
  - Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells. Diabetes. 61. 2012
  - Expression of Pro- and Antiapoptotic Molecules of the Bel-2 Family in Human Islets Postisolation. Cell Transplantation. 21. 2012
  - Granzyme B Is Dispensable in the Development of Diabetes in Non-Obese Diabetic Mice. PLoS One. 7. 2012
  - Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression. European Journal of Immunology. 42. 2012
  - Pathogenic mechanisms in type 1 diabetes: The islet is both target and driver of disease. The Review of Diabetic Studies. 9. 2012
  - Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors. International Immunology. 24. 2012
2011
- Journal Articles Refereed
  - Autoreactive Cytotoxic T Lymphocytes Acquire Higher Expression of Cytotoxic Effector Markers in the Islets of NOD Mice after Priming in Pancreatic Lymph Nodes. American Journal of Pathology. 178. 2011
  - TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice. Journal of Immunology. 187. 2011
  - The pro-apoptotic BH3-only protein Bid is dispensable for development of insulitis and diabetes in the non-obese diabetic mouse. Apoptosis. 16. 2011
2010
- Journal Articles Refereed
  - Glucose Induces Pancreatic Islet Cell apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax. Diabetes. 59. 2010
- Other Refereed Contribution to Refereed Journals
  - A method for extracting tissue proteins for use in lymphocyte. Journal of Immunological Methods. 359. 2010
  - The role of perforin and granzymes in diabetes. Cell Death & Differentiation. 17. 2010
2009
- Journal Articles Refereed
  - In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes. Immunology and Cell Biology. 87. 2009
2008
- Research Book Chapters
  - Cytotoxic T cell mechanisms of beta cell destruction in non-obese diabetic mice. Defining Optimal Immunotherapies For Type 1 Diabetes. John Wiley & Sons. 2008
- Journal Articles Refereed
  - Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice. Journal of Immunology. 180. 2008
  - Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro. Human Immunology. 69. 2008
  - Proapoptotic BH3-only protein bid is essential for death receptor-induced apoptosis of pancreatic beta-cells. Diabetes. 57. 2008
2007
- Journal Articles Refereed
  - Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets. Xenotransplantation. 14. 2007
2006
- Journal Articles Refereed
  - A critical role for Granzyme B, in addition to perforin and TNFα, in alloreactive CTL-induced mouse pancreatic beta cell death. Transplantation. 81. 2006
  - Granzyme B-mediated death of pancreatic β-Cells requires the proapoptotic BH3-only molecule bid. Diabetes. 55. 2006
  - IL-1β breaks tolerance through expansion of CD25+ effector T cells1. Journal of Immunology. 176. 2006
  - Perforin and Fas induced by IFNγ and TNFα mediate beta cell death by OT-I CTL. International Immunology. 18. 2006
  - Perturbations in nuclear factor-κB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death. Immunology and Cell Biology. 84. 2006
  - SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes . Journal of Autoimmunity. 27. 2006

Research

Investigator on

Grant
- CELL DEATH PATHWAYS AND TYPE 1 DIABETES (NHMRC/JDRF Special Program Grants in Type 1 Diabetes) awarded by NHMRC 2007 - 2012

Supervision

Available for supervision

Y

Contact Details
- hthomas@unimelb.edu.au
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