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PROF Richard Gilbert

Positions

Honorary, Medicine - St Vincent's Hospital

Publications

Selected publications

2018
- Journal Articles Refereed
  - Hypertension Canada's 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children. Canadian Journal of Cardiology. 34. 2018
  - Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overloadmodel by modifying Smad2/3 transactivation. Cardiovascular Research. 114. 2018
- Journal Articles Unrefereed
  - Effect of Basal Insulin Glargine on First and Recurrent Episodes of Heart Failure Hospitalization The ORIGIN Trial (Outcome Reduction With Initial Glargine Intervention). Circulation. 137. 2018
2017
- Journal Articles Refereed
  - Chronic Kidney Disease, Basal Insulin Glargine, and Health Outcomes in People with Dysglycemia: The ORIGIN Study. American Journal of Medicine. 130. 2017
  - Effects of Canagliflozin on Serum Magnesium in Patients With Type 2 Diabetes Mellitus: A Post Hoc Analysis of Randomized Controlled Trials 2017
  - Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults. Canadian Journal of Cardiology. 33. 2017
2013
- Journal Articles Refereed
  - A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction. International Journal of Cardiology. 168. 2013
  - Combination Angiotensin Converting Enzyme and Direct Renin Inhibition in Heart Failure following Experimental Myocardial Infarction. Cardiovascular Therapeutics. 31. 2013
2012
- Journal Articles Refereed
  - A purpose-Synthesised Anti-Fibrotic Agent Attenuates Experimental Kidney Diseases in the Rat. PLoS One. 7. 2012
  - FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy. European Journal of Heart Failure. 14. 2012
2011
- Journal Articles Refereed
  - Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart. Clinical and Experimental Pharmacology and Physiology. 38. 2011
  - Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in eperimental diabetic nephropathy. Nephrology. 16. 2011
  - Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism. American Journal of Pathology. 178. 2011
  - Protein kinase C ß inhibition ameliorates experimental mesangial proliferative glomerulonephritis. Nephrology. 16. 2011
  - The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy. Journal of Hypertension. 29. 2011
2010
- Journal Articles Refereed
  - Culture-Modified Bone Marrow Cells Attenuate Cardiac and Renal Injury in a Chronic Kidney Disease Rat Model via a Novel Antifibrotic Mechanism. PLoS One. 5. 2010
  - Effect of Atorvastatin on Cardiac Remodelling and Mortality in Rats Following Hyperglycemia and Myocardial Infarction. International Journal of Cardiology. 143. 2010
  - Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. American Journal of Physiology - Heart and Circulatory Physiology. 298. 2010
2009
- Journal Articles Refereed
  - EGFR-PLC gamma 1 signaling mediates high glucose-induced PKC beta 1-Akt activation and collagen I upregulation in mesangial cells. American Journal of Physiology: Renal Physiology. 297. 2009
  - PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells. Journal of the American Society of Nephrology. 20. 2009
2008
- Journal Articles Refereed
  - Activated Protein C and Diabetic Nephropathy. New England Journal of Medicine. 10. 2008
  - Effect of urotensin II on skin microvessel tone in diabetic patients without heart failure or essential hypertension. Clinical and Experimental Pharmacology and Physiology. 35. 2008
  - Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control. Diabetologia. 51. 2008
  - Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats. Nephrology. 13. 2008
  - Tranilast ameliorates experimental mesangial proliferative glomerulonephritis. Nephron Experimental Nephrology. 109. 2008
- Journal Articles Unrefereed Letters or Notes
  - Letter by Connelly et al regarding article, "Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension". Circulation. 117. 2008
- Patents
  - Preparation of cinnamoyl anthranilates and analogs thereof with antifibrotic activity 2008
2007
- Journal Articles Refereed
  - Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?. Kidney International. 72. 2007
  - Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats.. Diabetologia. 50. 2007
  - Effects on protein kinase C-β inhibition on glomerular vascular endothelial growth factor expression and endothelial cells in advanced experimental diabetic nephropathy. American Journal of Physiology: Renal Physiology. 293. 2007
  - Expression of filtrin in human glomerular diseases. Nephrology, Dialysis, Transplantation. 22. 2007
  - Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat. Cardiovascular Research. 76. 2007
  - High glucose induces macrophage inflammatory protein-3α in renal proximal tubule cells via a transforming growth factor-β1 dependent mechanism. Nephrology, Dialysis, Transplantation. 22. 2007
  - High glucose-induced Thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-β1. American Journal of Pathology. 171. 2007
  - Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions. Proceedings of the National Academy of Sciences of the United States of America. 104. 2007
  - The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1. Nephrology. 12. 2007
  - Tranilast attenuates diastolic dysfunction and structural injury in experimental diabetic cardiomyopathy. American Journal of Physiology - Heart and Circulatory Physiology. 293. 2007
- Journal Articles Unrefereed
  - Macrophage infiltration and cellular proliferation in the non-ischemic kidney and heart following prolonged unilateral renal ischemia. Nephron Physiology. 106. 2007
- Journal Articles Unrefereed Letters or Notes
  - Clinically relevant models of diabetic cardiac complications. Circulation Research. 101. 2007
- Other Refereed Contribution to Refereed Journals
  - Effect of Ruboxistaurin on urinary transforming growth factor-β in patients with diabetic nephropathy and type 2 diabetes. Diabetes Care. 30. 2007
  - Progressive diabetic nephropathy in the Ren-2 rat. American Journal of Physiology: Renal Physiology. 292. 2007
2006
- Journal Articles Refereed
  - Combination therapy with tranilast and angiotensin-converting enzyme inhibition provides additional renoprotection in the remnant kidney model. Kidney International. 69. 2006
  - Heart failure and nephropathy: catastrophic and interrelated complications of diabetes. Journal of the American Society of Nephrology. 1. 2006
  - Importance of renin in blood pressure regulation and therapeutic potential of renin inhibition. International Journal of Clinical Practice. 60. 2006
  - Intra-coronary high-dose CD34+ stem cells in patients with chronic ischemic heart disease: A 12-month follow-up. International Journal of Cardiology. 109. 2006
  - Load-sensitive measures may overestimate global systolic function in the presence of left ventricular hypertrophy: a comparison with load-insensitive measures. American Journal of Physiology - Heart and Circulatory Physiology. 290. 2006
  - SB-267268, a nonpeptidic antagonist of αvβ3 and αvβ5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity. Investigative Ophthalmology and Visual Science. 47. 2006
  - TGF-β1 induces IL-8 and MCP-1 through a connective tissue growth factor-independant pathway. American Journal of Physiology: Renal Physiology. 290. 2006
  - Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells. Kidney International. 69. 2006
  - Transforming growth factor-β in human diabetic nephropathy: effects of ACE inhibition. Diabetes Care. 29. 2006
  - Transforming growth factor-β1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells. American Journal of Physiology: Renal Physiology. 291. 2006
2005
- Journal Articles Refereed
  - Cells expressing the stem cell factor receptor, c-kit, contribute to neoangiogenesis in diabetes. Diabetes and Vascular Disease Research. 2. 2005
  - Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapy*. Internal Medicine Journal. 35. 2005
  - High glucose transactivates the EGF receptor and up-regulates serum glucocorticoid kinase in the proximal tubule. Kidney International. 68. 2005
  - Independent and Additive Impact of Blood Pressure Control and Angiotensin II Receptor Blockade on Renal Outcomes in the Irbesartan Diabetic Nephropathy Trial: Clinical Implications and Limitations. Journal of the American Society of Nephrology. 16. 2005
  - Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology. 39. 2005
  - Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosis. American Journal of Physiology: Renal Physiology. 2005
  - Protein Kinase CΒ Inhibition Attenuates Osteopontin Expression, Macrophage Recruitment, and Tubulointerstitial Injury in Advanced Experimental Diabetic Nephropathy. Journal of the American Society of Nephrology. 16. 2005
  - Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-B. Cardiovascular Research. 65. 2005
- Journal Articles Unrefereed Letters or Notes
  - Renin Inhibition New Potential for an Old Therapeutic Target. Hypertension. 46. 2005
2004
- Journal Articles Refereed
  - Epidermal growth factor receptor inhibition attenuates early kidney enlargement in experimental diabetes. Kidney International. 66. 2004
  - Fas-induced apoptosis is a feature of progressive diabetic nephropathy in transgenic (mRen-2)27 rats: attentuation with renin-angiotensin blockade. Nephrology. 9. 2004
  - Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy. American Journal of Kidney Diseases. 44. 2004
  - Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy. American Journal of Pathology. 164. 2004
  - Long-term renoprotection by perindopril or nifedipine in non-hypertensive patients with type 2 diabetes and microaluminuria. Diabetic Medicine. 21. 2004
  - Platelet-derived growth factor receptor transactivation mediates the trophic effects of angiotensin II in vivo. Hypertension. 44. 2004
  - Tranilast attenuates structural and functional aspects of renal injury in the remnant kidney model. Journal of the American Society of Nephrology. 15. 2004
  - Tranilast reduces mesenteric vascular collagen deposition and chymase-positive mast cells in experimental diabetes. Journal of Diabetes and its Complications. 18. 2004
- Journal Articles Unrefereed Letters or Notes
  - Angiotensin-II induced proteinuria and expression of the podocyte slit pore membrane protein, nephrin. Nephrology, Dialysis, Transplantation. 19. 2004
- Other Refereed Contribution to Refereed Journals
  - Drug therapy for the cardiac complications of diabetes. Drug Discovery Today: Therapeutic Strategies. 1. 2004
2003
- Research Book Chapters
  - Metabolic comorbid conditions in chronic heart failure: diabetes and hypercholesterolaemia. Heart Failure Updates. Martin Dunitz. 2003
- Book Chapters Other
  - The pathogenesis of diabetic nephropathy. Hypertension in diabetes. Martin Dunitz. 2003
- Journal Articles Refereed
  - Are β-blockers as efficacious in patients with diabetes mellitus as in patients without diabetes mellitus who have chronic heart failure? A meta-analysis of large-scale clinical trials. American Heart Journal. 146. 2003
  - COX-2 inhibtion and retinal angiogenesis in a mouse model of retinopathy of prematurity. Investigative Ophthalmology and Visual Science. 44. 2003
  - Comparative metabolic effects of hydrochlorothiazide and indapamide in hypertensive diabetic patients receiving ACE inhibitor therapy. Diabetic Medicine. 20. 2003
  - Direct actions of urotensin II on the heart implications for cardiac fibrosis and hypertrophy. Circulation Research. 93. 2003
  - Does vascular endothelial growth factor (VEGF) play a role in the pathogenesis of minimal change disease?. Nephrology, Dialysis, Transplantation. 18. 2003
  - Mast cell infiltration and chemokine expression in progressive renal disease. Kidney International. 64. 2003
  - Over-expression of platelet-derived growth factor in human diabetic nephropathy. Nephrology, Dialysis, Transplantation. 18. 2003
  - Protein kinase C β inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Diabetes. 52. 2003
  - STI-571 inhibits in vitro angiogenesis. Biochemical and Biophysical Research Communications. 310. 2003
  - The renin-angiotensin system influences ocular endothelial cell proliferation in Diabetes. American Journal of Pathology. 162. 2003
  - Tranilast attenuates vascular hypertrophy, matrix accumulation and growth factor overexpression in experimental diabetes. Diabetes & Metabolism. 29. 2003
  - Urinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathy. Diabetes Care. 26. 2003
  - Vascular endothelial growth factor expression and glomerular endothelial cell loss in the remnant kidney model. Nephrology, Dialysis, Transplantation. 18. 2003
- Journal Articles Unrefereed
  - Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy. Nephron Physiology. 95. 2003
- Other Refereed Contribution to Refereed Journals
  - Demographics and concomitant disorders in heart failure. The Lancet. 362. 2003
  - The renin-angiotensin system and the long-term complications of diabetes: pathophysiological and therapeutic considerations. Diabetic Medicine. 20. 2003
  - Urotensin II: a new player in vascular and myocardial disease?. Clinical Science. 104. 2003
2002
- Journal Articles Refereed
  - Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2rats. Kidney International. 61. 2002
  - Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activites of matrix metalloproteinases. Diabetologia. 45. 2002
  - Expression of the slit-diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of anti-proteinuric therapies. Nephrology, Dialysis, Transplantation. 17. 2002
  - Progression of tubulointerstitial injury by osteopontin-induced macrophage recruitment in advanced diabetic nephropathy of transgenic (mREN-2)27 rats. Nephrology, Dialysis, Transplantation. 17. 2002
  - Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition. Diabetologia. 45. 2002
  - Renal ischemia-reperfusion increases endothelial VEGFR-2 without increasing VEGF or VEGFR-1 expression. Kidney International. 61. 2002
  - Urinary transforming growth factor-β excretion in patients with hypertension, type 2 diabetes, and elevated albumin excretion rate. Diabetes Care. 25. 2002
2001
- Journal Articles Refereed
  - Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy. Journal of the American Society of Nephrology. 12. 2001
  - Angiotensin and Renal Fibrosis. Contributions to Nephrology. 135. 2001
  - Angiotensin-converting enzyme inhibition attenuates renal platelet-derived growth factor gene expression and cell proliferation in subtotal nephrectomy.. Nephrology. 6. 2001
  - Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis. Journal of Hepatology. 35. 2001
  - Long-term Comparison Between Perindopril and Nifedipine in Normotensive Patients With Type 1 Diabetes and Microalbuminuria.. American Journal of Kidney Diseases. 37. 2001
  - Nephropathy in type 2 diabetes: current therapeutic strategies.. Nephrology. 6. 2001
  - PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis.. Kidney International. 59. 2001
  - Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockade.. Diabetologia. 44. 2001
  - The interaction between the Renin-Angiotensin System and Vascular Endothelial Growth Factor in the Pathogenesis of Retinal Neovascularization in Diabetes.. Journal of Vascular Research. 38. 2001
  - Transforming growth factor-beta1 and tumor growth factor-beta-inducible gene-H3 in nonrenal transplant cyclosporing nephropathy.. Transplantation. 72. 2001
  - Urinary transforming growth factor-beta in patients with diabetic nephropathy: implications for the pathogenesis of tubulointerstitial pathology.. Nephrology, Dialysis, Transplantation. 16. 2001
  - Vasopeptidase inhibition attenuates the progression of renal injury in subtotal nephrectomized rats. Kidney International. 60. 2001
- Journal Articles Unrefereed
  - Novel approaches to the treatment of progressive renal disease.. Current Opinion in Pharmacology. 1. 2001
- Journal Articles Unrefereed Letters or Notes
  - Letter to the Editor. Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes.. New England Journal of Medicine. 345. 2001
  - Renal protection by angiotensin II receptor antagonists in patients with type 2 diabetes.. Medical Journal of Australia. 175. 2001

Research

Investigator on

Contract
- EFFECT OF UROTENSIN II ANATGONISM IN A RAT MODEL OF PRESSURE-OVERLOAD HYPERTROPHY awarded by GLAXOSMITHKLINE AUSTRALIA PTY LTD (GSK) 2006 - 2009
- BLOCKADE OF RENIN INHIBITION IN EXPERIMENTAL DIABETIC NEPHROPATHY: EFFECTS OF ALISKIREN awarded by NOVARTIS INSTITUTES OF BIOMEDICAL RESEARCH 2005 - 2006
- MEASUREMENT OF URINARY TGF-BETA IN LY333531 TREATED PATIENTS awarded by ELI LILLY AUST PTY LTD 2005 - 2006
- Novel Therapies in Rats with Progressive Renal Disease awarded by GLAXOSMITHKLINE AUSTRALIA PTY LTD (GSK) 2002 - 2007
Grant
- NOVEL THERAPEUTIC STRATEGIES TO REDUCE THE BURDEN OF CHRONIC HEART FAILURE (Program Grants) awarded by MONASH UNIVERSITY 2005 - 2009
- A new model of diabetic cardiomyopathy; structural, functional and molecular biological aspects (Postgraduate Medical Research Scholarships) awarded by NATIONAL HEART FOUNDATION 2003 - 2005
- GLAXOSMITHKLINE FELLOWSHIP IN EPILEPSY - Populated from Themis conversion (GSK Post Graduate Support Grant) awarded by GLAXOSMITHKLINE AUSTRALIA PTY LTD (GSK) 2002 - 2006
- Novel strategies for the early identification, prevention and treatment of the microvascular complications of diabetes (NHMRC/JDRF Special Program Grants in Type 1 Diabetes) awarded by NHMRC 2002 - 2006
- The role of the mast cell in left ventricular remodeling following myocardial infarction (Medical & Dental Postgraduate Scholarships) awarded by NHMRC 2002 - 2005

Awards

Education and training

PhD, Institution not known
MB, Institution not known
BS, Institution not known

Awards and honors

Fellow of the Royal Australasian College of Physicians, 2004

Supervision

Available for supervision

Y

Contact Details
- rgilbert@unimelb.edu.au
- 03 9288 2574
- fax: 03 9288 2581
- Location
  - Level: Room:, Clinical Sciences Block, St Vincents Hospital
Graduate Study
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