Roberto Cappai

Relationships between the Bone Expression of Alzheimer's Disease-Related Genes, Bone Remodelling Genes and Cortical Bone Structure in Neck of Femur Fracture

Catherine JM Stapledon, Roumen Stamenkov, Roberto Cappai, Jillian M Clark, Alice Bourke, L Bogdan Solomon, Gerald J Atkins

Journal article  |  2021  |  CALCIFIED TISSUE INTERNATIONAL

Neck of femur (NOF) fracture is a prevalent fracture type amongst the ageing and osteoporotic populations, commonly requiring tota..

Interaction of alpha-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease

Upasana Ganguly, Anindita Banerjee, Sankha Shubhra Chakrabarti, Upinder Kaur, Oishimaya Sen, Roberto Cappai, Sasanka Chakrabarti

Journal article  |  2020  |  Biochemical Journal

The toxicity of accumulated α-synuclein plays a key role in the neurodegeneration of Parkinson's disease (PD). This study has demo..

Genetic Modulators of Traumatic Brain Injury in Animal Models and the Impact of Sex-Dependent Effects

Chaitanya Inampudi, Giuseppe D Ciccotosto, Roberto Cappai, Peter J Crack

Journal article  |  2020  |  JOURNAL OF NEUROTRAUMA

Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, du..

Optimizing red blood cell protein extraction for biomarker quantitation with mass spectrometry

Stephan Klatt, Anne Roberts, Amber Lothian, Colin L Masters, Roberto Cappai, Christopher Fowler, Blaine R Roberts

Journal article  |  2020  |  ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Red blood cells (RBC) are the most common cell type found in blood. They might serve as reservoir for biomarker research as they a..

Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex

Phan H Truong, Giuseppe D Ciccotosto, Roberto Cappai

Journal article  |  2019  |  NEUROCHEMICAL RESEARCH

The amyloid precursor protein (APP) is a member of a conserved gene family that includes the amyloid precursor-like proteins 1 (AP..

Dopamine Cytotoxicity on SH-SY5Y Cells: Involvement of alpha-Synuclein and Relevance in the Neurodegeneration of Sporadic Parkinson's Disease

Upasana Ganguly, Anirban Ganguly, Oishimaya Sen, Gargi Ganguly, Roberto Cappai, Arghyadip Sahoo, Sasanka Chakrabarti

Journal article  |  2019  |  NEUROTOXICITY RESEARCH

The cytotoxicity of dopamine on cultured cells of neural origin has been used as a tool to explore the mechanisms of dopaminergic ..

The crystal structure of amyloid precursor-like protein 2 E2 domain completes the amyloid precursor protein family

Laila C Roisman, Sen Han, Mun Joo Chuei, Andrea R Connor, Roberto Cappai

Journal article  |  2019  |  FASEB JOURNAL

The amyloid precursor-like protein 2 (APLP2) molecule is a type I transmembrane protein that is crucial for survival, cell-cell ad..

Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons

Phan H Truong, Giuseppe D Ciccotosto, Tobias D Merson, Loredana Spoerri, Mun Joo Chuei, Margaret Ayers, Yao Lulu Xing, Ben Emery, Roberto Cappai

Journal article  |  2019  |  GLIA

The identification of factors that regulate myelination provides important insight into the molecular mechanisms that coordinate n..

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth

Luan Luu, Giuseppe D Ciccotosto, Laura J Vella, Lesley Cheng, Laila C Roisman, Gerhard Multhaup, Andrew F Hill, Lisa-Marie Munter, Roberto Cappai

Journal article  |  2019  |  MOLECULAR NEUROBIOLOGY

The amyloid precursor protein (APP) undergoes extensive metabolism, and its transport and proteolytic processing can be modulated ..

Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention

Chongshan Dai, Xilong Xiao, Jichang Li, Giuseppe D Ciccotosto, Roberto Cappai, Shusheng Tang, Elena K Schneider-Futschik, Daniel Hoyer, Tony Velkov, Jianzhong Shen

Journal article  |  2019  |  ACS CHEMICAL NEUROSCIENCE

Neurotoxicity is one major unwanted side-effects associated with polymyxin (i.e., colistin and polymyxin B) therapy. Clinically, c..