Dr Justin Denholm is an infectious diseases physician and ethicist, based at the Royal Melbourne Hospital in Victoria, Australia. He is the Medical Director of the Victorian Tuberculosis Program, and is actively involved in clinical and epidemiologic research and supervision. He is a member of the Ethics Advisory Group of the International Union against TB and Lung Disease, and the current Chair of the Australasian Tuberculosis Forum.
Ethical issues relating to latent tuberculosis A/Prof Denholm is currently engaged in a broad research project on ethical issues related to latent tuberculosis infection. This encompasses ethical issues arising from both public health policy, including mandatory screening of healthcare workers and migration screening for LTBI, as well as the ethical implications of particular characteristics of latency. He is also interested in how core elements of risk and uncertainty relating to LTBI and treatment are communicated cross-culturally, especially in relation to appropriately understood consent and equity in healthcare. Mathematical modelling of tuberculosis infection A/Prof Denholm is also engaged in a variety of research projects relating to the use of mathematical modelling approaches to tuberculosis, particularly epidemiological models related to TB elimination. These include: geo-spatial approaches to TB epidemiology in Australia and Papua New Guinea; virtual implementation of programmatic management of multidrug resistant (MDR) TB introduction and expansion; evaluation of public health strategies towards TB elimination; and modelling insights into TB vaccine programs and research. These models include partnerships with a variety of national and state TB organisations, as well as international collaborations for evaluating post-2015 MDG strategies towards TB elimination. Whole-genome sequencing of M. TB as a tool for improved public health This group of collaborative projects between the Victorian Tuberculosis Program and the Department of Microbiology and Immunology involve the use of WGS for understanding TB transmission and biology. In particular, these projects will continue to refine understanding of transmission of TB in low-prevalence areas, and an improved understanding of risk of reactivation following recent exposure. Clinical and programmatic management of tuberculosis in low-prevalence regions A range of novel approaches to the