Cryo-EM studies of bacterial and viral proteins important for vaccine development and treatment of infectious diseases (Viral glycoproteins, Bacterial transporters, Antibiotic resistance, HIV, Influenza, Flu)
Structural and functional studies of ion channels (Pain sensing, TACAN, TMEM)
Structural and functional studies of proteins involved in cellular homeostasis (AAA ATPase, p97, VCP)
Structural studies of protein complexes important in mitochondrial and neuronal health; Alzheimer’s and Huntington's diseases, IMBPFD, ALS (AAA ATPase p97, Dynamin related protein (DRP1), Optic Atrophy 1 (OPA1))
Isabelle Rouiller graduated as a Biochemical Engineer from INSA Lyon in 1994. She obtained her PhD in 1998 for studying the assembly of African Swine Fever Virus (ASFV) at the Institute for Animal Health (Pirbright laboratories, UK). She trained as a postdoctoral fellow in single particle cryo-electron microscopy and electron tomography at The Scripps Research Institute (San Diego, USA) and at The Burnham Institute (San Diego, USA). In 2007, she established her our laboratory at McGill University (Montreal, Canada) where she conducted cryo-EM studies of medically important macromolecular complexes. In 2017, she joined the department of Biochemistry and Molecular Biology at the University of Melbourne (Melbourne Australia). The core of the research lab on structure-function studies of macromolecular complexes using cryo-EM. A particular focus is proteins that are promising for vaccine development and proteins that are important for the treatment of cancer and neurological diseases.
I strongly believe that the most important role of a supervisor is to encourage and support trainees to develop critical thinking skills in order to conduct independent science projects. Research projects in my laboratory use a combination of approaches to unravel the molecular mechanisms by which protein complexes function and we can modify them to treat and prevent diseases. These projects will suit trainees interested in using multidisciplinary approaches including wet-lab techniques combined with imaging and computational analyses.