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PROF John Zalcberg

Positions

Honorary, Medicine - St Vincent's Hospital

Publications

Selected publications

2019
- Journal Articles
  - Clearing the air: towards agreement about access to high cost cancer medicines. Annals of Oncology. 30. 2019
  - Development of a binational thyroid cancer clinical quality registry: A protocol paper. BMJ Open. 9. 2019
  - Monitoring quality of care for patients with pancreatic cancer: a modified Delphi consensus. HPB: The Official Journal of the IHPBA. 21. 2019
  - The 4th St. Gallen EORTC Gastrointestinal Cancer Conference: Controversial issues in the multimodal primary treatment of gastric, junctional and oesophageal adenocarcinoma. European Journal of Cancer. 112. 2019
2018
- Journal Articles
  - Telehealth models could be extended to conducting clinical trials—a teletrial approach. European Journal of Cancer Care. 27. 2018
  - Towards a strategy for clinical quality registries in Australia. Australian Health Review. 2018
- Journal Articles Refereed
  - Age does not influence efficacy of ramucirumab in advanced gastric cancer: Subgroup analyses of REGARD and RAINBOW. Journal of Gastroenterology and Hepatology. 33. 2018
  - Biosimilars are coming: ready or not. Internal Medicine Journal. 48. 2018
  - Consensus statement on essential patient characteristics in systemic treatment trials for metastatic colorectal cancer: Supported by the ARCAD Group. European Journal of Cancer. 100. 2018
  - Exploring patient-reported outcomes following percutaneous coronary intervention: A qualitative study. Health Expectations. 21. 2018
  - Feasibility of 5-fluorouracil pharmacokinetic monitoring using the My-5FU PCM (TM) system in a quaternary oncology centre. Cancer Chemotherapy and Pharmacology. 82. 2018
  - Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial 2018
  - Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project. Journal of the National Cancer Institute. 110. 2018
  - Symptoms and feelings valued by patients after a percutaneous coronary intervention: a discrete-choice experiment to inform development of a new patient-reported outcome. BMJ Open. 8. 2018
- Journal Articles Unrefereed
  - Understanding and Communicating Measures of Treatment Effect on Survival: Can We Do Better?. Journal of the National Cancer Institute. 110. 2018
- Journal Articles Unrefereed Letters or Notes
  - Telehealth. New England Journal of Medicine. 378. 2018
  - The value of participating in clinical trials: the whole is greater than the sum of its parts. Medical Journal of Australia. 209. 2018
- Other Refereed Contribution to Refereed Journals
  - Rationale, Opportunities, and Reality of Biosimilar Medications. New England Journal of Medicine. 379. 2018
2017
- Journal Articles
  - Germline polymorphisms as biomarkers of tumor response in colorectal cancer patients treated with anti-EGFR monoclonal antibodies: a systematic review and meta-analysis 2017
- Journal Articles Refereed
  - An International Collaborative Standardizing a Comprehensive Patient-Centered Outcomes Measurement Set for Colorectal Cancer. JAMA Oncology. 3. 2017
  - An appraisal of analytical tools used in predicting clinical outcomes following radiation therapy treatment of men with prostate cancer: A systematic review. Radiation Oncology. 12. 2017
  - Optimum Tools for Predicting Clinical Outcomes in Prostate Cancer Patients Undergoing Radical Prostatectomy: A Systematic Review of Prognostic Accuracy and Validity 2017
  - Patient-Reported Outcomes After Radiation Therapy in Men With Prostate Cancer: A Systematic Review of Prognostic Tool Accuracy and Validity. International Journal of Radiation: Oncology - Biology - Physics. 98. 2017
  - Safety and tolerability of veliparib combined with capecitabine plus radiotherapy in patients with locally advanced rectal cancer: a phase 1b study 2017
  - TOPGEAR: A Randomized, Phase III Trial of Perioperative ECF Chemotherapy with or Without Preoperative Chemoradiation for Resectable Gastric Cancer: Interim Results from an International, Intergroup Trial of the AGITG, TROG, EORTC and CCTG. Annals of Surgical Oncology. 24. 2017
  - Ten-Year Progression-Free and Overall Survival in Patients With Unresectable or Metastatic GI Stromal Tumors: Long-Term Analysis of the European Organisation for Research and Treatment of Cancer, Italian Sarcoma Group, and Australasian Gastrointestinal Trials Group Intergroup Phase III Randomized Trial on Imatinib at Two Dose Levels. Journal of Clinical Oncology. 35. 2017
  - Tools for Predicting Clinical and Patient-reported Outcomes in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Systematic Review of Prognostic Accuracy and Validity 2017
  - Tools for predicting patient-reported outcomes in prostate cancer patients undergoing radical prostatectomy: A systematic review of prognostic accuracy and validity. Prostate Cancer and Prostatic Diseases. 20. 2017
- Journal Articles Unrefereed Letters or Notes
  - A need to simplify informed consent documents in cancer clinical trials. A position paper of the ARCAD Group. Annals of Oncology. 28. 2017
  - Do all services provided as part of a clinical trial require research ethics and governance review?. Internal Medicine Journal. 47. 2017
  - “Mind the Gap” Revisited. Seminars in Oncology. 44. 2017
- Conference Papers Refereed
  - 3rd St. Gallen EORTC Gastrointestinal Cancer Conference: Consensus recommendations on controversial issues in the primary treatment of pancreatic cancer. European Journal of Cancer. 2017
2016
- Research Book Chapters
  - Colorectal cancer. Oxford Textbook of Oncology. Oxford University Press. 2016
- Journal Articles
  - Advances in Molecular Pathology and Treatment of Periampullary Cancers. Pancreas. 45. 2016
  - Development of South Australian-Victorian Prostate Cancer Health Outcomes Research Dataset. BMC Research Notes. 9. 2016
  - Enough is enough … a call to action to improve ethical and governance review processes in Australia. Internal Medicine Journal. 46. 2016
  - Erratum: Corrigendum to “2nd St. Gallen EORTC Gastrointestinal Cancer Conference: Consensus recommendations on controversial issues in the primary treatment of rectal cancer” (European Journal of Cancer (2016) 68 (208–209) (S0959804916320780) (10.1016/j.ejca.2016.04.010)). European Journal of Cancer. 68. 2016
  - Oxaliplatin and 5-FU/folinic acid (modified FOLFOX6) with or without aflibercept in first-line treatment of patients with metastatic colorectal cancer: the AFFIRM study. Annals of Oncology. 27. 2016
  - Reply. Cancer Research. 51. 2016
  - Second St. Gallen European Organisation for Research and Treatment of Cancer Gastrointestinal Cancer Conference: Consensus recommendations on controversial issues in the primary treatment of rectal cancer. European Journal of Cancer. 63. 2016
  - Serious adverse event reporting in investigator-initiated clinical trials. Medical Journal of Australia. 204. 2016
- Journal Articles Refereed
  - Fc-gamma Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer. Clinical Cancer Research. 22. 2016
  - Music's Relevance for People Affected by Cancer: A Meta-Ethnography and Implications for Music Therapists. Journal of Music Therapy. 53. 2016
  - Regorafenib for the Treatment of Advanced Gastric Cancer (INTEGRATE): A Multinational Placebo-Controlled Phase II Trial. Journal of Clinical Oncology. 34. 2016
  - TACTIC: a multicentre, open-label, single-arm phase II trial of panitumumab, cisplatin, and gemcitabine in biliary tract cancer. Cancer Chemotherapy and Pharmacology. 78. 2016
  - The impact on health-related quality of life in the first 12 months: A randomised comparison of preoperative short-course radiation versus long-course chemoradiation for T3 rectal cancer (Trans-Tasman Radiation Oncology Group Trial 01.04). European Journal of Cancer. 55. 2016
2015
- Journal Articles
  - Clinical utility of ramucirumab in advanced gastric cancer. Biologics: targets & therapy. 9. 2015
  - Evaluation of efficacy and safety markers in a phase II study of metastatic colorectal cancer treated with aflibercept in the first-line setting. British Journal of Cancer. 113. 2015
  - Gastric cancer: past progress and present challenges. Gastric Cancer. 18. 2015
  - Location of colon cancer (right-sided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17. European Journal of Cancer. 51. 2015
  - NEUROENDOCRINE TUMOURS - MODELS FOR RARE TUMOUR MANAGEMENT. Cancer Forum. 39. 2015
  - Oxaliplatin/5-fluorouracil-based adjuvant chemotherapy as a standard of care for colon cancer in clinical practice: Outcomes of the ACCElox registry. Asia Pacific Journal of Clinical Oncology. 11. 2015
  - Regorafenib plus modified FOLFOX6 as first-line treatment of metastatic colorectal cancer: A phase II trial. European Journal of Cancer. 51. 2015
  - Time to Definitive Failure to the First Tyrosine Kinase Inhibitor in Localized GI Stromal Tumors Treated With Imatinib As an Adjuvant: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Intergroup Randomized Trial in Collaboration With the Australasian Gastro-Intestinal Trials Group, UNICANCER, French Sarcoma Group, Italian Sarcoma Group, and Spanish Group for Research on Sarcomas. Journal of Clinical Oncology. 33. 2015
- Journal Articles Refereed
  - Accepting risk in the acceleration of drug development for rare cancers. Lancet Oncology. 16. 2015
  - An overview of experimental and investigational multikinase inhibitors for the treatment of metastatic colorectal cancer. Expert Opinion on Investigational Drugs. 24. 2015
  - Development and validation of prognostic nomograms for metastatic gastrointestinal stromal tumour treated with imatinib. European Journal of Cancer. 51. 2015
  - TOPGEAR: a randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG). BMC Cancer. 15. 2015
  - Views of Australian Medical Oncologists Regarding the Use of Mismatch Repair Status to Assist Adjuvant Chemotherapy Recommendations for Patients With Early-Stage Colon Cancer. Clinical Colorectal Cancer. 14. 2015
2014
- Journal Articles
  - PIK3CA, BRAF, and PTEN Status and Benefit from Cetuximab in the Treatment of Advanced Colorectal Cancer-Results from NCIC CTG/AGITG CO.17. Clinical Cancer Research. 20. 2014
  - Realising opportunities for evidence-based cancer service delivery and research: Linking cancer registry and administrative data in Australia. European Journal of Cancer Care. 23. 2014
  - Registry of gastric cancer treatment evaluation (REGATE): I baseline disease characteristics. Asia Pacific Journal of Clinical Oncology. 10. 2014
- Journal Articles Refereed
  - "A quiet still voice that just touches": music's relevance for adults living with life-threatening cancer diagnoses. Supportive Care in Cancer. 22. 2014
  - Adjuvant therapy for colorectal cancer. Cancer Forum. 38. 2014
  - Bespoke treatment: Drivers beware!. Asia Pacific Journal of Clinical Oncology. 10. 2014
  - Controversies in the management of gastrointestinal stromal tumors. Asia Pacific Journal of Clinical Oncology. 10. 2014
  - Epiregulin gene expression as a biomarker of benefit from cetuximab in the treatment of advanced colorectal cancer. British Journal of Cancer. 110. 2014
  - Phase II trial evaluating the feasibility of interdigitating folfox with chemoradiotherapy in locally advanced and metastatic rectal cancer. British Journal of Cancer. 111. 2014
  - Quality of Life in Patients With K-RAS Wild-Type Colorectal Cancer. Cancer. 120. 2014
  - Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. The Lancet. 383. 2014
  - Regorafenib in gastrointestinal stromal tumors: clinical evidence and place in therapy. Therapeutic Advances in Medical Oncology. 6. 2014
  - The relationship between rash, tumour KRAS mutation status and clinical and quality of life outcomes in patients with advanced colorectal cancer treated with cetuximab in the NCIC CTG/AGITG CO.17. Acta Oncologica. 53. 2014
- Other Refereed Contribution to Refereed Journals
  - Broken doctor-patient relationships: why won't they listen? Patient-doctor relationships may break down. We present and discuss a hypothetical case. Medical Journal of Australia. 201. 2014
2013
- Journal Articles
  - Reducing clinical trial monitoring resource allocation and costs through remote access to electronic medical records. Journal of Oncology Practice. 9. 2013
- Journal Articles Refereed
  - A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer. Journal of Hematology & Oncology. 6. 2013
  - A phase I trial of imatinib in combination with mFOLFOX6-bevacizumab in patients with advanced colorectal cancer. Cancer Chemotherapy and Pharmacology. 71. 2013
  - Registry of gastric cancer treatment evaluation (REGATE): II treatment practice. Asia Pacific Journal of Clinical Oncology. 9. 2013
  - Sound Continuing Bonds with the Deceased: The Relevance of Music, Including Preloss Music Therapy, for Eight Bereaved Caregivers. Death Studies. 37. 2013
- Other Refereed Contribution to Refereed Journals
  - Clinical Trials - Advancing National Cancer Care. Cancer Forum. 37. 2013
2012
- Journal Articles
  - Single-agent irinotecan or 5-fluorouracil and leucovorin (FOLFIRI) as second-line chemotherapy for advanced colorectal cancer; results of a randomised phase II study (DaVINCI) and meta-analysis (vol 47, pg 1826, 2011). European Journal of Cancer. 48. 2012
- Journal Articles Refereed
  - Current and emerging strategies for the management of imatinib-refractory advanced gastrointestinal stromal tumors. Therapeutic Advances in Medical Oncology. 4. 2012
  - Dose optimization of tyrosine kinase inhibitors to improve outcomes in GIST.. Asia Pacific Journal of Clinical Oncology. 8. 2012
  - Highlights of the EORTC st. gallen international expert consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer - Differential treatment strategies for subtypes of early gastroesophageal cancer. European Journal of Cancer. 48. 2012
  - Randomized Trial of Short-Course Radiotherapy Versus Long-Course Chemoradiation Comparing Rates of Local Recurrence in Patients With T3 Rectal Cancer: Trans-Tasman Radiation Oncology Group Trial 01.04. Journal of Clinical Oncology. 30. 2012
- Journal Articles Unrefereed Letters or Notes
  - Comparative effectiveness research - a proposal for a new NHMRC funding stream. Medical Journal of Australia. 196. 2012
- Other Refereed Contribution to Refereed Journals
  - The Role of Biological Agents in the Resection of Colorectal Liver Metastases. Clinical Oncology. 24. 2012
2011
- Research Book Chapters
  - Gastrointestinal Stromal Tumors. GASTROINTESTINAL ONCOLOGY: A PRACTICAL GUIDE. Springer Verlag. 2011
- Journal Articles
  - Biological markers in patients with early-stage colon cancer: Consensus and controversies. Current Colorectal cancer Reports. 7. 2011
  - Overview of controversies in oesophagogastric cancer. Cancer Forum. 35. 2011
  - The diagnosis and management of gastric cancer: expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2010. Annals of Oncology. 22. 2011
- Journal Articles Refereed
  - A survey of reimbursement practices of private health insurance companies for pharmaceuticals not covered under the Pharmaceutical Benefits Scheme 2008. Australian Health Review. 35. 2011
  - Delivering affordable cancer care in high-income countries. Lancet Oncology. 12. 2011
  - Music Among Family Carers of People With Life-Threatening Cancer. Music and Medicine. 3. 2011
  - Phase I trial of docetaxel, cisplatin and concurrent radical radiotherapy in locally advanced oesophageal cancer. British Journal of Cancer. 104. 2011
  - Single-agent irinotecan or 5-fluorouracil and leucovorin (FOLFIRI) as second-line chemotherapy for advanced colorectal cancer; results of a randomised phase II study (DaVINCI) and meta-analysis. European Journal of Cancer. 47. 2011
  - Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis. Lancet Oncology. 12. 2011
- Journal Articles Unrefereed Letters or Notes
  - What constitutes a multidisciplinary team meeting?. Asia-Pacific Journal of Clinical Oncology. 7. 2011
- Other Refereed Contribution to Refereed Journals
  - Neurofibromatosis type 1-associated wild-type gastrointestinal stromal tumor treated with anti-IGF-1R monoclonal antibody. Medical Oncology. 28. 2011
2010
- Journal Articles Refereed
  - Association of KRAS p.G13D Mutation With Outcome in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer Treated With Cetuximab. JAMA: Journal of the American Medical Association. 304. 2010
  - Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: Results of the Australasian gastrointestinal trials group randomized Phase III MAX study. Journal of Clinical Oncology. 28. 2010
- Journal Articles Unrefereed
  - Randomised, non-comparative phase II study of weekly docetaxel with cisplatin and 5-fluorouracil or with capecitabine in oesophagogastric cancer: the AGITG ATTAX trial. British Journal of Cancer. 102. 2010
- Journal Articles Unrefereed Letters or Notes
  - Antitumor Effect of Somatostatin Analogs in Neuroendocrine Tumors. Journal of Clinical Oncology. 28. 2010
2009
- Journal Articles
  - A phase I trial of Capecitabine plus Gemcitabine with radical radiation for locally advanced pancreatic cancer. British Journal of Cancer. 100. 2009
  - Radiology reporting templates in oncology: A time for change. Journal of Medical Imaging and Radiation Oncology. 53. 2009
- Journal Articles Refereed
  - To Tell or Not to Tell: The Community Wants to Know About Expensive Anticancer Drugs As a Potential Treatment Option. Journal of Clinical Oncology. 27. 2009
- Other Refereed Contribution to Refereed Journals
  - Discussing Expensive Anticancer Drugs. Journal of Clinical Oncology. 27. 2009
2008
- Journal Articles
  - A phase II study of the heparanase inhibitor PI-88 in patients with advanced melanoma. Investigational New Drugs. 26. 2008
  - Progress and challenges in the adjuvant treatment of stage II and III colon cancers. Expert Review of Anticancer Therapy. 8. 2008
  - Progress in targeted therapies for cancer: Overview. Cancer Forum. 32. 2008
  - The diagnosis and management of rectal cancer: expert discussion and recommendations derived from the 9th World Congress on Gastrointestinal Cancer, Barcelona, 2007. Annals of Oncology. 19. 2008
- Journal Articles Refereed
  - K-ras mutations and benefit from cetuximab in advanced colorectal cancer. New England Journal of Medicine. 359. 2008
  - Optimizing the dose of imatinib for treatment of gastrointestinal stromal tumours: lessons from the phase 3 trials. European Journal of Cancer. 44. 2008
  - Pancreatic cancer—is the wall crumbling?. Annals of Oncology. 19. 2008
- Journal Articles Unrefereed Letters or Notes
  - Role of palifermin in fluorouracil-based therapy for metastatic colorectal cancer. Journal of Clinical Oncology. 26. 2008
2007
- Journal Articles
  - Modification of leucovorin dose within a simplified FOLFOX regimen improves tolerability without compromising efficacy. Clinical Colorectal Cancer. 6. 2007
  - NCCN task force report: Management of patients with Gastrointestinal Stromal Tumor (GIST) - Update of the NCCN clinical practice guidelines. Journal of the National Comprehensive Cancer Network. 5. 2007
  - Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis. Lancet Oncology. 8. 2007
- Journal Articles Refereed
  - A phase I/II trial of celecoxib with chemotherapy and radiotherapy in the treatment of patients with locally advanced oesophageal cancer. Investigational New Drugs. 25. 2007
  - Cetuximab for the treatment of colorectal cancer. New England Journal of Medicine. 357. 2007
- Other Refereed Contribution to Refereed Journals
  - Severe hypoglycaemia after long-acting octreotide in a patient with an unrecognized malignant insulinoma. Internal Medicine Journal. 37. 2007
- Conference Proceedings
  - The management of pancreatic cancer. Current expert opinion and recommendations derived from the 8th World Congress on Gastrointestinal Cancer, Barcelona, 2006. Annals of Oncology. 2007
2006
- Journal Articles
  - Addition of gabapentin to a modified FOLFOX regimen does not reduce oxaliplatin-induced neurotoxicity. Clinical Colorectal Cancer. 6. 2006
  - Adjuvant and neoadjuvant therapy for gastric carcinoma: An evidence-based review. American Journal of Cancer. 5. 2006
  - KIT immunohistochemistry and mutation status in gastrointestinal stromal tumours (GISTs) evaluated for treatment with imatinib. Histopathology. 49. 2006
  - KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. European Journal of Cancer. 42. 2006
  - Pathological response of gastrointestinal stromal tumour to imatinib treatment correlates with tumour KIT mutational status in individual tumour clones. Histopathology. 49. 2006
  - Recent developments in the systemic therapy of advanced gastroesophageal malignancies. Expert Opinion on Investigational Drugs. 15. 2006
  - Special section on music therapy. Journal of the Society for Integrative Oncology. 4. 2006
  - The multidisciplinary management of patients with cancer. Annals of Oncology. 17. 2006
  - The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study. British Journal of Cancer. 95. 2006
- Journal Articles Refereed
  - Relationship of Hepatic Functional Imaging to Irinotecan Pharmacokinetics and Genetic Parameters of Drug Elimination. Clinical Oncology. 24. 2006
2005
- Journal Articles
  - Australian experience of a modified schedule of FOLFOX with high activity and tolerability and improved convenience in untreated metastatic colorectal cancer patients. British Journal of Cancer. 92. 2005
  - Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs. Oncogene. 24. 2005
  - Erratum: An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin (Cancer Research (May 15, 2005) 65 (4031-4040)). Cancer Research. 65. 2005
  - Evidence-based adjuvant treatment of resectable pancreatic adenocarcinoma. American Journal of Cancer. 4. 2005
  - Recent advances in the systemic therapy of metastatic colorectal cancer. American Journal of Cancer. 4. 2005
- Journal Articles Refereed
  - An Expression-Based Site of Origin Diagnostic Method Designed for Clinical Application to Cancer of Unknown Origin. Cancer Research. 65. 2005
  - Medical paternalism and expensive unsubsidised drugs. British Medical Journal. 331. 2005
  - Oxaliplatin combined with infusional 5-fluorouracil and concomitant radiotherapy in inoperable and metastatic rectal cancer: a phase 1 trial. British Journal of Cancer. 92. 2005
  - Signal Therapy of Breast Cancers by the HDAC Inhibitor FK228 that blocks the activation of PAK1 and Abrogates the Tamoxifen-Resistance. Cancer Biology & Therapy. 4. 2005
- Journal Articles Unrefereed Letters or Notes
  - The Contribution of Cytotoxic Chemotherapy to the Management of Cancer. Clinical Oncology. 17. 2005
- Other Refereed Contribution to Refereed Journals
  - Beyond 5-fluorouracil: new horizons in systemic therapy for advanced colorectal cancer. Expert Opinion on Investigational Drugs. 14. 2005
  - Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800mg after progression on 400mg. European Journal of Cancer. 41. 2005
- Conference Proceedings
  - Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Annals of Oncology. 2005
2004
- Journal Articles Refereed
  - A novel combination of cisplatin, irinotecan, and capecitabine in patients with advanced cancer. Investigational New Drugs. 22. 2004
  - A phase I trial of preoperative radiotherapy and capecitabine for locally advanced, potentially resectable rectal cancer. British Journal of Cancer. 91. 2004
- Journal Articles Unrefereed Letters or Notes
  - How should we introduce clinical positron emission tomography in the UK? Oncologists need to have a (clearer) view. Clinical Oncology. 16. 2004
- Other Refereed Contribution to Refereed Journals
  - Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib:randomised trial. The Lancet. 364. 2004
  - Rapid screening for depression- validation of the Brief Case-Find for Depression (BCD) in medical oncolodgy and palliative care patients. British Journal of Cancer. 91. 2004
  - Systemic or regional chemotherapy for liver metastases from colorectal cancer: has the wheel stopped spinning?. The Cancer Journal. 10. 2004
2003
- Book Chapters Other
  - The treatment of carcinoma of the colon and rectum. Evidence-based oncology. BMJ Publishing Group. 2003
- Journal Articles Refereed
  - A phase I dose-escalation study of docetaxel with granulocyte colony-stimulating factor support in patients with solid tumours. Annals of Oncology. 14. 2003
  - Adjuvant and neoadjuvant therapy for gastric cancer using epirubicin/cisplatin/5-fluorouracil (ECF) and alternative regimens before and after chemoradiation. British Journal of Cancer. 89. 2003
  - Applications of Positron Emission tomography in the development of molecular targeted cancer therapeutics. BioDrugs. 17. 2003
- Journal Articles Unrefereed Letters or Notes
  - A case report of oxaliplatin extravasation. Annals of Oncology. 14. 2003
  - Is improving local control sufficient indication for radiotherapy in the management of rectal cancer? A response. ANZ Journal of Surgery. 73. 2003
- Other Refereed Contribution to Refereed Journals
  - Palliative chemotherapy: a clinical oxymoron. The Lancet. 362. 2003
2002
- Journal Articles
  - Adjuvant therapy for rectal cancer 2002
  - Efficacy, tolerability and management of raltitrexed (Tomudex (TM)) monotherapy in patients with advanced colorectal cancer: a review of phase II/III trials. European Journal of Cancer. 38. 2002
  - Phase I and pharmacokinetic study of docetaxel in combination with epirubicin and cyclophosphamide in advanced cancer: dose escalation possible with granulocyte colony-stimulating factor, but not with prophylactic antibiotics. Annals of Oncology. 13. 2002
  - Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation. Molecular and Cellular Biology. 22. 2002
  - Variability in administration of 5-fluorouracil and folinic acid in standard treatment regimens for advanced colorectal cancer. Internal Medicine Journal. 32. 2002
- Journal Articles Refereed
  - Rectal cancer in Victoria in 1994: Patterns of reported management. ANZ Journal of Surgery. 72. 2002
2001
- Journal Articles
  - Adjuvant radiotherapy for rectal cancer: A systematic overview of 8507 patients from 22 randomised trials. The Lancet. 358. 2001
  - Chemotherapy for advanced colorectal cancer. British Medical Journal (Clinical Research Edition). 322. 2001
  - Pilot study of oral eniluracil/5-FU in the palliation of hormone-refractory prostate cancer 2001
- Journal Articles Refereed
  - Randomized trial of coordinated psychosocial interventions based on patient self-assessments versus standard care to improve the psychosocial functioning of patients with cancer.. Journal of Clinical Oncology. 19. 2001
  - Training general practitioners in flexible sigmoidoscopy to screen for colorectal cancer.. ANZ Journal of Surgery. 71. 2001
2000
- Journal Articles
  - A phase I trial of docetaxel and gemcitabine in patients with advanced cancer. Annals of Oncology. 11. 2000
  - Chemotherapy for advanced colorectal cancer: It can improve quality of care and offer modest increases in survival. British Medical Journal (Clinical Research Edition). 321. 2000
  - Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer. Journal of Clinical Oncology. 18. 2000
  - MRP1 not MDR1 gene expression is the predominant mechanism of acquired multidrug resistance in two prostate carcinoma cell lines. Prostate Cancer and Prostatic Diseases. 3. 2000
  - Open label, multi-centre phase II study of raltitrexed ('Tomudex') in patients with inoperable squamous-cell carcinoma of head and neck. Annals of Oncology. 11. 2000
  - Regulation of MDR1 gene expression: emerging concepts. Drug Resistance Update. 3. 2000
  - The optimal 5-fluorouracil regimen for the adjuvant therapy of colon cancer: Where to from here?. Annals of Oncology. 11. 2000
  - Use of (F-18)-fluorodeoxyglucose positron emission tomography in monitoring response of recurrent neurotropic desmoplastic melanoma to radiotherapy. Otolaryngology-Head and Neck Surgery. 122. 2000
1999
- Journal Articles
  - Absolute quantitation of MDR1 transcripts using heterologous DNA standards - Validation of the competitive RT-PCR (CRT-PCR) approach. Biotechniques. 26. 1999
  - Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line. British Journal of Cancer. 79. 1999
  - Altered multidrug resistance phenotype caused by anthracycline analogues and cytosine arabinoside in myeloid leukemia. Blood. 93. 1999
  - Colorectal cancer (multiple letters) 1. Medical Journal of Australia. 170. 1999
  - Does biomodulation of 5-fluorouracil improve results?. European Journal of Cancer. 35. 1999
  - Gemcitabine and the blood brain barrier. Australian and New Zealand Journal of Medicine. 29. 1999
  - Induction of MDR1 gene expression by anthracycline analogues in a human drug resistant leukaemia cell line. British Journal of Cancer. 79. 1999
  - Induction of insulin-like growth factor binding protein expression by ICI 182,780 in a tamoxifen-resistant human breast cancer cell line. Breast Cancer Research and Treatment. 55. 1999
  - Overview of docetaxel (Taxotere)/cisplatin combination in non-small cell lung cancer. Seminars in Oncology. 26. 1999
  - Phase I and subsequent phase II study of filgrastim (r-met-HuG-CSF) and dose intensified cyclophosphamide plus epirubicin in patients with non-Hodgkin's lymphoma and advanced solid tumors. Annals of Oncology. 10. 1999
  - Physical mapping of a tandem duplication on the long arm of chromosome 7 associated with a multidrug resistant phenotype. Cancer Genetics and Cytogenetics. 110. 1999
  - Positron emission tomography (PET): experience with a large-field-of-view three-dimensional PET scanner. Medical Journal of Australia. 171. 1999
  - Repetitive high-dose therapy with ifosfamide, thiotepa and paclitaxel with peripheral blood progenitor cell and filgrastim support for metastatic and locally advanced breast cancer: Results of a phase I study. Annals of Oncology. 10. 1999
1998
- Journal Articles
  - 5-fluorouracil: A pharmacological paradigm in the use of cytotoxics. Clinical and Experimental Pharmacology and Physiology. 25. 1998
  - Edrecolomab (Monoclonal antibody 17-1A). Drugs. 56. 1998
  - Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle number. European Journal of Cancer. 34. 1998
  - Hormone replacement therapy and breast cancer. Medical Journal of Australia. 169. 1998
  - Hormone replacement therapy and breast cancer (multiple letters) 5. Medical Journal of Australia. 169. 1998
  - Phase II study of docetaxel and cisplatin in advanced non-small-cell lung cancer. Journal of Clinical Oncology. 16. 1998
  - Relationships among liver and kidney volumes, lean body mass and drug clearance. British Journal of Clinical Pharmacology. 46. 1998
  - Second line treatment options in advanced colorectal cancer. European Journal of Cancer. 34. 1998
  - Update on adjuvant treatment of colorectal cancer. Current Opinion in Oncology. 10. 1998
1997
- Journal Articles
  - Accuracy of volume measurement using helical CT. Journal of Computer Assisted Tomography. 21. 1997
  - Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance. Clinical Cancer Research. 3. 1997
  - Australian multicentre phase II trial of paclitaxel in women with metastatic breast cancer and prior chemotherapy. Medical Journal of Australia. 166. 1997
  - Clinical issues in euthanasia. Medical Journal of Australia. 166. 1997
  - Erratum: Final results of a randomised trial comparing 'Tomudex'® (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. (Ann Oncol (1996) 7 (9) (961-965)). Annals of Oncology. 8. 1997
  - Expression of mdr1 and mrp in the normal B-cell homologue of B-cell chronic lymphocytic leukaemia. British Journal of Haematology. 96. 1997
  - In vitro binding of mx2 (krn8602) and epirubicin to human plasma protein. Pharmacology. 55. 1997
  - Phase I study of paclitaxel and oral etoposide in previously untreated non-small-cell and extensive small-cell lung cancer. Annals of Oncology. 8. 1997
  - Phase I trial of docetaxel and cisplatin in previously untreated patients with advanced non-small-cell lung cancer. Journal of Clinical Oncology. 15. 1997
  - Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood. 89. 1997
  - Sequential extraction of DNA and DNA-binding proteins from low cell numbers. Biotechniques. 22. 1997
- Conference Proceedings
  - Overview of the tolerability of 'Tomudex' (raltitrexed): Collective clinical experience in advanced colorectal cancer. Anti-Cancer Drugs: international journal on anti-cancer agents. 1997
1996
- Journal Articles
  - 'Tomudex' (ZD1694): A novel thymidylate synthase inhibitor with clinical antitumour activity in a range of solid tumours. Annals of Oncology. 7. 1996
  - 'Tomudex' (ZD1694): Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia. European Journal of Cancer. 32. 1996
  - A phase II study in advanced breast cancer: ZD1694 ('Tomudex') a novel direct and specific thymidylate synthase inhibitor. British Journal of Cancer. 74. 1996
  - Bilateral orchidectomy and flutamide versus orchidectomy alone in newly diagnosed patients with metastatic carcinoma of the prostate - An Australian multicentre trial. British Journal of Urology. 77. 1996
  - Cyclosporin a and PSC 833 prevent up-regulation of MDR1 expression by anthracyclines in a human multidrug-resistant cell line. Clinical Cancer Research. 2. 1996
  - Erratum: Treatment principles in advanced colorectal cancer (Australian and New Zealand Journal of Surgery (1996) 66 (202-205)). Australian and New Zeland Journal of Surgery. 66. 1996
  - Final results of a randomised trial comparing 'Tomudex'(R) (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. Annals of Oncology. 7. 1996
  - Hormone replacement therapy and breast cancer: What are the facts? 1. Medical Journal of Australia. 164. 1996
  - Inheritance of chromosome 7 is associated with a drug-resistant phenotype in somatic cell hybrids. British Journal of Cancer. 73. 1996
  - Liver transplantation in metastatic carcinoid tumour. Australian and New Zealand Journal of Medicine. 26. 1996
  - Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine. Biochemical Pharmacology. 52. 1996
  - Outpatient chemotherapy: There's no place like home - sometimes. Medical Journal of Australia. 165. 1996
  - Patients' beliefs about cancer management. Supportive Care in Cancer. 4. 1996
  - The role of 5-fluorouracil dose in the adjuvant therapy of colorectal cancer. Annals of Oncology. 7. 1996
  - The role of chemotherapy in malignant thymoma. Australian and New Zealand Journal of Medicine. 26. 1996
  - Treatment principles in advanced colorectal cancer. Australian and New Zeland Journal of Surgery. 66. 1996
  - Treatment principles in advanced non-small-cell lung cancer. Australian and New Zeland Journal of Surgery. 66. 1996
  - ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. Journal of Clinical Oncology. 14. 1996
1995
- Journal Articles
  - 'Tomudex' (ZD1694): Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia. European Journal of Cancer. 31. 1995
  - Hypoxemia due to right-to-left shunt in the carcinoid syndrome; beneficial response to octreotide. Annals of Oncology. 6. 1995
  - QUALITY OF PHARMACOKINETIC RESEARCH IN ONCOLOGY. British Journal of Cancer. 72. 1995
  - RAPID UP-REGULATION OF MDR1 EXPRESSION BY ANTHRACYCLINES IN A CLASSICAL MULTIDRUG-RESISTANT CELL-LINE. British Journal of Cancer. 71. 1995
  - The euthanasia controversy. Decision-making in extreme circumstances.. Medical Journal of Australia. 163. 1995
  - The pure antiestrogen ICI 182,780 binds to a high‐affinity site distinct from the estrogen receptor. International Journal of Cancer. 62. 1995
1994
- Journal Articles
  - A phase I II study of the intralesional injection of ricin-monoclonal antibody conjugates in patients with hepatic metastases. European Journal of Cancer. 30. 1994
  - CELLULAR AND KARYOTYPIC CHARACTERIZATION OF 2 DOXORUBICIN-RESISTANT CELL-LINES ISOLATED FROM THE SAME PARENTAL HUMAN LEUKEMIA-CELL LINE. International Journal of Cancer. 57. 1994
  - LEAN BODY-MASS, BODY-SURFACE AREA AND EPIRUBICIN KINETICS. Anti-Cancer Drugs: international journal on anti-cancer agents. 5. 1994
  - Multiple atypical nevi: A cutaneous marker of germ cell tumors. Journal of Clinical Oncology. 12. 1994
  - P-GLYCOPROTEIN EXPRESSION IN CLASSICAL MULTIDRUG, RESISTANT LEUKEMIA-CELLS DOES NOT CORRELATE WITH ENHANCED CHLORIDE CHANNEL ACTIVITY. Clinical and Experimental Pharmacology and Physiology. 21. 1994
  - PRESCRIBING OPIOIDS - A PAINFUL EXPERIENCE. Medical Journal of Australia. 161. 1994
  - Safe administration of oral etoposide after hypersensitivity reaction to intravenous etoposide. Anti-Cancer Drugs: international journal on anti-cancer agents. 5. 1994
1993
- Journal Articles
  - Antitumor activity of idarubicin-monoclonal antibody conjugate on multidrug resistant cells 1993
  - Circumvention of tamoxifen resistance by the pure anti‐estrogen ICI 182, 780. International Journal of Cancer. 55. 1993
  - Clinical application of a rapid, functional assay for multidrug resistance based on accumulation of the fluorescent dye, fluo-3. European Journal of Cancer. 29. 1993
  - DIFFERENTIAL-EFFECTS OF ESTROGEN, TAMOXIFEN AND THE PURE ANTIESTROGEN ICI-182,780 IN HUMAN DRUG-RESISTANT LEUKEMIA-CELL LINES. Cancer Chemotherapy and Pharmacology. 33. 1993
  - Migraine following the use of a 5‐hydroxytryptamine antagonist. Australian and New Zealand Journal of Medicine. 23. 1993
1992
- Journal Articles
  - Carboplatin-containing regimens for small cell lung cancer: Implications for management in the elderly. Seminars in Oncology. 19. 1992
  - FAMILIAL OCCURRENCE OF MULTIPLE NONMELANOMA SKIN-CANCER. Cancer Genetics and Cytogenetics. 61. 1992
  - Interaction of epirubicin with other cytotoxics and anti-emetic drugs. Anti-Cancer Drugs: international journal on anti-cancer agents. 3. 1992
  - PHASE-II STUDY OF 10-EDAM IN PATIENTS WITH SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK, PREVIOUSLY UNTREATED WITH CHEMOTHERAPY. Investigational New Drugs. 10. 1992
  - Prolonged release of morphine alkaloid from a lipophilic suppository base in vitro and in vivo 1992
  - RECENT ADVANCES IN THE TREATMENT OF COLORECTAL-CANCER. Australian and New Zealand Journal of Medicine. 22. 1992
  - SKIN-CANCER AND HLA ANTIGENS. New England Journal of Medicine. 326. 1992
  - Serum methotrexate in childhood ALL 2. British Journal of Cancer. 66. 1992
- Conference Proceedings
  - Open phase II study on the efficacy and tolerance of casodex (ICI 176,334), a new nonsteroid antiandrogen, in the treatment of advanced prostate carcinoma 1992
1991
- Journal Articles
  - ADJUVANT THERAPY OF COLORECTAL CANCER: AN OVERVIEW. Australian and New Zeland Journal of Surgery. 61. 1991
  - CIRCUMVENTION OF DOXORUBICIN RESISTANCE IN MULTIDRUG RESISTANT HUMAN LEUKEMIA AND LUNG-CANCER CELLS BY THE PURE ANTIESTROGEN ICI-164384. European Journal of Cancer. 27. 1991
  - Correspondence re: Xiu F. Hu et al., combined use of cyclosporin A and verapamil in modulating multidrug resistance in human leukemia cell lines. Cancer Res., 50: 2953-2957, 1990. 1. Cancer Research. 51. 1991
  - INTERACTION OF CISPLATIN WITH OTHER CYTOTOXICS AND NONSTEROIDAL ANTIINFLAMMATORY DRUGS. Anti-Cancer Drugs: international journal on anti-cancer agents. 2. 1991
  - Rapid functional assay for multidrug resistance in human tumor cell lines using the fluorescent indicator fluo-3. Journal of the National Cancer Institute. 83. 1991
1990
- Journal Articles
  - CHARACTERISTICS OF A BREAST CANCER-ASSOCIATED ANTIGEN DEFINED BY RCC-1 ANTIBODY. Immunology and Cell Biology. 68. 1990
  - Combined Use of Cyclosporin A and Verapamil in Modulating Multidrug Resistance in Human Leukemia Cell Lines. Cancer Research. 50. 1990
  - ETOPOSIDE, CARBOPLATIN, CYCLOPHOSPHAMIDE AND VINCRISTINE IN PREVIOUSLY UNTREATED PATIENTS WITH SMALL-CELL LUNG-CANCER. Cancer Chemotherapy and Pharmacology. 25. 1990
  - Effect of cyclosporin and verapamil on the cellular kinetics of daunorubicin 1990
  - MEDICAL-EDUCATION IN PALLIATIVE CARE. Medical Journal of Australia. 152. 1990
  - Not-for-resuscitation orders in cancer patients - Principles of decision-making. Medical Journal of Australia. 153. 1990
1988
- Journal Articles
  - FLARE RESPONSES IN SMALL CELL-CARCINOMA OF THE LUNG. Clinical Nuclear Medicine. 13. 1988
  - Structure of t cell antigen receptor β chain in synovial fluid cells from patients with rheumatoid arthritis. Arthritis and Rheumatism. 31. 1988
1987
- Journal Articles
  - CARBOPLATIN (CBDCA, JM-8) AND VP-16-213 IN PREVIOUSLY UNTREATED PATIENTS WITH SMALL-CELL LUNG-CANCER. Journal of Clinical Oncology. 5. 1987
  - HETEROGENEITY OF THE HUMAN TRANSFERRIN RECEPTOR AND USE OF ANTI-TRANSFERRIN RECEPTOR ANTIBODIES TO DETECT TUMORS INVIVO. Immunology and Cell Biology. 65. 1987
  - THE USE OF MONOCLONAL-ANTIBODY CONJUGATES FOR THE DIAGNOSIS AND TREATMENT OF CANCER. Immunology and Cell Biology. 65. 1987
  - The presence of clonogenic cells in high-grade malignant lymphoma: A prognostic factor. Blood. 69. 1987
1986
- Journal Articles
  - Molecular evidence for the clonal origin of blast crisis in chronic myeloid leukaemia. British Journal of Cancer. 53. 1986
  - The structure of the T cell gamma chain gene in lymphoproliferative disorders and lymphoma cell lines. Blood. 68. 1986
  - Visualization of metastases from colon carcinoma using an lodine 131‐radiolabeled monoclonal antibody. Cancer. 57. 1986
1985
- Journal Articles
  - APPARENT T-CELL NEOPLASMS WITH IMMUNOGLOBULIN GENE REARRANGEMENTS. The Lancet. 326. 1985
  - Monoclonal antibodies to drugs: Novel diagnostic and therapeutic reagents. Pharmacology and Therapeutics. 28. 1985
  - Phenotypic and molecular characterization of lymphoma cell lines 1985
  - TUMOR-ASSOCIATED ANTIGENS - AN OVERVIEW. Journal of Clinical Oncology. 3. 1985
  - Tumor localization using radiolabeled monoclonal antibodies: An overview. American Journal of Clinical Oncology - Cancer Clinical Trials. 8. 1985
1984
- Journal Articles
  - DESCRIPTION OF A MURINE B-LYMPHOMA TUMOR-SPECIFIC ANTIGEN. Journal of Immunology. 133. 1984
  - TUMOR-IMMUNOTHERAPY IN THE MOUSE WITH THE USE OF I-131-LABELED MONOCLONAL-ANTIBODIES. Journal of the National Cancer Institute. 72. 1984
1983
- Journal Articles
  - HEPARIN-INDUCED THROMBOCYTOPENIA WITH ASSOCIATED DISSEMINATED INTRAVASCULAR COAGULATION. British Journal of Haematology. 54. 1983
  - LOCALIZATION OF HUMAN COLORECTAL TUMOR XENOGRAFTS IN THE NUDE-MOUSE WITH THE USE OF RADIOLABELED MONOCLONAL-ANTIBODY. Journal of the National Cancer Institute. 71. 1983
  - MONOCLONAL-ANTIBODIES TO DRUGS - DIGOXIN. International Journal of Immunopharmacology. 5. 1983
  - TUMOR VISUALIZATION USING A RADIOLABELED MONOCLONAL-ANTIBODY. Australian and New Zealand Journal of Medicine. 13. 1983
1982
- Journal Articles
  - Chronic lymphatic leukemia developing in a patient with multiple myeloma. Immunologic demonstration of a clonally distinct second malignancy. Cancer. 50. 1982
  - HYBRIDOMAS AND MONOCLONAL-ANTIBODIES - APPLICATIONS IN ONCOLOGY. Australian and New Zeland Journal of Surgery. 52. 1982
  - INTRALIPID INDUCED HAEMOLYSIS. British Journal of Haematology. 50. 1982

Research

Investigator on

Contract
- Upper Gastrointestinal Cancer SYMPTOM Study (SYMPTOM-UGI) administered by General Practice 2019 - 2020
Grant
- ESTABLISHMENT OF ACRF ADVANCED CENTRE FOR CANCER CELL ISOLATION AND IMAGING (Research Grants) awarded by AUST CANCER RESEARCH FOUNDATION 2013 - 2020
- CHARACTERISATION OF THE ANTI-APOPTOTIC FUNCTION OF P-GLYCOPROTEIN AND TRANSCRIPTIONAL REGULATION OF THE MDR1 GENE (Project Grants) awarded by NHMRC 2005 - 2007

Awards

Education and training

PhD, University of Melbourne 1983
MBBS, University of Melbourne 1975

Awards and honors

Fellow of the Royal Australasian College of Physicians, 1984

Contact Details
- 03 9656 1749
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  - Level: Room:, No Building, Peter Maccallum Hospital
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