Development of frontier technologies for measuring biomolecular interactions, such as protein-protein & protein-drug interactions. (Biophysical Characterisation of Biomolecular Interactions)
Structure, function, regulation and inhibition of enzymes of the lysine biosynthesis pathway in bacteria, plants and lower eukaryotes. (Lysine Biosynthesis in Bacteria and Plants)
A/Prof Perugini was awarded his PhD at The University of Melbourne in the field of Biochemistry and Molecular Biology in 2002. His PhD studies focused on the comparison of the structure and function of human apolipoprotein E isoforms linked to common diseases, namely cardiovascular and Alzheimer's disease. He also generated skills in peptide chemistry and the measurement of biomolecular interactions (e.g. protein-protein and protein-ligand interactions) using a suite of biophysical techniques, namely analytical ultracentrifugation, circular dichroism spectroscopy, fluorescence spectroscopy, and isothermal titration microcalorimetry.
Following award of the Young Biophysicist Award from the Australian Society for Biophysics and an Australian Research Council (ARC) Australian Postdoctoral (APD) fellowship in 2004, A/Prof Perugini moved to the Bio21 Molecular Science and Biotechnology Institute (Bio21 Institute) in Melbourne in February 2005. As a lab head at the Bio21 Institute, he co-established the Macromolecular Interactions Facility at the Bio21 Institute, which houses the most sophisticated analytical ultracentrifugation instruments in the southern hemisphere, including absorbance, interference and fluorescence optical systems. He has also developed skills in bacteriology, biodefence, drug discovery, enzymology and structural biology as a research leader at the Bio21 Institute.
In 2007, A/Prof Perugini was awarded the Edman Prize from the Australian Society for Biochemistry & Molecular Biology and a multi-million dollar competitive research grant from the Defense Threat Reduction Agency in the United States. In 2009, A/Prof Perugini was awarded an inaugural ARC Future Fellowship and was promoted to Reader at The University of Melbourne based on his research. community service, and teaching achievements. He currently serves as Co-Leader of the Chemical and Biological Defence theme of the rec