Dr Jenny Gunnersen received her BSc(Hons) in Marine Biochemistry from James Cook University in 1986 and her PhD from the University of Melbourne in 1994. In her first post-doctoral position, she worked with Michael Sendtner in Würzburg, Germany investigating trophic factors for motoneuron survival and regeneration.
In 1998, Jenny was awarded an NHMRC Howard Florey Centenary Fellowship and worked with Seong-Seng Tan in the Brain Development Group at the Howard Florey Institute. During her Fellowship, Jenny utilized emerging gene expression profiling techniques to obtain the first molecular inventory of the developing cortex and produced gene knockout mouse models to determine functional roles for some of the novel genes identified.
In 2011, Jenny moved to the Department of Anatomy and Neuroscience at the University of Melbourne as a Senior Lecturer and Head of the Neuron Development and Plasticity Laboratory. Her work, funded by the NHMRC, is focussed on:
(i) the molecular and cellular mechanisms controlling synapse development;
(ii) synapse loss in the earliest stages of Alzheimer’s disease and how this might be slowed or prevented;
(iii) synapse formation/strengthening and how these processes contribute to the pathology of psychostimulant abuse and neuropathic pain.
Funding: Dr Gunnersen’s research has been continuously funded by the NHMRC through 7 Project grants since 2005 (6 as CIA, 1 as CIB), totaling >$4.2 million.
Zhu K, Xiang X, Filser S, Marinković P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Gunnersen JM*, Herms J* (2017) BACE1 inhibition impairs synaptic plasticity via Seizure Protein 6. Biol Psychiatry 2016 Dec 26. pii: S0006-3223(16)33157-2. [Epub ahead of print]. *Equal senior authors.
Simon CM*, Rauskolb S*, GUNNERSEN JM*, Holtmann B, Drepper C, Dombert B, Braga M, Wiese S, Jablonka S, Pühringer D, Zielasek J, Hoeflich A, Silani V, Wolf E, Kneitz S, Sommer C, Toyka KV, Sendtner M (2015) Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy. Acta Neuropathologica 130:373-87. *Equal first authors.
Li SS, Qu Z, Haas M, Ngo L, Heo YJ, Kang HJ, Britto JM, Cullen HD, Vanyai HK, Tan SS, Chan-Ling T, Gunnersen JM, Heng JI (2016) The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome. Sci Rep 6:29514.
Evin, GMJ, Fuller SJ, GUNNERSEN JM (2015) BACE inhibition as a therapeutic strategy for Alzheimer’s disease. Frontiers in Clinical Drug Research – Alzheimer Disorders. Vol. 3, Chapter 4 pp. 135-230. Series Editor Atta-ur-Raahman. Bentham Science Publishers. ISSN: 2214-5168.
Hammond VE*, GUNNERSEN JM*, Goh CP, Low LH, Hyakumura T, Tang MM, Britto JM, Putz U, Howitt JA, Tan SS (2014) Ndfip1 Is required for the development of pyramidal neuron dendrites and spines in the neocortex. Cereb Cortex 24:3289-300. *Equal first authors.
GUNNERSEN JM, Kim MH, Fuller SJ, De Silva M, Britto JM, Hammond VE, Davies PJ, Petrou S, Faber ESL, Sah P, Tan SS (2007) Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons. Neuron 56:621-639.
Wiese S*, Digby MR*, GUNNERSEN JM, Gotz R, Pei G, Holtmann B, Lowenthal J, Sendtner M (1999) The anti-apoptotic protein ITA is essential for NGF-mediated survival of embryonic chick neurons. Nature Neurosci 2:978-983. *Equal first authors.
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Jenny Gunnersen's highlights
Jenny Gunnersen's selected work
Combatting The Opioid Epidemic Through Identification Of Novel Drug Targets For Relapse Pr..
Internal Research Grant
Evidence that a defined population of neurons in lateral amygdala is directly involved in ..
Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain-associa..
Displaying the 18 most recent projects by Jenny Gunnersen.
Internal Research Grant
Displaying the 53 most recent scholarly works by Jenny Gunnersen.
Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties.
Amelia Nash, Timothy D Aumann, Martina Pigoni, Stefan F Lichtenthaler, Hiroshi Takeshima, Kathryn M Munro, Jenny M Gunnersen
Journal article | 2020 | Cerebral Cortex
Seizure-related gene 6 (Sez6), Sez6-Like (Sez6L), and Sez6-Like 2 (Sez6L2) comprise a family of homologous proteins widely express..
Evidence that a defined population of neurons in lateral amygdala is directly involved in auditory fear learning and memory
Christopher W Butler, Yvette M Wilson, Samuel A Mills, Jenny M Gunnersen, Mark Murphy
Journal article | 2020 | Neurobiology of Learning and Memory
Memory is thought to be encoded within networks of neurons within the brain, but the identity of the neurons involved and circuits..
Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain-associated conditions.
Maria Roitman, Laura E Edgington-Mitchell, Jon Mangum, James Ziogas, Alexios A Adamides, Paul Myles, Hearan Choo-Bunnett, Nigel W Bunnett, Jenny M Gunnersen
Journal article | 2019 | PAIN Reports
Introduction: Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain ..
MAIT cells protect against pulmonary Legionella longbeachae infection
Huimeng Wang, Criselle D'Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J Pediongco, Sidonia BG Eckle, Bronwyn S Meehan, Mai Shi, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey YW Mak, David P Fairlie, Yoichiro Iwakura, Jennifer M Gunnersen, Andrew W Stent, Dale I Godfrey, Jamie Rossjohn, Glen P Westall, Lars Kjer-Nielsen, et al.
Journal article | 2018 | Nature Communications
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
Mirsada Causevic, Kristina Dominko, Martina Malnar, Lea Vidatic, Stjepko Cermak, Martina Pigoni, Peer-Hendrik Kuhn, Alessio Colombo, Daniel Havas, Stefanie Flunkert, Jessica McDonald, Jenny M Gunnersen, Birgit Hutter-Paier, Sabina Tahirovic, Manfred Windisch, Dimitri Krainc, Stefan F Lichtenthaler, Silva Hecimovic
Journal article | 2018 | PLOS ONE
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6
Kaichuan Zhu, Xianyuan Xiang, Severin Filser, Petar Marinkovic, Mario M Dorostkar, Sophie Crux, Ulf Neumann, Derya R Shimshek, Gerhard Rammes, Christian Haass, Stefan F Lichtenthaler, Jenny M Gunnersen, Jochen Herms
Journal article | 2018 | Biological Psychiatry
Legionella protection and vaccination mediated by Mucosal Associated Invariant T (MAIT) cells
Huimeng Wang, Criselle D’Souza, Xin Yi Lim, Lyudmila Kostenko, Troi Pediongco, Sidonia BG Eckle, Bronwyn Meehan, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey YW Mak, David Fairlie, Yoichiro Iwakura, Jennifer Gunnersen, Andrew Stent, Jamie Rossjohn, Glen Westall, Lars Kjer-Nielsen, Richard Strugnell, James McCluskey, et al.
Journal article | 2017
Abstract Mucosal associated invariant T (MAIT) cells recognize conserved microbial metabolites from riboflavin synthesis. Striking..
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons
Martina Pigoni, Johanna Wanngren, Peer-Hendrik Kuhn, Kathryn M Munro, Jenny M Gunnersen, Hiroshi Takeshima, Regina Feederle, Iryna Voytyuk, Bart De Strooper, Mikail D Levasseur, Brian J Hrupka, Stephan A Mueller, Stefan F Lichtenthaler
Journal article | 2016 | Molecular Neurodegeneration
The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome
Shan Shan Li, Zhengdong Qu, Matilda Haas, Ngo Linh, You Jeong Heo, Hyo Jung Kang, Joanne Maria Britto, Hayley Daniella Cullen, Hannah Kate Vanyai, Seong-Seng Tan, Tailoi Chan-Ling, Jenny Margaret Gunnersen, Julian Ik-Tsen Heng
Journal article | 2016 | Scientific Reports
Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy
CM Simon, S Rauskolb, JM Gunnersen, B Holtmann, C Drepper, B Dombert, M Braga, S Wiese, S Jablonka, D Pühringer, J Zielasek, A Hoeflich, V Silani, E Wolf, S Kneitz, C Sommer, KV Toyka, M Sendtner
Journal article | 2015 | Acta Neuropathologica
Diabetic neuropathy (DNP), afflicting sensory and motor nerve fibers, is a major complication in diabetes. The underlying cellular..
TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons
Linh Ngo, Matilda Haas, Zhengdong Qu, Shan Shan Li, Jennifer Zenker, Kathleen Sue Lyn Teng, Jenny Margaret Gunnersen, Martin Breuss, Mark Habgood, David Anthony Keays, Julian Ik-Tsen Heng
Journal article | 2014 | Human Molecular Genetics
Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons
Jenny M Gunnersen, Mary H Kim, Stephanie J Fuller, Melanie De Silva, Joanne M Britto, Vicki E Hammond, Philip J Davies, Steve Petrou, ES Louise Faber, Pankaj Sah, Seong-Seng Tan
Journal article | 2007 | Neuron
Automated analysis of neurite branching in cultured cortical neurons using HCA-Vision
Pascal Vallotton, Ryan Lagerstrom, Changming Sun, Michael Buckley, Dadong Wang, Melanie De Silva, Seong-Seng Tan, Jenny A Gunnersen
Journal article | 2007 | Cytometry. Part A : the journal of the International Society for Analytical Cytology
Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury
Qian Sang, Mary H Kim, Sharad Kumar, Nicole Bye, Maria C Morganti-Kossman, Jenny Gunnersen, Stephanie Fuller, Jason Howitt, Lavinia Hyde, Tim Beissbarth, Hamish S Scott, John Silke, Seong-Seng Tan
Journal article | 2006 | Journal of Neuroscience
Anatomy And Neuroscience
Florey Department Of Neuroscience And Mental Health
Doctorate in Biochemistry
University of Melbourne
Bachelor of Science (Honours)
James Cook University of North Queensland