DR Andrew Deans

DR Andrew Deans

Positions

  • Bloom's Syndrome
  • DNA repair
  • Drug discovery
  • Enzyme function
  • Fanconi anaemia
  • Gene editing using CRISPR
  • Structural Biology
  • cancer predisposition

Overview

OverviewText1

  • Andrew completed his PhD with Prof Grant McArthur at the Peter MacCallum Cancer Centre, where he developed an interest in how the cell cycle and DNA repair are involved in the development of breast cancer. In 2006, he moved to the UK to work as a postdoc with Prof Steve West at the London Research Institute. During this time he published several papers on the role of DNA repair proteins in familial cancer syndromes such as Fanconi anaemia and Bloom's Syndrome. In 2012, Andrew returned to Australia to St Vincent's Institute. He now heads a team that continues to explore how defective DNA repair processes contribute to familial cancer, with a particular interest in Fanconi anemia and familial breast cancer. More recently, he has applied this knowledge to the generation of new potential chemotherapeutics that target DNA repair, and mechanisms of DNA repair that are involved in gene editing by CRISPR-Cas9.   

Publications

Selected publications

Research

Additional Grant Information

  • Andrew's lab is funded by grants from NHMRC, Cancer Australia, the National Breast Cancer Foundation and private foundations.   

Awards

Education and training

  • PhD, University of Melbourne 2005
  • BSc (hons), University of Melbourne 2000

Supervision

Available for supervision

  • Y

Supervision Statement

  • Available for supervision of honours or PhD students. Specific projects focus on role of DNA repair genes in gene editing or protecting against cancer. Expertise in biochemistry, genetics or microbiology is preferred. Students should have an interest in understanding how enzymes function, and how these functions act in gene editing or tumour pathogenesis.