PROF Matthew Watt

PROF Matthew Watt


  • Characterisation of the intracellular and ligand-dependent mechanisms through which excess fatty acids induce toxicity in skeletal muscle.
  • Examination of the interrelationships between skeletal muscle fatty acid metabolism and insulin-stimulated glucose uptake.
  • Investigation of the cellular mechanisms that regulate fat breakdown in health and disease. (Obesity)



  • Finding news ways to get healthy
    Professor Matthew Watt leads an innovative research program that seeks to identify how defects of lipid metabolism and inter-tissue communication cause obesity-related disorders, and to use this information to discover novel targets that can be transitioned to clinical therapeutics. His team’s research strategy encompasses two major streams:
    1.  Target identification- where protein expression is modulated in cultured cells and combined with discovery-based transcriptomic, proteomic and lipidomic approaches with targeted functional cell biology to unravel the regulation of biological functions (metabolism, endocrine function, energy metabolism).
    2.  In vivo validation- involves the utilisation of mouse metabolic phenotyping and biochemical assessment of unique transgenic murine models to understand integrative biology systems. This is followed by pre-clinical studies in human tissues to demonstrate potential therapeutic efficacy.
    Professor Watt has authored >120 peer-reviewed manuscripts and contributes to the discipline through his roles as National Secretary of the Australian Physiological Society and as a reviewing editor of the American Journal of Physiology (Endocrinology & Metabolism).


Selected publications


Investigator on


Education and training

  • PhD, Deakin University 2002
  • BAppSci (Hons), Deakin University 1998

Awards and honors

  • AK McIntyre Award, Australian Physiological Society, 2004
  • Distinction Award at the Doctoral level, Australian Council for Health, Physical Education and Recreation (ACHPER), 2001
  • International Student Award, American College of Sports Medicine (ACSM), 2001
  • Post-Graduate Award, Deakin University, 1998



Available for supervision

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