DR Mike Clark

DR Mike Clark

Positions

  • Bioinformatics
  • Gene Expression (Nanopore sequencing, RNA-seq)
  • Genome Structure and Regulation (Transcription, non-coding RNAs)
  • Genomics
  • Neurogenetics (Risk genes for neuropsychiatric disorders)

Overview

OverviewText1

  • My group sits at the intersection of genomics and neuroscience, utilising a number of genomic approaches (RNA-Seq, long-read sequencing, targeted RNA sequencing and single cell sequencing) to investigate gene expression and function in the human brain and in neuropsychiatric disorders. Many regions in our DNA are known to confer risk to disease, including neuropsychiatric disorders, but the genes responsible and how they confer risk are often unknown. We are interested in identifying these genes (both protein coding and noncoding) and how their expression can change to cause disease risk. We utilise both post-mortem human brain and neurons derived from induced pluripotent stem cells (iPSCs) to help answer these questions.


    A second research interest of my group is to develop and utilise novel sequencing methods. We have worked in the past to help develop targeted RNA sequencing to allow highly sensitive detection and quantification of genes of interest. More recently we have focused on utilising Nanopore sequencing, a technology that can sequence both DNA and native RNA. We are very interested in applying Nanopore sequencing to many research questions and in developing novel applications for this technology.


    In addition I have long-standing interests in multiple aspects of RNA biology including noncoding RNAs and RNA post-transcriptional regulation.

       

Publications

Selected publications

Research

Additional Grant Information

  • 2017-2019 Co-investigator MRC (Research Grant). Brain-enriched voltage-gated calcium channel isoforms: novel, genetically informed, therapeutic targets for psychiatric disorders. £429,572
    2016-2017 CIA Wellcome Trust (Seed Award). Capture NanoporeSeq: A novel technique for targeted full-length transcript sequencing and gene expression analysis. £86,822   

Awards

Education and training

  • PhD, The University of Queensland 2012
  • MSc, University of Otago 2009
  • BSc (Hons), University of Otago 2006

Awards and honors

  • Australian RNA Special Interest Group Young Investigator Award, 2013
  • CJ Martin Biomedical Fellowship, 2013
  • EMBO Long Term Fellowship, 2013
  • Dean's Award for Research Higher Degree Excellence, 2012

Linkages

Supervision

Available for supervision

  • Y

Supervision Statement

  • The Clark group has an active research program in neuropsychiatric disease genomics, transcriptomics and in applications of Nanopore sequencing. We encourage enthusiastic students from a range of backgrounds to get in touch for further information on available research projects.