The invasive fungus threatening Earth’s biodiversity

Thursday, Mar 28, 2019, 01:02 AM | Source: Pursuit

By Lee Berger, Lee Skerratt

The invasive fungus threatening Earth's biodiversity

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In the 1970s, frogs in remote regions of Australia and Central America began to suddenly disappear.

Researchers investigated whether climate change, UV radiation or pollution were the cause, but there was no clear explanation until a small team in northern Queensland realised the population declines resembled the pattern of an extraordinary disease outbreak.

Litoria serrata (the Green-eyed Treefrog) from the Queensland rainforest has declined due to chytridiomycosis. Picture: Lee Skerratt/ University of Melbourne

By combining disease outbreak approaches from human medical science with ecology and veterinary medicine, Lee Berger discovered chytridiomycosis in 1998, a previously unknown disease caused by parasitic fungi which invades the skin of amphibians.

The discovery earned her Australia's Frank Fenner Prize for Life Scientist of the Year in 2018.

Now a new global analysis by 41 researchers at the Australian National University (ANU), the University of Melbourne and institutions from every inhabited continent has shown chytridiomycosis is responsible for dramatic population declines in 501 species of amphibians, including 90 extinctions – mostly frogs, but also toads and salamanders. In Australia, 40 species have declined and seven have become extinct.

This represents "the greatest recorded loss of biodiversity attributable to a disease," according to lead author Dr Ben Scheele, Postdoctoral Fellow at the Fenner School of Environment and Society at ANU whose postdoctoral studies were supervised by the Melbourne Veterinary School's One Health Research Group, led by Associate Professor Berger and Associate Professor Lee Skerratt.

"This also places Batrachochytrium dendrobatidis (B. dendrobatidis), the fungus that is the most common cause of chytridiomycosis, among the most destructive invasive species we have ever seen," Dr Scheele says.

"In terms of impact, it is comparable to rodents and cats, which threaten 420 and 430 species with extinction, respectively."

Among the 501 amphibian species which have suffered declines, 90 are confirmed or presumed extinct in the wild and a further 124 have lost more than 90 per cent of their population, disappearing from many environments where they were abundant.

A photo using a scanning electron microscope shows an infected frog with fungal tubes poking through the skin's surface. Picture: Lee Berger/ University of Melbourne

"That is an enormous loss of biodiversity, but these are only the species that have been confirmed to be affected – it's very likely there are others that have suffered loss or become extinct, including species that we never had the opportunity to see," Dr Scheele says.

What is chytridiomycosis?

Chytridiomycosis is caused by two parasitic chytrid fungi, most commonly B. dendrobatidis, with B. salamandrivorans affecting fire salamanders in Europe. B. dendrobatidis is likely native to East Asia but is now known to be present in more than 60 countries.

Associate Professor Berger, a co-author of the study and Principal Research Fellow (Wildlife Health and Conservation), says when chytridiomycosis is introduced to a susceptible amphibian population, its effects are sudden and devastating.

"The fungus invades the skin of adult amphibians, living inside epidermal cells and disrupting skin function," she says.

"Unlike mammals, amphibians absorb water and electrolytes through their thin, permeable skin, but chytridiomycosis inhibits that process. Frogs lose potassium and sodium until their blood levels are too low and their hearts begin to malfunction. They become lethargic and die."

The Mountain Yellow-Legged frog was listed as endangered in 2014 after more than 90 per cent of the population disappeared. Picture: Isaac Chellman/NPS/ Flickr

Declines and extinctions

Infected frog populations can crash within months of the fungus arriving. However, some species may have a genetic resistance to chytrid fungi, but that can present its own problems.

"Frog species that tolerate infection can become 'reservoirs' for the fungus, allowing it to persist and spread to new areas," Associate Professor Berger says.

"For many species, chytridiomycosis is the principal driver of decline, exemplified by rapid mass mortalities in undisturbed environments. In other species, chytridiomycosis acts in concert with habitat loss, altered climatic conditions, and invasive species to exacerbate declines."

While declines and extinctions of amphibians peaked in the 1980s, chytridiomycosis still threatens new populations and stifles the recovery of those it has affected. Of the 501 species the researchers examined, there are 292 surviving species for which population trends are known; 232 of these have shown no signs of recovery.

There are signs of recovery in 60 of the species Dr Scheele studied, but he says this generally reflects localised increases in number rather than a return to pre-outbreak abundance.

"We analysed the data to determine the probability of species returning to previous numbers and found species that experienced more recent or more severe declines, lived at higher elevations, were large or nocturnal. These are less likely to recover," he said.

"Taking those factors into account, we found that if a species had lost more than 90 per cent of its previous numbers, the chance of it recovering was less than one in ten."

Chytridiomycosis is responsible for dramatic population declines in 501 species of amphibians, including salamanders. Picture: Shutterstock

The broken barriers against disease

To give these frogs, toads and salamanders the best possible chance of survival and recovery we must limit the further spread of chytridiomycosis and do better to manage other threats, says Associate Professor Skerratt, Principal Research Fellow (Wildlife Biosecurity) at the Melbourne Veterinary School and a co-author on the paper.

"Amphibians are one of the most threatened groups of animals, with 32 per cent of all species at risk of extinction," he says.

"Chytridiomycosis is the major threat and many species will disappear unless we develop a targeted sustainable solution. Although other factors could help push them over the edge, chytridiomycosis is the main driver and needs to addressed urgently."

He says the catastrophic damage chytridiomycosis has done to Earth's biodiversity illustrates the importance of biosecurity, underpinned by good wildlife health surveillance, outbreak response and research.

Funding for the future

It took more than 15 years for Australia to cobble together enough funds to have then PhD student – Lee Berger – look at mass amphibian decline and extinction. And according to Associate Professor Skerratt, she made one of Australia's major discoveries.

"Imagine if we did more than just pass the hat around once a decade. Imagine if Australia had a National Wildlife Health Centre dealing with wildlife disease outbreaks like comparable countries. Maybe we would have saved hundreds of species from decline and extinction," says Associate Professor Skerratt.

Queensland's Common Mistfrog populations have declined due to chytridiomycosis. Picture: Lee Skerratt/University of Melbourne

"Unlike other invasive species, diseases of wildlife are insidious and do not tend to garner political attention and support. Hence, there is a dire need for a call to arms and sustained funding to maintain capacity and progress on finding a solution to this biodiversity crisis."

He says the unprecedented lethality of a single disease affecting almost an entire vertebrate class highlights the threat from the spread of previously unrecognised pathogens in a globalised world.

"Around 300 million years ago, there was one supercontinent, called Pangaea, and species could move across almost the whole of the world's landmass without barriers. Global trade has recreated a functional Pangaea for infectious diseases in wildlife, with far reaching impacts on biodiversity, livestock, and human health.

"The world urgently needs effective biosecurity and an immediate reduction in wildlife trade to reduce the risk of outbreaks like chytridiomycosis."

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