Search

DR Christophe Lefevre

Positions

Honorary, Medical Biology (W.E.H.I.)

Bioinformatics, software development, genomics (Microarray, DNA, genomic, sequence)

Overview

Has subject area

For 2008 6 Digit Code
- Bioinformatics Software
Seo 2008 6 Digit Code
- Computer Software and Services not elsewhere classified

Publications

Selected publications

2019
- Journal Articles
  - Guiding Development of the Neonate: Lessons from Mammalia.. Nestle Nutrition Institute Workshop Series. 90. 2019
2018
- Journal Articles
  - The effect of mammary extracellular matrix in controlling oral and mammary cancer cells. Asian Pacific Journal of Cancer Prevention. 19. 2018
- Journal Articles Refereed
  - Dietary Cows' Milk Protein A1 Beta-Casein Increases the Incidence of T1D in NOD Mice. Nutrients. 10. 2018
  - Gene expression profiling of postnatal lung development in the marsupial gray short-tailed opossum (Monodelphis domestica) highlights conserved developmental pathways and specific characteristics during lung organogenesis. BMC Genomics. 19. 2018
2017
- Journal Articles Refereed
  - Dimeric but not monomeric alpha-lactalbumin potentiates apoptosis by up regulation of ATF3 and reduction of histone deacetylase activity in primary and immortalised cells. Cellular Signaling. 33. 2017
  - Hormonal regulation of platypus Beta-lactoglobulin and monotreme lactation protein genes. General and Comparative Endocrinology. 242. 2017
  - The tammar wallaby: A marsupial model to examine the timed delivery and role of bioactives in milk. General and Comparative Endocrinology. 244. 2017
  - Transcriptome analysis of mammary epithelial cell gene expression reveals novel roles of the extracellular matrix.. Biochemistry and Biophysics Reports. 12. 2017
2016
- Journal Articles
  - Analysis of human breast milk cells: gene expression profiles during pregnancy, lactation, involution, and mastitic infection. Functional & Integrative Genomics. 16. 2016
  - BacHbpred: Support Vector Machine Methods for the Prediction of Bacterial Hemoglobin-Like Proteins.. Advances in Bioinformatics. 2016. 2016
  - Marsupial tammar wallaby delivers milk bioactives to altricial pouch young to support lung development. Mechanisms of Development. 142. 2016
- Journal Articles Refereed
  - The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE". PLoS Medicine. 13. 2016
2015
- Journal Articles
  - Exposing HPC and sequential applications as services through the development and deployment of a SaaS cloud. Future Generation Computer Systems. 43-44. 2015
  - Human Milk MicroRNA and Total RNA Differ Depending on Milk Fractionation. Journal of Cellular Biochemistry. 116. 2015
  - Role of marsupial tammar wallaby milk in lung maturation of pouch young. BMC Developmental Biology. 15. 2015
2014
- Journal Articles
  - Bioactive Functions of Milk Proteins: a Comparative Genomics Approach. Journal of Mammary Gland Biology and Neoplasia. 19. 2014
  - Comparative analysis of caveolins in mouse and tammar wallaby: Role in regulating mammary gland function. Gene. 552. 2014
  - Differential temporal expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii). BMC Genomics. 15. 2014
  - Monotreme Lactation Protein Is Highly Expressed in Monotreme Milk and Provides Antimicrobial Protection. Genome Biology & Evolution. 6. 2014
  - Support vector machine (SVM) based multiclass prediction with basic statistical analysis of plasminogen activators.. BMC Research Notes. 7. 2014
2013
- Journal Articles
  - Comparative Gene Expression Profiling of Stromal Cell Matrices that Support Expansion of Hematopoietic Stem/Progenitor Cells. Stem Cell Research & Therapy. 3. 2013
  - Identification and Functional Characterization of a Novel Monotreme- Specific Antibacterial Protein Expressed during Lactation. PLoS One. 8. 2013
  - The extracellular matrix locally regulates asynchronous concurrent lactation in tammar wallaby (Macropus eugenii). Matrix Biology. 32. 2013
  - The extracellular matrix regulates MaeuCath1a gene expression. Developmental and Comparative Immunology. 40. 2013
- Journal Articles Refereed
  - Molecular evolution of a novel marsupial S100 protein (S100A19) which is expressed at specific stages of mammary gland and gut development. Molecular Phylogenetics and Evolution. 69. 2013
- Conference Papers Refereed
  - Rheological properties and microstructure of buffalo yoghurt 2013
2012
- Journal Articles
  - EXP-PAC: Providing comparative analysis and storage of next generation gene expression data. Genomics. 100. 2012
  - Monotremes and marsupials: Comparative models to better understand the function of milk. Journal of Biosciences. 37. 2012
  - The tammar wallaby: A model system to examine domain-specific delivery of milk protein bioactives. Seminars in Cell & Developmental Biology. 23. 2012
  - WFDC2 is differentially expressed in the mammary gland of the tammar wallaby and provides immune protection to the mammary gland and the developing pouch young. Developmental and Comparative Immunology. 36. 2012
  - miRNA_Targets: A database for miRNA target predictions in coding and non-coding regions of mRNAs. Genomics. 100. 2012
- Journal Articles Refereed
  - The mammary gland-specific marsupial ELP and eutherian CTI share a common ancestral gene. BMC Evolutionary Biology. 12. 2012
2011
- Book Chapters
  - Milk: Milk of Monotremes and Marsupials. Encyclopedia of Dairy Sciences: Second Edition. 2011
- Journal Articles
  - Tammar wallaby mammary cathelicidins are differentially expressed during lactation and exhibit antimicrobial and cell proliferative activity. Comparative Biochemistry and Physiology A - Molecular and Integrative Physiology. 160. 2011
- Journal Articles Refereed
  - Acute involution in the tammar wallaby: Identification of genes and putative novel milk proteins implicated in mammary gland function. Genomics. 97. 2011
- Other Refereed Contribution to Refereed Journals
  - Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development (vol 12, pg R81, 2011). Genome Biology. 12. 2011
- Conference Proceedings
  - Electromagnetic field and other physical methods influencing cell growth in mammal cell culture systems 2011
2010
- Books
  - Evolution of Lactation: Ancient Origin and Extreme Adaptations of the Lactation System. Vol. 11. Annual Reviews. 2010
- Book Chapters
  - Comparative Genomics and Transcriptomics of Lactation. 13th Evolutionary Biology Meeting. Springer Verlag. 2010
- Research Book Chapters
  - Marsupial Milk - Identifying Signals for Regulating Mammary Function and Development of the Young. MARSUPIAL GENETICS AND GENOMICS. Springer Verlag. 2010
- Journal Articles Refereed
  - Developmental changes of gene expression after spinal cord injury in neonatal opossums. Brain Research. 1363. 2010
  - Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants. Functional & Integrative Genomics. 10. 2010
- Conference Proceedings
  - Harnessing Clusters for High Performance Computation of Gene Expression Microarray Comparative Analysis. Lecture Notes in Computer Science. 2010
2009
- Book Chapters
  - Significance, origin and function of bovine milk proteins: the biological implications of manipulation or modification. MILK PROTEINS: FROM EXPRESSION TO FOOD. Academic Press. 2009
- Research Book Chapters
  - Significance, origin and function of bovine milk proteins: the biological implications of manipulation or modification. Milk Proteins - From Expression to Food. Academic Press. 2009
  - The comparative genomics of tammar wallaby and Cape fur seal lactation models to examine function of milk proteins. MILK PROTEINS: FROM EXPRESSION TO FOOD. Academic Press. 2009
- Journal Articles Refereed
  - A novel approach identified the FOLR1 gene, a putative regulator of milk protein synthesis. Mammalian Genome. 20. 2009
  - Characterisation of monotreme caseins reveals lineage-specific expansion of an ancestral casein locus in mammals. Reproduction, Fertility and Development. 21. 2009
  - Characterization of the tammar wallaby (Macropus eugenii) whey acidic protein gene; new insights into the function of the protein. Evolution & Development. 11. 2009
  - Insulin regulates milk protein synthesis at multiple levels in the bovine mammary gland. Functional & Integrative Genomics. 9. 2009
  - Molecular analysis of tammar (Macropus eugenii) mammary epithelial cells stimulated with lipopolysaccharide and lipoteichoic acid. Veterinary Immunology and Immunopathology. 129. 2009
2008
- Journal Articles
  - CD14 and TLR4 are expressed early in tammar (Macropus eugenii) neonate development. Journal of Experimental Biology. 211. 2008
  - Characterization and expression of Peroxiredoxin 1 in the neonatal tammar wallaby (Macropus eugenii). Comparative Biochemistry and Physiology B - Biochemistry and Molecular Biology. 149. 2008
  - Identification and transcript analysis of a novel wallaby (Macropus eugenii) basal-like breast cancer cell line. Molecular Cancer. 7. 2008
  - Lack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein as an apoptotic milk factor in mammary gland involution. BMC Biology. 6. 2008
  - Uncoupling the mechanisms that facilitate cell survival in hormone-deprived bovine mammary explants. Journal of Molecular Endocrinology. 41. 2008
- Journal Articles Refereed
  - A population of mammary epithelial cells do not require hormones or growth factors to survive. Journal of Endocrinology. 196. 2008
  - Filtering microarray correlations by statistical literature analysis yields potential hypotheses for lactation research. The Python Papers. 3. 2008
  - Genome analysis of the platypus reveals unique signatures of evolution. Nature. 453. 2008
  - Genome analysis of the platypus reveals unique signatures of evolution (vol 453, pg 175, 2008). Nature. 455. 2008
  - Identification, characterization and expression of cathelicidin in the pouch young of tammar wallaby (Macropus eugenii). Comparative Biochemistry and Physiology B - Biochemistry and Molecular Biology. 149. 2008
  - RNA expression Microarray analysis in mouse prospermatogonia: Identification of candidate epigenetic modifiers. Developmental Dynamics. 237. 2008
2007
- Research Book Chapters
  - Reconstruction of protein-protein interaction pathways by mining subject-verb-objects intermediates. Lecture Notes in Computer Science. Springer Verlag. 2007
- Journal Articles
  - Analysis of the expression of immunoglobulins throughout lactation suggests two periods of immune transfer in the tammar wallaby (Macropus eugenii). Veterinary Immunology and Immunopathology. 120. 2007
- Journal Articles Refereed
  - Lactation transcriptomics in the Australian marsupial, Macropus eugenii: transcript sequencing and quantification. BMC Genomics. 8. 2007
  - Molecular evolution of monotreme and marsupial whey acidic protein genes. Evolution & Development. 9. 2007
  - The fur seal - a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution. Journal of Mammary Gland Biology and Neoplasia. 12. 2007
  - The tammar wallaby and fur seal: Models to examine local control of lactation. Journal of Dairy Science. 90. 2007
2006
- Journal Articles Refereed
  - Characterization of two whey protein genes in the Australian dasyurid marsupial, the stripe-faced dunnart (Sminthopsis macroura). Cytogenetic and Genome Research. 115. 2006
  - Fur seal adaptations to lactation: Insights into mammary gland function. Current Topics in Developmental Biology. 72. 2006
1997
- Journal Articles
  - A novel tandem repeat sequence located on human chromosome 4p: isolation and characterization.. Genomics. 42. 1997
1994
- Journal Articles
  - Erratum: A fast word search algorithm for the representation of sequence similarity in genomic DNA (Nucleic Acids Research (1994) 22 (404-411)). Nucleic Acids Research. 22. 1994
1987
- Journal Articles
  - Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.. EMBO Journal. 6. 1987

Awards

Education and training

PhD, Universite Montpellier 1984
MSc, Universite Montpellier 1982
BSc/BA, Universite Montpellier 1981

Awards and honors

Fellowship, French Governmental, 1984

Linkages

Geographic focus

Australia

Contact Details
- christophe.lefevre@unimelb.edu.au
- 47040
- fax: 8344 7909
- Location
  - Level: 03 Room: 047, Biosciences 4, Parkville
Graduate Study
- - Interested in Graduate Study at Melbourne? Next steps:
    - Graduate Research Programs in Medicine Dentistry and Health Sciences
Visualization Gallery
- Collaboration
  - Co-Author Network
- Research Area Visualizations
  - Map Of Science