Heather Young

Role of JNK, MEK and adenylyl cyclase signalling in speed and directionality of enteric neural crest-derived cells

Marlene M Hao, Annette J Bergner, TH Nguyen Huynh, Paige Dissanayake, Laura E Burnett, C Danielle Hopkins, Kevin Zeng, Heather M Young, Lincon A Stamp

Journal article  |  2019  |  DEVELOPMENTAL BIOLOGY

BACKGROUND: Cells derived from the neural crest colonize the developing gut and give rise to the enteric nervous system. The rate ..

Technologies for Live Imaging of Enteric Neural Crest-Derived Cells

Marlene M Hao, Annette J Bergner, Donald F Newgreen, Hideki Enomoto, Heather M Young

Journal article  |  2019  |  NEURAL CREST CELLS

Time-lapse imaging of gut explants from embryonic mice in which neural crest-derived cells express fluorescent proteins allows the..

Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death (vol 6, 2017)

Caroline S Hirst, Lincon A Stamp, Annette J Bergner, Marlene M Hao, Mai X Tran, Jan M Morgan, Matthias Dutschmann, Andrew M Allen, George Paxinos, Teri M Furlong, Sonja J McKeown, Heather M Young

Journal article  |  2018  |  SCIENTIFIC REPORTS

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fix..

Development of the Enteric Nervous System

HM Young, LA Stamp, T Uesaka, MM Hao, DF Newgreen, H Enomoto

Book Chapter  |  2018

Enteric neurons and glial cells arise from neural crest cells, most of which emigrate from the caudal hindbrain ("vagal" level) an..

Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death

Caroline S Hirst, Lincon A Stamp, Annette J Bergner, Marlene M Hao, Mai X Tran, Jan M Morgan, Matthias Dutschmann, Andrew M Allen, George Paxinos, Teri M Furlong, Sonja J McKeown, Heather M Young

Journal article  |  2017  |  SCIENTIFIC REPORTS

Goldberg-Shprintzen syndrome is a poorly understood condition characterized by learning difficulties, facial dysmorphism, microcep..

Spontaneous calcium waves in the developing enteric nervous system

Marlene M Hao, Annette J Bergner, Caroline S Hirst, Lincon A Stamp, Franca Casagranda, Joel C Bornstein, Werend Boesmans, Pieter Vanden Berghe, Heather M Young

Journal article  |  2017  |  DEVELOPMENTAL BIOLOGY

The enteric nervous system (ENS) is an extensive network of neurons in the gut wall that arises from neural crest-derived cells. L..

Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells

Lincon A Stamp, Rachel M Gwynne, Jaime PP Foong, Alan E Lomax, Marlene M Hao, David I Kaplan, Christopher A Reid, Steven Petrou, Andrew M Allen, Joel C Bornstein, Heather M Young

Journal article  |  2017  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Cell therapy offers the potential to treat gastrointestinal motility disorders caused by diseased or absent ent..

Exposure to GDNF Enhances the Ability of Enteric Neural Progenitors to Generate an Enteric Nervous System

Sonja J McKeown, Mitra Mohsenipour, Annette J Bergner, Heather M Young, Lincon A Stamp

Journal article  |  2017  |  STEM CELL REPORTS

Cell therapy is a promising approach to generate an enteric nervous system (ENS) and treat enteric neuropathies. However, for tran..

Recent advances in regenerative medicine to treat enteric neuropathies: use of human cells

LA Stamp, HM Young

Journal article  |  2017  |  NEUROGASTROENTEROLOGY AND MOTILITY

As current options for treating most enteric neuropathies are either non-effective or associated with significant ongoing problems..

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

Alan J Burns, Allan M Goldstein, Donald F Newgreen, Lincon Stamp, Karl-Herbert Schaefer, Marco Metzger, Ryo Hotta, Heather M Young, Peter W Andrews, Nikhil Thapar, Jaime Belkind-Gerson, Nadege Bondurand, Joel C Bornstein, Wood Yee Chan, Kathryn Cheah, Michael D Gershon, Robert O Heuckeroth, Robert MW Hofstra, Lothar Just, Raj P Kapur, et al.

Journal article  |  2016  |  DEVELOPMENTAL BIOLOGY

Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of..