PROF Jose Villadangos

PROF Jose Villadangos


  • Anti-Viral Immunity
  • Antigen Presentation
  • Dendritic Cells
  • Proteases and their inhibitors (Cystatins)
  • Protein Trafficking
  • Tumour Immunology



  • Jose Villadangos is a Profesor of the University of Melbourne with a dual appointment in the Department of Microbiology and Immunology (M&I) and the Department of Biochemistry and Molecular Biology (BMB). He has a laboratory in the main campus (Bldg, 505, M&I) and another in  Bio21 (BMB). His work straddles biochemistry, cell biology and immunology. He has contributed to elucidate the function of  dendritic cells, important components of the immune system involved in infection, immunity and cancer, and the mechanisms employed by immune cells to capture, process and present antigens.

    Jose obtained his Ph. D. from the Universidad Autonoma de Madrid in 1994 under the supervision of Prof. Jose A. Lopez de Castro, studying the role of MHC polymorphism in peptide selection and T cell recognition. He then joined the laboratory of Prof. Hidde Ploegh in the USA, first at MIT and later at Harvard Medical School, where he contributed to the identification of proteases involved in MHC class II antigen presentation. In 1998, he joined the laboratory of Prof. Ken Shortman at the Walter and Eliza Hall Institute (WEHI) in Melbourne, Australia, to apply his expertise to the study of dendritic cells. He started his own laboratory at the WEHI in 2001 and moved to The University of Melbourne in November 2011.

    Jose has authored over 80 original articles, reviews and book chapters and is regularly invited to speak at major National and International conferences. He has received awards from the Human Frontiers Science Program and the Leukemia and Lymphoma Society and is currently a NH&NMC Senior Research Fellow. Jose has been awarded research grants from the Humans Frontiers Science Program (2x), the Anti-Cancer Council, the Australian Research Council and the NH&MRC (3x Program and 8x Project grants). He regularly reviews grants for multiple National and International funding organisations, is invited to review manuscripts for leading j   


Member of

  • American Association of Immunologists. Member 2010 -
  • National Association of Research Fellows. Member 2009 -
  • Spanish Society of Immunology. Member 2009 -
  • Australasian Society for Immunology. Member 1998 -
  • Australasian Society for Immunology. Secretary 2005 - 2009
  • International Proteolysis Society. Member 2001 - 2004


Selected publications


Investigator on

Additional Grant Information

  • Previously Held Grants
    Anti-Cancer Council of Victoria (ACCV)
    Chief Investigator
    Title: “Role of endosomal proteases in MHC class II presentation and MHC I cross-presentation”
    Duration: June 2001-December 2002
    Amount: $50,000 p.a.

    Program Grant of the Human Frontiers Science Program Organization (HFSPO)
    Principal Investigator
    Title: “Role of proteolysis in MHC class II antigen presentation by dendritic cells”
    Co-PI: Prof. Hidde L. Ploegh (USA), and Prof. Christoph Peters (Germany).
    Duration: January 2002-December 2004
    Amount: US$250,000 p.a. (I received US$83,333 p.a.)

    Program Grant of the National Health and Medical Research Council (NH&MRC)
    Chief Investigator
    Title: “The development and immunological function of mouse and human dendritic cells”.
    Co-CI: Prof. Ken Shortman (WEHI, Melbourne), Dr. Li Wu (WEHI, Melbourne) and Dr. Eugene Maraskovsky (The Ludwig Institute, Melbourne and CSL inc.).
    Duration: January 2002-December 2006
    Amount: $1,035,000 p.a. (I received $196,515 p.a.)

    Anti-Cancer Council of Victoria (ACCV) Grant-in-Aid
    Principal Investigator
    Title: “Mechanisms of cross-presentation in dendritic cells”
    Duration: January 2003-December 2005
    Amount: $60,000 p.a.

    Medical Bioinformatics, Genomics and Proteomics Program (MBGPP) Grant of the National Health and Medical Research Council (NH&MRC)
    Chief Investigator
    Title: “Genomic and Proteomic Profiling of Dendritic Cell Heterogeneity”.
    Co-CIs: Prof. K. Shortman (WEHI, Melbourne), Dr W Heath (WEHI, Melbourne), Dr M Lahoud (WEHI, Melbourne), Dr M Wright (The Burnett Institute, Melbourne), Prof. R Simpson (The Ludwig Institute, Melbourne), and Dr S. Amigorena (Curie Institute, Paris, France)


Education and training

  • PhD, Autonomous University of Madrid 1994
  • MSc, Autonomous University of Madrid 1989

Awards and honors

  • Achievement Award for the Highest-Scoring Program Grant of the 2010 Funding Round (McCluskey, Heath, Carbone, Brooks, Rossjohn, Villadangos, Shortman), NH&MRC, 2011
  • Senior Research Fellowship (Level B), NH&MRC, 2009
  • Scholar Award, Leukemia and Lymphoma Society, 2004
  • Special Fellow Award, Leukemia and Lymphoma Society, 2000
  • Post-doctoral Fellowship, Human Frontiers Science Program, 1998
  • Post-doctoral Fellowship, Lady Tata Memorial Trust, 1995
  • Post-doctoral Fellowship, Spanish Ministry for Science and Education, 1994
  • (Declined), Conchita Rabago Foundation, 1990
  • Spanish Ministry for Science and Education, 1990



Available for supervision

  • Y