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DR Paul Kalitsis

Positions

Honorary, Paediatrics Royal Children's Hospital

Publications

Selected publications

2019
- Journal Articles
  - Loss of TOP3B leads to increased R-loop formation and genome instability. Open Biology. 9. 2019
- Journal Articles Refereed
  - A Roberts Syndrome Individual With Differential Genotoxin Sensitivity and a DNA Damage Response Defect. International Journal of Radiation: Oncology - Biology - Physics. 103. 2019
  - Effect of MUC1 length polymorphisms on the NLRP3 inflammasome response of human macrophages. Human Immunology. 80. 2019
- Journal Articles Unrefereed
  - Knocking in Multifunctional Gene Tags into SMC Complex Subunits Using Gene Editing. Methods in Molecular Biology. 2004. 2019
2018
- Journal Articles Refereed
  - Identification of an Immortalized Human Airway Epithelial Cell Line with Dyskinetic Cilia. American Journal of Respiratory Cell and Molecular Biology. 59. 2018
  - Polymyxin B causes DNA damage in HK-2 cells and mice 2018
  - Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells. Nature Communications. 9. 2018
  - Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers. Proceedings of the National Academy of Sciences of the United States of America. 115. 2018
2017
- Journal Articles Refereed
  - Condensin, master organizer of the genome. Chromosome Research. 25. 2017
  - The Role of Centromere Defects in Cancer 2017
2016
- Journal Articles Refereed
  - Active centromere and chromosome identification in fixed cell lines. Molecular Cytogenetics. 9. 2016
  - Condensin I and II behaviour in interphase nuclei and cells undergoing premature chromosome condensation. Chromosome Research. 24. 2016
  - Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome. PLoS Genetics. 12. 2016
2015
- Research Book Chapters
  - Centromeres in health, disease and evolution. Genomic Elements in Health, Disease and Evolution: Junk DNA. 2015
- Journal Articles Refereed
  - Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo. Metallomics: integrated biometal science. 7. 2015
  - Contribution of the Two Genes Encoding Histone Variant H3.3 to Viability and Fertility in Mice. PLoS Genetics. 11. 2015
  - Disruption of a Conserved CAP-D3 Threonine Alters Condensin Loading on Mitotic Chromosomes Leading to Chromosome Hypercondensation. Journal of Biological Chemistry. 290. 2015
2014
- Journal Articles Refereed
  - Chromosome Y Centromere Array Deletion Leads to Impaired Centromere Function. PLoS One. 9. 2014
- Conference Proceedings
  - The Role of Centromere Defects in Cancer Formation and Progression. Molecular Biology of the Cell. 2014
2013
- Journal Articles Refereed
  - Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes. Nature Communications. 4. 2013
2012
- Journal Articles
  - Mitotic map of condensin I in vertebrate cells.. Molecular Biology of the Cell. 23. 2012
- Journal Articles Refereed
  - Contrasting roles of condensin I and condensin II in mitotic chromosome formation. Journal of Cell Science. 125. 2012
  - Normal DNA Methylation Dynamics in DICER1-Deficient Mouse Embryonic Stem Cells. PLoS Genetics. 8. 2012
  - The evolutionary life cycle of the resilient centromere. Chromosoma. 121. 2012
2010
- Journal Articles
  - Streptavidin-Binding Peptide (SBP)-tagged SMC2 allows single-step affinity fluorescence, blotting or purification of the condensin complex. BMC Biochemistry. 11. 2010
2009
- Journal Articles Refereed
  - Inherent promoter bidirectionality facilitates maintenance of sequence integrity and transcription of parasitic DNA in mammalian genomes. BMC Genomics. 10. 2009
  - Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability. Genome Research. 19. 2009
  - Small CGG repeat expansion alleles of FMR1 gene are associated with parkinsonism. Clinical Genetics. 76. 2009
- Other Refereed Contribution to Refereed Journals
  - Orchestrating Twosome and Foursome Chromosome Parties. Developmental Cell. 17. 2009
2008
- Journal Articles
  - An improved Diagnostic PCR Assay for identification of Cryptic Heterozygosity for CGG Triplet Repeat Alleles in the Fragile X Gene (FMR1). Molecular Cytogenetics. 1. 2008
- Journal Articles Refereed
  - ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger, mammalian centromere protein. Chromosoma. 117. 2008
2007
- Conference Proceedings
  - Identification and characterisation of a novel chromatin modifying protein. Chromosome Research. 2007
2006
- Journal Articles Refereed
  - Mouse telocentric sequences reveal a high rate of homogenization and possible role in Robertsonian translocation. Proceedings of the National Academy of Sciences of the United States of America. 103. 2006
2005
- Journal Articles Refereed
  - Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice. Genes, Chromosomes & Cancer. 44. 2005
  - Spef1, a conserved novel testis protein found in mouse sperm flagella. Gene. 353. 2005
2004
- Other Refereed Contribution to Refereed Journals
  - Building the centromere: from foundation proteins to 3D organization. Trends in Cell Biology. 14. 2004
2003
- Journal Articles Refereed
  - Partially functional Cenpa-GFP fusion protein causes increased chromosome missegregation and apoptosis during mouse embryogenesis. Chromosome Research. 11. 2003
2002
- Journal Articles Refereed
  - Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated. Journal of Biological Chemistry. 277. 2002
  - Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc. Human Molecular Genetics. 11. 2002
2001
- Journal Articles
  - A 330 kb CENP-A binding domain and altered replication timing at a human neocentromere. EMBO Journal. 20. 2001
  - A novel chromatin immunoprecipitation and array (CIA) analysis identifies a 460-kb CENP-A-binding neocentromere DNA. Genome Research. 11. 2001
2000
- Journal Articles
  - Assignment of the Centromere Protein H (Cenph) gene to mouse chromosome band 13D1 by in situ hybridization and interspecific backcross analyses. Cytogenetics and Cell Genetics. 90. 2000
  - Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes & Development. 14. 2000
  - Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes. Human Genetics. 107. 2000
  - Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice. Proceedings of the National Academy of Sciences of the United States of America. 97. 2000
  - Human centromeres and neocentromeres show identical distribution patterns of > 20 functionally important kinetochore-associated proteins. Human Molecular Genetics. 9. 2000
1999
- Journal Articles
  - Conservation of centromere proteins in vertebrates. Chromosome Research. 7. 1999
  - Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice. Human Molecular Genetics. 8. 1999
  - Mouse mitotic spindle checkpoint Bub3 gene maps to the distal region of Chromosome 7 by interspecific backcross analysis. Cytogenetics and Cell Genetics. 87. 1999
  - Trisomy 20p resulting from inverted duplication and neocentromere formation. American Journal of Medical Genetics. 85. 1999
- Conference Proceedings
  - Trisomy 20p resulting from inverted duplication and neocentromere formation. American Journal of Medical Genetics. 1999
1998
- Journal Articles
  - Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights. Journal of Cell Biology. 141. 1998
  - Gene structure and sequence analysis of mouse centromere proteins A and C. Genomics. 47. 1998
  - Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death. Proceedings of the National Academy of Sciences of the United States of America. 95. 1998
1997
- Journal Articles
  - A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA. Nature Genetics. 16. 1997
  - Chromosomal localization of mouse Cenpa gene. Cytogenetics and Cell Genetics. 79. 1997
1994
- Journal Articles
  - A NOVEL NUCLEAR-PROTEIN BINDS CENTROMERIC ALPHA-SATELLITE DNA. Human Molecular Genetics. 3. 1994
1993
- Journal Articles
  - A CHROMOSOME-13-SPECIFIC HUMAN SATELLITE-I DNA SUBFAMILY WITH MINOR PRESENCE ON CHROMOSOME-21 - FURTHER-STUDIES ON ROBERTSONIAN TRANSLOCATIONS. Genomics. 16. 1993
1992
- Journal Articles
  - A CHROMOSOME-14-SPECIFIC HUMAN SATELLITE-III DNA SUBFAMILY THAT SHOWS VARIABLE PRESENCE ON DIFFERENT CHROMOSOMES-14. American Journal of Human Genetics. 50. 1992
  - IDENTIFICATION OF DNA-SEQUENCES FLANKING THE BREAKPOINT OF HUMAN T(14Q21Q) ROBERTSONIAN TRANSLOCATIONS. American Journal of Human Genetics. 50. 1992
  - NONINACTIVATION OF A PORTION OF XQ28 IN A BALANCED X-AUTOSOME TRANSLOCATION. American Journal of Medical Genetics. 42. 1992
1991
- Journal Articles
  - A SURVEY OF THE GENOMIC DISTRIBUTION OF ALPHA-SATELLITE DNA ON ALL THE HUMAN-CHROMOSOMES, AND DERIVATION OF A NEW CONSENSUS SEQUENCE. Nucleic Acids Research. 19. 1991
  - DUPLICATIONS OF THE X-CHROMOSOME IN MALES - EVIDENCE THAT MOST PARTS OF THE X-CHROMOSOME CAN BE ACTIVE IN 2 COPIES. Human Genetics. 86. 1991
  - X-CHROMOSOME INACTIVATION IN FIBROBLASTS OF MENTALLY-RETARDED FEMALE CARRIERS OF THE FRAGILE SITE XQ27.3 - APPLICATION OF THE PROBE M27-BETA TO EVALUATE X-INACTIVATION STATUS. American Journal of Medical Genetics. 38. 1991
1990
- Journal Articles
  - UNUSUAL X-CHROMOSOME INACTIVATION IN A MENTALLY-RETARDED GIRL WITH AN INTERSTITIAL DELETION XQ27 - IMPLICATIONS FOR THE FRAGILE X-SYNDROME. Human Genetics. 84. 1990
1989
- Journal Articles
  - PLANT RETROTRANSPOSON FROM LILIUM-HENRYI IS RELATED TO TY3 OF YEAST AND THE GYPSY GROUP OF DROSOPHILA. Proceedings of the National Academy of Sciences of the United States of America. 86. 1989

Research

Investigator on

Grant
- Taming the intruders: the domestication of Tigger transposable elements in mammals (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2007 - 2010

Supervision

Available for supervision

Y

Contact Details
- kalitsis@unimelb.edu.au
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