Kirstan Vessey

P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration.

Candace Drysdale, Keunha Park, Kirstan A Vessey, Xin Huang, Emily Caruso, Yihan Li, Joelyn Wong, James S Wiley, Erica Fletcher, Robyn H Guymer, Ben J Gu

Journal article  |  2022  |  Purinergic Signal

We have shown deficits in monocyte phagocytosis from patients with age-related macular degeneration (AMD). Cell membrane fluidity ..

Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E)

Kirstan A Vessey, Andrew Jobling, Mai X Tran, Anna Y Wang, Ursula Greferath, Erica L Fletcher

Journal article  |  2022  |  AUTOPHAGY

Age-related macular degeneration (AMD) is a leading cause of vision loss with recent evidence indicating an important role for mac..

Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate immune system.

Josephine HC Wong, Jessica YW Ma, Andrew I Jobling, Alice Brandli, Ursula Greferath, Erica L Fletcher, Kirstan A Vessey

Journal article  |  2022  |  Front Neurosci

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the older population. Classical hallmarks..

Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy

Samuel A Mills, Andrew Jobling, Michael A Dixon, Bang Bui, Kirstan A Vessey, Joanna A Phipps, Ursula Greferath, Gene Venables, Vickie HY Wong, Connie HY Wong, Zheng He, Flora Hui, James C Young, Josh Tonc, Elena Ivanova, Botir T Sagdullaev, Erica L Fletcher

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local blood flow control within the central nervous system (CNS) is critical to proper function and is dependent on coordination b..

Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease

Ben J Gu, Xin Huang, Pavan K Avula, Emily Caruso, Candace Drysdale, Kirstan A Vessey, Amber Ou, Christopher Fowler, Tian-Hua Liu, Yong Lin, Adam Horton, Colin L Masters, James S Wiley, Robyn H Guymer, Erica L Fletcher

Journal article  |  2021  |  FRONTIERS IN MEDICINE

Age-related macular degeneration (AMD) is characterized by the accumulation of debris in the posterior eye. In this study we evalu..

Retinal ganglion cell dysfunction in mice following acute intraocular pressure is exacerbated by P2X7 receptor knockout

Anna YM Wang, Vickie HY Wong, Pei Ying Lee, Bang V Bui, Stefanie Dudczig, Kirstan A Vessey, Erica L Fletcher

Journal article  |  2021  |  SCIENTIFIC REPORTS

There is increasing evidence for the vulnerability of specific retinal ganglion cell (RGC) types in those with glaucoma and in ani..

Dorsal-Ventral Differences in Retinal Structure in the Pigmented Royal College of Surgeons Model of Retinal Degeneration

Una Greferath, Mario Huynh, Andrew Ian Jobling, Kirstan Anne Vessey, Gene Venables, Denver Surrao, Helen Christine O'Neill, Ioannis J Limnios, Erica Lucy Fletcher

Journal article  |  2021  |  FRONTIERS IN CELLULAR NEUROSCIENCE

Retinitis pigmentosa is a family of inherited retinal degenerations associated with gradual loss of photoreceptors, that ultimatel..

Photoreceptor Degeneration in Pro23His Transgenic Rats (Line 3) Involves Autophagic and Necroptotic Mechanisms

Kiana Kakavand, Andrew I Jobling, Ursula Greferath, Kirstan A Vessey, Robb U de Iongh, Erica L Fletcher

Journal article  |  2020  |  FRONTIERS IN NEUROSCIENCE

Photoreceptor death contributes to 50% of irreversible vision loss in the western world. Pro23His (P23H) transgenic albino rat str..

Potential mechanisms of retinal ganglion cell type-specific vulnerability in glaucoma

Anna YM Wang, Pei Ying Lee, Bang Bui, Andrew Jobling, Ursula Greferath, Alice Brandli, Michael A Dixon, Quan Findlay, Erica L Fletcher, Kirstan A Vessey

Journal article  |  2020  |  CLINICAL AND EXPERIMENTAL OPTOMETRY

Glaucoma is a neurodegenerative disease characterised by progressive damage to the retinal ganglion cells (RGCs), the output neuro..

An axonal calibre-independent program that promotes central myelination and repair

F Daemi, T Aumann, M Biemond, RJ Wood, JL Fletcher, E Hoffmann, J Pasquet, S Yoo, KA Vessey, M Nicholson, DG Gonsalvez, JM Gunnersen, EL Fletcher, SS Murray, J Xiao

Conference Proceedings  |  2020  |  MULTIPLE SCLEROSIS JOURNAL