Hui Gan

Expression of EGFR and conformational forms of EGFR in malignant pleural mesothelioma and its impact on survival

Puey Ling Chia, Sagun Parakh, Prudence Russell, Hui K Gan, Khashayer Asadi, Val Gebski, Carmel Murone, Marzena Walkiewicz, Zhanqi Liu, Bibhusal Thapa, Fiona E Scott, Andrew M Scott, Thomas John

Journal article  |  2021  |  Lung Cancer

AIM: Conformational forms of the epidermal growth factor receptor (EGFR) are pro-tumorigenic. The prevalence and impact of conform..

Prevalence of hypoxia and correlation with glycolytic metabolism and angiogenic biomarkers in metastatic colorectal carcinoma

ST Lee, V Muralidharan, N Tebbutt, P Wong, C Fang, Z Liu, H Gan, J Sachinidis, K Pathmaraj, C Christophi, AM Scott

Journal article  |  2020  |  European Journal of Nuclear Medicine and Molecular Imaging

PURPOSE: Hypoxia is associated with aggressive tumour behaviour and can influence response to systemic therapy and radiotherapy. T..

New insights into ErbB3 function and therapeutic targeting in cancer

Umbreen Hafeez, Adam C Parslow, Hui K Gan, Andrew M Scott

Journal article  |  2020  |  Expert Review of Anticancer Therapy

INTRODUCTION: The importance of ErbB3 receptor tyrosine kinase in cancer progression, primary and acquired drug resistance, has be..

Prognostic performance of qSOFA in oncology patients admitted to the emergency department with suspected infection

Tze Lui Koh, Emmanuel Canet, Sobia Amjad, Rinaldo Bellomo, David Taylor, Hui K Gan, Nada Marhoon, Andrew Lim, Wee Loon Ong, Vivek Krishnan, Richard Khor

Journal article  |  2020  |  Asia-Pacific Journal of Clinical Oncology

AIM: We aimed to test the performance of the quick Sequential Organ Failure Assessment score (qSOFA) in predicting the outcomes of..

Targeting and Efficacy of Novel mAb806-Antibody-Drug Conjugates in Malignant Mesothelioma

Puey-Ling Chia, Sagun Parakh, Ming-Sound Tsao, Nhu-An Pham, Hui K Gan, Diana Cao, Ingrid JG Burvenich, Angela Rigopoulos, Edward B Reilly, Thomas John, Andrew M Scott

Journal article  |  2020  |  Pharmaceuticals

Epidermal growth factor receptor (EGFR) is highly overexpressed in malignant mesothelioma (MM). MAb806 is a novel anti-EGFR antibo..

Targeting Multiple EGFR-expressing Tumors with a Highly Potent Tumor-selective Antibody-Drug Conjugate

Mark G Anderson, Hugh D Falls, Michael J Mitten, Anatol Oleksijew, Kedar S Vaidya, Erwin R Boghaert, Wenqing Gao, Joann P Palma, Diana Cao, Puey-Ling Chia, Thomas John, Hui K Gan, Andrew M Scott, Edward B Reilly

Journal article  |  2020  |  Molecular Cancer Therapeutics

ABBV-321 (serclutamab talirine), a next-generation EGFR-targeted antibody-drug conjugate (ADC) incorporates a potent pyrrolobenzod..

Antibody-Drug Conjugates for Cancer Therapy

Umbreen Hafeez, Sagun Parakh, Hui K Gan, Andrew M Scott

Journal article  |  2020  |  Molecules

Antibody-drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antige..

1021O Safety and antitumor activity of AK104, a bispecific antibody targeting PD-1 and CTLA-4, in patients with mesothelioma which is relapsed or refractory to standard therapies

M Millward, S Frentzas, HK Gan, A Prawira, B Tran, J Coward, X Jin, B Li, M Wang, KY Kwek, Y Xia, J Desai

Conference Proceedings  |  2020  |  Annals of Oncology

Response to combined BRAF/MEK inhibition in adult BRAF V600E mutant spinal pilocytic astrocytoma

Adithya Balasubramanian, Ashray Gunjur, Hui Kong Gan, Yuliya Perchyonok, Lawrence Myron Cher

Journal article  |  2020  |  Journal of Clinical Neuroscience

Practical Considerations for Treating Patients With Cancer in the COVID-19 Pandemic

Eva Segelov, Craig Underhill, Hans Prenen, Christos Karapetis, Christopher Jackson, Louise Nott, Tim Clay, Nick Pavlakis, Sabe Sabesan, Ellen Heywood, Christopher Steer, Carrie Lethborg, Hui K Gan, Desmond Yip, Narayan Karanth, Deme Karikios, C Raina MacIntyre

Journal article  |  2020  |  JCO Oncology Practice

Cancer has become a prevalent disease, affecting millions of new patients globally each year. The COVID-19 pandemic is having far-..