DR Huiling Xu

DR Huiling Xu

Positions

  • Genetics, cell biology (oncology)

Overview

OverviewText1

  • Xu, H., Yan, Y., Deb, S., Rangasamy D., Germann, M., Malaterre, M., Eder, N.C., Ward R.L., Hawkins, N.J., Tothill R.W., Chen, L., Mortensen, N.J., FoX, S.B., McKay, M.J., and Ramsay, R.G. Cohesin Rad21 mediates LOH and is up-regulated via Wnt promoting transcriptional dysregulation in GI tumors. Cell Reports 2014, 9:1781-1797.

    Germann, M., Xu, H., Malaterre, J., Sampurno, S., Huyghe, M., Cheasley, D., Fre, S., Ramsay, R.G. Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis. Stem Cell Res. 2014, 13:355-366.

    Deb, S*., Xu, H.*, Tuynman, J., George, J., Yan, Y. Li, J., Ward, R. L., Mortensen, N., Hawkins, N. J., McKay, M. J., Ramsay, R. G. and Fox, S. B. (2014) RAD21 cohesin over-expression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas. British Journal of Cancer, 2014, 110:1606-1613. *co-1st author

    Murdoch, B., Owen, N., Stevense, M., Smith, H., Nagaoka, S., Hassold, T., McKay, M., Xu, H., Fu, J., Revenkova, E., Jessberger, R. and Hunt, P. Altered cohesin gene dosage affects Mammalian meiotic chromosome structure and behavior. PLoS Genet, 2013. 9(2): p. e1003241.

    Wojtasz, L., Daniel, K., Roig, I., Bolcun-Filas, E., Xu, H., Boonsanay, V., Eckmann, C. R., Cooke, H. J., Jasin, M., Keeney, S., McKay, M. J., Toth, A. Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. PLoS Genet, 2009. 5(10): p. e1000702.

    Kudo NR, Wassmann K, Anger M, Schuh M, Wirth KG, Xu H, Helmhart W, Kudo H, McKay M, Maro B, Ellenberg J, Boer P and Nasmyth K. (2006) Resolution of Chiasmata in oocytes requires separase-mediated protolysis. Cell, 126, 135-146. This article was selected for the cover

    Xu, H., Beasley, M., Warren, WD., van der Horst, GTJ., and McKay, M.    

Publications

Selected publications

Research

Additional Grant Information

  • Cohesion role in germ cell chromosomal segregation, awarded by
    Australian National Health and Medical Research Council (NHMRC) , 2006-2008

    Cohesion dysfunction: potential new route to tumourigenesis, awarded by
    Australian National Health and Medical Research Council (NHMRC) , 2006-2008   

Awards

Education and training

  • PhD, University of Melbourne 1992
  • MSc, Beijing Agricultural University 1986
  • BSc, Yunnan Univeristy 1983

Linkages

Supervision

Available for supervision

  • Y

Supervision Statement

  • Incorrect chromosome segregation during cell division results in the wrong number of chromosomes (aneuploidy) in daughter cells. Chromosome imbalances have extremely damaging consequences, such as altered gene dosage and loss of heterozygosity, events commonly associated with human cancer development. Errors in chromosome segregation during meiosis can manifest infertility, spontaneous miscarriage and whole chromosome dosage disorders such as Down Syndrome (trisomy 21). My research focus on a multi-protein complex, called cohesin, which plays a vital role in regulating chromosome segregation during cell division and in repair of DNA double strand breaks. We are investigating the possible effect of cohesin deregulation on human cancers. Our recent work on cohesin made significant contributions to the understanding of the molecular mechanisms underlying chromosome behaviour in human reproductive and cancer cells.