Mark completed his PhD in 2007 at the Queensland Institute of Medical Research under the supervision of Assoc. Prof. Sri Sriprakash focussing on comparative genomics of Streptococcal pathogens. He then undertook a postdoctoral position at the University of York in the UK where he studied the evolution and functional role of lipopolysaccharide modification systems in Salmonella. In 2009 Mark was awarded an NHMRC overseas postdoctoral training fellow and between 2010 and 2014 he worked between the Wellcome Trust Sanger Institute, UK and the University of Queensland under the supervision of Prof Gordon Dougan and Prof Mark Walker where he employed genome sequencing methodologies to examine the genome dynamics of microbial pathogens such as Group A and Group B Streptococcus. Mark was recently recruited to the Department of Microbiology and Immunology at the Peter Doherty Institute, University of Melbourne, where he is growing his own research themes around the application of genome sequencing to bacterial pathogens. Mark has grown extensive international collaborations and applies bioinformatic tools to examine the evolution of bacterial pathogens with a focus on antimicrobial resistance, virulence and transmission along with examining the genomic epidemiology of bacterial populations within geographical regions such as sub-Saharan Africa and remote populations in the Northern Territory of Australia. Mark's objective is to link bacterial genotype with phenotype with the objective of understanding disease mechanisms along with pathogen emergence and spread.
Mark has a number of projects aimed at exploiting genomic approaches to look at bacterial pathogen macroevolution, microevolution, disease associations, antimicrobial resistance as well as expanding into host response and host-pathogen interactions. Co-supervision with the Department of Microbiology and Immunology, the Microbial Diagnostics Unit and other departments is encouraged.