Professor Sims is Head of the Bone Cell Biology and Disease Unit at St. Vincent's Institute of Medical Research, where she is also the Deputy Director, and is a Professorial Fellow at The University of Melbourne.
She completed her PhD at the University of Adelaide in 1995, followed by postdoctoral work at the Garvan Institute (Sydney) and Yale School of Medicine (Connecticut, USA).
Her laboratory studies the cellular interactions responsible for development, maintenance and strength of the skeleton, and has defined the roles of a number of key pathways, including the IL-6 family of cytokines and estrogen receptor isoforms in bone through the use of genetically altered mouse models and in vitro systems.
Her work has been recognised by the American Society of Bone and Mineral Research Fuller Albright Award (2010) and the International Bone and Mineral Society Herbert A Fleisch Award (2013), and was appointed a Fellow of the American Society of Bone and Mineral Research (2018).
She is an Associate Editor of the Journal of Bone and Mineral Research, and at Endocrine Reviews, and she serves on the Editorial Board of the Journal of Biological Chemistry. She is President-Elect of the Australia and New Zealand Bone and Mineral Society.