Hui Gan

Clinical and dosimetric risk stratification for patients at high-risk of feeding tube use during definitive IMRT for head and neck cancer.

James E Jackson, Nigel J Anderson, Morikatsu Wada, Michal Schneider, Michael Poulsen, Maureen Rolfo, Maziar Fahandej, Hui Gan, Daryl Lim Joon, Vincent Khoo

Journal article  |  2020  |  Technical Innovations & Patient Support in Radiation Oncology

Introduction: To identify organs to which dose limitation using intensity modulated radiotherapy (IMRT) can potentially modify the..

Antibody Targeting of Eph Receptors in Cancer

Peter W Janes, Mary E Vail, Hui K Gan, Andrew M Scott

Journal article  |  2020  |  Pharmaceuticals

Driving innovation through collaboration: development of clinical annotation datasets for brain cancer biobanking

Craig Gedye, Mythily Sachchithananthan, Robyn Leonard, Rosalind L Jeffree, Michael E Buckland, David S Ziegler, Manuel B Graeber, Bryan W Day, Kerrie L McDonald, Arian Lasocki, Anna K Nowak

Journal article  |  2020  |  Neuro-Oncology Practice

Current Development of Monoclonal Antibodies in Cancer Therapy.

Sagun Parakh, Dylan King, Hui K Gan, Andrew M Scott

Book Chapter  |  2020  |  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer

Exploiting the unique specificity of monoclonal antibodies has revolutionized the treatment and diagnosis of haematological and so..

A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia

Jason D Lickliter, Hui K Gan, Mark Voskoboynik, Surein Arulananda, Bo Gao, Adnan Nagrial, Peter Grimison, Michelle Harrison, Jianjun Zou, Lianshan Zhang, Stacey Luo, Michael Lahn, Howard Kallender, Andrea Mannucci, Catello Somma, Katherine Woods, Andreas Behren, Pablo Fernandez-Penas, Michael Millward, Tarek Meniawy

Journal article  |  2020  |  Drug Design, Development and Therapy

Longitudinal molecular trajectories of diffuse glioma in adults

Floris P Barthel, Kevin C Johnson, Frederick S Varn, Anzhela D Moskalik, Georgette Tanner, Emre Kocakavuk, Kevin J Anderson, Olajide Abiola, Kenneth Aldape, Kristin D Alfaro, Donat Alpar, Samirkumar B Amin, David M Ashley, Pratiti Bandopadhayay, Jill S Barnholtz-Sloan, Rameen Beroukhim, Christoph Bock, Priscilla K Brastianos, Daniel J Brat, Andrew R Brodbelt, et al.

Journal article  |  2019  |  Nature

Clinical Development of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma

Paul Gougis, Camille Moreau Bachelard, Maud Kamal, Hui K Gan, Edith Borcoman, Nouritza Torossian, Ivan Bieche, Christophe Le Tourneau

Journal article  |  2019  |  JNCI Cancer Spectrum

A Phase 1 study of AK104, a tetrameric bispecific antibody that targets PD-1 and CTLA-4 in patients with advanced solid tumors

Ben Markman, Ben Tran, Hui Gan, Amy Prawira, Jermaine Coward, Xiaoping Jin, Baiyong Li, Max Wang, Yu Xia, Jayesh Desai, Michael Millward

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Open-label, multicenter phase 1/2 dose escalation and expansion study of THOR-707 as a single agent and in combination with a PD-1 inhibitor in adult subjects with advanced or metastatic solid tumors

David Luo, Raghad Abdul-Karim, Arun Azad, Joanna Bendell, Hui Gan, Filip Janku, Shiraj Sen, Tira Tan, Judy Wang, Lisa Schechet, Lauren Baker, Joseph Leveque, Tarek Meniawy

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

iPREDICT: Incorporating complex profiling of patients to enrol onto molecularly directed cancer therapeutics. Preliminary results of the adult and paediatric

Kortnye Smith, Sophie O'Haire, Khuong-Quang Dong-Anh, Ben Markman, Hui Gan, Paul G Ekert, Ken O'Byrne, Michael Milward, Ben Solomon, Ben Tran, Clare Scott, Grant McArthur, Damien Kee, Andrew Fellowes, Huiling Xu, Melissa Martyn, Elly Lynch, Paula Lorgelly, Clara Gaff, Stephen Fox, et al.

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Study evaluating the impact of AI software to identify and validate patients for clinical trials

Rachael Chang Lee, Hui Gan, Nada Marhoon, Sianna Panagiotopoulos, Richard Khor

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

PRELIMINARY FINDINGS OF A PHASE I SAFETY AND BIOIMAGING TRIAL OF KB004 (IFABOTUZUMAB) IN PATIENTS WITH GLIOBLASTOMA

Hui Gan, Lawrence Cher, Po Inglis, Zarnie Lwin, Eddie Lau, Uwe Ackermann, Nicole Coombs, Kirsten Remen, Nancy Guo, Sze Ting Lee, Sylvia Gong, Jodie Palmer, Kunthi Pathmaraj, Graeme O'Keefe, Fiona Scott, Bryan Day, Andrew Boyd, Paul Thomas, Cameron Durrant, Andrew Scott

Conference Proceedings  |  2019  |  NEURO-ONCOLOGY

Safety, antitumor activity, and pharmacokinetics (PK) of pamiparib (BGB-290), a PARP1/2 inhibitor, in patients (pts) with advanced solid tumours: Updated phase I dose-escalation/expansion results

M Voskoboynik, L Mileshkin, H Gan, M Millward, G Au-Yeung, TM Meniawy, G Kichenadasse, K Zhang, M Zhang, S Mu, JD Lickliter

Conference Proceedings  |  2019  |  ANNALS OF ONCOLOGY

Young adults diagnosed with high grade gliomas: Patterns of care, outcomes, and impact on employment

Umbreen Hafeez, Siddarth Menon, Bella Nguyen, Caroline Lum, Gregory Gaughran, Ganesalingham Pranavan, Lawrence Cher, Anna K Nowak, Hui K Gan, Sagun Parakh

Journal article  |  2019  |  Journal of Clinical Neuroscience

First-in-Human Phase I Study of the Selective MET Inhibitor, Savolitinib, in Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, and Antitumor Activity

Hui K Gan, Michael Millward, Ye Hua, Chuan Qi, Yang Sai, Weiguo Su, Jian Wang, Lilin Zhang, Melanie M Frigault, Shethah Morgan, Liu Yang, Jason D Lickliter

Journal article  |  2019  |  Clinical Cancer Research

The changing landscape of head and neck cancer radiotherapy patients: is high-risk, prolonged feeding tube use indicative of on-treatment weight loss?

Nigel J Anderson, James E Jackson, Morikatsu Wada, Michal Schneider, Michael Poulsen, Maureen Rolfo, Maziar Fahandej, Hui Gan, Vincent Khoo

Journal article  |  2019  |  Journal of Medical Radiation Sciences

A systematic review of adverse events in randomized trials assessing immune checkpoint inhibitors

Patrick Arnaud-Coffin, Denis Maillet, Hui K Gan, Jean-Jacques Stelmes, Benoit You, Stephane Dalle, Julien Peron

Journal article  |  2019  |  International Journal of Cancer

Changes in the Use of Comprehensive Geriatric Assessment in Clinical Trials for Older Patients with Cancer over Time

Olivia Le Saux, Claire Falandry, Hui K Gan, Benoit You, Gilles Freyer, Julien Peron

Journal article  |  2019  |  The Oncologist

Preliminary findings of a Phase I safety and bioimaging trial of KB004 (ifabotuzumab) in patients with glioblastoma

Hui Gan, Lawrence Cher, Po Inglis, Zarnie Lwin, Eddie Lau, Christian Wichmann, Uwe Ackermann, Nicole Coombs, Kirsten Remen, Nancy Guo, Sze Ting Lee, Sylvia Gong, Jodie B Palmer, Kunthi Pathmaraj, Graeme O'Keefe, Fiona Scott, Bryan W Day, Andrew W Boyd, Paul Thomas, Cameron Durrant, et al.

Conference Proceedings  |  2019  |  Clinical Trials

Comparison of Biomarker Assays for EGFR: Implications for Precision Medicine in Patients with Glioblastoma

Andrew B Lassman, Lisa Roberts-Rapp, Irina Sokolova, Minghao Song, Ekaterina Pestova, Rupinder Kular, Carolyn Mullen, Zheng Zha, Xin Lu, Erica Gomez, Anahita Bhathena, David Maag, Priya Kumthekar, Hui K Gan, Andrew M Scott, Maria Guseva, Kyle D Holen, Peter J Ansell, Martin J van den Bent

Journal article  |  2019  |  Clinical Cancer Research

BI 853520, a FAK-Simile of Prior FAK Inhibitors?

Rachael Chang Lee, Hui K Gan

Journal article  |  2019  |  Targeted Oncology

Safety and efficacy of depatuxizumab mafodotin plus temozolomide in patients with EGFR-amplified, recurrent glioblastoma: results from an international phase I multicenter trial

Andrew B Lassman, Martin J van den Bent, Hui K Gan, David A Reardon, Priya Kumthekar, Nicholas Butowski, Zarnie Lwin, Tom Mikkelsen, Louis B Nabors, Kyriakos P Papadopoulos, Marta Penas-Prado, John Simes, Helen Wheeler, Tobias Walbert, Andrew M Scott, Erica Gomez, Ho-Jin Lee, Lisa Roberts-Rapp, Hao Xiong, Peter J Ansell, et al.

Journal article  |  2019  |  Neuro-Oncology

Clinical correlates of severe thrombocytopenia from temozolomide in glioblastoma patients

Surein Arulananda, James Lynam, Mun Sem Liew, Morikatsu Wada, Lawrence Cher, Hui K Gan

Journal article  |  2018  |  Internal Medicine Journal

A single-institution prospective evaluation of a neuro-oncology multidisciplinary team meeting

Malaka Ameratunga, Dorothea Miller, Wayne Ng, Mori Wada, Augusto Gonzalvo, Lawrence Cher, Hui K Gan

Journal article  |  2018  |  Journal of Clinical Neuroscience

First in human study with GSK3359609 [GSK609], inducible T cell co-stimulator (ICOS) receptor agonist in patients [Pts] with advanced, solid tumors: Preliminary results from INDUCE-1

A Hansen, TM Bauer, V Moreno, M Maio, S Groenland, J Martin-Liberal, H Gan, D Rischin, M Millward, AJ Olszanski, DC Cho, E Paul, M Ballas, C Ellis, H Zhou, S Yadavilli, J Sadik Shaik, EV Schmidt, A Hoos, E Angevin

Conference Proceedings  |  2018  |  Annals of Oncology

Pretreatment risk stratification of feeding tube use in patients treated with intensity-modulated radiotherapy for head and neck cancer

Nigel J Anderson, James E Jackson, Jennifer G Smith, Morikatsu Wada, Michal Schneider, Michael Poulsen, Maureen Rolfo, Maziar Fahandej, Hui Gan, Daryl Lim Joon, Vincent Khoo

Journal article  |  2018  |  Head & Neck

Emerging Gene Fusion Drivers in Primary and Metastatic Central Nervous System Malignancies: A Review of Available Evidence for Systemic Targeted Therapies

Priscilla K Brastianos, Franziska Maria Ippen, Umbreen Hafeez, Hui K Gan

Journal article  |  2018  |  The Oncologist

Monoclonal antibodies as immunomodulatory therapy against cancer and autoimmune diseases

Umbreen Hafeez, Hui K Gan, Andrew M Scott

Journal article  |  2018  |  Current Opinion in Pharmacology

Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

Kenneth Aldape, Samirkumar B Amin, David M Ashley, Jill S Barnholtz-Sloan, Amanda J Bates, Rameen Beroukhim, Christoph Bock, Daniel J Brat, Elizabeth B Claus, Joseph F Costello, John F de Groot, Gaetano Finocchiaro, Pim J French, Hui K Gan, Brent Griffith, Christel C Herold-Mende, Craig Horbinski, Antonio Iavarone, Steven N Kalkanis, Konstantina Karabatsou, et al.

Journal article  |  2018  |  Neuro-Oncology

Safety, pharmacokinetics, and antitumor response of depatuxizumab mafodotin as monotherapy or in combination with temozolomide in patients with glioblastoma

Hui K Gan, David A Reardon, Andrew B Lassman, Ryan Merrell, Martin van den Bent, Nicholas Butowski, Zarnie Lwin, Helen Wheeler, Lisa Fichtel, Andrew M Scott, Erica J Gomez, Judee Fischer, Helen Mandich, Hao Xiong, Ho-Jin Lee, Wijith P Munasinghe, Lisa A Roberts-Rapp, Peter J Ansell, Kyle D Holen, Priya Kumthekar

Journal article  |  2018  |  Neuro-Oncology

Characterization of ABBV-221, a Tumor-Selective EGFR-Targeting Antibody Drug Conjugate

Andrew C Phillips, Erwin R Boghaert, Kedar S Vaidya, Hugh D Falls, Michael J Mitten, Peter J DeVries, Lorenzo Benatuil, Chung-Ming Hsieh, Jonathan A Meulbroek, Sanjay C Panchal, Fritz G Buchanan, Kenneth R Durbin, Martin J Voorbach, David R Reuter, Sarah R Mudd, Lise I Loberg, Sherry L Ralston, Diana Cao, Hui K Gan, Andrew M Scott, et al.

Journal article  |  2018  |  Molecular Cancer Therapeutics

Outcomes after second surgery for recurrent glioblastoma: a retrospective case-control study

Alysson Wann, Patrick A Tully, Elizabeth H Barnes, Zarnie Lwin, Rosalind Jeffree, Katharine J Drummond, Hui Gan, Mustafa Khasraw

Journal article  |  2018  |  Journal of Neuro-Oncology

Receptor Occupancy Imaging Studies in Oncology Drug Development

Ingrid JG Burvenich, Sagun Parakh, Adam C Parslow, Sze Ting Lee, Hui K Gan, Andrew M Scott

Journal article  |  2018  |  The AAPS Journal

Preliminary results from patients with urothelial carcinoma (UC) in a phase 1A/1B study of bgb-A317, an anti-PD-1 monoclonal antibody.

Shahneen Kaur Sandhu, Andrew Graham Hill, Hui Kong Gan, Michael Friedlander, Mark Voskoboynik, Paula Barlow, Amanda Rose Townsend, James Song, Yun Zhang, Zhirong Shen, Qinzhou Qi, Jayesh Desai

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE.

Brian M Alexander, Sujuan Ba, Mitchel S Berger, Donald A Berry, Webster K Cavenee, Susan M Chang, Timothy F Cloughesy, Tao Jiang, Mustafa Khasraw, Wenbin Li, Robert Mittman, George H Poste, Patrick Y Wen, WK Alfred Yung, Anna D Barker, undefined GBM AGILE Network

Journal article  |  2018  |  Clinical Cancer Research

Glioblastoma (GBM) is a deadly disease with few effective therapies. Although much has been learned about the molecular characteri..

Molecular imaging of T cell co-regulator factor B7-H3 with Zr-89-DS-5573a

Ingrid Julienne Georgette Burvenich, Sagun Parakh, Fook-Thean Lee, Nancy Guo, Zhanqi Liu, Hui Kong Gan, Angela Rigopoulos, Graeme Joseph O'Keefe, Sylvia Jie Gong, Yit Wooi Goh, Henri Tochon-Danguy, Fiona Elizabeth Scott, Masakatsu Kotsuma, Kenji Hirotani, Giorgio Senaldi, Andrew Mark Scott

Journal article  |  2018  |  THERANOSTICS

Efficacy of depatuxizumab mafodotin (ABT-414) monotherapy in patients with EGFR-amplified, recurrent glioblastoma: results from a multi-center, international study

Martin van den Bent, Hui K Gan, Andrew B Lassman, Priya Kumthekar, Ryan Merrell, Nicholas Butowski, Zarnie Lwin, Tom Mikkelsen, Louis B Nabors, Kyriakos P Papadopoulos, Marta Penas-Prado, John Simes, Helen Wheeler, Tobias Walbert, Andrew M Scott, Erica Gomez, Ho-Jin Lee, Lisa Roberts-Rapp, Hao Xiong, Earle Bain, et al.

Journal article  |  2017  |  Cancer Chemotherapy and Pharmacology

Antibody-drug conjugates in glioblastoma therapy: the right drugs to the right cells

Hui K Gan, Martin van den Bent, Andrew B Lassman, David A Reardon, Andrew M Scott

Journal article  |  2017  |  Nature Reviews Clinical Oncology

Evolution of anti-HER2 therapies for cancer treatment

Sagun Parakh, Hui K Gan, Adam C Parslow, Ingrid JG Burvenich, Antony W Burgess, Andrew M Scott

Journal article  |  2017  |  Cancer Treatment Reviews

Efficacy and safety results of ABT-414 in combination with radiation and temozolomide in newly diagnosed glioblastoma

David A Reardon, Andrew B Lassman, Martin van den Bent, Priya Kumthekar, Ryan Merrell, Andrew M Scott, Lisa Fichtel, Erik P Sulman, Erica Gomez, JuDee Fischer, Ho-Jin Lee, Wijith Munasinghe, Hao Xiong, Helen Mandich, Lisa Roberts-Rapp, Peter Ansell, Kyle D Holen, Hui K Gan

Journal article  |  2017  |  Neuro-Oncology

L-Tyrosine Confers Residualizing Properties to a D-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies

Fook T Lee, Ingrid JG Burvenich, Nancy Guo, Pece Kocovski, Henri Tochon-Danguy, Uwe Ackermann, Graeme J O'Keefe, Sylvia Gong, Angela Rigopoulos, Zhanqi Liu, Hui K Gan, Andrew M Scott

Journal article  |  2016  |  Molecular Imaging

Dual targeting of EGFR: ready for prime time?

Hui K Gan, Antony W Burgess, Adam C Parslow, Andrew M Scott

Journal article  |  2016  |  Translational Cancer Research

Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with Zr-89-DS-8895a

Ingrid JG Burvenich, Sagun Parakh, Hui K Gan, Fook-Thean Lee, Nancy Guo, Angela Rigopoulos, Sze-Ting Lee, Sylvia Gong, Graeme J O'Keefe, Henri Tochon-Danguy, Masakatsu Kotsuma, Jun Hasegawa, Giorgio Senaldi, Andrew M Scott

Journal article  |  2016  |  Journal of Nuclear Medicine

Antibody-mediated delivery of therapeutics for cancer therapy

Sagun Parakh, Adam C Parslow, Hui K Gan, Andrew M Scott

Journal article  |  2016  |  Expert Opinion on Drug Delivery

Recurrent glioblastoma: Current patterns of care in an Australian population

Sagun Parakh, Vicky Thursfield, Lawrence Cher, Michael Dally, Katharine Drummond, Michael Murphy, Mark A Rosenthal, Hui K Gan

Journal article  |  2016  |  Journal of Clinical Neuroscience

In Vitro and In Vivo Evaluation of Zr-89-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy

Ingrid JG Burvenich, Fook-Thean Lee, Nancy Guo, Hui K Gan, Angela Rigopoulos, Adam C Parslow, Graeme J O'Keefe, Sylvia J Gong, Henri Tochon-Danguy, Stacey E Rudd, Paul S Dormelly, Masakatsu Kotsuma, Toshiaki Ohtsuka, Giorgio Senaldi, Andrew M Scott

Journal article  |  2016  |  Theranostics

Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer

Marika Ciprotti, Niall C Tebbutt, Fook-Thean Lee, Sze-Ting Lee, Hui K Gan, David C McKee, Graeme J O'Keefe, Sylvia J Gong, Geoffrey Chong, Wendie Hopkins, Bridget Chappell, Fiona E Scott, Martin W Brechbiel, Archie N Tse, Mendel Jansen, Manabu Matsumura, Masakatsu Kotsuma, Rira Watanabe, Ralph Venhaus, Robert A Beckman, et al.

Journal article  |  2015  |  Journal of Clinical Oncology

Mistaken identity: Granular cell astrocytoma masquerading as histiocytosis of the central nervous system

Robert N Campbell, Mun Sem Liew, Hui K Gan, Lawrence Cher

Journal article  |  2014  |  Journal of Clinical Neuroscience

Adult medulloblastoma: feasibility and effectiveness of utilising high-dose chemotherapy with autologous stem cell rescue in newly diagnosed patients Reply

SF Wong, G Mak, MA Rosenthal, L Cher, HK Gan

Journal article  |  2014  |  Internal Medicine Journal

Assumptions of Expected Benefits in Randomized Phase III Trials Evaluating Systemic Treatments for Cancer

Hui K Gan, Benoit You, Gregory R Pond, Eric X Chen

Journal article  |  2012  |  Journal of the National Cancer Institute

Immuno-PET Quantitation of de2-7 Epidermal Growth Factor Receptor Expression in Glioma Using I-124-IMP-R4-Labeled Antibody ch806

Fook T Lee, Graeme J O'Keefe, Hui K Gan, Angela J Mountain, Gareth R Jones, Timothy H Saunder, Jessica Sagona, Angela Rigopoulos, Fiona E Smyth, Terrance G Johns, Serengulam V Govindan, David M Goldenberg, Lloyd J Old, Andrew M Scott

Journal article  |  2010  |  Journal of Nuclear Medicine

A phase II trial of primary temozolomide in patients with grade III oligodendroglial brain tumors

Hui K Gan, Mark A Rosenthal, Anthony Dowling, Renate Kalnins, Elizabeth Algar, Nicholas Wong, Angela Benson, Anne-Marie Woods, Lawrence Cher

Journal article  |  2010  |  Neuro-Oncology

Neurolymphomatosis: diagnosis, management, and outcomes in patients treated with rituximab

Hui K Gan, Arun Azad, Lawrence Cher, Paul LR Mitchell

Journal article  |  2010  |  Neuro-Oncology

A phase 1 and pharmacokinetic study of gemcitabine and oxaliplatin in patients with solid tumors

HK Gan, PL Mitchell, P Galettis, ID Davis, J Cebon, P de Souza, M Links

Journal article  |  2006  |  Cancer Chemotherapy and Pharmacology