A/PROF Frederic Hollande

A/PROF Frederic Hollande


  • Cancer Treatment resistance (plasticity, EMT, metastatic cancer)
  • Patient-derived Tumour organoids
  • Precision oncology (colorectal cancer, pancreatic cancer)
  • Tumour Heterogeneity (functional genomics)



  • Fred is Deputy Head at the Dept of Clinical Pathology and works at the University of Melbourne Centre for Cancer Research, located within the Victorian Comprehensive Cancer Centre (VCCC).

    He obtained his PhD in 1994 from the University of Montpellier, France, then worked as a post-doctoral research fellow at the Ludwig Institute for Cancer Research and the University of Melbourne (94-96). He was recruited as a CNRS Research Fellow in France in 1996 to study molecular mechanisms that underlie the progression of colon cancer. Fred has been a senior Research Fellow since 2009 and Headed the Oncology Research Department at the Institute of Functional Genomics of Montpellier in 2011-2012. In parallel with his academic work he co-founded in 2007 a small biotech company developing therapeutic monoclonal antibodies. He was the joint-scientific director of this company and designed its Intellectual Property portfolio. The company was acquired by the French Pharmaceutical company Servier in June 2011.

    Fred moved to Melbourne in September 2012 to take up a position as Associate Professor in the Department of Pathology at the University of Melbourne. He joined the Department of Clinical Pathology upon its creation in January 2018.


Member of

  • OzMRS. Member 2019 -
  • University of Melbourne Centre for Cancer Research. Member 2018 -
  • International Society for Stem Cell Research (ISSCR). Member 2017 -
  • Metastasis Research Society. member 2016 -


Selected publications


Investigator on


Education and training

  • PhD, Universite Montpellier 1994
  • MSci, Universite Montpellier 1990
  • BSci, Universite Montpellier 1988



Available for supervision

  • Y

Supervision Statement

  • Student projects are regularly offered in our group, in line with the main interests of our laboratory, studying inter and intra-tumour heterogeneity in solid tumours, particularly in the context of advanced/metastatic cancers, The group also aims to characterise the molecular mechanisms that underlie the phenotypic plasticity of cancer cells and to understand how this plasticity affects the response of tumour-initiating cells to anti-cancer treatments. Finally, we are interested to further analyse the respective contributions of intrinsic programs and of extrinsic/micro-environmental cues in the control of these processes.

    We welcome applications from outstanding and highly motivated students willing to join the group and work on one of these topics