Understanding the diversity of pathogens and their human hosts and developing novel approaches to monitor, control and eliminate malaria.
Research in the Barry lab focuses on understanding the diversity of pathogens and their human hosts and developing novel approaches to monitor, control and eliminate malaria.
Current topics of research include disease spread, transmission dynamics and evolution, vaccine development, drug resistance, diagnostics and naturally acquired immunity in the human host.
We are using cutting edge approaches to inform malaria control and elimination. Genome sequencing allows us to track the spread of malaria infections through communities and determine their source. Genomic data also provides an early warning system for drug resistance and determines which strains are circulating, aiding the development of vaccines.
We aim to introduce genomic surveillance into malaria control programs as a way to target control to regions where it can make the greatest impact. The technology we develop for malaria is also being translated for use in other infectious diseases.
Our research is investigating pathogen and human host genomic diversity in different geographic areas, with a view to developing new strategies to control and eliminate infectious diseases.
We are investigating disease transmission patterns to understand:
- the sources and spread of infections
- the emergence and spread of antimicrobial drug resistance
- how microbes avoid detection by the host immune response.
Our research also investigates human genetic diversity and immune responses, to understand natural resistance to disease.
Our research is highly cross-disciplinary including high quality epidemiological surveys, genomics, systems biology, immunology, biostatistics and bioinformatics. We collaborate with researchers and malaria control programs in countries of the Asia-Pacific and Africa, and with leading researchers in Australia, Europe and the USA.