Antibody dependent cellular cytotoxicity (a neglected anti-HIV immune response)
CD4 T cell subsets: what really counts in preventing HIV disease?
Combined Influenza-AIDS vaccines
HIV vaccines to induce broadly neutralising antibodies
How fast do anti-HIV T cells kill infected cells? (differences in killing kinetics across HIV vaccines)
Immune escape. (We are studying how immune pressures result in immune escape variants and the impact this has on the fitness of the virus)
Immune therapy. (We have shown that reinfusing autologous cells coated with overlapping peptide (termed OPAL) can induce high levels of T cell immunity)
Nanoparticle vaccines. (We are investigating these vaccines which have the potential for controlled release of important HIV vaccine antigens)
Utility of anti-envelope T cell immunity
Professor Kent trained as an infectious diseases physician, immunologist and HIV vaccine scientist in Melbourne and the USA. As a physician-scientist he is national leader in developing and testing HIV vaccines and is internationally recognised in this important field. He developed and manages a biologically secure facility to test promising HIV vaccines, one of very few in the Southern hemisphere. Vaccine concepts tested in recent years have shown sufficient promise to progress into human clinical trials. Further, his lab has developed exciting leads on analysing immune responses and immune evasion from HIV that provide unique insights into the usefulness of various immune responses. This in turn helps guide better vaccine design. Dr Kent~s group has over 150 scientific publications. Dr Kent is confident that one day, with sufficient intellectual capability and effort worldwide, we will be able to provide protection from HIV and AIDS through vaccination. Dr Kent remains active in infectious diseases clinical medicine at the Alfred Hospital and Melbourne Sexual Health Centre, caring for people with HIV/AIDS and assisting in the clinical development of new vaccine strategies. He keeps active hiking, biking and running. Dr Kent manages a vibrant laboratory of Post-doctoral fellows, research assistants and students. Stephen was recently honored to recieve the Peter Doherty Outstanding PhD Supervisor award from the University of Melbourne and a National Citation for Outstanding Contribution to Student Learning, reflecting the good fortune he~s had to have a great crop of PhD studentsand dedicated staff come through the lab. Recent news from the lab can be found at the website: http://www.microbiol.unimelb.edu.au/research/virology/kent/index.html
The Kent laboratory at the University of Melbourne has had great success in training excellent PhD and Honours students over the years. Prof Kent was recently honored to recieve the Peter Doherty Outstanding PhD Supervisor award from the University of Melbourne. All our Honours students have achieved First Class Honours, and our PhD students are highly productive, producing several first- and co-authored scientific publications. Our PhD students typically finish in under 3.5 years, well below the average time taken. Many recent Australian PhD students have received prestigious NHMRC post doctoral fellowships to continue their research. Our philosophy is that it is important for students to learn to become very productive in the scientific world and to do all we can to facilitate their move to the next stage of their career. We are always happy to hear from potential students. Interested students should review our projects and publications pages, and email their CV and transcripts to firstname.lastname@example.org. Prospective PhD students should also see the Melbourne School of Graduate Research website for eligibility criteria and scholarship information.