Hui Gan

A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers

Hui K Gan, Sagun Parakh, FT Lee, Niall C Tebbutt, Malaka Ameratunga, Sze Ting Lee, Graeme J O'Keefe, Sylvia J Gong, Christine Vanrenen, Jaren Caine, Mara Giovannetti, Carmel Murone, Fiona E Scott, Nancy Guo, Ingrid JG Burvenich, Cameron Paine, Mary J Macri, Masakatsu Kotsuma, Giorgio Senaldi, Ralph Venhaus, et al.

Journal article  |  2022  |  INVESTIGATIONAL NEW DRUGS

Ephrin type-A 2 (EphA2) is a transmembrane receptor expressed in epithelial cancers. We report on a phase I dose escalation and bi..

Radiolabeled Antibodies for Cancer Imaging and Therapy

Sagun Parakh, Sze Ting Lee, Hui K Gan, Andrew M Scott

Journal article  |  2022  |  CANCERS

Radioimmunoconjugates consist of a monoclonal antibody (mAb) linked to a radionuclide. Radioimmunoconjugates as theranostics tools..

Antibody Drug Conjugates in Glioblastoma - Is There a Future for Them?

Sagun Parakh, Joseph Nicolazzo, Andrew M Scott, Hui Kong Gan

Journal article  |  2021  |  FRONTIERS IN ONCOLOGY

Glioblastoma (GBM) is an aggressive and fatal malignancy that despite decades of trials has limited therapeutic options. Antibody ..

Prevalence of hypoxia and correlation with glycolytic metabolism and angiogenic biomarkers in metastatic colorectal carcinoma

ST Lee, V Muralidharan, N Tebbutt, P Wong, C Fang, Z Liu, H Gan, J Sachinidis, K Pathmaraj, C Christophi, AM Scott

Journal article  |  2021  |  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

PURPOSE: Hypoxia is associated with aggressive tumour behaviour and can influence response to systemic therapy and radiotherapy. T..

Evaluation of F-18-FMISO PET and F-18-FDG PET Scans in Assessing the Therapeutic Response of Patients With Metastatic Colorectal Cancer Treated With Anti-Angiogenic Therapy

Sze Ting Lee, Niall Tebbutt, Hui Kong Gan, Zhanqi Liu, John Sachinidis, Kunthi Pathmaraj, Andrew Mark Scott

Journal article  |  2021  |  FRONTIERS IN ONCOLOGY

INTRODUCTION: Tumor hypoxia and angiogenesis are implicated in tumor growth and metastases, and anti-angiogenic therapies have an ..

EGFRvIII Promotes Cell Survival during Endoplasmic Reticulum Stress through a Reticulocalbin 1-Dependent Mechanism

Juliana Gomez, Zammam Areeb, Sarah F Stuart, Hong PT Nguyen, Lucia Paradiso, Ahmad Zulkifli, Sonakshi Madan, Vijay Rajagopal, Magdalene K Montgomery, Hui K Gan, Andrew M Scott, Jordan Jones, Andrew H Kaye, Andrew P Morokoff, Rodney B Luwor

Journal article  |  2021  |  CANCERS

Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in promoting cell survival during pathophysiol..

Prognostic performance of qSOFA in oncology patients admitted to the emergency department with suspected infection

Tze Lui Koh, Emmanuel Canet, Sobia Amjad, Rinaldo Bellomo, David Taylor, Hui K Gan, Nada Marhoon, Andrew Lim, Wee Loon Ong, Vivek Krishnan, Richard Khor

Journal article  |  2021  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Aim We aimed to test the performance of the quick Sequential Organ Failure Assessment score (qSOFA) in predicting the outcomes of ..

Radiolabelling and preclinical characterization of Zr-89-Df-radiolabelled bispecific anti-PD-L1/TGF-beta RII fusion protein bintrafusp alfa

Ingrid Julienne Georgette Burvenich, Yit Wooi Goh, Nancy Guo, Hui Kong Gan, Angela Rigopoulos, Diana Cao, Zhanqi Liu, Uwe Ackermann, Christian Werner Wichmann, Alexander Franklin McDonald, Nhi Huynh, Graeme Joseph O'Keefe, Sylvia Jie Gong, Fiona Elizabeth Scott, Linghui Li, Wanping Geng, Anup Zutshi, Yan Lan, Andrew Mark Scott

Journal article  |  2021  |  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

PURPOSE: Τhis study aimed to optimize the 89Zr-radiolabelling of bintrafusp alfa investigational drug product and controls, and pe..

Expression of EGFR and conformational forms of EGFR in malignant pleural mesothelioma and its impact on survival

Puey Ling Chia, Sagun Parakh, Prudence Russell, Hui K Gan, Khashayer Asadi, Val Gebski, Carmel Murone, Marzena Walkiewicz, Zhanqi Liu, Bibhusal Thapa, Fiona E Scott, Andrew M Scott, Thomas John

Journal article  |  2021  |  LUNG CANCER

AIM: Conformational forms of the epidermal growth factor receptor (EGFR) are pro-tumorigenic. The prevalence and impact of conform..

Bintrafusp alfa (M7824), a bifunctional fusion protein targeting TGF-β and PD-L1: results from a phase I expansion cohort in patients with recurrent glioblastoma.

Mustafa Khasraw, Michael Weller, David Lorente, Kathryn Kolibaba, Chee Khoon Lee, Craig Gedye, Macarena I de La Fuente, David Vicente, David A Reardon, Hui K Gan, Andrew M Scott, Isabelle Dussault, Christoph Helwig, Laureen S Ojalvo, Carole Gourmelon, Morris Groves

Journal article  |  2021  |  Neurooncol Adv

BACKGROUND: For patients with recurrent glioblastoma (rGBM), there are few options following treatment failure with radiotherapy p..