Our laboratory applies medicinal chemistry and chemical biology approaches to basic and translational research. We collaborate closely with researchers, both at the institute and externally, to undertake multidisciplinary research programs encompassing chemistry, structural biology, high throughput screening, biochemistry and biology.
A core research goal of our laboratory is to use small molecule probes to understand the key pathways—apoptosis and necroptosis—that govern whether a cell lives or dies. Cell survival or death is an important contributor to many diseases. Our research aims to develop improved therapies for cancers, ischaemic brain injury and stroke.
We are also interested in:
- Designing small molecules called peptidomimetics, and understanding how these bind their target proteins.
- Efficiently synthesising biologically active natural products to facilitate structure-activity relationship studies.