A/PROF Kulmira Nurgali

A/PROF Kulmira Nurgali

Positions

  • Enteric nervous system (Neuronal excitability)
  • Enteric neuropathy (Chemotherapy)
  • Neuro-immune interaction in cancer development and progression (Colorectal cancer)
  • Novel treatments for Inflammatory Bowel Disease (IBD)
  • Stem cell-based therapy (Stem cells)

Overview

OverviewText1

  • I am a research and teaching academic with 50% of teaching and course coordination and 50% of research workload. My research is focused on enteric neuropathy associated with Inflammatory Bowel Disease (IBD), colorectal cancer (2nd most common cancer in the world) and side-effects of anti-cancer chemotherapy (experienced by 90% of cancer patients). My research significantly contributes to understanding of mechanisms underlying these problems and proposes novel therapies. Being a medical graduate, I focus on pre-clinical studies that have translational value and direct impact on patient’s life and outcomes of the treatment. My research is original and internationally valued as evidenced by 82 presentations (oral and poster) at including 26 invited speaker/oral presentations the National and International meetings. I have organized and chaired 3 international and 1 national symposiums. My research program has been funded by 4 NHMRC grants (CIA in 2), NHMRC Peter Doherty Fellowship, equipment grants, 4 near-miss NHMRC grants and several competitive grants from other external funding bodies. I have established a functional research laboratory at the Western Center for Health, Research and Education (WCHRE) at Sunshine Hospital (currently 1.5 staff and 17 students) and pre-clinical animal models of IBD, colorectal cancer, chemotherapy, inflammation-induced cancer and methamphetamine-induced depression. Studies in pre-clinical animal models of disease have significantly progressed into the development of novel therapies. Moreover, this attracted a number of international visiting scientists (postgraduate students and senior researchers) from Austria, Canada, Germany, Netherlands, Spain, and China working on collaborative research projects in my lab. Active collaborations with Prof Kelley (USA), Prof Abalo (Spain), Prof Schaefer (Germany), Prof Bornstein (Melbourne University), Prof Apostolopoulos (Victoria University), A/Prof Eri (Tasmania University) and many other inte   

Affiliation

Member of

  • International Society of Autonomic Neuroscience (ISAN). Full member 2007 -
  • GESA (Gastroenterological Society of Australia). Science Graduate 2004 -
  • Australian Neuroscience Society (ANS). Full member 2000 -

Publications

Selected publications

Research

Investigator on

Additional Grant Information

  • GRANTS RECEIVED: 2007 Early Career Researcher Grant Dr K Nurgali Neuronal injury and apoptosis following intestinal inflammation $40,000 2006 RA013/06 Clive and Vera Ramaciotti Foundation Establishment Grant Nurgali Equipment for electrophysiological study of the changes in the enteric nervous system during intestinal inflammation $30,000 2006 NHMRC/RAGS Major Equipment Scheme Dr K Nurgali, Prof JC Bornstein, Prof JB Furness, Prof DA Williams Inverted microscope with PlasDIC optics for electrophysiological recording apparatus $26,250 2006-2010 400472 NHMRC Peter Doherty (Biomedical) Fellowship Dr K Nurgali Effects of inflammation on the excitability of enteric neurons 4 years 2005-2008 400020 NHMRC Project grant Prof JB Furness and Dr K Nurgali The effects of intestinal inflammation on the currents and channels of identified enteric neurons 3 years $466,500: 2006 $155,500, 2007 $155,500, 2008 $155,500 2009-2011 566502 NHMRC Project grant Dr K Nurgali (CIA) and Prof JB Furness (CIB) The role of voltage-gated Na+ and Ca2+ channels in post-inflammatory hyperexcitability of enteric neurons $405,000 2012-2014 1032414 NHMRC project grant Dr K Nurgali (CIA) and Prof S Brookes (CIB) Effects of intestinal inflammation on functioning of enteric neurons: from animal models to humans $333,510 2019-2021 1158952 NHMRC project grant Prof J Bornstein (CIA), Prof T Savidge (CIB), A/Prof K Nurgali (CIC) Role of the enteric nervous system in antibiotic associated diarrhoea $871,416.00 2017 Australian Institute of Musculoskeletal Sciences K Nurgali Seed project “Inflammatory bowel disease-associated osteoporosis: identification of mechanisms and therapeutic targets” $10,000 2019 Surecell V Apostolopoulos, K Nurgali, J Kiatos Characterisation of blood-derived stem cells   

Awards

Education and training

  • PhD, University of Melbourne 2004
  • MSc, Kazakh Academy of Science 1992

Awards and honors

  • Vice-Chancellor’s Award for Excellence in Research and Research Training (supervision) (VU), 2018
  • Teaching Excellence Award (VU), 2016
  • Publication Award (VU), 2016
  • Vice-Chancellor’s Award for Excellence in Research and Research Training (individual) (VU), 2016
  • International Society of Autonomic Neuroscience (ISAN) Congress Travel Award (Kyoto, Japan), 2007
  • Early Career Researcher Award (Melbourne University), 2007
  • Australian Neuroscience Society Travel Award (Sydney), 2006
  • NHMRC Fellowship, 2005
  • Melbourne University Travel Award (Banff, Canada), 2003
  • The University of Melbourne, 2001

Linkages

Supervision

Available for supervision

  • Y

Supervision Statement

  • My research is focused on enteric neuropathy associated with Inflammatory Bowel Disease (IBD), colorectal cancer (2nd most common cancer in the world) and side-effects of anti-cancer chemotherapy (experienced by 90% of cancer patients). My research significantly contributes to understanding of mechanisms underlying these problems and proposes novel therapies. My laboratory locates at the Western Center for Health, Research and Education (WCHRE) at Sunshine Hospital (currently 1.5 staff and 17 students). We are working on pre-clinical animal models of IBD, colorectal cancer, chemotherapy, inflammation-induced cancer and methamphetamine-induced depression. To date, I have supervised 55 research students including 12 PhD, 4 MSc and provide mentoring to early career researchers.