Peptide and Oligonucleotide drug discovery (Brain drug delivery)
Fazel shabanpoor graduated from the University of Melbourne in 2004 with the degree of bachelor of biomedical science. In 2005 he was awarded an honours degree from the department of Pharmacology. In 2006, Fazel took up a position as research assistant in the laboratory of Prof. John Wade at Howard Florey Institute as a peptide chemist synthesising a wide range of peptides. Fazel received his PhD in 2010 working under the co-supervision of Professor John Wade (Howard Florey Institute) and Professor Frances Separovic (School of Chemistry) developing therapeutic analogues of Insulin-like peptide 3 and relaxin-3. In 2011, Fazel received a CJ. Martin Fellowship from NHMRC and moved to the Laboratory of Molecular Biology in Cambridge, UK where he continued his research training on developing peptide-based drug delivery platform to deliver therapeutic antisense oligonucleotides across the blood-brain barrier for the treatment of neuromuscular and neurodegenerative disease. In 2014, Fazel returned back to the Florey Department of Neuroscience and Mental Health where he is currently establishing his own research subgroup within the neuropeptide division working on the development of peptide-oligonucleotide hybrids as antisense therapy in the treatment of neurodegenerative diseases.
American Peptide Society.
Associate Member 2009 -
Australian Peptide Society.
Member 2005 -
AUSTRALIAN SOCIETY FOR MEDICAL RESEARCH.
Registered Member 2011 - 2015
C.J. Martin Research Fellowship (National Health & Medical Research Council, Australia),
David Hay post-graduate write-up award, University of Melbourne,
Student presentation prize, Australian Society for Biophysics,
Young Investigtors Travel Grant,
March of Dimes Travel Grant, American Peptide Society,
Young Investigtors Travel Award, University of Illinois at Urbana-Champaign,
CEM prize, Australian Peptide Association,
Student presentation prize, Howard Florey Institute,
Whelan Prize, Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists,
Available for supervision
My research interests are in the field peptide drug discovery and delivery. Recently, the focus of my research has been on developing synthetic antisense oligonucleotide for modulating gene activities and their application in the area of gene therapy. I have also been developing peptides as delivery vector for antisense oligonucleotides. This includes optimization of both peptide and antisense oligonuclotides as well as the chemistry of conjugation of these two biomolecules which has been exemplified in my recent publications in the journals, ChemComm and Nucleic Acid Research.