Marian Todaro

Association between CYP2C9 polymorphisms and ischemic stroke following endovascular neurointervention.

Subhashaan Sreedharan, Leonid Churilov, Jianxiong Chan, Marian Todaro, Alan Coulthard, Jeffrey Hocking, Kate Mahady, Peter Mitchell, Richard Dowling, Steven Bush, Patrick Kwan, Bernard Yan

Journal article  |  2020  |  Journal of Stroke and Cerebrovascular Diseases

OBJECTIVE: Polymorphisms in the CYP2C9 gene may be associated with adverse vascular events following endovascular procedures indep..

Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load

Piero Perucca, Alison Anderson, Dana Jazayeri, Alison Hitchcock, Janet Graham, Marian Todaro, Torbjorn Tomson, Dina Battino, Emilio Perucca, Meritxell Martinez Ferri, Anne Rochtus, Lieven Lagae, Maria Paola Canevini, Elena Zambrelli, Ellen Campbell, Bobby PC Koeleman, Ingrid E Scheffer, Samuel F Berkovic, Patrick Kwan, Sanjay M Sisodiya, et al.

Journal article  |  2020  |  Annals of Neurology

OBJECTIVE: The mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown. Data suggest that AED-induced..

Polygenic burden in focal and generalized epilepsies.

Costin Leu, Remi Stevelink, Alexander W Smith, Slavina B Goleva, Masahiro Kanai, Lisa Ferguson, Ciaran Campbell, Yoichiro Kamatani, Yukinori Okada, Sanjay M Sisodiya, Gianpiero L Cavalleri, Bobby PC Koeleman, Holger Lerche, Lara Jehi, Lea K Davis, Imad M Najm, Aarno Palotie, Mark J Daly, Robyn M Busch, undefined Epi25 Consortium, et al.

Journal article  |  2019  |  Brain

Rare genetic variants can cause epilepsy, and genetic testing has been widely adopted for severe, paediatric-onset epilepsies. The..

Rapid Detection of HLA-B*57:01-Expressing Cells Using a Label-Free Interdigitated Electrode Biosensor Platform for Prevention of Abacavir Hypersensitivity in HIV Treatment

Jianxiong Chan, Gita V Soraya, Lauren Craig, Shah M Uddin, Marian Todaro, Duc H Huynh, Chathurika D Abeyrathne, Lyudmila Kostenko, James McCluskey, Efstratios Skafidas, Patrick Kwan

Journal article  |  2019  |  Sensors

Pre-treatment screening of individuals for human leukocyte antigens (HLA) HLA-B*57:01 is recommended for the prevention of life-th..

Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals

Yen-Chen Anne Feng, Daniel P Howrigan, Liam E Abbott, Katherine Tashman, Felecia Cerrato, Tarjinder Singh, Henrike Heyne, Andrea Byrnes, Claire Churchhouse, Nick Watts, Matthew Solomonson, Dennis Lal, Erin L Heinzen, Ryan S Dhindsa, Kate E Stanley, Gianpiero L Cavalleri, Hakon Hakonarson, Ingo Helbig, Roland Krause, Patrick May, et al.

Journal article  |  2019  |  The American Journal of Human Genetics

Acquired cardiac channelopathies in epilepsy: Evidence, mechanisms, and clinical significance

Michael CH Li, Terence J O'Brien, Marian Todaro, Kim L Powell

Journal article  |  2019  |  Epilepsia

There is growing evidence that cardiac dysfunction in patients with chronic epilepsy could play a pathogenic role in sudden unexpe..

A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine

B Berghuis, C Stapleton, ACM Sonsma, J Hulst, GJ de Haan, D Lindhout, R Demurtas, R Krause, C Depondt, WS Kunz, F Zara, P Striano, J Craig, P Auce, AG Marson, H Stefansson, TJ O'Brien, MR Johnson, GJ Sills, S Wolking, et al.

Journal article  |  2019  |  Epilepsia Open

Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

Bassel Abou-Khalil, Pauls Auce, Andreja Avbersek, Melanie Bahlo, David J Balding, Thomas Bast, Larry Baum, Albert J Becker, Felicitas Becker, Bianca Berghuis, Samuel F Berkovic, Katja E Boysen, Jonathan P Bradfield, Lawrence C Brody, Russell J Buono, Ellen Campbell, Gregory D Cascino, Claudia B Catarino, Gianpiero L Cavalleri, Stacey S Cherny, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

An interdigitated electrode biosensor platform for rapid HLA-B*15:02 genotyping for prevention of drug hypersensitivity

Gita V Soraya, Jianxiong Chan, Thanh C Nguyen, Duc H Huynh, Chathurika D Abeyrathne, Gursharan Chana, Marian Todaro, Efstratios Skafidas, Patrick Kwan

Journal article  |  2018  |  Biosensors and Bioelectronics

The pathophysiology of cardiac dysfunction in epilepsy

Krishnan Ravindran, Kim L Powell, Marian Todaro, Terence J O'Brien

Journal article  |  2016  |  Epilepsy Research

The antiepileptic medications carbamazepine and phenytoin inhibit native sodium currents in murine osteoblasts

Sandra J Petty, Carol J Milligan, Marian Todaro, Kay L Richards, Pamuditha K Kularathna, Charles N Pagel, Chris R French, Elisa L Hill-Yardin, Terence J O'Brien, John D Wark, Eleanor J Mackie, Steven Petrou

Journal article  |  2016  |  Epilepsia

Monotherapy with Levetiracetam Versus Older AEDs: A Randomized Comparative Trial of Effects on Bone Health

Tahir Hakami, Terence J O'Brien, Sandra J Petty, Mary Sakellarides, Jemma Christie, Susan Kantor, Marian Todaro, Alexandra Gorelik, Markus J Seibel, Raju Yerra, John D Wark

Journal article  |  2016  |  CALCIFIED TISSUE INTERNATIONAL

Association between CYP2C19 Polymorphisms and Outcomes in Cerebral Endovascular Therapy

M Lin, M Todaro, J Chan, L Churilov, WS Zhu, S Ramdave, PJ Mitchell, RJ Dowling, P Kwan, B Yan

Journal article  |  2016  |  American Journal of Neuroradiology

Point-of-care molecular diagnostic devices: an overview

Lan Nguyen Vu Chi, Jianxiong Chan, Marian Todaro, Stan Skafidas, Patrick Kwan

Journal article  |  2015  |  Pharmacogenomics

Disseminated Scedosporium prolificans infection in an 'extensive metaboliser': navigating the minefield of drug interactions and pharmacogenomics

JA Trubiano, E Paratz, M Wolf, BW Teh, M Todaro, KA Thursky, MA Slavin

Journal article  |  2014  |  Mycoses

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy

Doug Speed, Clive Hoggart, Slave Petrovski, Ioanna Tachmazidou, Alison Coffey, Andrea Jorgensen, Hariklia Eleftherohorinou, Maria De Iorio, Marian Todaro, Tisham De, David Smith, Philip E Smith, Margaret Jackson, Paul Cooper, Mark Kellett, Stephen Howell, Mark Newton, Raju Yerra, Meng Tan, Chris French, et al.

Journal article  |  2014  |  Human Molecular Genetics

MRI-identified pathology in adults with new-onset seizures

Tahir Hakami, Anne Mcintosh, Marian Todaro, Elaine Lui, Raju Yerra, K Meng Tan, Chris French, Simon Li, Patricia Desmond, Zelko Matkovic, Terence J O'Brien

Journal article  |  2013  |  Neurology

Older vs Newer Antiepileptic Drugs: Is Old Still Gold? reply

Terence J O'Brien, Tahir Hakami, Marian Todaro

Journal article  |  2013  |  JAMA Neurology

lder vs Newer Antiepileptic Drugs: Is Old Still Gold?-Reply

TJ O'Brien, T HAKAMI, M Todaro

Journal article  |  2013  |  JAMA Neurology

Substitution Monotherapy With Levetiracetam vs Older Antiepileptic Drugs A Randomized Comparative Trial

Tahir Hakami, Marian Todaro, Slave Petrovski, Lachlan MacGregor, Dennis Velakoulis, Meng Tan, Zelko Matkovic, Alexandra Gorelik, Danny Liew, Raju Yerra, Terence J O'Brien

Journal article  |  2012  |  Archives of Neurology

Effects of levetiracetam and older antiepileptic drugs on bone and body composition: A comparative randomised controlled trial

JD Wark, T Hakami, TJ O'Brien, M Sakellarides, J Christie, S Kantor, M Todaro, A Gorelik, M Seibel, SJ Petty

Conference Proceedings  |  2012  |  BONE