A/PROF Salvatore Pepe

A/PROF Salvatore Pepe


  • Cord Blood Stem Cell Therapy, Cardiopulmonary Bypass Surgery, Ventricular Assist Device, Heart Transplantation (Fetal & Neonatal Development, Preterm Birth, Adult aging/senescence)
  • Heart failure, Cardiomyopathy, Congenital Heart Disorders (cardioprotective therapies, cardiopulmonary bypass support, heart transplantation, cardiac complications of genetic disorders and cancer therapy)
  • Mitochondrial metabolism, Pharmacotherapeutics, Antioxidant/REDOX agents, Paracrine/Exosomal signalling (Agents regulating post-injury and other adaptive remodelling)



  • Assoc/Prof. Salvatore Pepe is a clinical scientist who leads the Molecular & Cellular Cardiology Laboratory in the Heart Research Group (Clinical Sciences Theme) at the Murdoch Children's Research Institute (MCRI) and is a clinical research manager in the Department of Cardiology, Royal Children's Hospital.

    After initially training in clinical pharmacology and completing a doctorate in cardiovascular physiology he undertook four years post-doctoral training (NIH Fogarty Postdoctoral Fellow) at Johns Hopkins Hospital, Bayview Campus, Baltimore, USA, in the NIH, National Institute on Aging Intramural Research Program (Cardiovascular Science).

    Previous to working at Melbourne Children's Campus he was Head of the Cardiothoracic Surgical Research Laboratory, (Dept of Cardiothoracic Surgery), at the Alfred Hospital, and Adjunct Senior Lecturer, Department of Surgery (Alfred), Monash University, Melbourne, involved in clinical trial and laboratory research focused on cellular and mitochondrial processes in heart failure, transplantation, and cardiopulmonary bypass surgery.

    Working with cardiac surgery, cardiology and intensive care clinicians, Dr Pepe's work is focused on cardiovascular complications arising from congenital and acquired heart and lung disorders, premature birth and surgical interventions. The emphasis of the research effort is to translate new understanding of disease mechanisms and novel therapeutic agents to clinical use. Currently he is investigating the safety and efficacy of cord blood stem cell therapy as an adjunct to cardiopulmonary bypass surgery in children with severe heart malformations (i.e. hypoplastic left heart syndrome) or with cardiomyopathy. The research program over the past decade spans from in vitro and in vivo laboratory studies to clinical trials.

    A/Prof Pepe has served NHMRC, NHF and ARC as a panel member and external reviewer, and is an invited reviewer for numerous medical a   


Member of

  • Perinatal Society of Australia and New Zealand. Membership of the Perinatal Society of Australia and New Zealand 2014 -
  • American Physiological Society. American Physiological Society -Cardiovascular Section 2012 -
  • Cardiac Society of Australia and New Zealand. Fellowship of the Cardiac Society of Australia and New Zealand 2008 -
  • American Heart Association. Fellowship of American Heart Association 2006 -
  • International Society for Heart Research. International Society for Heart Research -Australasian Section 1988 -


Selected publications


Additional Grant Information

  • Grants held through other employing institutions   


Education and training

  • GDipHealthCounsell, University of South Australia
  • BScHonsMed, Flinders University of South Australia
  • PhD, Adelaide University 1992

Awards and honors

  • Fellow of the Cardiac Society of Australia and New Zealand, 2008
  • Fellow of the Society for Gerontological Cardiology, 2007
  • Fellow of the American Heart Association, 2006



Available for supervision

  • Y

Supervision Statement

  • Available for PhD supervision. Highly experienced supervisor of more than 10 higher degree students.