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MS Nicole Walsh

Positions

    Overview

    OverviewText1

    • Education and Professional Experience:
      1996               BSc (Biochemistry) University of Queensland
      1997               BSc Postgraduate Honours (Biochemistry), University of Queensland
      2003               PhD (Biochemistry-Molecular Biology), University of Queensland
      2003-06          Postdoctoral Research Fellow, Division of Rheumatology, Beth Israel Deaconess Medical 
                             Center, Harvard Institutes of Medicine, Boston, USA
      2006-08          Senior Postdoctoral Research Fellow, Division of Rheumatology,
                             University of Massachusetts Medical School, Worcester, USA
      2008               Instructor in Medicine, University of Massachusetts Medical School, Worcester, USA
      2009               Senior Research Officer, Bone Cell Biology and Disease Unit, St Vincent’s Institute of 
                             Medical Research
      2010-present  Guest Lecturer and joint co-ordinator of Rheumatoid Arthritis Module 3rd Yr Biomedicine, 
                             Molecules to   

    Publications

    Selected publications

    Research

    Additional Grant Information

    • Research Support (Chronological Order)
      06/2005 - 06/2006 Arthritis National Research Foundation (USA) Postdoctoral Fellowship (CI)
      06/2006 - 06/2007 Arthritis National Research Foundation (USA) Postdoctoral Fellowship, Sontag 
                                    Foundation Fellowship, Competitive Renewal, highest ranked application (CI)
      2009 - SVH Research Endowment Fund, Grant-in-aid (CIA)
      2009 - Arthritis Australia, The Barbara Cameron Memorial Grant (CIA).
      2010 - Arthritis Australia, The Barbara Cameron Memorial Grant (CIA)
      2010 - Perpetual Trust Research Grant (CI)
      2010 - Melbourne Materials Institute, Inter-disciplinery Seed Funding (CIB)
      2011 - St Vincent’s Hospital Research Endowment Fund (CIA)
      2011 - NHMRC Project Grant 1001027 (2011-2013) (CIA)
      2011 - NHMRC Project Grant 1002728 (2011-2013) (CIC)
      2012 - Arthritis Australia, Zimmer Grant (CIB).
      2012 - Perpetual Trust Research Grant (for purchase of a tissue processor for SVIMR) (CI)
      2014 - Arthritis Australia, Zimmer Grant (CIA).
         

    Awards

    Education and training

    • PhD, The University of Queensland 2003

    Awards and honors

    • Young Investigator Travel Award, 1st International Conference on Osteoimmunology, Crete, Greece, 2006
    • The Sontag Foundation Fellow Award for the Arthritis National Research Foundation (USA) (Highest ranked grant proposal), Arthritis National Research Foundation (USA), 2006
    • Christopher & Margie Nordin Young Investigator Award, International Conference for Metabolic Bone Disease and ANZBMS, 2003

    Supervision

    Available for supervision

    • Y

    Supervision Statement

    • Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common forms of arthritis in Australia and represent significant burdens on healthcare expenditure. Although both OA and RA result in destruction of the cartilage within the affected joints, dysregulated bone remodelling, (resorption by osteoclasts, and bone formation by osteoblasts) within the affected joints results in different pathologic outcomes, with net focal bone loss in RA, and net focal bone gain in OA. Our research goal is to identify specific mechanisms that regulate changes in bone remodelling within RA- and OA-affected joints, which ultimately contribute to joint degeneration. This research will aid the development of therapeutics that may halt progression of bone changes in these degenerative joint diseases and augment the preservation of joint integrity, thus improving outcomes for RA and OA patients. To achieve our research goals, we use a combination of in vivo and in vitro approaches including: animal models of osteoarthritis and rheumatoid arthritis, micro CT, histology, bone histomorphometry, immunohistochemistry, in vitro cell culture, gene expression analyses, analyses for activation of cellular signalling pathways