Professor Elizabeth Vincan is a Senior Medical Scientist and Researcher at the Doherty Institute for Infection and Immunity, with joint appointments at the University of Melbourne’s Doherty Department and the Victorian Infectious Diseases Reference Laboratory (VIDRL, Melbourne Health). Her role as Medical Scientist is Deputy Section Head of the Molecular Hepatitis Laboratory, a routine diagnostic laboratory at VIDRL. Elizabeth also heads an independent research lab. Her dual role in diagnostics and research has enabled seamless adoption of research discoveries into a clinical setting. She is internationally recognised in the Wnt signalling field; has published two books and several highly cited reviews on Wnt signalling, and was the convenor of the first international Wnt meeting, and the first EMBO workshop, held in Australia (Cable Beach, Broome, 2014). Elizabeth is an adjunct Professor at the Curtin University, Perth, WA and a founding member of the Australian Living Organoid Alliance (ALOA), a non-profit initiative to establish organoid Biobanks nationally as a research and diagnostic resource.
At the heart of our research projects is the Wnt signal transduction pathway. The Wnt pathway is an ancient form of cell-cell communication that is highly conserved through evolution from simple organisms to man. Wnt proteins bind to Frizzled, their cell surface receptors, to regulate embryonic development, but also homeostasis, repair and regeneration of adult tissues. Deregulated Wnt signaling impacts on many human diseases, including cancer.
In the Vincan lab, we incorporate biochemical, genetic and cell biological approaches to investigate how Wnt and Frizzled regulate these processes. As model systems, we use transgenic mice and three-dimensional organoids (means “organ-like”) established from mouse and human tissues. Tissue-restricted stem cell-derived organoids faithfully recapitulate
Australian Society for Stem Cell Research (ASSCR).
Member 2017 -
International Society for Stem Cell Research (ISSCR).
Member 2017 -
Aus&NZ Soc Cell Dev Biol (ANZSCDB).
Member 2014 -
Australian Society for Medical Research (ASMR).
Member 2004 -
The International EMT Association (TEMTIA).
Member 2003 -
2011-2012: Vincan, Barker, Phesse, Clevers – Project Grant from Melbourne Health (#605030) “Frizzled function in intestinal stem cells”. $120,000
2016-2018: Vincan, Phesse, Ebert, Warner, Fifis, Christophi, Helmut, Clevers – Project Grant from Melbourne Health (PG-002-2016) “Mini-liver organoids, an innovative tool to understand oncogenic Wnt signalling and HBV infection“. $240,000.