Search

PROF John Zalcberg

Positions

Honorary, Medicine - St Vincent's Hospital

Publications

Selected publications

2019
- Journal Articles
  - Clearing the air: towards agreement about access to high cost cancer medicines. Annals of Oncology. 30. 2019
  - Development of a binational thyroid cancer clinical quality registry: a protocol paper.. BMJ Open. 9. 2019
  - Monitoring quality of care for patients with pancreatic cancer: a modified Delphi consensus. HPB: The Official Journal of the IHPBA. 21. 2019
  - Seven electrocardiographs for seven clinical research studies.. British Medical Journal. 365. 2019
  - The 4th St. Gallen EORTC Gastrointestinal Cancer Conference: Controversial issues in the multimodal primary treatment of gastric, junctional and oesophageal adenocarcinoma. 2019
2018
- Journal Articles
  - Telehealth models could be extended to conducting clinical trials-a teletrial approach. 2018
  - Towards a strategy for clinical quality registries in Australia. Australian Health Review. 2018
- Journal Articles Refereed
  - Age does not influence efficacy of ramucirumab in advanced gastric cancer: Subgroup analyses of REGARD and RAINBOW.. Journal of Gastroenterology and Hepatology. 33. 2018
  - Biosimilars are coming: ready or not.. Internal Medicine Journal. 48. 2018
  - Consensus statement on essential patient characteristics in systemic treatment trials for metastatic colorectal cancer: Supported by the ARCAD Group. 2018
  - Exploring patient-reported outcomes following percutaneous coronary intervention: A qualitative study.. Health Expectations. 21. 2018
  - Feasibility of 5-fluorouracil pharmacokinetic monitoring using the My-5FU PCM (TM) system in a quaternary oncology centre. Cancer Chemotherapy and Pharmacology. 82. 2018
  - Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial 2018
  - Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project. Journal of the National Cancer Institute. 110. 2018
  - Symptoms and feelings valued by patients after a percutaneous coronary intervention: a discrete-choice experiment to inform development of a new patient-reported outcome. BMJ Open. 8. 2018
- Journal Articles Unrefereed
  - Understanding and Communicating Measures of Treatment Effect on Survival: Can We Do Better? 2018
- Journal Articles Unrefereed Letters or Notes
  - Rationale, Opportunities, and Reality of Biosimilar Medications. New England Journal of Medicine. 379. 2018
  - Telehealth. New England Journal of Medicine. 378. 2018
  - The value of participating in clinical trials: the whole is greater than the sum of its parts. Medical Journal of Australia. 209. 2018
2017
- Journal Articles Refereed
- Journal Articles Unrefereed Letters or Notes
  - "Mind the Gap" Revisited. 2017
  - A need to simplify informed consent documents in cancer clinical trials. A position paper of the ARCAD Group.. Annals of Oncology. 28. 2017
  - Do all services provided as part of a clinical trial require research ethics and governance review?. Internal Medicine Journal. 47. 2017
- Conference Papers Refereed
  - 3rd St. Gallen EORTC Gastrointestinal Cancer Conference: Consensus recommendations on controversial issues in the primary treatment of pancreatic cancer. 2017
2016
- Research Book Chapters
  - Colorectal cancer. Oxford Textbook of Oncology. Oxford University Press. 2016
- Journal Articles
  - Advances in Molecular Pathology and Treatment of Periampullary Cancers. 2016
  - Development of South Australian-Victorian Prostate Cancer Health Outcomes Research Dataset.. BMC Research Notes. 9. 2016
  - Enough is enough … a call to action to improve ethical and governance review processes in Australia.. Internal Medicine Journal. 46. 2016
  - Erratum: Corrigendum to “2nd St. Gallen EORTC Gastrointestinal Cancer Conference: Consensus recommendations on controversial issues in the primary treatment of rectal cancer” (European Journal of Cancer (2016) 68 (208–209) (S0959804916320780) (10.1016/j.ejca.2016.04.010)). European Journal of Cancer. 68. 2016
  - Oxaliplatin and 5-FU/folinic acid (modified FOLFOX6) with or without aflibercept in first-line treatment of patients with metastatic colorectal cancer: the AFFIRM study. Annals of Oncology. 27. 2016
  - Reply. Cancer Research. 51. 2016
  - Second St. Gallen European Organisation for Research and Treatment of Cancer Gastrointestinal Cancer Conference: consensus recommendations on controversial issues in the primary treatment of rectal cancer. 2016
  - Serious adverse event reporting in investigator-initiated clinical trials. Medical Journal of Australia. 204. 2016
- Journal Articles Refereed
  - Fc-gamma Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer. Clinical Cancer Research. 22. 2016
  - Music's Relevance for People Affected by Cancer: A Meta-Ethnography and Implications for Music Therapists. Journal of Music Therapy. 53. 2016
  - Regorafenib for the Treatment of Advanced Gastric Cancer (INTEGRATE): A Multinational Placebo-Controlled Phase II Trial. Journal of Clinical Oncology. 34. 2016
  - TACTIC: a multicentre, open-label, single-arm phase II trial of panitumumab, cisplatin, and gemcitabine in biliary tract cancer. Cancer Chemotherapy and Pharmacology. 78. 2016
  - The impact on health-related quality of life in the first 12 months: A randomised comparison of preoperative short-course radiation versus long-course chemoradiation for T3 rectal cancer (Trans-Tasman Radiation Oncology Group Trial 01.04). European Journal of Cancer. 55. 2016
2015
- Journal Articles
  - Clinical utility of ramucirumab in advanced gastric cancer. Biologics: targets & therapy. 9. 2015
  - Evaluation of efficacy and safety markers in a phase II study of metastatic colorectal cancer treated with aflibercept in the first-line setting.. British journal of cancer. 113. 2015
  - Gastric cancer: past progress and present challenges. 2015
  - Location of colon cancer (right-sided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17. European Journal of Cancer. 51. 2015
  - NEUROENDOCRINE TUMOURS - MODELS FOR RARE TUMOUR MANAGEMENT. Cancer Forum. 39. 2015
  - Oxaliplatin/5-fluorouracil-based adjuvant chemotherapy as a standard of care for colon cancer in clinical practice: Outcomes of the ACCElox registry. Asia Pacific Journal of Clinical Oncology. 11. 2015
  - Regorafenib plus modified FOLFOX6 as first-line treatment of metastatic colorectal cancer: A phase II trial. 2015
  - Time to Definitive Failure to the First Tyrosine Kinase Inhibitor in Localized GI Stromal Tumors Treated With Imatinib As an Adjuvant: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Intergroup Randomized Trial in Collaboration With the Australasian Gastro-Intestinal Trials Group, UNICANCER, French Sarcoma Group, Italian Sarcoma Group, and Spanish Group for Research on Sarcomas. Journal of Clinical Oncology. 33. 2015
- Journal Articles Refereed
  - Accepting risk in the acceleration of drug development for rare cancers. Lancet Oncology. 16. 2015
  - An overview of experimental and investigational multikinase inhibitors for the treatment of metastatic colorectal cancer. Expert Opinion on Investigational Drugs. 24. 2015
  - Development and validation of prognostic nomograms for metastatic gastrointestinal stromal tumour treated with imatinib. European Journal of Cancer. 51. 2015
  - TOPGEAR: a randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG). BMC Cancer. 15. 2015
  - Views of Australian Medical Oncologists Regarding the Use of Mismatch Repair Status to Assist Adjuvant Chemotherapy Recommendations for Patients With Early-Stage Colon Cancer. Clinical Colorectal Cancer. 14. 2015
2014
- Journal Articles
  - PIK3CA, BRAF, and PTEN Status and Benefit from Cetuximab in the Treatment of Advanced Colorectal Cancer-Results from NCIC CTG/AGITG CO.17. Clinical Cancer Research. 20. 2014
  - Realising opportunities for evidence-based cancer service delivery and research: linking cancer registry and administrative data in Australia. 2014
  - Registry of gastric cancer treatment evaluation (REGATE): I baseline disease characteristics. Asia Pacific Journal of Clinical Oncology. 10. 2014
- Journal Articles Refereed
  - "A quiet still voice that just touches": music's relevance for adults living with life-threatening cancer diagnoses. Supportive Care in Cancer. 22. 2014
  - Adjuvant therapy for colorectal cancer. Cancer Forum. 38. 2014
  - Bespoke treatment: Drivers beware!. Asia Pacific Journal of Clinical Oncology. 10. 2014
  - Controversies in the management of gastrointestinal stromal tumors. Asia Pacific Journal of Clinical Oncology. 10. 2014
  - Epiregulin gene expression as a biomarker of benefit from cetuximab in the treatment of advanced colorectal cancer. British Journal of Cancer. 110. 2014
  - Phase II trial evaluating the feasibility of interdigitating folfox with chemoradiotherapy in locally advanced and metastatic rectal cancer. British Journal of Cancer. 111. 2014
  - Quality of Life in Patients With K-RAS Wild-Type Colorectal Cancer. Cancer. 120. 2014
  - Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. The Lancet. 383. 2014
  - Regorafenib in gastrointestinal stromal tumors: clinical evidence and place in therapy. Therapeutic Advances in Medical Oncology. 6. 2014
  - The relationship between rash, tumour KRAS mutation status and clinical and quality of life outcomes in patients with advanced colorectal cancer treated with cetuximab in the NCIC CTG/AGITG CO.17. Acta Oncologica. 53. 2014
- Other Refereed Contribution to Refereed Journals
  - Broken doctor-patient relationships: why won't they listen? Patient-doctor relationships may break down. We present and discuss a hypothetical case. Medical Journal of Australia. 201. 2014
2013
- Journal Articles
  - Reducing clinical trial monitoring resource allocation and costs through remote access to electronic medical records.. Journal of Oncology Practice. 9. 2013
- Journal Articles Refereed
  - A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer. Journal of Hematology & Oncology. 6. 2013
  - A phase I trial of imatinib in combination with mFOLFOX6-bevacizumab in patients with advanced colorectal cancer. Cancer Chemotherapy and Pharmacology. 71. 2013
  - Phase III Randomized, Placebo-Controlled Study of Cetuximab Plus Brivanib Alaninate Versus Cetuximab Plus Placebo in Patients With Metastatic, Chemotherapy-Refractory, Wild-Type K-RAS Colorectal Carcinoma: The NCIC Clinical Trials Group and AGITG CO.20 Trial. Journal of Clinical Oncology. 31. 2013
  - Registry of gastric cancer treatment evaluation (REGATE): II treatment practice. Asia Pacific Journal of Clinical Oncology. 9. 2013
  - Sound Continuing Bonds with the Deceased: The Relevance of Music, Including Preloss Music Therapy, for Eight Bereaved Caregivers. Death Studies. 37. 2013
- Other Refereed Contribution to Refereed Journals
  - Clinical trials - Advancing national cancer care. Cancer Forum. 37. 2013
2012
- Journal Articles
  - Single-agent irinotecan or 5-fluorouracil and leucovorin (FOLFIRI) as second-line chemotherapy for advanced colorectal cancer; results of a randomised phase II study (DaVINCI) and meta-analysis (vol 47, pg 1826, 2011). European Journal of Cancer. 48. 2012
- Journal Articles Refereed
  - Current and emerging strategies for the management of imatinib-refractory advanced gastrointestinal stromal tumors. Therapeutic Advances in Medical Oncology. 4. 2012
  - Dose optimization of tyrosine kinase inhibitors to improve outcomes in GIST. Asia Pacific Journal of Clinical Oncology. 8. 2012
  - Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer - Differential treatment strategies for subtypes of early gastroesophageal cancer. European Journal of Cancer. 48. 2012
  - Randomized Trial of Short-Course Radiotherapy Versus Long-Course Chemoradiation Comparing Rates of Local Recurrence in Patients With T3 Rectal Cancer: Trans-Tasman Radiation Oncology Group Trial 01.04. Journal of Clinical Oncology. 30. 2012
- Journal Articles Unrefereed Letters or Notes
  - Comparative effectiveness research - a proposal for a new NHMRC funding stream. Medical Journal of Australia. 196. 2012
- Other Refereed Contribution to Refereed Journals
  - The Role of Biological Agents in the Resection of Colorectal Liver Metastases. Clinical Oncology. 24. 2012
2011
- Research Book Chapters
  - Gastrointestinal Stromal Tumors. GASTROINTESTINAL ONCOLOGY: A PRACTICAL GUIDE. Springer Verlag. 2011
- Journal Articles
  - Biological markers in patients with early-stage colon cancer: Consensus and controversies. Current Colorectal cancer Reports. 7. 2011
  - Overview of controversies in oesophagogastric cancer. Cancer Forum. 35. 2011
  - The diagnosis and management of gastric cancer: expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2010. Annals of Oncology. 22. 2011
- Journal Articles Refereed
  - A survey of reimbursement practices of private health insurance companies for pharmaceuticals not covered under the Pharmaceutical Benefits Scheme 2008. Australian Health Review. 35. 2011
  - Delivering affordable cancer care in high-income countries. Lancet Oncology. 12. 2011
  - Music Among Family Carers of People With Life-Threatening Cancer. Music and Medicine. 3. 2011
  - Phase I trial of docetaxel, cisplatin and concurrent radical radiotherapy in locally advanced oesophageal cancer. British Journal of Cancer. 104. 2011
  - Single-agent irinotecan or 5-fluorouracil and leucovorin (FOLFIRI) as second-line chemotherapy for advanced colorectal cancer; results of a randomised phase II study (DaVINCI) and meta-analysis. European Journal of Cancer. 47. 2011
  - Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis. Lancet Oncology. 12. 2011
- Journal Articles Unrefereed Letters or Notes
  - What constitutes a multidisciplinary team meeting?. Asia Pacific Journal of Clinical Oncology. 7. 2011
- Other Refereed Contribution to Refereed Journals
  - Neurofibromatosis type 1-associated wild-type gastrointestinal stromal tumor treated with anti-IGF-1R monoclonal antibody. Medical Oncology. 28. 2011
2010
- Journal Articles Refereed
  - Association of KRAS p.G13D Mutation With Outcome in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer Treated With Cetuximab. JAMA: Journal of the American Medical Association. 304. 2010
  - Capecitabine, Bevacizumab, and Mitomycin in First-Line Treatment of Metastatic Colorectal Cancer: Results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study. Journal of Clinical Oncology. 28. 2010
- Journal Articles Unrefereed
  - Randomised, non-comparative phase II study of weekly docetaxel with cisplatin and 5-fluorouracil or with capecitabine in oesophagogastric cancer: the AGITG ATTAX trial. British Journal of Cancer. 102. 2010
- Journal Articles Unrefereed Letters or Notes
  - Antitumor Effect of Somatostatin Analogs in Neuroendocrine Tumors. Journal of Clinical Oncology. 28. 2010
2009
- Journal Articles
  - A phase I trial of Capecitabine plus Gemcitabine with radical radiation for locally advanced pancreatic cancer. British Journal of Cancer. 100. 2009
  - Radiology reporting templates in oncology: A time for change. Journal of Medical Imaging and Radiation Oncology. 53. 2009
- Journal Articles Refereed
  - To Tell or Not to Tell: The Community Wants to Know About Expensive Anticancer Drugs As a Potential Treatment Option. Journal of Clinical Oncology. 27. 2009
- Other Refereed Contribution to Refereed Journals
  - Discussing Expensive Anticancer Drugs. Journal of Clinical Oncology. 27. 2009
2008
- Journal Articles
  - A phase II study of the heparanase inhibitor PI-88 in patients with advanced melanoma. Investigational New Drugs. 26. 2008
  - Progress and challenges in the adjuvant treatment of stage II and III colon cancers. Expert Review of Anticancer Therapy. 8. 2008
  - Progress in targeted therapies for cancer: Overview. Cancer Forum. 32. 2008
  - The diagnosis and management of rectal cancer: expert discussion and recommendations derived from the 9th World Congress on Gastrointestinal Cancer, Barcelona, 2007. Annals of Oncology. 19. 2008
- Journal Articles Refereed
  - K-ras mutations and benefit from cetuximab in advanced colorectal cancer. New England Journal of Medicine. 359. 2008
  - Optimizing the dose of imatinib for treatment of gastrointestinal stromal tumours: Lessons from the phase 3 trials. European Journal of Cancer. 44. 2008
  - Pancreatic cancer - is the wall crumbling?. Annals of Oncology. 19. 2008
- Journal Articles Unrefereed Letters or Notes
  - Role of palifermin in fluorouracil-based therapy for metastatic colorectal cancer. Journal of Clinical Oncology. 26. 2008
2007
- Journal Articles
  - Modification of leucovorin dose within a simplified FOLFOX regimen improves tolerability without compromising efficacy. Clinical Colorectal Cancer. 6. 2007
  - NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)--update of the NCCN clinical practice guidelines.. Journal of the National Comprehensive Cancer Network. 5 Suppl 2. 2007
  - Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis. Lancet Oncology. 8. 2007
- Journal Articles Refereed
  - A phase I/II trial of celecoxib with chemotherapy and radiotherapy in the treatment of patients with locally advanced oesophageal cancer. Investigational New Drugs. 25. 2007
  - Cetuximab for the treatment of colorectal cancer. New England Journal of Medicine. 357. 2007
- Other Refereed Contribution to Refereed Journals
  - Severe hypoglycaemia after long-acting octreotide in a patient with an unrecognized malignant insulinoma. Internal Medicine Journal. 37. 2007
- Conference Proceedings
  - The management of pancreatic cancer. Current expert opinion and recommendations derived from the 8th World Congress on Gastrointestinal Cancer, Barcelona, 2006. Annals of Oncology. 2007
2006
- Journal Articles
  - Addition of gabapentin to a modified FOLFOX regimen does not reduce oxaliplatin-induced neurotoxicity. Clinical Colorectal Cancer. 6. 2006
  - Adjuvant and neoadjuvant therapy for gastric carcinoma: An evidence-based review. American Journal of Cancer. 5. 2006
  - KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. European Journal of Cancer. 42. 2006
  - Recent developments in the systemic therapy of advanced gastroesophageal malignancies. Expert Opinion on Investigational Drugs. 15. 2006
  - Special section on music therapy. Journal of the Society for Integrative Oncology. 4. 2006
  - The multidisciplinary management of patients with cancer. Annals of Oncology. 17. 2006
  - The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study. British Journal of Cancer. 95. 2006
- Journal Articles Refereed
  - KIT immunohistochemistry and mutation status in gastrointestinal stromal tumours (GISTs) evaluated for treatment with imatinib. Histopathology. 49. 2006
  - Relationship of hepatic functional Imaging to irinotecan pharmacokinetics and genetic parameters of drug elimination. Journal of Clinical Oncology. 24. 2006
- Journal Articles Unrefereed
  - Pathological response of gastrointestinal stromal tumour to imatinib treatment correlates with tumour KIT mutational status in individual tumour clones. Histopathology. 49. 2006
2005
- Journal Articles
  - Australian experience of a modified schedule of FOLFOX with high activity and tolerability and improved convenience in untreated metastatic colorectal cancer patients. British Journal of Cancer. 92. 2005
  - Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs. Oncogene. 24. 2005
  - Erratum: An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin (Cancer Research (May 15, 2005) 65 (4031-4040)). Cancer Research. 65. 2005
  - Evidence-based adjuvant treatment of resectable pancreatic adenocarcinoma. American Journal of Cancer. 4. 2005
  - Recent advances in the systemic therapy of metastatic colorectal cancer. American Journal of Cancer. 4. 2005
- Journal Articles Refereed
  - An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin. Cancer Research. 65. 2005
  - Medical paternalism and expensive unsubsidised drugs. British Medical Journal. 331. 2005
  - Oxaliplatin combined with infusional 5-fluorouracil and concomitant radiotherapy in inoperable and metastatic rectal cancer: a phase I trial. British Journal of Cancer. 92. 2005
  - Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance. Cancer Biology & Therapy. 4. 2005
- Journal Articles Unrefereed Letters or Notes
  - The contribution of cytotoxic chemotherapy to the management of cancer. Clinical Oncology. 17. 2005
- Other Refereed Contribution to Refereed Journals
  - Beyond 5-fluorouracil: new horizons in systemic therapy for advanced colorectal cancer. Expert Opinion on Investigational Drugs. 14. 2005
  - Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg. European Journal of Cancer. 41. 2005
2004
- Journal Articles Refereed
  - A novel combination of cisplatin, irinotecan, and capecitabine in patients with advanced cancer. Investigational New Drugs. 22. 2004
  - A phase I trial of preoperative radiotherapy and capecitabine for locally advanced, potentially resectable rectal cancer. British Journal of Cancer. 91. 2004
- Journal Articles Unrefereed Letters or Notes
  - How should we introduce clinical positron emission tomography in the UK? Oncologists need to have a (clearer) view. Clinical Oncology. 16. 2004
- Other Refereed Contribution to Refereed Journals
  - Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. The Lancet. 364. 2004
  - Rapid screening for depression - validation of the Brief Case-Find for Depression (BCD) in medical oncology and palliative care patients. British Journal of Cancer. 91. 2004
  - Systemic or regional chemotherapy for liver metastases from colorectal cancer: Has the wheel stopped spinning?. The Cancer Journal. 10. 2004
2003
- Book Chapters Other
  - The treatment of carcinoma of the colon and rectum. Evidence-based oncology. BMJ Publishing Group. 2003
- Journal Articles Refereed
  - A phase I dose-escalation study of docetaxel with granulocyte colony-stimulating factor support in patients with solid tumours. Annals of Oncology. 14. 2003
  - Adjuvant and neoadjuvant therapy for gastric cancer using epirubicin/cisplatin/5-fluorouracil (ECF) and alternative regimens before and after chemoradiation. British Journal of Cancer. 89. 2003
  - Applications of positron emission tomography in the development of molecular targeted cancer therapeutics. BioDrugs. 17. 2003
- Journal Articles Unrefereed Letters or Notes
  - A case report of oxaliplatin extravasation. Annals of Oncology. 14. 2003
  - Is improving local control sufficient indication for radiotherapy in the management of rectal cancer? A response. ANZ Journal of Surgery. 73. 2003
- Other Refereed Contribution to Refereed Journals
  - Palliative chemotherapy: a clinical oxymoron. The Lancet. 362. 2003
2002
- Journal Articles
  - Adjuvant therapy for rectal cancer 2002
  - Efficacy, tolerability and management of raltitrexed (Tomudex (TM)) monotherapy in patients with advanced colorectal cancer: a review of phase II/III trials. European Journal of Cancer. 38. 2002
  - Phase I and pharmacokinetic study of docetaxel in combination with epirubicin and cyclophosphamide in advanced cancer: dose escalation possible with granulocyte colony-stimulating factor, but not with prophylactic antibiotics. Annals of Oncology. 13. 2002
  - Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation. Molecular and Cellular Biology. 22. 2002
  - Variability in administration of 5-fluorouracil and folinic acid in standard treatment regimens for advanced colorectal cancer. Internal Medicine Journal. 32. 2002
- Journal Articles Refereed
  - Rectal cancer in Victoria in 1994: Patterns of reported management. ANZ Journal of Surgery. 72. 2002
2001
- Journal Articles
  - Adjuvant radiotherapy for rectal cancer: A systematic overview of 8507 patients from 22 randomised trials. The Lancet. 358. 2001
  - Chemotherapy for advanced colorectal cancer. British Medical Journal (Clinical Research Edition). 322. 2001
  - Pilot study of oral eniluracil/5-FU in the palliation of hormone-refractory prostate cancer 2001
- Journal Articles Refereed
  - Randomized trial of coordinated psychosocial interventions based on patient self-assessments versus standard care to improve the psychosocial functioning of patients with cancer. Journal of Clinical Oncology. 19. 2001
  - Training general practitioners in flexible sigmoidoscopy to screen for colorectal cancer. ANZ Journal of Surgery. 71. 2001
2000
- Journal Articles
  - A phase I trial of docetaxel and gemcitabine in patients with advanced cancer. Annals of Oncology. 11. 2000
  - Chemotherapy for advanced colorectal cancer.. British Medical Journal (Clinical Research Edition). 321. 2000
  - Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer. Journal of Clinical Oncology. 18. 2000
  - MRP1 not MDR1 gene expression is the predominant mechanism of acquired multidrug resistance in two prostate carcinoma cell lines. Prostate Cancer and Prostatic Diseases. 3. 2000
  - Open label, multi-centre phase II study of raltitrexed ('Tomudex') in patients with inoperable squamous-cell carcinoma of head and neck. Annals of Oncology. 11. 2000
  - Regulation of MDR1 gene expression: emerging concepts. Drug Resistance Update. 3. 2000
  - The optimal 5-fluorouracil regimen for the adjuvant therapy of colon cancer: Where to from here?. Annals of Oncology. 11. 2000
  - Use of (F-18)-fluorodeoxyglucose positron emission tomography in monitoring response of recurrent neurotropic desmoplastic melanoma to radiotherapy. Otolaryngology-Head and Neck Surgery. 122. 2000
1999
- Journal Articles
  - Absolute quantitation of MDR1 transcripts using heterologous DNA standards - Validation of the competitive RT-PCR (CRT-PCR) approach. Biotechniques. 26. 1999
  - Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line. British Journal of Cancer. 79. 1999
  - Altered multidrug resistance phenotype caused by anthracycline analogues and cytosine arabinoside in myeloid leukemia. Blood. 93. 1999
  - Colorectal cancer (multiple letters) 1. Medical Journal of Australia. 170. 1999
  - Does biomodulation of 5-fluorouracil improve results?. European Journal of Cancer. 35. 1999
  - Gemcitabine and the blood brain barrier. Australian and New Zealand Journal of Medicine. 29. 1999
  - Induction of MDR1 gene expression by anthracycline analogues in a human drug resistant leukaemia cell line. British Journal of Cancer. 79. 1999
  - Induction of insulin-like growth factor binding protein expression by ICI 182,780 in a tamoxifen-resistant human breast cancer cell line. Breast Cancer Research and Treatment. 55. 1999
  - Overview of docetaxel (Taxotere)/cisplatin combination in non-small cell lung cancer.. Seminars in Oncology. 26. 1999
  - Phase I and subsequent phase II study of filgrastim (r-met-HuG-CSF) and dose intensified cyclophosphamide plus epirubicin in patients with non-Hodgkin's lymphoma and advanced solid tumors. Annals of Oncology. 10. 1999
  - Physical mapping of a tandem duplication on the long arm of chromosome 7 associated with a multidrug resistant phenotype. Cancer Genetics and Cytogenetics. 110. 1999
  - Positron emission tomography (PET): experience with a large-field-of-view three-dimensional PET scanner. Medical Journal of Australia. 171. 1999
  - Repetitive high-dose therapy with ifosfamide, thiotepa and paclitaxel with peripheral blood progenitor cell and filgrastim support for metastatic and locally advanced breast cancer: Results of a phase I study. Annals of Oncology. 10. 1999
1998
- Journal Articles
  - 5-fluorouracil: A pharmacological paradigm in the use of cytotoxics. Clinical and Experimental Pharmacology and Physiology. 25. 1998
  - Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle number. European Journal of Cancer. 34. 1998
  - Hormone replacement therapy and breast cancer. Medical Journal of Australia. 169. 1998
  - Phase II study of docetaxel and cisplatin in advanced non-small-cell lung cancer. Journal of Clinical Oncology. 16. 1998
  - Relationships among liver and kidney volumes, lean body mass and drug clearance. British Journal of Clinical Pharmacology. 46. 1998
  - Second line treatment options in advanced colorectal cancer. European Journal of Cancer. 34. 1998
  - Update on adjuvant treatment of colorectal cancer.. Current Opinion in Oncology. 10. 1998
1997
- Journal Articles
  - Accuracy of volume measurement using helical CT. Journal of Computer Assisted Tomography. 21. 1997
  - Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance. Clinical Cancer Research. 3. 1997
  - Australian multicentre phase II trial of paclitaxel in women with metastatic breast cancer and prior chemotherapy. Medical Journal of Australia. 166. 1997
  - Clinical issues in euthanasia.. Medical Journal of Australia. 166. 1997
  - Erratum: Final results of a randomised trial comparing 'Tomudex'® (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. (Ann Oncol (1996) 7 (9) (961-965)). Annals of Oncology. 8. 1997
  - Expression of mdr1 and mrp in the normal B-cell homologue of B-cell chronic lymphocytic leukaemia. British Journal of Haematology. 96. 1997
  - In vitro binding of MX2 (KRN8602) and epirubicin to human plasma protein.. Pharmacology. 55. 1997
  - Phase I study of paclitaxel and oral etoposide in previously untreated non-small-cell and extensive small-cell lung cancer. Annals of Oncology. 8. 1997
  - Phase I trial of docetaxel and cisplatin in previously untreated patients with advanced non-small-cell lung cancer. Journal of Clinical Oncology. 15. 1997
  - Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood. 89. 1997
  - Sequential extraction of DNA and DNA-binding proteins from low cell numbers. Biotechniques. 22. 1997
- Conference Proceedings
  - Overview of the tolerability of 'Tomudex' (raltitrexed): collective clinical experience in advanced colorectal cancer.. Anti-Cancer Drugs: international journal on anti-cancer agents. 1997
1996
- Journal Articles
  - 'Tomudex' (ZD1694): Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia. European Journal of Cancer. 32. 1996
  - 'Tomudex' (ZD1694): a novel thymidylate synthase inhibitor with clinical antitumour activity in a range of solid tumours. 'Tomudex' International Study Group.. Annals of Oncology. 7. 1996
  - A phase II study in advanced breast cancer: ZD1694 ('Tomudex') a novel direct and specific thymidylate synthase inhibitor. British Journal of Cancer. 74. 1996
  - Bilateral orchidectomy and flutamide versus orchidectomy alone in newly diagnosed patients with metastatic carcinoma of the prostate--an Australian multicentre trial.. British Journal of Urology. 77. 1996
  - Cyclosporin a and PSC 833 prevent up-regulation of MDR1 expression by anthracyclines in a human multidrug-resistant cell line. Clinical Cancer Research. 2. 1996
  - Erratum: Treatment principles in advanced colorectal cancer (Australian and New Zealand Journal of Surgery (1996) 66 (202-205)). Australian and New Zeland Journal of Surgery. 66. 1996
  - Final results of a randomised trial comparing 'Tomudex'(R) (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. Annals of Oncology. 7. 1996
  - Hormone replacement therapy and breast cancer: what are the facts?. Medical Journal of Australia. 164. 1996
  - Inheritance of chromosome 7 is associated with a drug-resistant phenotype in somatic cell hybrids. British Journal of Cancer. 73. 1996
  - Liver transplantation in metastatic carcinoid tumour. Australian and New Zealand Journal of Medicine. 26. 1996
  - Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine. Biochemical Pharmacology. 52. 1996
  - Outpatient chemotherapy: there's no place like home--sometimes.. Medical Journal of Australia. 165. 1996
  - Patients' beliefs about cancer management.. Supportive Care in Cancer. 4. 1996
  - The role of 5-fluorouracil dose in the adjuvant therapy of colorectal cancer.. Annals of Oncology. 7. 1996
  - The role of chemotherapy in malignant thymoma.. Australian and New Zealand Journal of Medicine. 26. 1996
  - Treatment principles in advanced colorectal cancer.. Australian and New Zeland Journal of Surgery. 66. 1996
  - Treatment principles in advanced non-small-cell lung cancer.. Australian and New Zeland Journal of Surgery. 66. 1996
  - ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. Tomudex Colorectal Study Group.. Journal of Clinical Oncology. 14. 1996
1995
- Journal Articles
  - 'Tomudex' (ZD1694): results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia. The 'Tomudex' Colorectal Cancer Study Group.. European Journal of Cancer. 31A. 1995
  - Hypoxemia due to right-to-left shunt in the carcinoid syndrome; beneficial response to octreotide.. Annals of Oncology. 6. 1995
  - Impaired cell-mediated immunity of apparently normal patients who had multiple skin cancers.. Cancer. 76. 1995
  - QUALITY OF PHARMACOKINETIC RESEARCH IN ONCOLOGY. British Journal of Cancer. 72. 1995
  - RAPID UP-REGULATION OF MDR1 EXPRESSION BY ANTHRACYCLINES IN A CLASSICAL MULTIDRUG-RESISTANT CELL-LINE. British Journal of Cancer. 71. 1995
  - The euthanasia controversy. Decision-making in extreme circumstances.. Medical Journal of Australia. 163. 1995
  - The pure antiestrogen ICI 182,780 binds to a high-affinity site distinct from the estrogen receptor.. International Journal of Cancer. 62. 1995
1994
- Journal Articles
  - A phase I/II study of the intralesional injection of ricin-monoclonal antibody conjugates in patients with hepatic metastases.. European Journal of Cancer. 30A. 1994
  - CELLULAR AND KARYOTYPIC CHARACTERIZATION OF 2 DOXORUBICIN-RESISTANT CELL-LINES ISOLATED FROM THE SAME PARENTAL HUMAN LEUKEMIA-CELL LINE. International Journal of Cancer. 57. 1994
  - LEAN BODY-MASS, BODY-SURFACE AREA AND EPIRUBICIN KINETICS. Anti-Cancer Drugs: international journal on anti-cancer agents. 5. 1994
  - Multiple atypical nevi: a cutaneous marker of germ cell tumors.. Journal of Clinical Oncology. 12. 1994
  - P-GLYCOPROTEIN EXPRESSION IN CLASSICAL MULTIDRUG, RESISTANT LEUKEMIA-CELLS DOES NOT CORRELATE WITH ENHANCED CHLORIDE CHANNEL ACTIVITY. Clinical and Experimental Pharmacology and Physiology. 21. 1994
  - PRESCRIBING OPIOIDS - A PAINFUL EXPERIENCE. Medical Journal of Australia. 161. 1994
  - Safe administration of oral etoposide after hypersensitivity reaction to intravenous etoposide.. Anti-Cancer Drugs: international journal on anti-cancer agents. 5. 1994
1993
- Journal Articles
  - Antitumor activity of idarubicin-monoclonal antibody conjugate on multidrug resistant cells 1993
  - Circumvention of tamoxifen resistance by the pure anti-estrogen ICI 182,780.. International Journal of Cancer. 55. 1993
  - Clinical application of a rapid, functional assay for multidrug resistance based on accumulation of the fluorescent dye, fluo-3.. European Journal of Cancer. 29A. 1993
  - DIFFERENTIAL-EFFECTS OF ESTROGEN, TAMOXIFEN AND THE PURE ANTIESTROGEN ICI-182,780 IN HUMAN DRUG-RESISTANT LEUKEMIA-CELL LINES. Cancer Chemotherapy and Pharmacology. 33. 1993
  - Migraine following the use of a 5-hydroxytryptamine antagonist.. Australian and New Zealand Journal of Medicine. 23. 1993
1992
- Journal Articles
  - Carboplatin-containing regimens for small cell lung cancer: implications for management in the elderly.. Seminars in Oncology. 19. 1992
  - FAMILIAL OCCURRENCE OF MULTIPLE NONMELANOMA SKIN-CANCER. Cancer Genetics and Cytogenetics. 61. 1992
  - Interaction of epirubicin with other cytotoxics and anti-emetic drugs.. Anti-Cancer Drugs: international journal on anti-cancer agents. 3. 1992
  - PHASE-II STUDY OF 10-EDAM IN PATIENTS WITH SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK, PREVIOUSLY UNTREATED WITH CHEMOTHERAPY. Investigational New Drugs. 10. 1992
  - Prolonged release of morphine alkaloid from a lipophilic suppository base in vitro and in vivo. 1992
  - RECENT ADVANCES IN THE TREATMENT OF COLORECTAL-CANCER. Australian and New Zealand Journal of Medicine. 22. 1992
  - SKIN-CANCER AND HLA ANTIGENS. New England Journal of Medicine. 326. 1992
  - Serum methotrexate in childhood ALL.. British Journal of Cancer. 66. 1992
- Conference Proceedings
  - Open phase II study on the efficacy and tolerance of casodex (ICI 176,334), a new nonsteroid antiandrogen, in the treatment of advanced prostate carcinoma 1992
1991
- Journal Articles
  - Adjuvant therapy of colorectal cancer: an overview.. Australian and New Zeland Journal of Surgery. 61. 1991
  - CIRCUMVENTION OF DOXORUBICIN RESISTANCE IN MULTIDRUG RESISTANT HUMAN LEUKEMIA AND LUNG-CANCER CELLS BY THE PURE ANTIESTROGEN ICI-164384. European Journal of Cancer. 27. 1991
  - INTERACTION OF CISPLATIN WITH OTHER CYTOTOXICS AND NONSTEROIDAL ANTIINFLAMMATORY DRUGS. Anti-Cancer Drugs: international journal on anti-cancer agents. 2. 1991
  - Rapid functional assay for multidrug resistance in human tumor cell lines using the fluorescent indicator fluo-3.. Journal of the National Cancer Institute. 83. 1991
1990
- Journal Articles
  - CHARACTERISTICS OF A BREAST CANCER-ASSOCIATED ANTIGEN DEFINED BY RCC-1 ANTIBODY. Immunology and Cell Biology. 68. 1990
  - Combined use of cyclosporin A and verapamil in modulating multidrug resistance in human leukemia cell lines.. Cancer Research. 50. 1990
  - ETOPOSIDE, CARBOPLATIN, CYCLOPHOSPHAMIDE AND VINCRISTINE IN PREVIOUSLY UNTREATED PATIENTS WITH SMALL-CELL LUNG-CANCER. Cancer Chemotherapy and Pharmacology. 25. 1990
  - Effect of cyclosporin and verapamil on the cellular kinetics of daunorubicin.. European Journal of Cancer. 26. 1990
  - MEDICAL-EDUCATION IN PALLIATIVE CARE. Medical Journal of Australia. 152. 1990
  - Not-for-resuscitation orders in cancer patients--principles of decision-making.. Medical Journal of Australia. 153. 1990
1988
- Journal Articles
  - FLARE RESPONSES IN SMALL CELL-CARCINOMA OF THE LUNG. Clinical Nuclear Medicine. 13. 1988
  - Structure of T cell antigen receptor beta chain in synovial fluid cells from patients with rheumatoid arthritis.. Arthritis and Rheumatism. 31. 1988
1987
- Journal Articles
  - CARBOPLATIN (CBDCA, JM-8) AND VP-16-213 IN PREVIOUSLY UNTREATED PATIENTS WITH SMALL-CELL LUNG-CANCER. Journal of Clinical Oncology. 5. 1987
  - HETEROGENEITY OF THE HUMAN TRANSFERRIN RECEPTOR AND USE OF ANTI-TRANSFERRIN RECEPTOR ANTIBODIES TO DETECT TUMORS INVIVO. Immunology and Cell Biology. 65. 1987
  - THE USE OF MONOCLONAL-ANTIBODY CONJUGATES FOR THE DIAGNOSIS AND TREATMENT OF CANCER. Immunology and Cell Biology. 65. 1987
  - The presence of clonogenic cells in high-grade malignant lymphoma: a prognostic factor.. Blood. 69. 1987
1986
- Journal Articles
  - Molecular evidence for the clonal origin of blast crisis in chronic myeloid leukaemia.. British Journal of Cancer. 53. 1986
  - The structure of the T cell gamma chain gene in lymphoproliferative disorders and lymphoma cell lines.. Blood. 68. 1986
  - Visualization of metastases from colon carcinoma using an iodine 131-radiolabeled monoclonal antibody.. Cancer. 57. 1986
1985
- Journal Articles
  - Apparent T-cell neoplasms with immunoglobulin gene rearrangements.. The Lancet. 2. 1985
  - Monoclonal antibodies to drugs: novel diagnostic and therapeutic reagents.. Pharmacology and Therapeutics. 28. 1985
  - Phenotypic and molecular characterization of lymphoma cell lines 1985
  - TUMOR-ASSOCIATED ANTIGENS - AN OVERVIEW. Journal of Clinical Oncology. 3. 1985
  - Tumor localization using radiolabeled monoclonal antibodies. An overview.. American Journal of Clinical Oncology - Cancer Clinical Trials. 8. 1985
1984
- Journal Articles
  - DESCRIPTION OF A MURINE B-LYMPHOMA TUMOR-SPECIFIC ANTIGEN. Journal of Immunology. 133. 1984
  - TUMOR-IMMUNOTHERAPY IN THE MOUSE WITH THE USE OF I-131-LABELED MONOCLONAL-ANTIBODIES. Journal of the National Cancer Institute. 72. 1984
1983
- Journal Articles
  - HEPARIN-INDUCED THROMBOCYTOPENIA WITH ASSOCIATED DISSEMINATED INTRAVASCULAR COAGULATION. British Journal of Haematology. 54. 1983
  - LOCALIZATION OF HUMAN COLORECTAL TUMOR XENOGRAFTS IN THE NUDE-MOUSE WITH THE USE OF RADIOLABELED MONOCLONAL-ANTIBODY. Journal of the National Cancer Institute. 71. 1983
  - MONOCLONAL-ANTIBODIES TO DRUGS - DIGOXIN. International Journal of Immunopharmacology. 5. 1983
  - TUMOR VISUALIZATION USING A RADIOLABELED MONOCLONAL-ANTIBODY. Australian and New Zealand Journal of Medicine. 13. 1983
1982
- Journal Articles
  - Chronic lymphatic leukemia developing in a patient with multiple myeloma: immunologic demonstration of a clonally distinct second malignancy.. Cancer. 50. 1982
  - HYBRIDOMAS AND MONOCLONAL-ANTIBODIES - APPLICATIONS IN ONCOLOGY. Australian and New Zeland Journal of Surgery. 52. 1982
  - Intralipid induced haemolysis.. British Journal of Haematology. 50. 1982

Research

Investigator on

Contract
- Upper Gastrointestinal Cancer SYMPTOM Study (SYMPTOM-UGI) administered by General Practice 2019 - 2020
Grant
- ESTABLISHMENT OF ACRF ADVANCED CENTRE FOR CANCER CELL ISOLATION AND IMAGING (Research Grants) awarded by AUST CANCER RESEARCH FOUNDATION 2013 - 2020
- CHARACTERISATION OF THE ANTI-APOPTOTIC FUNCTION OF P-GLYCOPROTEIN AND TRANSCRIPTIONAL REGULATION OF THE MDR1 GENE (Project Grants) awarded by NHMRC 2005 - 2007

Awards

Education and training

PhD, University of Melbourne 1983
MBBS, University of Melbourne 1975

Awards and honors

Fellow of the Royal Australasian College of Physicians, 1984

Contact Details
- 03 9656 1749
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  - Level: Room:, No Building, Peter Maccallum Hospital
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