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DR Robert Center

Positions

  • Antibody-based HIV vaccines (antibody, HIV, vaccine)
  • Molecular virology with a specific focus of HIV envelope protein-based vaccine approaches (Molecular Virology, viral vaccines, HIV)

Overview

OverviewText1

  • The current main focus of my work is directed toward HIV vaccine development. Infection with HIV is initiated when the HIV envelope protein mediates binding of the virus to a target cell. Our aim is to harness the power of protective antibodies which can bind to the envelope protein and block infection. Vaccines can generate better immune responses when two different vaccine modalities are used in so-called prime/boost strategies. We have used DNA vectors expressing envelope protein for the first vaccination (prime) followed by a boost using purified protein. One aspect of my work involves improving the design of our DNA vectors to give more efficient priming. A hurdle to an HIV vaccine is the variability of the envelope protein across different viral strains. By manipulating the envelope protein to expose more conserved regions I hope to generate antibodies capable of blocking infection in diverse HIV isolates. These strategies will be utilized for preventative vaccine development and for producing antibodies that may be used in a topical microbicide. I am also involved in other studies focusing on the structure and function of the envelope protein.   

Affiliation

Member of

  • The Australian Society for Medical Research. Member 2006 -

Publications

Selected publications

Research

Investigator on

Additional Grant Information

  • NHMRC Program Grant 510488. 2009-2014. HIV & HCV Vaccines and Immunopathogenesis. Co-Investigator.

    Australian Centre for Hepatitis Virology & HIV Virology Project Grant. 2010-2011. Assessing the immunogenicity of a novel brain-derived HIV envelope protein. Chief Investigator.

    NHMRC Development Grant 1000761. 2010. A Novel Vaccine Platform for Trimeric Envelope Proteins: HIV-1 envelope. Chief Investigator.

    Australian Centre for Hepatitis Virology & HIV Virology Project Grant. 2007-2008. Antibody-based HIV vaccines targeting critical gp41 domains presented on VLP. Chief Investigator.

    NHMRC Project Grant 433915. 2007-2009. Pathogenesis of CCR5-restricted HIV-1. Chief Investigator.

    Australian Centre for Hepatitis Virology & HIV Virology Project Grant. 2004-2006. Rapid assays for HIV-1 Neutralizing antibody. Chief Investigator.   

Awards

Education and training

  • PhD, University of Melbourne 1998
  • BSc(Hons), La Trobe University 1988

Linkages

Supervision

Available for supervision

  • Y