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A/PROF Richard Hughes

Positions

Academic, Medicine, Dentistry and Health Sciences
Academic, Pharmacology and Therapeutics

Affiliation

Member of

Australian Peptide Society. Ordinary member 2005 -

Publications

Selected publications

2018
- Journal Articles Refereed
  - Targeting TrkB with a Brain-Derived Neurotrophic Factor Mimetic Promotes Myelin Repair in the Brain. Journal of Neuroscience. 38. 2018
2017
- Journal Articles Refereed
  - A Brain-Derived Neurotrophic Factor-Based p75(NTR) Peptide Mimetic Ameliorates Experimental Autoimmune Neuritis Induced Axonal Pathology and Demyelination 2017
2016
- Journal Articles Refereed
  - Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist. Journal of Medicinal Chemistry. 59. 2016
  - The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity. Amino Acids. 48. 2016
2015
- Journal Articles Refereed
  - Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins. International Journal of Molecular Sciences. 16. 2015
2014
- Journal Articles Refereed
  - TDP6, a brain-derived neurotrophic factor-based trkB peptide mimetic, promotes oligodendrocyte myelination. Molecular and Cellular Neurosciences. 63. 2014
2013
- Journal Articles Refereed
  - A small peptide mimetic of brain-derived neurotrophic factor promotes peripheral myelination. Journal of Neurochemistry. 125. 2013
2012
- Journal Articles Refereed
  - The structural determinants of insulin-like peptide 3 activity. Frontiers in Endocrinology. 3. 2012
2011
- Journal Articles Refereed
  - Design and Development of Analogues of Dimers of Insulin-like Peptide 3 B-Chain as High-Affinity Antagonists of the RXFP2 Receptor. Biopolymers. 96. 2011
2010
- Journal Articles Refereed
  - Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3. Amino Acids. 38. 2010
  - Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2. Peptides. 31. 2010
  - Synthesis of "Difficult" Fluorescence Quenched Substrates of Granzyme C. International Journal of Peptide Research and Therapeutics. 16. 2010
2009
- Research Book Chapters
  - Development of lanthanide-labelled human INSL3 as an alternative probe to radioactively-labelled INSL3 for use in bioassays. Relaxin and Related Peptides: Fifth International Conference, Ann NY Acad Sci Vol 1160. Wiley-Blackwell Publishing. 2009
  - The chemistry and biology of insulin-like peptide 3, a novel member of the insulin superfamily.. Bioactive Peptides. Taylor & Francis Ltd. 2009
- Journal Articles Refereed
  - Brain-derived neurotrophic factor regulates early postnatal developmental cell death of dopamine neurons of the substantia negra in vivo. Molecular and Cellular Neurosciences. 41. 2009
  - Modified low molecular weight cyclic peptides as mimetics of BDNF with improved potency, proteolytic stability and transmembrane passage in vitro. Bioorganic & Medicinal Chemistry. 17. 2009
2008
- Journal Articles Refereed
  - Design of a conformationally-defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor. Journal of Biological Chemistry. 283. 2008
  - Solid-Phase Synthesis of Europium-Labeled Human INSL3 as a Novel Probe for the Study of Ligand-Receptor Interactions. Bioconjugate Chemistry. 19. 2008
  - Understanding the cardioprotective effects of flavonols: Discovery of relaxant flavonols without antioxidant activity. Journal of Medicinal Chemistry. 51. 2008
2007
- Journal Articles Refereed
  - 2-Methoxyestradiol - a unique blend of activities generating a new class of anti-tumor/anti-inflammatory agents. Drug Discovery Today: Therapeutic Strategies. 12. 2007
  - Carbohydrate-based VEGF inhibitors. European Journal of Organic Chemistry. 2007. 2007
  - Design, synthesis and pharmacological evaluation of cyclic mimetics of the insulin-like peptide 3 (INSL3) B-chain. Journal of Peptide Science. 13. 2007
- Conference Papers Refereed
  - Molecular pathways for the lymphangiogenesis and their role in human disease. 2007
2006
- Journal Articles Refereed
  - Analogs of insulin-like peptide 3 (INSL3) B-Chain are LGR8 antagonists in vitro and in vivo. Journal of Biological Chemistry. 281. 2006
  - Current strategies for modulating lymphangiogenesis signalling pathways in human disease.. Current Medicinal Chemistry. 13. 2006
  - Novel monocyclic and bicyclic loop mimetics of brain-derived neurotrophic factor. Journal of Peptide Science. 12. 2006
  - Solution structure and characterization of the receptor binding surface of insulin-like peptide 3*. Journal of Biological Chemistry. 281. 2006
- Conference Papers Refereed
  - Design of Conformationally-Constrained Peptides as Mimetics of Cellular Growth Factors 2006
- Patents
  - VEGF-D/VEG-C/VEGF peptidomimetic inhibitor 2006
2005
- Journal Articles Refereed
  - Conformationality constrained single-chain peptide mimics of relaxin B-chain secondary structure. Journal of Peptide Science. 11. 2005
  - The next generation of phosphodiesterase inhibitors: Structural clues to ligand and substrate selectivity of phosphodiesterases. Journal of Medicinal Chemistry. 48. 2005
2004
- Journal Articles Refereed
  - A novel approach to the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide mimetic of brain-derived neurotrophic factor. Tetrahedron Letters. 45. 2004
  - Molecular targeting of lymphatics for therapy. Current Pharmaceutical Design. 10. 2004
2003
- Research Book Chapters
  - Mechanisms of neurodegenerative diseases. Molecular pathomechanisms and new trends in drug research. Taylor & Francis Ltd. 2003
- Journal Articles Refereed
  - Design of potent peptide mimetics of brain-derived neurotrophic factor. Journal of Biological Chemistry. 278. 2003
2002
- Journal Articles Refereed
  - 2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding. Molecular Pharmacology. 61. 2002
2001
- Research Book Chapters
  - Oestradiol Metabolites. Effects on Airway Remodelling. New Drugs for Asthma, Allergy and COPD. Karger AG. 2001

Research

Investigator on

Grant
- DESIGN AND SYNTHESIS OF TRICYCLIC DIMER PEPTIDE MIMETICS OF BDNF AS POTENTIAL REMYELINATING THERAPEUTICS TO TREAT MULTIPLE SCLEROSIS (Project Grant) awarded by MULTIPLE SCLEROSIS RESEARCH AUSTRALIA LTD 2017 - 2019
- NOVEL STRATEGIES TO PROMOTE MYELIN REPAIR IN THE BRAIN (Project Grants) awarded by NHMRC 2016 - 2018
- Towards new drugs for multiple sclerosis (Science & Medicine Grants) awarded by THE CASS FOUNDATION LTD 2016 - 2017
- Towards new drugs for multiple sclerosis: Synthetic strategies for the synthesis of novel peptide BDNF-mimetics (Incubator Grant) awarded by MULTIPLE SCLEROSIS RESEARCH AUSTRALIA LTD 2016
- A NEW STRATEGY FOR TREATING DEMYELINATING DISEASES (Project Grants) awarded by NHMRC 2014 - 2017
- Development of INSL5 peptide analogues as novel therapeutics (Linkage Projects) awarded by AUST RESEARCH COUNCIL 2012 - 2016
- Brain derived neurotrophic factor applied locally to the ear to improve hearing (Project Grants) awarded by GARNETT PASSE & RODNEY WILLIAMS MEMORIAL FUND 2012 - 2015
- Enhancing the clinical potential of relaxin (Project Grants) awarded by NHMRC 2012 - 2014
- Examination of BDNF mimetics as promoters of central nervous system myelination (Incubator Grant) awarded by MULTIPLE SCLEROSIS RESEARCH AUSTRALIA LTD 2012 - 2013
- New treatments for cancer (Project Grants) awarded by NHMRC 2009 - 2011
- Structure-function relationship of human insulin-like peptide 3. (Project Grants) awarded by NHMRC 2008 - 2010
- Structure-function relationship of human relaxins. (Project Grants) awarded by NHMRC 2008 - 2010
- DEVELOPMENT OF EPHA4 PEPTIDE INHIBITORS FOR THE TREATMENT OF NEUROTRAUMA (Victorian Neurotrauma Initiative) awarded by TRANSPORT ACCIDENT COMMISSION 2007 - 2009
- Structure-function and domain minimization of insulin-like peptide 3, a novel member of the insulin superfamily (Project Grants) awarded by NHMRC 2005 - 2007

Awards

Education and training

PhD, University of London 1990
MPharm, Victorian College of Pharmacology 1988

Awards and honors

AMRAD, 2005

Supervision

Available for supervision

Y

Contact Details
- rahughes@unimelb.edu.au
- 83448604
- fax: 40241
- Location
  - Level: 08 Room: W811, Medical Building, Parkville
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