Roberto Cappai

Genetic Modulators of Traumatic Brain Injury in Animal Models and the Impact of Sex-Dependent Effects.

Chaitanya Inampudi, Giuseppe D Ciccotosto, Roberto Cappai, Peter J Crack

Journal article  |  2020  |  Journal of Neurotrauma

Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, du..

Optimizing red blood cell protein extraction for biomarker quantitation with mass spectrometry

Stephan Klatt, Anne Roberts, Amber Lothian, Colin L Masters, Roberto Cappai, Christopher Fowler, Blaine R Roberts

Journal article  |  2020  |  Analytical and Bioanalytical Chemistry

Red blood cells (RBC) are the most common cell type found in blood. They might serve as reservoir for biomarker research as they a..

Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex

Phan H Truong, Giuseppe D Ciccotosto, Roberto Cappai

Journal article  |  2019  |  Neurochemical Research

Dopamine Cytotoxicity on SH-SY5Y Cells: Involvement of alpha-Synuclein and Relevance in the Neurodegeneration of Sporadic Parkinson's Disease

Upasana Ganguly, Anirban Ganguly, Oishimaya Sen, Gargi Ganguly, Roberto Cappai, Arghyadip Sahoo, Sasanka Chakrabarti

Journal article  |  2019  |  Neurotoxicity Research

The crystal structure of amyloid precursor-like protein 2 E2 domain completes the amyloid precursor protein family

Laila C Roisman, Sen Han, Mun Joo Chuei, Andrea R Connor, Roberto Cappai

Journal article  |  2019  |  The FASEB Journal

Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons

Phan H Truong, Giuseppe D Ciccotosto, Tobias D Merson, Loredana Spoerri, Mun Joo Chuei, Margaret Ayers, Yao Lulu Xing, Ben Emery, Roberto Cappai

Journal article  |  2019  |  Glia

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth

Luan Luu, Giuseppe D Ciccotosto, Laura J Vella, Lesley Cheng, Laila C Roisman, Gerhard Multhaup, Andrew F Hill, Lisa-Marie Munter, Roberto Cappai

Journal article  |  2019  |  Molecular Neurobiology

Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention

Chongshan Dai, Xilong Xiao, Jichang Li, Giuseppe D Ciccotosto, Roberto Cappai, Shusheng Tang, Elena K Schneider-Futschik, Daniel Hoyer, Tony Velkov, Jianzhong Shen

Journal article  |  2019  |  ACS Chemical Neuroscience

Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

Amber Lothian, Larissa Lago, Soumya Mukherjee, Andrea R Connor, Chris Fowler, Catriona A McLean, Malcolm Horne, Colin L Masters, Roberto Cappai, Blaine R Roberts

Journal article  |  2019  |  Metallomics

Probing Structural Changes during Self-assembly of Surface-Active Hydrophobin Proteins that Form Functional Amyloids in Fungi

Chi LL Pham, Borja Rodriguez de Francisco, Isabel Valsecchi, Regine Dazzoni, Ariane Pille, Victor Lo, Sarah R Ball, Roberto Cappai, Frank Wien, Ann H Kwan, J Inaki Guijarro, Margaret Sunde

Journal article  |  2018  |  Journal of Molecular Biology

DELINEATING THE NEUROPROTECTIVE ROLE OF THE AMYLOID PRECURSOR PROTEIN FAMILY IN TRAUMATIC BRAIN INJURY

Roberto Cappai, Chaitanya Inampudi, Frances Corrigan, Linh Lam, Blaine Roberts, Emma Thornton, Robert Vink, Giuseppe Ciccotosto, Peter Crack, Corinna Van den Heuvel

Conference Proceedings  |  2018  |  JOURNAL OF NEUROTRAUMA

The Human Amyloid Precursor Protein Binds Copper Ions Dominated by a Picomolar-Affinity Site in the Helix-Rich E2 Domain

Tessa R Young, Tara L Pukala, Roberto Cappai, Anthony G Wedd, Zhiguang Xiao

Journal article  |  2018  |  Biochemistry

Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways

Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Yang Wang, Shusheng Tang, Daniel Hoyer, Elena K Schneider, Tony Velkov, Xilong Xiao

Journal article  |  2018  |  ACS Chemical Neuroscience

The amyloid precursor protein derivative, APP96-110, is efficacious following intravenous administration after traumatic brain injury

Stephanie L Plummer, Frances Corrigan, Emma Thornton, Joshua A Woenig, Robert Vink, Roberto Cappai, Corinna Van Den Heuvel

Journal article  |  2018  |  PLOS ONE

Polymyxins for CNS infections: Pharmacology and neurotoxicity

Tony Velkov, Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Daniel Hoyer, Jian Li

Journal article  |  2018  |  Pharmacology & Therapeutics

Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis

Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Shusheng Tang, Daowen Li, Sanlei Xie, Xilong Xiao, Tony Velkov

Journal article  |  2018  |  Molecular Neurobiology

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Q-Z Tuo, P Lei, KA Jackman, X-I Li, H Xiong, X-L Li, Z-Y Liuyang, L Roisman, S-T Zhang, S Ayton, Q Wang, PJ Crouch, K Ganio, X-C Wang, L Pei, PA Adlard, Y-M Lu, R Cappai, J-Z Wang, R Liu, et al.

Journal article  |  2017  |  Molecular Psychiatry

Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress

Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Yang Wang, Shusheng Tang, Xilong Xiao, Tony Velkov

Journal article  |  2017  |  Journal of Antimicrobial Chemotherapy

Neurotoxicity of Prion Peptides on Cultured Cerebellar Neurons

Giuseppe D Ciccotosto, Metta Jana, Roberto Cappai

Journal article  |  2017  |  Methods in molecular biology (Clifton, N.J.)

"From past to future' - deciphering the molecular basis of Alzheimer's disease through the pages of the Journal of Neurochemistry

Roberto Cappai

Journal article  |  2016  |  Journal of Neurochemistry

Oligomeric Amyloid-beta Toxicity Can Be Inhibited by Blocking Its Cellular Binding in Cortical Neuronal Cultures with Addition of the Triphenylmethane Dye Brilliant Blue G

Metta K Jana, Roberto Cappai, Giuseppe D Ciccotosto

Journal article  |  2016  |  ACS Chemical Neuroscience

Preface

Nitin Kumar, Sivakumar Vasireddy, Devendra Pakhare

Book Chapter  |  2016  |  Catalysis Today

Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics

Virginie Dinet, Giuseppe D Ciccotosto, Kimberley Delaunay, Celine Borras, Isabelle Ranchon-Cole, Corinne Kostic, Michele Savoldelli, Mohamed El Sanharawi, Laurent Jonet, Caroline Pirou, Na An, Marc Abitbol, Yvan Arsenijevic, Francine Behar-Cohen, Roberto Cappai, Frederic Mascarelli

Journal article  |  2016  |  Molecular Brain

The Neuroprotective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury

Stephanie Plummer, Corinna Van den Heuvel, Emma Thornton, Frances Corrigan, Roberto Cappai

Journal article  |  2016  |  Aging and Disease

Membrane-bound tetramer and trimer A beta oligomeric species correlate with toxicity towards cultured neurons

Metta K Jana, Roberto Cappai, Chi LL Pham, Giuseppe D Ciccotosto

Journal article  |  2016  |  Journal of Neurochemistry

Distinct higher-order alpha-synuclein oligomers induce intracellular aggregation

Eva Illes-Toth, Mafalda Ribeiro Ramos, Roberto Cappai, Caroline Dalton, David P Smith

Journal article  |  2015  |  Biochemical Journal

peer review of grant funding - the Australian perspective

Roberto Cappai

Journal article  |  2015  |  Annals of Neurosciences

The N-Terminal Residues 43 to 60 Form the Interface for Dopamine Mediated alpha-Synuclein Dimerisation

Su Ling Leong, Mark G Hinds, Andrea R Connor, David P Smith, Eva Illes-Toth, Chi LL Pham, Kevin J Barnham, Roberto Cappai

Journal article  |  2015  |  PLOS ONE

Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study

Cyril C Curtain, Nigel M Kirby, Haydyn DT Mertens, Kevin J Barnham, Robert B Knott, Colin L Masters, Roberto Cappai, Agata Rekas, Vijaya B Kenche, Timothy Ryan

Journal article  |  2015  |  Molecular BioSystems

Small angle X-ray scattering analysis of Cu2 -induced oligomers of the Alzheimer's amyloid beta peptide

Timothy M Ryan, Nigel Kirby, Haydyn DT Mertens, Blaine Roberts, Kevin J Barnham, Roberto Cappai, Chi Le Lan Pham, Colin L Masters, Cyril C Curtain

Journal article  |  2015  |  Metallomics

alpha-synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: Implications in the pathogenesis of Parkinson's disease

Aritri Bir, Oishimaya Sen, Shruti Anand, Vineet Kumar Khemka, Priyanjalee Banerjee, Roberto Cappai, Arghyadip Sahoo, Sasanka Chakrabarti

Journal article  |  2014  |  Journal of Neurochemistry

Making sense of the amyloid precursor protein: its tail tells an interesting tale

Roberto Cappai

Journal article  |  2014  |  Journal of Neurochemistry

Amyloid Precursor Protein (APP)/APP-like Protein 2 (APLP2) Expression Is Required to Initiate Endosome-Nucleus-Autophagosome Trafficking of Glypican-1-derived Heparan Sulfate

Fang Cheng, Roberto Cappai, Jon Lidfeldt, Mattias Belting, Lars-Ake Fransson, Katrin Mani

Journal article  |  2014  |  Journal of Biological Chemistry

Neuroprotective Copper Bis(thiosemicarbazonato) Complexes Promote Neurite Elongation

Laura Bica, Jeffrey R Liddell, Paul S Donnelly, Clare Duncan, Aphrodite Caragounis, Irene Volitakis, Brett M Paterson, Roberto Cappai, Alexandra Grubman, James Camakaris, Peter J Crouch, Anthony R White

Journal article  |  2014  |  PLoS ONE

Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function

Su Ling Leong, Tessa R Young, Kevin J Barnham, Anthony G Wedd, Mark G Hinds, Zhiguang Xiao, Roberto Cappai

Journal article  |  2014  |  Metallomics: integrated biometal science

The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110

Frances Corrigan, Emma Thornton, Laila C Roisman, Anna V Leonard, Robert Vink, Peter C Blumbergs, Corinna van den Heuvel, Roberto Cappai

Journal article  |  2014  |  Journal of Neurochemistry

Guanidine hydrochloride denaturation of dopamine-induced alpha-synuclein oligomers: A small-angle X-ray scattering study

Chi LL Pham, Nigel Kirby, Kathleen Wood, Timothy Ryan, Blaine Roberts, Anna Sokolova, Kevin J Barnham, Colin L Masters, Robert B Knott, Roberto Cappai, Cyril C Curtain, Agata Rekas

Journal article  |  2014  |  Proteins: Structure, Function, and Bioinformatics

Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis

B Elise Needham, Giuseppe D Ciccotosto, Roberto Cappai

Journal article  |  2014  |  Metallomics

Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue

Giuseppe D Ciccotosto, Simon A James, Matteo Altissimo, David Paterson, Stefan Vogt, Barry Lai, Martin D de Jonge, Daryl L Howard, Ashley I Bush, Roberto Cappai

Journal article  |  2014  |  Metallomics

Erratum: Copper modulates the large dense core vesicle secretory pathway in PC12 cells (Metallomics (2013) 5 (700-714) DOI:10.1039/C3MT20231C)

C Duncan, L Bica, PJ Crouch, A Caragounis, GE Lidgerwood, SJ Parker, J Meyerowitz, I Volitakis, JR Liddell, R Raghupathi, BM Paterson, MD Duffield, R Cappai, PS Donnelly, A Grubman, J Camakaris, DJ Keating, AR White

Journal article  |  2013  |  Metallomics

Dopamine-Induced α-Synuclein Oligomers

A Rekas, R Cappai, C Curtain, C Le Lan Pham

Book Chapter  |  2013

Conformational Behavior and Aggregation of Ataxin-3 in SDS

Helen M Saunders, Victoria A Hughes, Roberto Cappai, Stephen P Bottomley

Journal article  |  2013  |  PLoS One

6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation (vol 281, pg 9824, 2006)

Cristine Alves da Costa, Julie Dunys, Frederic Brau, Sherwin Wilk, Roberto Cappai, Frederic Checler

Journal article  |  2013  |  Journal of Biological Chemistry

Copper modulates the large dense core vesicle secretory pathway in PC12 cells

Clare Duncan, Laura Bica, Peter J Crouch, Aphrodite Caragounis, Grace E Lidgerwood, Sarah J Parker, Jodi Meyerowitz, Irene Volitakis, Jeffrey R Liddell, Ravinarayan Raghupathi, Brett M Paterson, Michael D Duffield, Roberto Cappai, Paul S Donnelly, Alexandra Grubman, James Camakaris, Damien J Keating, Anthony R White

Journal article  |  2013  |  Metallomics: integrated biometal science

Development of a Platinum Complex as an anti-Amyloid Agent for the Therapy of Alzheimer's Disease

Vijaya B Kenche, Lin W Hung, Keyla Perez, Irene Volitakes, Guiseppe Ciccotosto, Jeffrey Kwok, Nicole Critch, Nikki Sherratt, Mikhalina Cortes, Varsha Lal, Colin L Masters, Kazuma Murakami, Roberto Cappai, Paul A Adlard, Kevin J Barnham

Journal article  |  2013  |  Angewandte Chemie - International Edition

The interplay between lipids and dopamine on alpha-synuclein oligomerization and membrane binding

Chi LL Pham, Roberto Cappai

Journal article  |  2013  |  Bioscience Reports

Synthetic dityrosine-linked beta-amyloid dimers form stable, soluble, neurotoxic oligomers

W Mei Kok, Jade M Cottam, Giuseppe D Ciccotosto, Luke A Miles, John A Karas, Denis B Scanlon, Blaine R Roberts, Michael W Parker, Roberto Cappai, Kevin J Barnham, Craig A Hutton

Journal article  |  2013  |  Chemical Science

Copper modulates the large dense core vesicle secretory pathway in PC12 cells (vol 5, pg 700, 2013)

Clare Duncan, Laura Bica, Peter J Crouch, Aphrodite Caragounis, Grace E Lidgerwood, Sarah J Parker, Jodi Meyerowitz, Irene Volitakis, Jeffrey R Liddell, Ravinarayan Raghupathi, Brett M Paterson, Michael D Duffield, Roberto Cappai, Paul S Donnelly, Alexandra Grubman, James Camakaris, Damien J Keating, Anthony R White

Journal article  |  2013  |  METALLOMICS

Role of the Amyloid Precursor Protein and Copper in Alzheimer's Disease

Loredana Spoerri, Kevin J Barnham, Gerd Multhaup, Roberto Cappai

Book Chapter  |  2013

In vitro characterization of [F-18]-florbetaben, an A beta imaging radiotracer

Michelle T Fodero-Tavoletti, Damian Brockschnieder, Victor L Villemagne, Lucas Martin, Andrea R Connor, Andrea Thiele, Mathias Berndt, Catriona A McLean, Sabine Krause, Christopher C Rowe, Colin L Masters, Ludger Dinkelborg, Thomas Dyrks, Roberto Cappai

Journal article  |  2012  |  Nuclear Medicine and Biology

The Amyloid Precursor Protein Copper Binding Domain Histidine Residues 149 and 151 Mediate APP Stability and Metabolism

Loredana Spoerri, Laura J Vella, Chi LL Pham, Kevin J Barnham, Roberto Cappai

Journal article  |  2012  |  Journal of Biological Chemistry

SERF Protein Is a Direct Modifier of Amyloid Fiber Assembly

S Fabio Falsone, N Helge Meyer, Evelyne Schrank, Gerd Leitinger, Chi LL Pham, Michelle T Fodero-Tavoletti, Mats Holmberg, Martin Dulle, Benjamin Scicluna, Bernd Gesslbauer, Hanna-Marie Rueckert, Gabriel E Wagner, David A Merle, Ellen A Nollen, Andreas J Kungl, Andrew F Hill, Roberto Cappai, Klaus Zangger

Journal article  |  2012  |  Cell Reports

Identification of a novel amyloid precursor protein processing pathway that generates secreted N-terminal fragments

Laura J Vella, Roberto Cappai

Journal article  |  2012  |  FASEB Journal

sAPPa rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury

Frances Corrigan, Robert Vink, Peter C Blumbergs, Colin L Masters, Roberto Cappai, Corinna van den Heuvel

Journal article  |  2012  |  Journal of Neurochemistry

Characterisation of the effect of knockout of the amyloid precursor protein on outcome following mild traumatic brain injury

Frances Corrigan, Robert Vink, Peter C Blumbergs, Colin L Masters, Roberto Cappai, Corinna van den Heuvel

Journal article  |  2012  |  Brain Research

Evaluation of the effects of treatment with sAPP alpha on functional and histological outcome following controlled cortical impact injury in mice

Frances Corrigan, Robert Vink, Peter C Blumbergs, Colin L Masters, Roberto Cappai, Corinna van den Heuvel

Journal article  |  2012  |  Neuroscience Letters

The hypoxia imaging agent Cu-II(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

Lin W Hung, Victor L Villemagne, Lesley Cheng, Nicki A Sherratt, Scott Ayton, Anthony R White, Peter J Crouch, SinChun Lim, Su Ling Leong, Simon Wilkins, Jessica George, Blaine R Roberts, Chi LL Pham, Xiang Liu, Francis CK Chiu, David M Shackleford, Andrew K Powell, Colin L Masters, Ashley I Bush, Graeme O'Keefe, et al.

Journal article  |  2012  |  Journal of Experimental Medicine

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce XW Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bush

Journal article  |  2012  |  Nature Medicine

Amyloid Precursor Protein Is Required for Normal Function of the Rod and Cone Pathways in the Mouse Retina

Tracy Ho, Kirstan A Vessey, Roberto Cappai, Virginie Dinet, Frederic Mascarelli, Giuseppe D Ciccotosto, Erica L Fletcher

Journal article  |  2012  |  PLoS One

Gene Knockout of tau Expression Does Not Contribute to the Pathogenesis of Prion Disease

Victoria A Lawson, Helen M Klemm, Jeremy M Welton, Colin L Masters, Peter Crouch, Roberto Cappai, Giuseppe D Ciccotosto

Journal article  |  2011  |  Journal of Neuropathology and Experimental Neurology

Amyloid-beta: The seeds of darkness

Michelle T Fodero-Tavoletti, Victor L Villemagne, Christopher C Rowe, Colin L Masters, Kevin J Barnham, Roberto Cappai

Journal article  |  2011  |  International Journal of Biochemistry and Cell Biology

Suppression of Amyloid beta A11 Antibody Immunoreactivity by Vitamin C POSSIBLE ROLE OF HEPARAN SULFATE OLIGOSACCHARIDES DERIVED FROM GLYPICAN-1 BY ASCORBATE-INDUCED, NITRIC OXIDE (NO)-CATALYZED DEGRADATION

Fang Cheng, Roberto Cappai, Giuseppe D Ciccotosto, Gabriel Svensson, Gerd Multhaup, Lars-Ake Fransson, Katrin Mani

Journal article  |  2011  |  Journal of Biological Chemistry

DEFINING THE NEUROPROTECTIVE ACTIVITY OF ENDOGENOUSLY EXPRESSED AMYLOID PRECURSOR PROTEIN IN TRAUMATIC BRAIN INJURY

R Cappai, F Corrigan, CL Pham, R Vink, CL Masters, PC Blumbergs, C van den Heuvel

Conference Proceedings  |  2011  |  JOURNAL OF NEUROCHEMISTRY

The neurotransmitter serotonin interrupts alpha-synuclein amyloid maturation

S Fabio Falsone, Gerd Leitinger, Anita Karner, Andreas J Kungl, Simone Kosol, Roberto Cappai, Klaus Zangger

Journal article  |  2011  |  Biochimica et Biophysica Acta-Proteins and Proteomics

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease.

Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagne

Journal article  |  2011  |  Brain

While considerable effort has focused on developing positron emission tomography β-amyloid imaging radiotracers for the early diag..

F-18-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagne

Journal article  |  2011  |  Brain

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

Paul A Adlard, Laura Bica, Anthony R White, Milawaty Nurjono, Gulay Filiz, Peter J Crouch, Paul S Donnelly, Roberto Cappai, David I Finkelstein, Ashley I Bush

Journal article  |  2011  |  PLoS One

The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains

Frances Corrigan, Chi LL Pham, Robert Vink, Peter C Blumbergs, Colin L Masters, Corinna van den Heuvel, Roberto Cappai

Journal article  |  2011  |  Brain Research

APP involvement in retinogenesis of mice

Virginie Dinet, Na An, Giuseppe D Ciccotosto, Julien Bruban, Agathe Maoui, Shayne A Bellingham, Andrew F Hill, Olav M Andersen, Anders Nykjaer, Laurent Jonet, Roberto Cappai, Frederic Mascarelli

Journal article  |  2011  |  Acta Neuropathologica

Stereospecific interactions are necessary for Alzheimer disease amyloid-beta toxicity

Giuseppe D Ciccotosto, Deborah J Tew, Simon C Drew, Danielle G Smith, Timothy Johanssen, Varsha Lal, Tong-Lay Lau, Keyla Perez, Cyril C Curtain, John D Wade, Frances Separovic, Colin L Masters, Jeffrey P Smith, Kevin J Barnham, Roberto Cappai

Journal article  |  2011  |  Neurobiology of Aging

The Cellular and Molecular Biology of Prion Disease

VA Lawson, SJ Collins, undefined Haigh, undefined Lewis, V Wall, MW Brazier, S Hawke, RA Bessen, JC Bartz, AE Kincaid, LJ Vella, R Cappai, AF Hill, L Gadtke, G Lutzny, C Krammer, R Bester, I Vorberg, M Bishop, JM Welton, et al.

Book  |  2011

Fluorine-18 labeled PET probes for imaging of neurofibrillary tangles

S Furumoto, N Okamura, M Fodero-Tavoletti, R Mulligan, R Cappai, R Iwata, Y Kudo, V Villemagne, K Yanai

Conference Proceedings  |  2010  |  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Iron-Export Ferroxidase Activity of beta-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

James A Duce, Andrew Tsatsanis, Michael A Cater, Simon A James, Elysia Robb, Krutika Wikhe, Su Ling Leong, Keyla Perez, Timothy Johanssen, Mark A Greenough, Hyun-Hee Cho, Denise Galatis, Robert D Moir, Colin L Masters, Catriona McLean, Rudolph E Tanzi, Roberto Cappai, Kevin J Barnham, Giuseppe D Ciccotosto, Jack T Rogers, et al.

Journal article  |  2010  |  Cell

The structure of dopamine induced alpha-synuclein oligomers

Agata Rekas, Robert B Knott, Anna Sokolova, Kevin J Barnham, Keyla A Perez, Colin L Masters, Simon C Drew, Roberto Cappai, Cyril C Curtain, Chi LL Pham

Journal article  |  2010  |  European Biophysics Journal with Biophysics Letters

Residues Surrounding the Glycosylphosphatidylinositol Anchor Attachment Site of PrP Modulate Prion Infection: Insight from the Resistance of Rabbits to Prion Disease

Rebecca M Nisbet, Christopher F Harrison, Victoria A Lawson, Colin L Masters, Roberto Cappai, Andrew F Hill

Journal article  |  2010  |  Journal of Virology

Conservation of a Glycine-rich Region in the Prion Protein Is Required for Uptake of Prion Infectivity

Christopher F Harrison, Victoria A Lawson, Bradley M Coleman, Yong-Sun Kim, Colin L Masters, Roberto Cappai, Kevin J Barnham, Andrew F Hill

Journal article  |  2010  |  Journal of Biological Chemistry

A domain level interaction network of amyloid precursor protein and A beta of Alzheimer's disease

Victoria M Perreau, Sandra Orchard, Paul A Adlard, Shayne A Bellingham, Roberto Cappai, Giuseppe D Ciccotosto, Tiffany F Cowie, Peter J Crouch, James A Duce, Genevieve Evin, Noel G Faux, Andrew F Hill, Ya Hui Hung, Simon A James, Qiao-Xin Li, Su San Mok, Deborah J Tew, Anthony R White, Ashley I Bush, Henning Hermjakob, et al.

Journal article  |  2010  |  Proteomics

A Serial Analysis of Gene Expression Profile of the Alzheimer's Disease Tg2576 Mouse Model

Amee J George, Lavinia Gordon, Tim Beissbarth, Irene Koukoulas, RM Damian Holsinger, Victoria Perreau, Roberto Cappai, Seong-Seng Tan, Colin L Masters, Hamish S Scott, Qiao-Xin Li

Journal article  |  2010  |  Neurotoxicity Research

alpha-Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease

Kalpita Banerjee, Maitrayee Sinha, Chi Le Lan Pham, Sirsendu Jana, Dalia Chanda, Roberto Cappai, Sasanka Chakrabarti

Journal article  |  2010  |  FEBS Letters

Alleviating Transcriptional Inhibition of the Norepinephrine Slc6a2 Transporter Gene in Depolarized Neurons

Harikrishnan Kn, Richard Bayles, Giuseppe D Ciccotosto, Scott Maxwell, Roberto Cappai, Gregory J Pelka, Patrick PL Tam, John Christodoulou, Assam El-Osta

Journal article  |  2010  |  Journal of Neuroscience

Histidine 14 Modulates Membrane Binding and Neurotoxicity of the Alzheimer's Disease Amyloid-beta Peptide

Danielle G Smith, Giuseppe D Ciccotosto, Deborah J Tew, Keyla Perez, Cyril C Curtain, John F Boas, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2010  |  Journal of Alzheimer's Disease

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques

SinChun Lim, Brett M Paterson, Michelle T Fodero-Tavoletti, Graeme J O'Keefe, Roberto Cappai, Kevin J Barnham, Victor L Villemagne, Paul S Donnelly

Journal article  |  2010  |  Chemical Communications

Bis(thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease

Michelle T Fodero-Tavoletti, Victor L Villemagne, Brett M Paterson, Anthony R White, Qiao-Xin Li, James Camakaris, Graeme J O'Keefe, Roberto Cappai, Kevin J Barnham, Paul S Donnelly

Journal article  |  2010  |  Journal of Alzheimer's Disease

Copper Coordination by Familial Mutants of Parkinson's Disease-Associated alpha-Synuclein

Simon C Drew, Deborah J Tew, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2009  |  Applied Magnetic Resonance

The Molecular Chaperone Hsp90 Modulates Intermediate Steps of Amyloid Assembly of the Parkinson-related Protein alpha-Synuclein

S Fabio Falsone, Andreas J Kungl, Angelika Rek, Roberto Cappai, Klaus Zangger

Journal article  |  2009  |  Journal of Biological Chemistry

MEROZOITE SURFACE PROTEIN 2 HAS A POTENTIAL ROLE IN THE ATTACHMENT OF PLASMODIUM FALCIPARUM MEROZOITES TO ERYTHROCYTES DURING INVASION

Jesse L Schloegel, Christopher G Adda, Fiona Durand, Vince J Murphy, Kleo Vingas, Giuseppe D Ciccotosto, Roberto Cappai, Barnham J Kevin, Michael Foley, Robin F Anders

Conference Proceedings  |  2009  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Modulation of alpha-Synuclein Aggregation by Dopamine: A Review

Su Ling Leong, Roberto Cappai, Kevin Jeffrey Barnham, Chi Le Lan Pham

Journal article  |  2009  |  Neurochemical Research

In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies

Michelle T Fodero-Tavoletti, Rachel S Mulligan, Nobuyuki Okamura, Shozo Furumoto, Christopher C Rowe, Yukitsuka Kudo, Colin L Masters, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagne

Journal article  |  2009  |  European Journal of Pharmacology

Amyloid Imaging in Alzheimer's Disease and Other Dementias

Michelle T Fodero-Tavoletti, Roberto Cappai, Catriona A McLean, Kerryn E Pike, Paul A Adlard, Tiffany Cowie, Andrea R Connor, Colin L Masters, Christopher C Rowe, Victor L Villemagne

Journal article  |  2009  |  Brain Imaging and Behaviour

THE GLYCINE RICH REGION OF THE PRION PROTEIN IS A DOMINANT MODULATOR OF PRION INFECTIVITY

AF Hill, C Harrison, VA Lawson, CL Masters, R Cappai, KJ Barnham

Conference Proceedings  |  2009  |  JOURNAL OF NEUROCHEMISTRY

MODULATION OF AMYLOID BETA PEPTIDE AGGREGATION AND TOXICITY

R Cappai

Conference Proceedings  |  2009  |  JOURNAL OF NEUROCHEMISTRY

DETERMINING THE NEUROPROTECTIVE PROPERTIES OF THE AMYLOID PRECURSOR PROTEIN IN VIVO

Frances Corrigan, Roberto Cappai, Robert Vink, Corinna Van Den Heuvel

Conference Proceedings  |  2009  |  JOURNAL OF NEUROTRAUMA

Chronic Exposure to High Levels of Zinc or Copper has Little Effect on Brain Metal Homeostasis or A beta Accumulation in Transgenic APP-C100 Mice

Christa J Maynard, Roberto Cappai, Irene Volitakis, Katrina M Laughton, Colin L Masters, Ashley I Bush, Qiao-Xin Li

Journal article  |  2009  |  Cellular & Molecular Neurobiology

Adipocyte GLUT4 Expression Influences Amyloid Precursor Protein Processing

Sophie E Yeo, Sean L Mcgee, Roberto Cappai, Mark Hargreaves

Conference Proceedings  |  2009  |  DIABETES

Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation

Su Ling Leong, Chi LL Pham, Denise Galatis, Michelle T Fodero-Tavoletti, Keyla Perez, Andrew F Hill, Colin L Masters, Feda E Ali, Kevin J Barnham, Roberto Cappai

Journal article  |  2009  |  Free Radical Biology and Medicine

Stimulus pattern dependence of the Alzheimer's disease amyloid-beta 42 peptide's inhibition of long term potentiation in mouse hippocampal slices

Jeffrey P Smith, Varsha Lal, David Bowser, Roberto Cappai, Colin L Masters, Giuseppe D Ciccotosto

Journal article  |  2009  |  Brain Research

Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of alpha-Synuclein in a pH-Dependent Manner

Chi LL Pham, Su Ling Leong, Feda E Ali, Vijaya B Kenche, Andrew F Hill, Sally L Gras, Kevin J Barnham, Roberto Cappai

Journal article  |  2009  |  Journal of Molecular Biology

Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence

Bradley M Coleman, Rebecca M Nisbet, Sen Han, Roberto Cappai, Danny M Hatters, Andrew F Hill

Journal article  |  2009  |  Biochemical and Biophysical Research Communications

PAMAM Dendrimers as Potential Agents against Fibrillation of alpha-Synuclein, a Parkinson's Disease-Related Protein

Agata Rekas, Victor Lo, Gerry E Gadd, Roberto Cappai, Seok I Yun

Journal article  |  2009  |  Macromolecular Bioscience

Engineered antibody intervention strategies for Alzheimer's disease and related dementias by targeting amyloid and toxic oligomers

Remy Robert, Olan Dolezal, Lynne Waddington, Meghan K Hattarki, Roberto Cappai, Colin L Masters, Peter J Hudson, Kim L Wark

Journal article  |  2009  |  Protein Engineering Design & Selection

Characterization of PiB Binding to White Matter in Alzheimer Disease and Other Dementias

Michelle T Fodero-Tavoletti, Christopher C Rowe, Catriona A McLean, Laura Leone, Qiao-Xin Li, Colin L Masters, Roberto Cappai, Victor L Villemagne

Journal article  |  2009  |  Journal of Nuclear Medicine

Increasing Cu bioavailability inhibits A beta oligomers and tau phosphorylation

Peter J Crouch, Lin Wai Hung, Paul A Adlard, Mikhalina Cortes, Varsha Lal, Gulay Filiz, Keyla A Perez, Milawaty Nurjono, Aphrodite Caragounis, Tai Du, Katrina Laughton, Irene Volitakis, Ashley I Bush, Qiao-Xin Li, Colin L Masters, Roberto Cappai, Robert A Cherny, Paul S Donnelly, Anthony R White, Kevin J Barnham

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease

Laura Bica, Peter J Crouch, Roberto Cappai, Anthony R White

Journal article  |  2009  |  Mol. BioSyst.

An update on the toxicity of Aβ in Alzheimer's disease

J Götz, LM Ittner, N Schonrock, R Cappai

Journal article  |  2008  |  Neuropsychiatric Disease and Treatment

Amyloid-beta Peptide (A beta) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: A beta Dimers and Trimers Correlate with Neurotoxicity

Lin Wai Hung, Giuseppe D Ciccotosto, Eleni Giannakis, Deborah J Tew, Keyla Perez, Colin L Masters, Roberto Cappai, John D Wade, Kevin J Barnham

Journal article  |  2008  |  Journal of Neuroscience

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

Laura J Vella, Deanne LV Greenwood, Roberto Cappai, Jean-Pierre Y Scheerlinck, Andrew F Hill

Journal article  |  2008  |  Veterinary Immunology and Immunopathology

The ART of loss: A beta imaging in the evaluation of Alzheimer's disease and other dementias

Victor L Villemagne, Michelle T Fodero-Tavoletti, Kerryn E Pike, Roberto Cappai, Colin L Masters, Christopher C Rowe

Journal article  |  2008  |  Molecular Neurobiology: a review journal

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial A beta

Paul A Adlard, Robert A Cherny, David I Finkelstein, Elisabeth Gautier, Elysia Robb, Mikhalina Cortes, Irene Volitakis, Xiang Liu, Jeffrey P Smith, Keyla Perez, Katrina Laughton, Qiao-Xin Li, Susan A Charman, Joseph A Nicolazzo, Simon Wilkins, Karolina Deleva, Toni Lynch, Gaik Kok, Craig W Ritchie, Rudolph E Tanzi, et al.

Journal article  |  2008  |  Neuron

ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro

Sharon L Chan, Woojin Scott Kim, John B Kwok, Andrew F Hill, Roberto Cappai, Kerry-Anne Rye, Brett Garner

Journal article  |  2008  |  Journal of Neurochemistry

Cu2 binding modes of recombinant alpha-synuclein - Insights from EPR spectroscopy

Simon C Drew, Su Ling Leong, Chi LL Pham, Deborah J Tew, Colin L Masters, Luke A Miles, Roberto Cappai, Kevin J Barnham

Journal article  |  2008  |  Journal of the American Chemical Society

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

BE Needham, ME Wlodek, GD Ciccotosto, BC Fam, CL Masters, J Proietto, S Andrikopoulos, R Cappai

Journal article  |  2008  |  Journal of Pathology

Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine

Valeria Albanese, Victoria A Lawson, Andrew F Hill, Cappai Roberto, Giovanni Di Guardo, Vasiliki Stalkopoulos, Michelle Thacker, John B Furness, Roberto Chiocchetti

Journal article  |  2008  |  Autonomic Neuroscience - Basic & Clinical

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

BE Needham, ME Wlodek, GD Ciccotosto, BC Fam, CL Masters, J Proietto, S Andrikopoulos, R Cappai

Journal article  |  2008  |  Journal of Pathology

Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

Kevin J Barnham, Vijaya B Kenche, Giuseppe D Ciccotosto, David P Smith, Deborah J Tew, Xiang Liu, Keyla Perez, Greg A Cranston, Timothy J Johanssen, Irene Volitakis, Ashley I Bush, Colin L Masters, Anthony R White, Jeffrey P Smith, Robert A Cherny, Roberto Cappai

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the A beta peptides associated with Alzheimer's disease

Kwok S Wun, Luke A Miles, Gabriela AN Crespi, Kaye Wycherley, David B Ascher, Kevin J Barnham, Roberto Cappai, Konrad Beyreuther, Colin L Masters, Michael W Parker, William J McKinstry

Journal article  |  2008  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide

Deborah J Tew, Stephen P Bottomley, David P Smith, Giuseppe D Ciccotosto, Jeffrey Babon, Mark G Hinds, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2008  |  Biophysical Journal

Dimeric structures of alpha-synuclein bind preferentially to lipid membranes

Eleni Giannakis, Jessica Pacifico, David P Smith, Lin Wai Hung, Colin L Masters, Roberto Cappai, John D Wade, Kevin J Barnhain

Journal article  |  2008  |  Biochimica et Biophysica Acta-Biomembranes

Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-Cell epitope

Luke A Miles, Kwok S Wun, Gabriela AN Crespi, Michelle T Fodero-Tavoletti, Denise Galatis, Christopher J Bagley, Konrad Beyreuther, Colin L Masters, Roberto Cappai, William J McKinstry, Kevin J Barnham, Michael W Parker

Journal article  |  2008  |  Journal of Molecular Biology

Delineating the mechanism of Alzheimer's disease A beta peptide neurotoxicity

Roberto Cappai, Kevin J Barnham

Journal article  |  2008  |  Neurochemical Research

Copper binding to the Alzheimer's disease amyloid precursor protein

Geoffrey K-W Kong, Luke A Miles, Gabriela AN Crespi, Craig J Morton, Hooi Ling Ng, Kevin J Barnham, William J McKinstry, Roberto Cappai, Michael W Parker

Journal article  |  2008  |  European Biophysics Journal with Biophysics Letters

The role of exosomes in the processing of proteins associated with neurodegenerative diseases

Laura J Vella, Robyn A Sharples, Rebecca M Nisbet, Roberto Cappai, Andrew F Hill

Journal article  |  2008  |  European Biophysics Journal

Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein

David P Smith, Deborah J Tew, Andrew F Hill, Stephen P Bottomley, Colin L Masters, Kevin J Barnham, Roberto Cappai

Journal article  |  2008  |  Biochemistry

Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation

Tai Du, Giuseppe D Ciccotosto, Greg A Cranston, Gulcan Kocak, Colin L Masters, Peter J Crouch, Roberto Cappai, Anthony R White

Journal article  |  2008  |  Free Radical Biology and Medicine

Neurotoxicity of prion peptides on cultured cerebellar neurons

GD Ciccotosto, R Cappai, AR White

Journal article  |  2008  |  Methods in Molecular Biology

Neurotoxicity of prion peptides on cultured cerebellar neurons.

Giuseppe D Ciccotosto, Roberto Cappai, Anthony R White

Book Chapter  |  2008  |  Methods in Molecular Biology

Prion peptide (PrP) neurotoxicity has been modelled in vitro by using synthetic peptides derived from the PrP(C) sequence. The maj..

Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture.

V LAWSON, L VELLA, J STEWART, R SHARPLES, H KLEMM, D MACHALEK, C MASTERS, R Cappai, SJ Collins, A HILL

Journal article  |  2008  |  International Journal of Biochemistry and Cell Biology

Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture

Victoria A Lawson, Laura J Velia, James D Stewart, Robyn A Sharples, Helen Klemm, Dorothy M Machalek, Colin L Masters, Roberto Cappai, Steven J Collins, Andrew F Hill

Journal article  |  2008  |  International Journal of Biochemistry and Cell Biology

A novel moderate-affinity metal binding ligand confers neuroprotection against 6-hydroxydopamine mediated chronic cell death and improves rotational behavior in a mouse model of Parkinson's disease

S Wilkins, E Gautier, J Parsons, M Nurjono, J George, I Volitakis, CL Masters, R Cappai, KJ Barnham, PA Adlard, AJ Bush, RA Cherny, D v Finkelstein

Conference Proceedings  |  2008  |  MOVEMENT DISORDERS

Monitoring the prevention of amyloid fibril formation by alpha-crystallin

Agata Rekas, Lucy Jankova, David C Thorn, Roberto Cappai, John A Carver

Journal article  |  2007  |  FEBS Journal

The aβcentric pathway of alzheimer's disease

VL Villemagne, R Cappai, KJ Barnham, RA Cherny, C Opazo, KE Novakovic, CC Rowe, CL Masters

Book Chapter  |  2007

Monitoring the prevention of amyloid fibril formation by α-crystallin

Agata Rekas, Lucy Jankova, David C Thorn, Roberto Cappai, John A Carver

Journal article  |  2007  |  FEBS Journal

The function of the amyloid precursor protein family

R Cappai, B Elise Needham, GD Ciccotosto

Book Chapter  |  2007

Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution

Geoffrey Kwai-Wai Kong, Julian J Adams, Roberto Cappai, Michael W Parker

Journal article  |  2007  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

In vitro characterization of Pittsburgh compound-B binding to Lewy bodies

Michelle T Fodero-Tavoletti, David P Smith, Catriona A McLean, Paul A Adlard, Kevin J Barnham, Lisa E Foster, Laura Leone, Keyla Perez, Mikhalina Cortes, Janetta G Culvenor, Qiao-Xin Li, Katrina M Laughton, Christopher C Rowe, Colin L Masters, Roberto Cappai, Victor L Villemagne

Journal article  |  2007  |  Journal of Neuroscience

The redox chemistry of the Alzheimer's disease amyloid beta peptide

Danielle G Smith, Roberto Cappai, Kevin J Barnham

Journal article  |  2007  |  Biochimica et Biophysica Acta-Biomembranes

Molecular determinants of Alzheimer's disease Aβ peptide neurotoxicity

R Cappai, KJ Barnham

Journal article  |  2007  |  Future Neurology

Plasma alpha-synuclein is decreased in subjects with Parkinson's disease

Qiao-Xin Li, Su San Mok, Katrina M Laughton, Catriona A McLean, Roberto Cappai, Colin L Masters, Janetta G Culvenor, Malcolm K Horne

Journal article  |  2007  |  Experimental Neurology

Packaging of prions into exosomes is associated with a novel pathway of PrP processing

LJ Vella, RA Sharples, VA Lawson, CL Masters, R Cappai, AF Hill

Journal article  |  2007  |  Journal of Pathology

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

Geoffrey K-W Kong, Julian J Adams, Hugh H Harris, John F Boas, Cyril C Curtain, Denise Galatis, Colin L Masters, Kevin J Barnham, William J McKinstry, Roberto Cappai, Michael W Parker

Journal article  |  2007  |  Journal of Molecular Biology

Concentration dependent Cu2 induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide

David P Smith, Giuseppe D Ciccotosto, Deborah J Tew, Michelle T Fodero-Tavoletti, Timothy Johanssen, Colin L Masters, Kevin J Barnham, Roberto Cappai

Journal article  |  2007  |  Biochemistry

Amyloid precursor protein

SL LEONG, K BARNHAM, undefined Multhaup, R CAPPAI

Scholarly edition  |  2007

Alois Alzheimer and Alzheimer's disease: a centennial perspective

David H Small, Roberto Cappai

Journal article  |  2006  |  Journal of Neurochemistry

La lunga attesa: towards a molecular approach to neuroimaging and therapeutics in Alzheimer's disease.

VL Villemagne, S Ng, R Cappai, KJ Barnham, MT Fodero-Tavoletti, CC Rowe, CL Masters

Journal article  |  2006  |  The Neuroradiology Journal

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by the gradual onset of dementia. The pathologi..

Delineating common molecular mechanisms in Alzheimer's and prion diseases

Kevin J Barnham, Roberto Cappai, Konrad Beyreuther, Colin L Masters, Andrew F Hill

Journal article  |  2006  |  Trends in Biochemical Sciences

Modulation of Amyloid Precursor Protein (APP) and amyloid-beta metabolism by APP binding proteins

R Cappai, O Andersen, K Mani, F Cheng, G Multhaup, C Masters, L Fransson, T Willnow

Conference Proceedings  |  2006  |  JOURNAL OF NEUROCHEMISTRY

Investigating the propagation and spread of infectious prions in neuronal cells

LJ Vella, RA Sharples, CL Masters, R Cappai, AF Hill

Conference Proceedings  |  2006  |  JOURNAL OF NEUROCHEMISTRY

Identification and characterization of disease associated epitopes of mammalian prion proteins

S Han, CC Curtain, KJ Barnham, CL Masters, R Cappai, AF Hill

Conference Proceedings  |  2006  |  JOURNAL OF NEUROCHEMISTRY

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge

David P Smith, Danielle G Smith, Cyril C Curtain, John F Boas, John R Pilbrow, Giuseppe D Ciccotosto, Tong-Lay Lau, Deborah J Tew, Keyla Perez, John D Wade, Ashley I Bush, Simon C Drew, Frances Separovic, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2006  |  Journal of Biological Chemistry

Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics

Colin L Masters, Roberto Cappai, Kevin J Barnham, Victor L Villemagne

Journal article  |  2006  |  Journal of Neurochemistry

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: Implications for Alzheimer beta-amyloid pathology

Christa J Maynard, Roberto Cappai, Irene Volitakis, Robert A Cherny, Colin L Masters, Qiao-Xin Li, Ashley I Bush

Journal article  |  2006  |  Journal of Inorganic Biochemistry

6-hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation

CA da Costa, J Dunys, F Brau, S Wilk, R Cappai, F Checler

Journal article  |  2006  |  Journal of Biological Chemistry

Decreased phosphatidylethanolamine binding protein expression correlates with A beta accumulation in the Tg2576 mouse model of Alzheimer's disease

AJ George, RMD Holsinger, CA McLean, SS Tan, HS Scott, T Cardamone, R Cappai, CL Masters, QX Li

Journal article  |  2006  |  Neurobiology of Aging

Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein

M Gralle, CLP Oliveira, LH Guerreiro, WJ McKinstry, D Galatis, CL Masters, R Cappai, MW Parker, CHI Ramos, I Torriani, ST Ferreira

Journal article  |  2006  |  Journal of Molecular Biology

Clioquinol treatment in familiar early onset of Alzheimer's disease: Ibach B et al., pharmacopsychiatry 2005; 38 : 178-79 - Letter to the editor

CW Ritchie, R Cappai, C Masters

Journal article  |  2006  |  Pharmacopsychiatry

Clioquinol treatment in familiar early onset of Alzheimer's disease: Ibach B et al., Pharmacopsychiatry 2005; 38: 178-179. Letter to the editor

CW Ritchie, R Cappai, C Masters

Journal article  |  2006  |  Pharmacopsychiatry

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11

OM Andersen, V Schmidt, R Spoelgen, J Gliemann, J Behlke, D Galatis, WJ McKinstry, MW Parker, CL Masters, BT Hyman, R Cappai, TE Willnow

Journal article  |  2006  |  Biochemistry

Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions

TL Lau, EE Ambroggio, DJ Tew, R Cappai, CL Masters, GD Fidelio, KJ Barnham, F Separovic

Journal article  |  2006  |  Journal of Molecular Biology

Correlative studies support lipid peroxidation is linked to PrPres propagation as art early primary pathogenic event in prion disease

MW Brazier, V Lewis, GD Ciccotosto, GM Klub, VA Lawson, R Cappai, JW Ironside, CL Masters, AF Hill, AR White, S Collins

Journal article  |  2006  |  Brain Research Bulletin

Molecular Dissection of the Interaction Between APP and Its Neuronal Trafficking Receptor SorLA/LR11

undefined Andersen, undefined Schmidt, undefined Spoelgen, undefined Gliemann, D CAPPAI, W MCKINSTRY, M PARKER, C MASTERS, undefined Hyman, R CAPPAI, undefined Willnow

Journal article  |  2006  |  Biochemistry

 Alois Alzheimer and Alzheimer’s disease:  a centennial perspective

H Small, R CAPPAI

Journal article  |  2006  |  Journal of Neurochemistry

Detection of prion epitopes on PrPc and PrPsc of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP

FF Yuan, S Biffin, MW Brazier, M Suarez, R Cappai, AF Hill, SJ Collins, JS Sullivan, D Middleton, G Multhaup, AF Geczy, CL Masters

Journal article  |  2005  |  Immunology and Cell Biology

Mechanisms of prion toxicity and their relationship to prion infectivity

L Vella, AF Hill, R Cappai

Book Chapter  |  2005

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

OM Andersen, J Reiche, V Schmidt, M Gotthardt, R Spoelgen, J Behlke, CAF von Arnim, T Breiderhoff, P Jansen, X Wu, KR Bales, R Cappai, CL Masters, J Gliemann, EJ Mufson, BT Hyman, SM Paul, A Nykjaer, TE Willnow

Journal article  |  2005  |  Proceedings of the National Academy of Sciences of the United States of America

Alpha-synuclein mutations increase sensitivity of human neuroblastoma cells to cytotoxicity

SS Mok, RM Holsinger, QX Li, R Cappai, CM Masters, JG Culvenor

Conference Proceedings  |  2005  |  JOURNAL OF NEUROCHEMISTRY

Modulation of alpha-synuclein aggregation

R Cappai, S Leck, DJ Tew, NA Williamson, DP Smith, D Galatis, RA Sharples, CC Curtain, FE Ali, RA Cherny, JG Culvenor, SP Bottomley, CL Masters, KJ Barnham, AF Hill

Conference Proceedings  |  2005  |  JOURNAL OF NEUROCHEMISTRY

Dopamine promotes α‐synuclein aggregation into SDS‐resistant soluble oligomers via a distinct folding pathway

Roberto Cappai, Su‐Ling Leck, Deborah J Tew, Nicholas A Williamson, David P Smith, Denise Galatis, Robyn A Sharpies, Cyril C Curtain, Feda' E Ali, Robert A Cherny, Janetta G Culvenor, Stephen P Bottomley, Colin L Masters, Kevin J Barnham, Andrew F Hill

Journal article  |  2005  |  FASEB Journal

Investigations into the propagation and spread of infectious prions in cultured cells

AF Hill, LJ Vella, RA Sharples, VA Lawson, SJ Collins, R Cappai, CL Masters

Conference Proceedings  |  2005  |  JOURNAL OF NEUROCHEMISTRY

Exploring the role of the histidine residues in the Alzheimer's disease Amyloid-beta peptide

DG Smith, GG Ciccotosto, CC Curtain, CL Masters, R Cappai, KJ Barnham

Conference Proceedings  |  2005  |  FEBS JOURNAL

Proteomic investigation into the propagation and spread of infectious prions in non-neuronal cells.

LJ Vella, RA Sharples, VA Lawson, SJ Collins, CL Masters, R Cappai, AF Hill

Conference Proceedings  |  2005  |  FEBS JOURNAL

Metals and amyloid-beta in Alzheimer's disease

CJ Maynard, AI Bush, CL Masters, R Cappai, QX Li

Journal article  |  2005  |  International Journal of Experimental Pathology

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

R Cappai, SL Leck, DJ Tew, NA Williamson, DP Smith, D Galatis, RA Sharples, CC Curtain, FE Ali, RA Cherny, JG Culvenor, SP Bottomley, CL Masters, KJ Barnham, AF Hill

Journal article  |  2005  |  FASEB Journal

The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-nitric oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo

R Cappai, F Cheng, GD Ciccotosto, BE Needham, CL Masters, G Multhaup, LA Fransson, K Mani

Journal article  |  2005  |  Journal of Biological Chemistry

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutaselike structures and inhibition of neurotoxicity

AK Tickler, DG Smith, GD Ciccotosto, DJ Tew, CC Curtain, D Carrington, CL Masters, AI Bush, RA Cherny, R Cappai, JD Wade, KJ Barnham

Journal article  |  2005  |  Journal of Biological Chemistry

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta(1-42)

PJ Crouch, R Blake, JA Duce, GD Ciccotosto, QX Li, KJ Barnham, CC Curtain, RA Cherny, R Cappai, T Dyrks, CL Masters, IA Trounce

Journal article  |  2005  |  Journal of Neuroscience

Understanding how the Alzheimer's Amyloid Presursor Protein binds Copper Ions

Geoffrey K-W Kong, William J Mc Kinstry, Julian J Adams, Denise Galatis, Colin L Masters, Kevin J Barnham, Roberto Cappai, Michael W Parker

Conference Proceedings  |  2005  |  Acta Crystallographica Section A Foundations of Crystallography

Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease

GKW Kong, D Galatis, KJ Barnham, G Polekhina, JJ Adams, CL Masters, R Cappai, MW Parker, WJ McKinstry

Journal article  |  2005  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

C Treiber, A Simons, M Strauss, M Hafner, R Cappai, TA Bayer, G Multhaup

Journal article  |  2004  |  Journal of Biological Chemistry

Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

GD Ciccotosto, D Tew, CC Curtain, D Smith, D Carrington, CL Masters, AI Bush, RA Cherny, R Cappai, KJ Barnham

Journal article  |  2004  |  Journal of Biological Chemistry

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

SA Bellingham, GD Ciccotosto, BE Needham, LR Fodero, AR White, CL Masters, R Cappai, J Camakaris

Journal article  |  2004  |  Journal of Neurochemistry

Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex

MJ Smith, RA Sharples, G Evin, CA McLean, B Dean, G Pavey, E Fantino, RGH Cotton, K Imaizumi, CL Masters, R Cappai, JG Culvenor

Journal article  |  2004  |  Molecular Brain Research

Interaction of the molecular chaperone alpha B-crystallin with alpha-synuclein: Effects on amyloid fibril formation and chaperone activity

A Rekas, CG Adda, JA Aquilina, KJ Barnham, M Sunde, D Galatis, NA Williamson, CL Masters, RF Anders, CV Robinson, R Cappai, JA Carver

Journal article  |  2004  |  Journal of Molecular Biology

Mutagenesis-toxicity studies of the amyloid beta peptide of Alzheimer's disease

GD Ciccotosto, CC Curtain, D Tew, D Carrington, CL Masters, RA Cherny, AI Bush, R Cappai, KJ Barnham

Conference Proceedings  |  2004  |  Neurobiology of Aging

SIRNA and antisense RNA mediated knockdown of mammalian PrP expression

AF Hill, H Sen, AR White, R Sharples, S Patrick, SJ Collins, R Cappai, CL Masters

Conference Proceedings  |  2004  |  Neurobiology of Aging

The mechanism by which A beta produces hydrogen peroxide and its role in neurotoxicity

KJ Barnham, F Haeffner, GD Ciccotosto, CC Curtain, D Tew, CL Masters, RA Chemy, R Cappai, AI Bush

Conference Proceedings  |  2004  |  Neurobiology of Aging

Structural and functional analysis of the Alzheimer's disease amyloid precursor protein copper binding domain

R Cappai, G Kong, W McKinstry, D Galatis, J Adams, S Bellingham, J Camakaris, C Curtain, N Williamson, A White

Conference Proceedings  |  2004  |  Neurobiology of Aging

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

KJ Barnham, F Haeffner, GD Ciccotosto, CC Curtain, D Tew, C Mavros, K Beyreuther, D Carrington, CL Masters, RA Cherny, R Cappai, AI Bush

Journal article  |  2004  |  FASEB Journal

Iron inhibits neurotoxicity induced by trace copper and biological reductants

AR White, KJ Barnham, X Huang, I Voltakis, K Beyreuther, CL Masters, RA Cherny, AI Bush, R Cappai

Journal article  |  2004  |  Journal of Biological Inorganic Chemistry

SorLA, a sorting receptor that regulates proteolytic processing of the amyloid precursor protein and A beta petpide production

O Andersen, J Reiche, X Wu, K Bales, P Jansen, J Gliemann, R Cappai, C Masters, S Paul, A Nykjaer, T Willnow

Conference Proceedings  |  2004  |  EUROPEAN JOURNAL OF CELL BIOLOGY

Structure activity studies of protein-metal interactions in Alzheimer's disease

R Cappai

Conference Proceedings  |  2004  |  JOURNAL OF NEUROCHEMISTRY

Redox-mediated A beta neurotoxicity

KJ Barnham, R Cappai, RA Cherny, AI Bush, CL Masters

Conference Proceedings  |  2004  |  JOURNAL OF NEUROCHEMISTRY

Metal-Protein Attenuating Compounds (MPACs) for the Treatment of Alzheimers Disease

Kevin Barnham, Robert Cherny, Roberto Cappai, Simon Melov, Colin Masters, Ashley Bush

Journal article  |  2004  |  Drug Design Reviews Online

Structural biology of prions.

Roberto Cappai, Steven J Collins

Book Chapter  |  2004  |  Contributions to Microbiology

Strategies for crystallizing the N-terminal growth factor domain of amyloid precursor protein

WJ McKinstry, SC Feil, D Galatis, R Cappai, MW Parker

Book Chapter  |  2004

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

KJ Barnham, GD Ciccotosto, AK Tickler, FE Ali, DG Smith, NA Williamson, YH Lam, D Carrington, D Tew, G Kocak, I Volitakis, F Separovic, CJ Barrow, JD Wade, CL Masters, RA Cherny, CC Curtain, AI Bush, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Cu2 -induced modification of the kinetics of A beta(1-42) channels

R Bahadi, PV Farrelly, BL Kenna, CC Curtain, CL Masters, R Cappai, KJ Barnham, JI Kourie

Journal article  |  2003  |  American Journal of Physiology - Cell Physiology

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

KJ Barnham, WJ McKinstry, G Multhaup, D Galatis, CJ Morton, CC Curtain, NA Williamson, AR White, MG Hinds, RS Norton, K Beyreuther, CL Masters, MW Parker, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain - A regulator of neuronal copper homeostasis

KJ Barnham, WJ McKinstry, G Multhaup, D Galatis, CJ Morton, CC Curtain, NA Williamson, AR White, MG Hinds, RS Norton, K Beyreuther, CL Masters, MW Parker, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments

JI Kourie, BL Kenna, D Tew, MF Jobling, CC Curtain, CL Masters, KJ Barnham, R Cappai

Journal article  |  2003  |  Journal of Membrane Biology

Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation

AR White, F Maher, MW Brazier, MF Jobling, J Thyer, LR Stewart, A Thompson, R Gibson, CL Masters, G Multhaup, K Beyreuther, CJ Barrow, SJ Collins, R Cappai

Journal article  |  2003  |  Brain Research

Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

AR White, R Cappai

Journal article  |  2003  |  Journal of Neuroscience Research

Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS - Differential effect of presenilin exon 9 deletion on gamma- and epsilon-cleavage

MF Sernee, G Evin, JG Culvenor, JA Villadangos, K Beyreuther, CL Masters, R Cappai

Journal article  |  2003  |  European Journal of Biochemistry

Methionine oxidation: Implications for the mechanism of toxicity of the beta-amyloid peptide from Alzheimer's disease

GD Ciccotosto, KJ Barnham, RA Cherny, CL Masters, AI Bush, CC Curtain, R Cappai, D Tew

Journal article  |  2003  |  Letters in Peptide Science

Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.

G EVIN, undefined Sernee, K BARNHAM, undefined Holsinger, J CULVENOR, D HOKE, Q LI, undefined Smith, C MAYNARD, N WILLIAMSON, G CICCOTOSTO, S MOK, I VOLITAKIS, G KOCAK, undefined Carrington, undefined Opazo, AK TICKLER, undefined Huang, undefined Beyreuther, R CAPPAI, et al.

Book Chapter  |  2003

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

CJ Maynard, R Cappai, I Volitakis, RA Cherny, AR White, K Beyreuther, CL Masters, AI Bush, QX Li

Journal article  |  2002  |  Journal of Biological Chemistry

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid - Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2

C Opazo, XD Huang, RA Cherny, RD Moir, AE Roher, AR White, R Cappai, CL Masters, RE Tanzi, NC Inestrosa, AI Bush

Journal article  |  2002  |  Journal of Biological Chemistry

Generation of a recombinant Fab antibody reactive with the Alzheimer's disease-related A beta peptide

AH Tammer, G Coia, R Cappai, S Fuller, CL Masters, P Hudson, JR Underwood

Journal article  |  2002  |  Clinical and Experimental Immunology

Prions in skeletal muscle

MW Brazier, R Cappai, SJ Collins

Journal article  |  2002  |  Australian Veterinary Journal

Evidence for a copper-binding superfamily of the amyloid precursor protein

A Simons, T Ruppert, C Schmidt, A Schlicksupp, R Pipkorn, J Reed, CL Masters, AR White, R Cappai, K Beyreuther, TA Bayer, G Multhaup

Journal article  |  2002  |  Biochemistry

Overexpression of the beta-amyloid protein regulates metal levels in transgenic mouse brain

C Maynard, R Cappai, A White, C Masters, I Volitakis, R Cherny, K Beyreuther, A Bush

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

Structure-function of the amyloid precursor protein copper-binding domain

R Cappai, K Barnham, N Williamson, C Masters, W McKinstry, D Galatis, C Curtain, M Parker, G Multhaup, K Beyreuther, A White, M Hinds, R Norton

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

Factors regulating the interactions between amyloid-beta and membrane lipids

K Barnham, D Smith, D Carrington, G Kocak, I Volitakis, R Cherny, R Cappai, C Masters, A Bush, C Curtain, F Ali, C Barrow, A Tickler, J Wade

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease

G Multhaup, S Scheuermann, A Schlicksupp, A Simons, M Strauss, A Kemmling, C Oehler, R Cappai, R Pipkorn, TA Bayer

Journal article  |  2002  |  Free Radical Biology and Medicine

A fluorescent assay to monitor gamma-secretase activity on APP and notch substrates

F Sernee, G Evin, J Culvenor, C Masters, R Cappai, K Beyreuther

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

Proteasome-dependent processing of the C-terminal fragment of the amyloid protein precursor alters the production of A beta

J Nunan, NA Williamson, R Cappai, CL Masters, DH Small, MS Shearman, K Beyreuther

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF)

JA Hamilton, G Whitty, AR White, MF Jobling, A Thompson, CJ Barrow, R Cappai, K Beyreuther, CL Masters

Journal article  |  2002  |  Brain Research

Alternative transcripts of presenilin-I associated with frontotemporal dementia

G Evin, MJ Smith, AF Tziotis, C McLean, L Canterford, RA Sharples, R Cappai, A Weidemann, K Beyreuther, RGH Cotton, CL Masters, JG Culvenor

Journal article  |  2002  |  NeuroReport

Alternative transcripts of presenilin-1 associated with frontotemporal dementia

Geneviève Evin, Margaret J Smith, Angela Tziotis, Catriona McLean, Louise Canterford, Robyn A Sharples, Roberto Cappai, Andreas Weidemann, Konrad Beyreuther, Richard GH Cotton, Colin L Masters, Janetta G Culvenor

Journal article  |  2002  |  NeuroReport

Alternative transcripts of presenilin-I associated with frontotemporal dementia

G Evin, MJ Smith, A Tziotis, C McLean, L Canterford, RA Sharples, R Cappai, A Weidemann, K Beyreuther, RGH Cotton, CL Masters, JG Culvenor

Journal article  |  2002  |  Neuroreport

Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein

AR White, G Multhaup, D Galatis, WJ McKinstry, MW Parker, R Pipkorn, K Beyreuther, CL Masters, R Cappai

Journal article  |  2002  |  Journal of Neuroscience

Metals modulate the aggregation and neurotoxic properties of the prion peptide Prp106-126

R CAPPAI

Book Chapter  |  2002

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

J Nunan, MS Shearman, F Checler, R Cappai, G Evin, K Beyreuther, CL Masters, DH Small

Journal article  |  2001  |  European Journal of Biochemistry

Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126

LR Stewart, AR White, MF Jobling, BE Needham, F Maher, J Thyer, K Beyreuther, CL Masters, SJ Collins, R Cappai

Journal article  |  2001  |  Journal of Neuroscience Research

The amyloid precursor protein and amyloid beta peptide of Alzheimer's syndrome: structure-function in syndrome and health.

R Cappai

Journal article  |  2001  |  JOURNAL OF NEUROCHEMISTRY

Interactions between fibroblast growth factors and Notch regulate neuronal differentiation

CH Faux, AM Turnley, R Epa, R Cappai, PF Bartlett

Journal article  |  2001  |  Journal of Neuroscience

Copper interaction with the amyloid precursor protein (APP)

G Multhaup, A Simons, C Schmidt, A Schlicksupp, J Reed, AR White, R Cappai, K Beyreuther

Journal article  |  2001  |  JOURNAL OF INORGANIC BIOCHEMISTRY

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126

MF Jobling, XD Huang, LR Stewart, KJ Barnham, C Curtain, I Volitakis, M Perugini, AR White, RA Cherny, CL Masters, CJ Barrow, SJ Collins, AI Bush, R Cappai

Journal article  |  2001  |  Biochemistry

Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons

AR White, R Guirguis, MW Brazier, MF Jobling, AF Hill, K Beyreuther, CJ Barrow, CL Masters, SJ Collins, R Cappai

Journal article  |  2001  |  Neurobiology of Disease

Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways

AR White, XD Huang, MF Jobling, CJ Barrow, K Beyreuther, CL Masters, AI Bush, R Cappai

Journal article  |  2001  |  Journal of Neurochemistry

Variable phenotype of Alzheimer's disease with spastic paraparesis

MJ Smith, JBJ Kwok, CA McLean, JJ Kril, GA Broe, GA Nicholson, R Cappai, M Hallupp, RGH Cotton, CL Masters, PR Schofield, WS Brooks

Journal article  |  2001  |  Annals of Neurology

Structural biology of prions.

R Cappai, MF Jobling, CJ Barrow, S Collins

Book Chapter  |  2001  |  Contributions to Microbiology

Interaction of linear homologous DNA duplexes via Holliday junction formation

MG Yakubovskaya, AA Neschastnova, KE Humphrey, JJ Babon, VI Popenko, MJ Smith, A Lambrinakos, ZV Lipatova, MA Dobrovolskaia, R Cappai, CL Masters, GA Belitsky, RG Cotton

Journal article  |  2001  |  European Journal of Biochemistry

Amyloidgenicity and neurotoxicity of peptides corresponding to the helical regions of PrPC

A Thompson, AR White, C McLean, CL Masters, R Cappai, CJ Barrow

Journal article  |  2000  |  Journal of Neuroscience Research

Accumulation of insoluble alpha-synuclein in dementia with Lewy bodies

BCV Campbell, QX Li, JG Culvenor, P Jakala, R Cappai, K Beyreuther, CL Masters, CA McLean

Journal article  |  2000  |  Neurobiology of Disease

Differential effects of zinc on amyloid precursor protein (APP) processing in copper-resistant variants of cultured Chinese hamster ovary cells

T Borchardt, C Schmidt, J Camakaris, R Cappai, CL Masters, K Beyreuther, G Multhaup

Journal article  |  2000  |  Cellular and molecular biology (Noisy-le-Grand, France)

Correct heteroduplex formation for mutation detection analysis

MJ Smith, KE Humphrey, R Cappai, K Beyreuther, CL Masters, RGH Cotton

Journal article  |  2000  |  Molecular Diagnosis

Presenilin I expression in yeast lowers secretion of the amyloid precursor protein

G Evin, D Le Brocque, JG Culvenor, D Galatis, A Weidemann, K Beyreuther, CL Masters, R Cappai

Journal article  |  2000  |  NeuroReport

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

T Borchardt, J Camakaris, R Cappai, CL Masters, K Beyreuther, G Multhaup

Journal article  |  1999  |  Biochemical Journal

The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons

MD Caswell, S San Mok, A Henry, R Cappai, G Klug, K Beyreuther, CL Masters, DH Small

Journal article  |  1999  |  European Journal of Biochemistry

It all sticks together - the APP-related family of proteins and Alzheimer's disease

TA Bayer, R Cappai, CL Masters, K Beyreuther, G Multhaup

Journal article  |  1999  |  Molecular Psychiatry

Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity

AR White, SJ Collins, F Maher, MF Jobling, LR Stewart, JM Thyer, K Beyreuther, CL Masters, R Cappai

Journal article  |  1999  |  The American Journal of Pathology

The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures

AR White, G Multhaup, F Maher, S Bellingham, J Camakaris, H Zheng, AI Bush, K Beyreuther, CL Masters, R Cappai

Journal article  |  1999  |  The Journal of Neuroscience

The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126

MF Jobling, LR Stewart, AR White, C McLean, A Friedhuber, F Maher, K Beyreuther, CL Masters, CJ Barrow, SJ Collins, R Cappai

Journal article  |  1999  |  Journal of Neurochemistry

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

AR White, R Reyes, JFB Mercer, J Camakaris, H Zheng, AI Bush, G Multhaup, K Beyreuther, CL Masters, R Cappai

Journal article  |  1999  |  Brain Research

Amyloid beta

R Cappai, AR White

Journal article  |  1999  |  The International Journal of Biochemistry & Cell Biology

Alzheimer's disease: Correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome

G Christie, RE Markwell, CW Gray, L Smith, F Godfrey, F Mansfield, H Wadsworth, R King, M McLaughlin, DG Cooper, RV Ward, DR Howlett, T Hartmann, SF Lichtenthaler, K Beyreuther, J Underwood, SK Gribble, R Cappai, CL Masters, A Tamaoka, et al.

Journal article  |  1999  |  Journal of Neurochemistry

Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice

QX Li, C Maynard, R Cappai, CA McLean, RA Cherny, T Lynch, JG Culvenor, J Trevaskis, JE Tanner, KA Bailey, C Czech, AI Bush, K Beyreuther, CL Masters

Journal article  |  1999  |  Journal of Neurochemistry

Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione

AR White, AI Bush, K Beyreuther, CL Masters, R Cappai

Journal article  |  1999  |  Journal of Neurochemistry

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

J Rossjohn, R Cappai, SC Feil, A Henry, WJ McKinstry, D Galatis, L Hesse, G Multhaup, K Beyreuther, CL Masters, MW Parker

Journal article  |  1999  |  Nature Structural Biology

The amyloid precursor protein of Alzheimer's disease and the A beta peptide

E Storey, R Cappai

Journal article  |  1999  |  Neuropathology and Applied Neurobiology

Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: Implications for the mechanism of prion formation

R Cappai, L Stewart, MF Jobling, JM Thyer, AR White, K Beyreuther, SJ Collins, CL Masters, CJ Barrow

Journal article  |  1999  |  Biochemistry

The synthesis and spectroscopic analysis of the neurotoxic prion peptide 106-126: Comparative use of manual Boc and Fmoc chemistry

MF Jobling, CJ Barrow, AR White, CL Masters, SJ Collins, R Cappai

Journal article  |  1999  |  Letters in Peptide Science

Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth

R Cappai, SS Mok, D Galatis, DF Tucker, A Henry, K Beyreuther, DH Small, CL Masters

Journal article  |  1999  |  FEBS Letters

Autoxidation of amyloid precursor protein and formation of reactive oxygen species

G Multhaup, L Hesse, T Borchardt, T Ruppert, R Cappai, CL Masters, K Beyreuther

Conference Proceedings  |  1999  |  Advances in Experimental Medicine and Biology

The synthesis and spectroscopic analysis of the neurotoxic prion peptide 106-126: Comparative use of manual Boc and Fmoc chemistry

MF Jobling, CJ Barrow, AR White, CL Masters, SJ Collins, R Cappai

Journal article  |  1999  |  International Journal of Peptide Research and Therapeutics

Increased sensitivity of primary APLP2 knockout neurons to neurotoxic insults.

R Cappai, L Stewart, A White, F Maher, M Jobling, D Galatis, K Beyreuther, C Masters

Journal article  |  1999  |  JOURNAL OF NEUROCHEMISTRY

Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein

A Henry, QX Li, D Galatis, L Hesse, G Multhaup, K Beyreuther, CL Masters, R Cappai

Journal article  |  1998  |  British Journal of Haematology

Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: Immunodetection of alpha-, beta-, and gamma-secretase products

D Le Brocque, A Henry, R Cappai, QX Li, JE Tanner, D Galatis, C Gray, S Holmes, JR Underwood, K Beyreuther, CL Masters, G Evin

Journal article  |  1998  |  Biochemistry

Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress

AR White, H Zheng, D Galatis, F Maher, L Hesse, G Multhaup, K Beyreuther, CL Masters, R Cappai

Journal article  |  1998  |  The Journal of Neuroscience

Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system

JG Culvenor, A Henry, T Hartmann, G Evin, D Galatis, A Friedhuber, ULHR Jayasena, JR Underwood, K Beyreuther, CL Masters, R Cappai

Journal article  |  1998  |  Amyloid

Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor-related protein on neurite outgrowth from sympathetic neurons in culture

RB Postuma, RN Martins, R Cappai, K Beyreuther, CL Masters, DK Strickland, SS Mok, DH Small

Journal article  |  1998  |  FEBS Letters

Products of the Alzheimer's disease amyloid precursor protein generated by,β-secretase are present in human platelets, and secreted upon degranulation

QX Li, R Cappai, G Evin, JE Tanner, CW Gray, K Beyreuther, CL Masters

Journal article  |  1998  |  American Journal of Alzheimer's Disease

Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease

SS Mok, G Sberna, D Heffernan, R Cappai, D Galatis, HJ Clarris, WH Sawyer, K Beyreuther, CL Masters, DH Small

Journal article  |  1997  |  FEBS Letters

Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum Golgi intermediate compartment

JG Culvenor, F Maher, G Evin, F MalchiodiAlbedi, R Cappai, JR Underwood, JB Davis, EH Karran, GW Roberts, K Beyreuther, CL Masters

Journal article  |  1997  |  Journal of Neuroscience Research

Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment.

JG Culvenor, F Maher, G Evin, F Malchiodi-Albedi, R Cappai, JR Underwood, JB Davis, EH Karran, GW Roberts, K Beyreuther, CL Masters

Journal article  |  1997  |  Journal of Neuroscience Research

The recently identified Alzheimer's disease-associated presenilin 1 and 2 (PS1 and PS2) genes encode two homologous multi membrane..

Comparative studies of PrPc and APP expression in neurotoxicity of Creutzfeldt-Jakob and Alzheimer's diseases using PrP and APP knockout mouse cultures

A White, R Cappai, S Collins, K Beyreuther, C Masters

Journal article  |  1997  |  BRAIN PATHOLOGY

Expression of human amyloid precursor protein ectodomains in Pichia pastoris: Analysis of culture conditions, purification, and characterization

A Henry, CL Masters, K Beyreuther, R Cappai

Journal article  |  1997  |  Protein Expression and Purification

Identification of heparin-binding domains in the amyloid precursor protein of Alzheimer's disease by deletion mutagenesis and peptide mapping

HJ Clarris, R Cappai, D Heffernan, K Beyreuther, CL Masters, DH Small

Journal article  |  1997  |  Journal of Neurochemistry

Distribution of amyloid precursor-like protein 2 in normal and Alzheimer's disease hippocampal formation

TA Bayer, S Weggen, L Hesse, R Cappai, CL Masters, K Beyreuther, G Multhaup

Journal article  |  1997  |  Alzheimer's Research

Secreted glypican binds to the amyloid protein precursor (APP) of Alzheimer's disease and inhibits APP-induced neurite outgrowth

TG Williamson, HJ Clarris, S SanMok, A Henry, R Cappai, V Nurcombe, K Beyreuther, CL Masters, DH Small

Conference Proceedings  |  1997  |  ALZHEIMER'S DISEASE: BIOLOGY, DIAGNOSIS AND THERAPEUTICS

Human amyloid precursor protein ectodomains inhibit adenosine diphosphate- and epinephrine-induced human platelet aggregation.

A Henry, QX Li, K Beyreuther, CL Masters, R Cappai

Journal article  |  1997  |  JOURNAL OF NEUROCHEMISTRY