A/Prof

Nicole La Gruta

Honorary

Microbiology And Immunology

A/Prof

Nicole La Gruta

Division

Medicine, Dentistry And Health Sciences

Primary Interest

CD8+ T cells

A/Prof

Nicole La Gruta

Print

Nicole's Short Profile

Find out more about Nicole La Gruta's experience

Nicole La Gruta's highlights

FEATURED Journal article

Overlapping Peptides Elicit Distinct CD8( ) T Cell Responses following Influenza A Virus Infection

Nicole La Gruta's selected work

Nicole La Gruta's selected work

LIMITING THE IMPACT OF INFLUENZA

Research Grant

Publisher Correction: Metabolic characteristics of CD8 T cell subsets in young and aged in..

Journal article

LIMITING THE IMPACT OF INFLUENZA

Research Grant

The Impact of MHC Class I Dose on Development and Maintenance of the Polyclonal Naive CD8(..

Journal article

LIMITING THE IMPACT OF INFLUENZA

Research Grant

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM ..

Journal article

Projects

Displaying the 10 most recent projects by Nicole La Gruta.

LIMITING THE IMPACT OF INFLUENZA

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

LIMITING THE IMPACT OF INFLUENZA

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

LIMITING THE IMPACT OF INFLUENZA

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

LIMITING THE IMPACT OF INFLUENZA

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

LIMITING THE IMPACT OF INFLUENZA

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

LIMITING THE IMPACT OF INFLUENZA

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

Determinants of CTL recruitment into the immune response

The size of CD8+ T cell (CTL) responses is central to their efficacy in virus control, and can be substantially influenced by how effectivel..

AN INVESTIGATION INTO THE FACTORS INFLUENCING THE COMPOSITION AND FUNCTION OF NAIVE EPITOPE-SPECIFIC CD8+ T CELL POPULATIONS

Defining factors that shape the antiviral immune response

CytotoxicT cells (CTLs) recognize and remove virus infected cells. Both the number and the diversity of T cells involved in the response inf..

Determinants of virus specific CD8+ T cell hierarchies.

The CD8+, or killer , T lymphocytes (white blood cells) are the hit men of immunity, recirculating continually around the body to eliminate ..

12

Projects

Project Types

11

Research Grant

1

Internal Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works by Nicole La Gruta.

Scholarly works icon

Overlapping Peptides Elicit Distinct CD8( ) T Cell Responses following Influenza A Virus Infection

Lisa M Assmus, Jing Guan, Ting Wu, Carine Farenc, Xavier YX Sng, Pirooz Zareie, Angela Nguyen, Andrea T Nguyen, David C Tscharke, Paul G Thomas, Jamie Rossjohn, Stephanie Gras, Nathan P Croft, Anthony W Purcell, Nicole L La Gruta

Journal article | 2020 | The Journal of Immunology

The presentation of pathogen-derived peptides on MHC class I molecules is essential for the initiation of adaptive CD8+ T cell imm..

Scholarly works icon

Publisher Correction: Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality.

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article | 2020 | Nature Communications

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Scholarly works icon

The Impact of MHC Class I Dose on Development and Maintenance of the Polyclonal Naive CD8( ) T Cell Repertoire

Xavier YX Sng, Jasmine Li, Pirooz Zareie, Lisa M Assmus, Jason KC Lee, Claerwen M Jones, Stephen J Turner, Stephen R Daley, Kylie M Quinn, Nicole L La Gruta

Journal article | 2020 | The Journal of Immunology

Naive CD8+ T cell survival in the periphery is critically dependent on tonic TCR signaling through peptide + MHC class I (MHCI) re..

Scholarly works icon

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice

Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen, et al.

Journal article | 2020 | Cell Host & Microbe

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..

Scholarly works icon

Metabolic characteristics of CD8( ) T cell subsets in young and aged individuals are not predictive of functionality

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article | 2020 | Nature Communications

Virtual memory T (TVM) cells are antigen-naïve CD8+ T cells that exist in a semi-differentiated state and exhibit marked prolifera..

Scholarly works icon

Characterisation of clinical and immune reactivity to barley and rye ingestion in children with coeliac disease

Melinda Y Hardy, Amy K Russell, Catherine Pizzey, Claerwen M Jones, Katherine A Watson, Nicole L La Gruta, Donald J Cameron, Jason A Tye-Din

Journal article | 2020 | Gut

OBJECTIVE: Barley and rye are major components of the Western diet, and historic feeding studies indicate that they cause clinical..

Scholarly works icon

MHC Restriction: Where Are We Now?

Pirooz Zareie, Carine Farenc, Nicole L La Gruta

Journal article | 2020 | Viral Immunology

Scholarly works icon

Simulation modelling for immunologists.

Andreas Handel, Nicole L La Gruta, Paul G Thomas

Journal article | 2020 | Nature Reviews Immunology

The immune system is inordinately complex with many interacting components determining overall outcomes. Mathematical and computat..

Scholarly works icon

Modified Vaccinia Virus Ankara Can Induce Optimal CD8( )T Cell Responses to Directly Primed Antigens Depending on Vaccine Design

Yik Chun Wong, Sarah Croft, Stewart A Smith, Leon CW Lin, Tania Cukalac, Nicole L La Gruta, Ingo Drexler, David C Tscharke

Journal article | 2019 | Journal of Virology

Scholarly works icon

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

Ting Wu, Jing Guan, Andreas Handel, David C Tscharke, John Sidney, Alessandro Sette, Linda M Wakim, Xavier YX Sng, Paul G Thomas, Nathan P Croft, Anthony W Purcell, Nicole L La Gruta

Journal article | 2019 | Nature Communications

80

Scholarly Works

Keyword Analysis

Clinical Health (organs, Diseases and Abnormal Conditions)

Clinical (organs, Diseases and Abnormal Conditions)

Specific Population Health (excl. Indigenous Health)

Medical Microbiology

Biochemistry and Cell Biology

Expanding Knowledge

Clinical Sciences

Applied Mathematics

Indigenous Health

Honours, Awards and Fellowships

1999

Monash University

1999

Gastric Biology scholarship

Monash University

1996

Federal Government Postgraduate Award

3

Awards

Credentials

Positions

Honorary

Microbiology And Immunology

Full

Australasian Society for Immunology

Education

Doctor of Philosophy

Monash University

Bachelor of Science (honours)

Monash University