DR Kate Sutherland

DR Kate Sutherland


  • Cancer metabolism
  • Cells-of-origin of lung cancer
  • Genetically engineered mouse models of lung cancer
  • Tumour microenvironment



  • www.wehi.edu.au/people/kate-sutherland

    Our laboratory focuses on lung cancer. Late detection of this cancer, and resistance to current anti-cancer therapies, have contributed to lung cancer being the leading cause of cancer deaths worldwide.

    Lung cancer research is limited by a lack of appropriate laboratory models in which to conduct preclinical studies. Generating preclinical lung cancer models is an important focus of our research. We are using these models to gain a better understanding of how lung cancer initiates, progresses and metastasises.   


Selected publications


Education and training

  • PhD, University of Melbourne 2005


Available for supervision

  • Y

Supervision Statement

  • Research interest

    We are interested in the development of novel models of lung cancer that closely resemble human lung cancer. Genetic alterations found in human lung cancer patients can be replicated in our model using Cre-loxP recombination technology. This enables us to switch oncogenes and tumour suppressor genes specifically in lung epithelial cells. Our current efforts are directed towards generating models of lung squamous cell cancer, the second most common type of lung cancer. These will serve as pre-clinical models for testing new therapeutic drug combinations in the treatment of this lung cancer subtype.

    Another important question in our research is the role of the cell-of-origin of lung squamous cell cancers. To address this question we have the ability to activate or inactivate oncogenes and tumour suppressor genes specifically in Clara cells, alveolar type 2 cells, neuroendocrine cells and basal cells in our model. This is providing insights into  which cells contribute to lung carcinogenesis.