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Kudo NR, Wassmann K, Anger M, Schuh M, Wirth KG, Xu H, Helmhart W, Kudo H, McKay M, Maro B, Ellenberg J, Boer P and Nasmyth K. (2006) Resolution of Chiasmata in oocytes requires separase-mediated protolysis. Cell, 126, 135-146. This article was selected for the cover
Xu, H., Beasley, M., Warren, WD., van der Horst, GTJ., and McKay, M.
Incorrect chromosome segregation during cell division results in the wrong number of chromosomes (aneuploidy) in daughter cells. Chromosome imbalances have extremely damaging consequences, such as altered gene dosage and loss of heterozygosity, events commonly associated with human cancer development. Errors in chromosome segregation during meiosis can manifest infertility, spontaneous miscarriage and whole chromosome dosage disorders such as Down Syndrome (trisomy 21). My research focus on a multi-protein complex, called cohesin, which plays a vital role in regulating chromosome segregation during cell division and in repair of DNA double strand breaks. We are investigating the possible effect of cohesin deregulation on human cancers. Our recent work on cohesin made significant contributions to the understanding of the molecular mechanisms underlying chromosome behaviour in human reproductive and cancer cells.