Nicole La Gruta

Simulation modelling for immunologists.

Andreas Handel, Nicole L La Gruta, Paul G Thomas

Journal article  |  2020  |  Nature Reviews Immunology

The immune system is inordinately complex with many interacting components determining overall outcomes. Mathematical and computat..

Modified Vaccinia Virus Ankara Can Induce Optimal CD8( )T Cell Responses to Directly Primed Antigens Depending on Vaccine Design

Yik Chun Wong, Sarah Croft, Stewart A Smith, Leon CW Lin, Tania Cukalac, Nicole L La Gruta, Ingo Drexler, David C Tscharke

Journal article  |  2019  |  Journal of Virology

Characterisation of clinical and immune reactivity to barley and rye ingestion in children with coeliac disease.

Melinda Y Hardy, Amy K Russell, Catherine Pizzey, Claerwen M Jones, Katherine A Watson, Nicole L La Gruta, Donald J Cameron, Jason A Tye-Din

Journal article  |  2019  |  Gut

OBJECTIVE: Barley and rye are major components of the Western diet, and historic feeding studies indicate that they cause clinical..

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

Ting Wu, Jing Guan, Andreas Handel, David C Tscharke, John Sidney, Alessandro Sette, Linda M Wakim, Xavier YX Sng, Paul G Thomas, Nathan P Croft, Anthony W Purcell, Nicole L La Gruta

Journal article  |  2019  |  Nature Communications

CD4( ) T help promotes influenza virus-specific CD8( ) T cell memory by limiting metabolic dysfunction

Jolie G Cullen, Hayley A McQuilten, Kylie M Quinn, Moshe Olshansky, Brendan E Russ, Alison Morey, Sanna Wei, Julia E Prier, Nicole L La Gruta, Peter C Doherty, Stephen J Turner

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

Most viral peptides displayed by class I MHC on infected cells are immunogenic

Nathan P Croft, Stewart A Smith, Jana Pickering, John Sidney, Bjoern Peters, Pouya Faridi, Matthew J Witney, Prince Sebastian, Inge EA Flesch, Sally L Heading, Alessandro Sette, Nicole L La Gruta, Anthony W Purcell, David C Tscharke

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

The clock is ticking: the impact of ageing on T cell metabolism

Kylie M Quinn, Riya Palchaudhuri, Clovis S Palmer, Nicole L La Gruta

Journal article  |  2019  |  Clinical & Translational Immunology

Understanding the drivers of MHC restriction of T cell receptors

Nicole L La Gruta, Stephanie Gras, Stephen R Daley, Paul G Thomas, Jamie Rossjohn

Journal article  |  2018  |  Nature Reviews Immunology

Age-Related Decline in Primary CD8( ) T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8( ) T Cells

Kylie M Quinn, Annette Fox, Kim L Harland, Brendan E Russ, Jasmine Li, Thi HO Nguyen, Liyen Loh, Moshe Olshanksy, Haroon Naeem, Kirill Tsyganov, Florian Wiede, Rosela Webster, Chantelle Blyth, Xavier YX Sng, Tony Tiganis, David Powell, Peter C Doherty, Stephen J Turner, Katherine Kedzierska, Nicole L La Gruta

Journal article  |  2018  |  Cell Reports

Clonally diverse CD38( )HLA-DR( )CD8( ) T cells persist during fatal H7N9 disease

Zhongfang Wang, Lingyan Zhu, Thi HO Nguyen, Yanmin Wan, Sneha Sant, Sergio M Quinones-Parra, Jeremy Chase Crawford, Auda A Eltahla, Simone Rizzetto, Rowena A Bull, Chenli Qiu, Marios Koutsakos, E Bridie Clemens, Liyen Loh, Tianyue Chen, Lu Liu, Pengxing Cao, Yanqin Ren, Lukasz Kedzierski, Tom Kotsimbos, et al.

Journal article  |  2018  |  Nature Communications

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8 T cell response magnitude

Kylie M Quinn, Wan-Ting Kan, Katherine A Watson, Brian J Liddicoat, Natasha G Swan, Hayley McQuilten, Alice E Denton, Jasmine Li, Weisan Chen, Lorena E Brown, David C Jackson, Patrick C Reading, Peter C Doherty, Katherine Kedzierska, Lukasz Kedzierski, Stephen J Turner, Nicole L La Gruta

Journal article  |  2017  |  PLOS ONE

CD4( )CD8( ) double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin

Nana H Overgaard, Jazmina L Cruz, Jennifer A Bridge, Hendrik J Nel, Ian H Frazer, Nicole L La Gruta, Antje Blumenthal, Raymond J Steptoe, James W Wells

Journal article  |  2017  |  Journal of Leukocyte Biology

Quantifiable predictive features define epitope-specific T cell receptor repertoires

Pradyot Dash, Andrew J Fiore-Gartland, Tomer Hertz, George C Wang, Shalini Sharma, Aisha Souquette, Jeremy Chase Crawford, E Bridie Clemens, Thi HO Nguyen, Katherine Kedzierska, Nicole L La Gruta, Philip Bradley, Paul G Thomas

Journal article  |  2017  |  Nature

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Joshua D Ooi, Jan Petersen, Yu H Tan, Megan Huynh, Zoe J Willett, Sri H Ramarathinam, Peter J Eggenhuizen, Khai L Loh, Katherine A Watson, Poh Y Gan, Maliha AA Likhan, Nadine L Dudek, Andreas Handel, Billy G Hudson, Lars Fugger, David A Power, Stephen G Holt, P Toby Coates, Jon W Gregersen, Anthony W Purcell, et al.

Journal article  |  2017  |  Nature

Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice

Jeanette E Villanueva, Stacey N Walters, Mitsuru Saito, Elisabeth K Malle, Nathan W Zammit, Katherine A Watson, Robert Brink, Nicole L La Gruta, Stephen I Alexander, Shane T Grey

Journal article  |  2017  |  Diabetologia

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host

Ada WC Yan, Pengxing Cao, Jane M Heffernan, Jodie McVernon, Kylie M Quinn, Nicole L La Gruta, Karen L Laurie, James M McCaw

Journal article  |  2017  |  Journal of Theoretical Biology

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response

Stephanie Gras, Jesseka Chadderton, Claudia M Del Campo, Carine Farenc, Florian Wiede, Tracy M Josephs, Xavier YX Sng, Michiko Mirams, Katherine A Watson, Tony Tiganis, Kylie M Quinn, Jamie Rossjohn, Nicole L La Gruta

Journal article  |  2016  |  Immunity

Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C

Lucy C Sullivan, Richard Berry, Natasha Sosnin, Jacqueline ML Widjaja, Felix A Deuss, Gautham R Balaji, Nicole L LaGruta, Michiko Mirams, Joseph A Trapani, Jamie Rossjohn, Andrew G Brooks, Daniel M Andrews

Journal article  |  2016  |  Journal of Biological Chemistry

Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection

Haiyin Liu, Reema Jain, Jing Guan, Vivian Vuong, Satoshi Ishido, Nicole L La Gruta, Daniel H Gray, Jose A Villadangos, Justine D Mintern

Journal article  |  2016  |  The Journal of Experimental Medicine

Heightened self-reactivity associated with selective survival, but not expansion, of naive virus-specific CD8( ) T cells in aged mice

Kylie M Quinn, Sophie G Zaloumis, Tania Cukalac, Wan-Ting Kan, Xavier YX Sng, Michiko Mirams, Katherine A Watson, James M McCaw, Peter C Doherty, Paul G Thomas, Andreas Handel, Nicole L La Gruta

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

Antigen Specificity of Type I NKT Cells Is Governed by TCR beta-Chain Diversity

Garth Cameron, Daniel G Pellicci, Adam P Uldrich, Gurdyal S Besra, Petr Illarionov, Spencer J Williams, Nicole L La Gruta, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2015  |  The Journal of Immunology

Sizing up the key determinants of the CD8( ) T cell response

David C Tscharke, Nathan P Croft, Peter C Doherty, Nicole L La Gruta

Journal article  |  2015  |  Nature Reviews Immunology

Consistency in Polyclonal T-cell Responses to Gluten Between Children and Adults With Celiac Disease

Melinda Y Hardy, Adam Girardin, Catherine Pizzey, Donald J Cameron, Katherine A Watson, Stefania Picascia, Renata Auricchio, Luigi Greco, Carmen Gianfrani, Nicole L La Gruta, Robert P Anderson, Jason A Tye-Din

Journal article  |  2015  |  Gastroenterology

Paired TCR alpha beta analysis of virus-specific CD8( ) T cells exposes diversity in a previously defined 'narrow' repertoire

Tania Cukalac, Wan-Ting Kan, Pradyot Dash, Jing Guan, Kylie M Quinn, Stephanie Gras, Paul G Thomas, Nicole L La Gruta

Journal article  |  2015  |  Immunology and Cell Biology

T cells recognizing a 11mer influenza peptide complexed to H-2D(b) show promiscuity for peptide length

Damien Zanker, Kylie Quinn, Jason Waithman, Roleen Lata, Roger Murphy, Nicole Louise La Gruta, Weisan Chen

Journal article  |  2015  |  Immunology and Cell Biology

Fixed Expression of Single Influenza Virus-Specific TCR Chains Demonstrates the Capacity for TCR alpha- and beta-Chain Diversity in the Face of Peptide-MHC Class I Specificity

E Bridie Clemens, Peter C Doherty, Nicole L La Gruta, Stephen J Turner

Journal article  |  2015  |  The Journal of Immunology

T cell mediated immunity to influenza: mechanisms of viral control

Nicole L La Gruta, Stephen J Turner

Journal article  |  2014  |  Trends in Immunology (formerly Immunology Today)

T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease

Jan Petersen, Veronica Montserrat, Jorge R Mujico, Khai Lee Loh, Dennis X Beringer, Menno van Lummel, Allan Thompson, M Luisa Mearin, Joachim Schweizer, Yvonne Kooy-Winkelaar, Jeroen van Bergen, Jan W Drijfhout, Wan-Ting Kan, Nicole L La Gruta, Robert P Anderson, Hugh H Reid, Frits Koning, Jamie Rossjohn

Journal article  |  2014  |  Nature Structural & Molecular Biology

The Influenza Virus-Specific CTL Immunodominance Hierarchy in Mice Is Determined by the Relative Frequency of High-Avidity T Cells

Tania Cukalac, Jesseka Chadderton, Weiguang Zeng, Jolie G Cullen, Wan Ting Kan, Peter C Doherty, David C Jackson, Stephen J Turner, Nicole L La Gruta

Journal article  |  2014  |  Journal of Immunology

Reproducible selection of high avidity CD8( ) T-cell clones following secondary acute virus infection

Tania Cukalac, Jesseka Chadderton, Andreas Handel, Peter C Doherty, Stephen J Turner, Paul G Thomas, Nicole L La Gruta

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

PTPN2 attenuates T-cell lymphopenia-induced proliferation

Florian Wiede, Nicole L La Gruta, Tony Tiganis

Journal article  |  2014  |  Nature Communications

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

Stephen W Scally, Jan Petersen, Soi Cheng Law, Nadine L Dudek, Hendrik J Nel, Khai Lee Loh, Lakshmi C Wijeyewickrema, Sidonia BG Eckle, Jurgen van Heemst, Robert N Pike, James McCluskey, Rene E Toes, Nicole L La Gruta, Anthony W Purcell, Hugh H Reid, Ranjeny Thomas, Jamie Rossjohn

Journal article  |  2013  |  Journal of Experimental Medicine

Interrogating the relationship between naive and immune antiviral T cell repertoires

Nicole L La Gruta, Paul G Thomas

Journal article  |  2013  |  Current Opinion in Virology

Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations

Paul G Thomas, Andreas Handel, Peter C Doherty, Nicole L La Gruta

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Influenza-induced, helper-independent CD8( ) T cell responses use CD40 costimulation at the late phase of the primary response

Shirley GK Seah, Jamie L Brady, Emma M Carrington, Wy Ching Ng, Robyn M Sutherland, Manuela S Hancock, Nicole L La Gruta, Lorena E Brown, Stephen J Turner, Andrew M Lew, Yifan Zhan

Journal article  |  2013  |  Journal of Leukocyte Biology

Unlike CD4( ) T-cell help, CD28 costimulation is necessary for effective primary CD8( ) T-cell influenza-specific immunity

Shirley GK Seah, Emma M Carrington, Wy C Ng, Gabrielle T Belz, Jamie L Brady, Robyn M Sutherland, Manuela S Hancock, Nicole L La Gruta, Lorena E Brown, Stephen J Turner, Yifan Zhan, Andrew M Lew

Journal article  |  2012  |  European Journal of Immunology

Precursor Frequency and Competition Dictate the HLA-A2-Restricted CD8( ) T Cell Responses to Influenza A Infection and Vaccination in HLA-A2.1 Transgenic Mice

Amabel CL Tan, Nicole L La Gruta, Weiguang Zeng, David C Jackson

Journal article  |  2011  |  Journal of Immunology

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8( ) T-cell responses

E Bridie Day, Carole Guillonneau, Stephanie Gras, Nicole L La Gruta, Dario AA Vignali, Peter C Doherty, Anthony W Purcell, Jamie Rossjohn, Stephen J Turner

Journal article  |  2011  |  Proceedings of the National Academy of Sciences of the United States of America

Effect of MHC Class I Diversification on Influenza Epitope-Specific CD8( ) T Cell Precursor Frequency and Subsequent Effector Function

E Bridie Day, Kim L Charlton, Nicole L La Gruta, Peter C Doherty, Stephen J Turner

Journal article  |  2011  |  Journal of Immunology

The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses

Shirley GK Seah, Robyn M Sutherland, Nicole L La Gruta, Lorena E Brown, Emma M Carrington, Gabrielle T Belz, Jamie L Brady, Stephen J Turner, Yifan Zhan, Andrew M Lew

Journal article  |  2011  |  European Journal of Immunology

Influenza Epitope-Specific CD8( ) T Cell Avidity, but Not Cytokine Polyfunctionality, Can Be Determined by TCR beta Clonotype

Jessica M Moffat, Andreas Handel, Peter C Doherty, Stephen J Turner, Paul G Thomas, Nicole L La Gruta

Journal article  |  2010  |  Journal of Immunology

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

Siew Siew Pang, Richard Berry, Zhenjun Chen, Lars Kjer-Nielsen, Matthew A Perugini, Glenn F King, Christina Wang, Sock Hui Chew, Nicole L La Gruta, Neal K Williams, Travis Beddoe, Tony Tiganis, Nathan P Cowieson, Dale I Godfrey, Anthony W Purcell, Matthew CJ Wilce, James McCluskey, Jamie Rossjohn

Journal article  |  2010  |  Nature

Multiplexed combinatorial tetramer staining in a mouse model of virus infection

Tania Cukalac, Sophie A Valkenburg, Nicole L La Gruta, Stephen J Turner, Peter C Doherty, Katherine Kedzierska

Journal article  |  2010  |  Journal of Immunological Methods

Protective Efficacy of Cross-Reactive CD8( ) T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

Sophie A Valkenburg, Stephanie Gras, Carole Guillonneau, Nicole L La Gruta, Paul G Thomas, Anthony W Purcell, Jamie Rossjohn, Peter C Doherty, Stephen J Turner, Katherine Kedzierska

Journal article  |  2010  |  PLoS Pathogens

Forewarned Is Forearmed

Nicole La Gruta, Stephen J Turner

Journal article  |  2010  |  Immunity

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

Nicole L La Gruta, William T Rothwell, Tania Cukalac, Natasha G Swan, Sophie A Valkenburg, Katherine Kedzierska, Paul G Thomas, Peter C Doherty, Stephen J Turner

Journal article  |  2010  |  Journal of Clinical Investigation

Altered CD8( ) T Cell Immunodominance after Vaccinia Virus Infection and the Naive Repertoire in Inbred and F-1 Mice

Inge EA Flesch, Wai-Ping Woo, Yang Wang, Vijay Panchanathan, Yik-Chun Wong, Nicole L La Gruta, Tania Cukalac, David C Tscharke

Journal article  |  2010  |  Journal of Immunology

Role of CD8( ) T-cell immunity in influenza infection: potential use in future vaccine development.

Nicole La Gruta, Anne Kelso, Lorena E Brown, Wiesan Chen, David C Jackson, Stephen J Turner

Journal article  |  2009  |  Expert Review of Respiratory Medicine

Continued circulation of the highly pathogenic avian H5N1 influenza A virus has many people worried that an influenza pandemic is ..

Functional implications of T cell receptor diversity

Stephen J Turner, Nicole L La Gruta, Katherine Kedzierska, Paul G Thomas, Peter C Doherty

Journal article  |  2009  |  Current Opinion in Immunology

Visualizing CTL activity for different CD8( ) effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing

MR Jenkins, NL La Gruta, PC Doherty, JA Trapani, SJ Turner, NJ Waterhouse

Journal article  |  2009  |  Cell Death & Differentiation

Killer T cells in influenza

John Stambas, Carole Guillonneau, Katherine Kedzierska, Justine D Mintern, Peter C Doherty, Nicole L La Gruta

Journal article  |  2008  |  Pharmacology and Therapeutics

Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8( ) T cells

Misty R Jenkins, Justine Mintern, Nicole L La Gruta, Katherine Kedzierska, Peter C Doherty, Stephen J Turner

Journal article  |  2008  |  Journal of Immunology

Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8( ) TCR repertoires and facilitates optimal CTL responses

Katherine Kedzierska, Paul G Thomas, Vanessa Venturi, Miles P Davenport, Peter C Doherty, Stephen J Turner, Nicole L La Gruta

Journal article  |  2008  |  Journal of Immunology

A trans-Golgi network golgin is required for the 14 regulated secretion of TNF in activated macrophages in vivo

Zi Zhao Lieu, John G Lock, Luke A Hammond, Nicole L La Gruta, Jennifer L Stow, Paul A Gleeson

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

Epitope-specific TCR beta repertoire diversity imparts no functional advantage on the CD8( ) T cell response to cognate viral peptides

Nicole L La Gruta, Paul G Thomas, Andrew I Webb, Michelle A Dunstone, Tania Cukalac, Peter C Doherty, Anthony W Purcell, Jamie Rossjohn, Stephen J Turner

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity

Katherine Kedzierska, Nicole L La Gruta, John Stambas, Stephen J Turner, Peter C Doherty

Journal article  |  2008  |  Molecular Microbiology

Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens

Louise J Young, Nicholas S Wilson, Petra Schnorrer, Adele Mount, Rachel J Lundie, Nicole L La Gruta, Brendan S Crabb, Gabrielle T Belz, William R Heath, Jose A Villadangos

Journal article  |  2007  |  Proceedings of the National Academy of Sciences of the United States of America

IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8( ) T cells

Alice E Denton, Peter C Doherty, Stephen J Turner, Nicole L La Gruta

Journal article  |  2007  |  European Journal of Immunology

A question of self-preservation: immunopathology in influenza virus infection

Nicole L La Gruta, Katherine Kedzierska, John Stambas, Peter C Doherty

Journal article  |  2007  |  Immunology and Cell Biology

A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8( ) T cell responses

Nicole L La Gruta, Peter C Doherty, Stephen J Turner

Journal article  |  2006  |  European Journal of Immunology

Specificity of CD4 T-cell response in murine Helicobacter pylori infections

M Tan, Z Chen, N La Gruta, OLC Wijburg, M Pearse, RA Strugnell

Conference Proceedings  |  2006  |  HELICOBACTER

Establishment and recall of CD8( ) T-cell memory in a model of localized transient infection

Katherine Kedzierska, Nicole L La Gruta, Stephen J Turner, Peter C Doherty

Journal article  |  2006  |  Immunological Reviews

A virus-specific CD8( ) T cell immunodominance hierarchy determined by antigen dose and precursor frequencies

NL La Gruta, K Kedzierska, K Pang, M Davenport, WS Chen, SJ Turner, PC Doherty

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

TCR clonotypic analysis of CMV antigen-specific CD8 T-cells from formaldehyde fixed peripheral blood

D Van Bockel, K Suzuki, K Warton, P Ammaranond, D Douek, N La Gruta, M Munier, C McGinley, K Nallaiah, K Stanley, SJ Turner, J Zaunders, DA Cooper, AD Kelleher

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130

M Howlett, LM Judd, B Jenkins, NL La Gruta, D Grail, M Ernst, AS Giraud

Journal article  |  2005  |  Gastroenterology

Contribution of T cell receptor affinity to overall avidity for virus-specific CD8( ) T cell responses

K Kedzierska, NL La Gruta, MP Davenport, SJ Turner, PC Doherty

Journal article  |  2005  |  Proceedings of the National Academy of Sciences of the United States of America

Effector CD8( ) T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression

DR Marshall, E Olivas, S Andreansky, NL La Gruta, GA Neale, A Gutierrez, DG Wichlan, S Wingo, C Cheng, PC Doherty, SJ Turner

Journal article  |  2005  |  Proceedings of the National Academy of Sciences of the United States of America

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8( ) T cell populations

SJ Turner, K Kedzierska, H Komodromou, NL La Gruta, MA Dunstone, AI Webb, R Webby, H Walden, WD Xie, J McCluskey, AW Purcell, J Rossjohn, PC Doherty

Journal article  |  2005  |  Nature Immunology

Characterization of CD8( ) T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection

SJ Turner, K Kedzierska, NL La Gruta, R Webby, PC Doherty

Journal article  |  2004  |  Science

Thymic expression of a gastritogenic epitope results in positive selection of self-reactive pathogenic T cells

KL Laurie, NL La Gruta, N Koch, IR van Driel, PA Gleeson

Journal article  |  2004  |  Journal of Immunology

Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8( ) T cell responses: Correlation of cytokine profile and TCR avidity

NL La Gruta, SJ Turner, PC Doherty

Journal article  |  2004  |  Journal of Immunology

Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation.

Nicole L La Gruta, Haiyan Liu, Smaroula Dilioglou, Michele Rhodes, David L Wiest, Dario AA Vignali

Journal article  |  2004  |  The Journal of Immunology

A hallmark of T cell activation is the ligation-induced down-modulation of the TCR:CD3 complex. However, little is known about the..

Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8( ) effector T cells

SJ Turner, NL La Gruta, J Stambas, G Diaz, PC Doherty

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America