Director of The Graeme Clark Institute, The Sir John Eccles Chair of Medicine and Director of Clinical Neurosciences at St. Vincent’s Hospital, Professor Cook specialises in the treatment of epilepsy. He is recognised internationally for his expertise in epilepsy management, particularly imaging and surgical planning.
After completing specialist training in Melbourne, he undertook an MD thesis while working as Brain Research Fellow at Queen Square, London. He returned to St. Vincent’s Hospital, Melbourne to continue his interest in management of complex epilepsy. He has worked closely with engineers for most of his career, developing novel therapies for epilepsy. His interests have included experimental models of epilepsy and seizure prediction, and he has led the commercialisation of an implantable seizure detection device about to start clinical trials.
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Critical Slowing On Long-Time Scales Is A Biomarker For Epileptic Seizure Forecasting
Ensembling crowdsourced seizure prediction algorithms using long-term human intracranial E..
Displaying the 29 most recent projects by Mark Cook.
Internal Research Grant
Displaying the 394 most recent scholarly works by Mark Cook.
Ensembling crowdsourced seizure prediction algorithms using long-term human intracranial EEG
Chip Reuben, Philippa Karoly, Dean R Freestone, Andriy Temko, Alexandre Barachant, Feng Li, Gilberto Titericz, Brian W Lang, Daniel Lavery, Kelly Roman, Derek Broadhead, Gareth Jones, Qingnan Tang, Irina Ivanenko, Oleg Panichev, Timothee Proix, Michal Nahlik, Daniel B Grunberg, David B Grayden, Mark J Cook, et al.
Journal article | 2020 | Epilepsia
Seizure prediction is feasible, but greater accuracy is needed to make seizure prediction clinically viable across a large group o..
Forecasting Cycles of Seizure Likelihood
Philippa Karoly, Matias Maturana, Mark Cook, Ewan Nurse, Daniel Payne, Benjamin Brinkmann, David Grayden, Sonya Dumanis, Mark Richardson, Greg Worrell, Andreas Schulze-Bonhage, Levin Kuhlmann, Dean Freestone
Journal article | 2019
Objective: Seizure unpredictability is rated as one of the most challenging aspects of living with epilepsy. Seizure likelihood ca..
Reducing glucose variability with continuous subcutaneous insulin infusion is associated with reversal of axonal dysfunction in type 1 diabetes mellitus
Jordan Kamel, Margaret Loh, Mark Cook, Richard J MacIsaac, Leslie J Roberts
Journal article | 2019 | Muscle & Nerve
INTRODUCTION: We assess whether improvement in control of type 1 diabetes mellitus (T1DM) with continuous subcutaneous insulin inf..
Standardized Brain MRI Acquisition Protocols Improve Statistical Power in Multicenter Quantitative Morphometry Studies
Allan George, Ruben Kuzniecky, Henry Rusinek, Heath R Pardoe, Jacqueline French, Daniel Lowenstein, Sabrina Cristofaro, Kevin McKenna, Vickie Mays, Darrell Shack, Sarah Barnard, Cheryl Burke, Manu Hegde, Tracy Glauser, Terence O'Brien, John Pollard, Tricia Ting, Kimford Meador, David Darby, Chris Morrison, et al.
Journal article | 2019 | Journal of Neuroimaging
Computer-assisted EEG diagnostic review for idiopathic generalized epilepsy.
Shannon Clarke, Philippa J Karoly, Ewan Nurse, Udaya Seneviratne, Janelle Taylor, Rory Knight-Sadler, Robert Kerr, Braden Moore, Patrick Hennessy, Dulini Mendis, Claire Lim, Jake Miles, Mark Cook, Dean R Freestone, Wendyl D'Souza
Journal article | 2019 | Epilepsy & Behavior
Epilepsy diagnosis can be costly, time-consuming, and not uncommonly inaccurate. The reference standard diagnostic monitoring is c..
Deep Brain Stimulation for Epilepsy: Biomarkers for Optimization
Katrina L Dell, Mark J Cook, Matias I Maturana
Journal article | 2019 | Current Treatment Options in Neurology
PURPOSE OF REVIEW: Two large-scale controlled clinical trials have provided Class I evidence for the benefit of deep brain stimula..
Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity (vol 56, pg 5471, 2019)
Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johanssen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce
Journal article | 2019 | Molecular Neurobiology
When can we trust responders? Serious concerns when using 50% response rate to assess clinical trials
Philippa J Karoly, Juan Romero, Mark J Cook, Dean R Freestone, Daniel M Goldenholz
Journal article | 2019 | Epilepsia
Individual seizure rates are highly volatile, with large fluctuations from month‐to‐month. Nevertheless, changes in individual mea..
Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity
Kathryn Cimdins, Hayley S Waugh, Vicki Chrysostomou, M Isabel G Lopez Sanchez, Vanessa A Johannsen, Mark J Cook, Jonathan G Crowston, Andrew F Hill, James A Duce, Ashley I Bush, Ian A Trounce
Journal article | 2019 | Molecular Neurobiology
A decision tree to determine fitness to drive in epilepsy: Results of a pilot in two Australian states.
Ernest R Somerville, undefined Driving Committee of the Epilepsy Society of Australia
Journal article | 2019 | Epilepsia
OBJECTIVE: Certification by treating physicians of fitness to drive in people with epilepsy creates a conflict of interest that ma..
Bilateral volume reduction in posterior hippocampus in psychosis of epilepsy
James Allebone, Richard Kanaan, Jerome Maller, Terry O'Brien, Saul Alator Mullen, Mark Cook, Sophia J Adams, Simon Vogrin, David N Vaughan, Alan Connelly, Patrick Kwan, SF Berkovic, Wendyl J D'Souza, Graeme Jackson, Dennis Velakoulis, Sarah J Wilson
Journal article | 2019 | Journal of Neurology, Neurosurgery & Psychiatry
Methods for the Detection of Seizure Bursts in Epilepsy
Udaya Seneviratne, Philippa Karoly, Dean R Freestone, Mark J Cook, Ray C Boston
Journal article | 2019 | Frontiers in Neurology
Background: Seizure clusters and “bursts” are of clinical importance. Clusters are reported to be a marker of antiepileptic drug r..
Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
Wei-Chih Chang, Jan Kudlacek, Jaroslav Hlinka, Jan Chvojka, Michal Hadrava, Vojtech Kumpost, Andrew D Powell, Radek Janca, Matias I Maturana, Philippa J Karoly, Dean R Freestone, Mark J Cook, Milan Palus, Jakub Otahal, John GR Jefferys, Premysl Jiruska
Journal article | 2018 | Nature Neuroscience
Epilepsyecosystem.org: crowd-sourcing reproducible seizure prediction with long-term human intracranial EEG
Levin Kuhlmann, Philippa Karoly, Dean R Freestone, Benjamin H Brinkmann, Andriy Temko, Alexandre Barachant, Feng Li, Gilberto Titericz, Brian W Lang, Daniel Lavery, Kelly Roman, Derek Broadhead, Scott Dobson, Gareth Jones, Qingnan Tang, Irina Ivanenko, Oleg Panichev, Timothee Proix, Michal Nahlik, Daniel B Grunberg, et al.
Journal article | 2018 | Brain
Common data elements for epilepsy mobile health systems
Daniel M Goldenholz, Robert Moss, David A Jost, Nathan E Crone, Gregory Krauss, Rosalind Picard, Chiara Caborni, Jose E Cavazos, John Hixson, Tobias Loddenkemper, Tracy Dixon Salazar, Laura Lubbers, Lauren C Harte-Hargrove, Vicky Whittemore, Jonas Duun-Henriksen, Eric Dolan, Nitish Kasturia, Mark Oberemk, Mark J Cook, Mark Lehmkuhle, et al.
Journal article | 2018 | Epilepsia
Is seizure frequency variance a predictable quantity?
Daniel M Goldenholz, Shira R Goldenholz, Robert Moss, Jacqueline French, Daniel Lowenstein, Ruben Kuzniecky, Sheryl Haut, Sabrina Cristofaro, Kamil Detyniecki, John Hixson, Philippa Karoly, Mark Cook, Alex Strashny, William H Theodore
Journal article | 2018 | Annals of Clinical and Translational Neurology
Development and Characterization of a Sucrose Microneedle Neural Electrode Delivery System
Nicholas V Apollo, Jonathan Jiang, Warwick Cheung, Sebastien Baquier, Alan Lai, Azadeh Mirebedini, Javad Foroughi, Gordon G Wallace, Mohit N Shivdasani, Steven Prawer, Shou Chen, Richard Williams, Mark J Cook, David AX Nayagam, David J Garrett
Journal article | 2018 | Advanced Biosystems
Epileptic Seizure Prediction Using Big Data and Deep Learning: Toward a Mobile System
Isabell Kiral-Kornek, Subhrajit Roy, Ewan Nurse, Benjamin Mashford, Philippa Karoly, Thomas Carroll, Daniel Payne, Susmita Saha, Steven Baldassano, Terence O'Brien, David Grayden, Mark Cook, Dean Freestone, Stefan Harrer
Journal article | 2018 | EBioMedicine
Does accounting for seizure frequency variability increase clinical trial power?
Daniel M Goldenholz, Shira R Goldenholz, Robert Moss, Jacqueline French, Daniel Lowenstein, Ruben Kuzniecky, Sheryl Haut, Sabrina Cristofaro, Kamil Detyniecki, John Hixson, Philippa Karoly, Mark Cook, Alex Strashny, William H Theodore, Carl Pieper
Journal article | 2017 | Epilepsy Research
Intracranial EEG fluctuates over months after implanting electrodes in human brain
Hoameng Ung, Steven N Baldassano, Hank Bink, Abba M Krieger, Shawniqua Williams, Flavia Vitale, Chengyuan Wu, Dean Freestone, Ewan Nurse, Kent Leyde, Kathryn A Davis, Mark Cook, Brian Litt
Journal article | 2017 | Journal of Neural Engineering
Ring and peg electrodes for minimally-Invasive and long-term sub-scalp EEG recordings
YB Benovitski, A Lai, CC McGowan, O Burns, V Maxim, DAX Nayagam, R Millard, GD Rathbone, MA le Chevoir, RA Williams, DB Grayden, CN May, M Murphy, WJ D'Souza, MJ Cook, CE Williams
Journal article | 2017 | Epilepsy Research
Simulating Clinical Trials With and Without Intracranial EEG Data.
Daniel M Goldenholz, Joseph J Tharayil, Rubin Kuzniecky, Philippa Karoly, William H Theodore, Mark J Cook
Journal article | 2017 | Epilepsia Open
OBJECTIVE: It is currently unknown if knowledge of clinically silent (electrographic) seizures improves the statistical efficiency..
Crowdsourcing seizure detection: algorithm development and validation on human implanted device recordings
Steven N Baldassano, Benjamin H Brinkmann, Hoameng Ung, Tyler Blevins, Erin C Conrad, Kent Leyde, Mark J Cook, Ankit N Khambhati, Joost B Wagenaar, Gregory A Worrell, Brian Litt
Journal article | 2017 | Brain
Cathodal transcranial direct-current stimulation for treatment of drug-resistant temporal lobe epilepsy: A pilot randomized controlled trial.
Maryam Zoghi, Terence J O'Brien, Patrick Kwan, Mark J Cook, Mary Galea, Shapour Jaberzadeh
Journal article | 2016 | Epilepsia Open
Objective: To investigate the effect of cathodal transcranial direct-current stimulation (c-tDCS) on seizure frequency in patients..
Effects of a common transcranial direct current stimulation (tDCS) protocol on motor evoked potentials found to be highly variable within individuals over 9 testing sessions
Jared Cooney Horvath, Simon J Vogrin, Olivia Carter, Mark J Cook, Jason D Forte
Journal article | 2016 | Experimental Brain Research
Antiepileptic Effects of Lacosamide Loaded Polymers Implanted Subdurally in GAERS
Sebastien H Bauquier, Jonathan L Jiang, Zhilian Yue, Alan Lai, Yu Chen, Simon E Moulton, Karen J McLean, Sara Vogrin, Amy J Halliday, Gordon Wallace, Mark J Cook
Journal article | 2016 | International Journal of Polymer Science
Intrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability over the wake/sleep cycle
Christian Meisel, Andreas Schulze-Bonhage, Dean Freestone, Mark James Cook, Peter Achermann, Dietmar Plenz
Journal article | 2015 | Proceedings of the National Academy of Sciences
Movement related directional tuning from broadband electrocorticography in humans
ES Nurse, DR Freestone, TJ Oxley, DC Ackland, SJ Vogrin, M Murphy, TJ O'Brien, MJ Cook, DB Grayden
Conference Proceedings | 2015 | 2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)
© 2015 IEEE. Directional tuning is the tendency for cortical neurons to exhibit a peak firing rate when a limb is moved in a prefe..
Injectable phenytoin loaded polymeric microspheres for the control of temporal lobe epilepsy in rats
Jonathan L Jiang, Zhilian Yue, Sebastien H Bauquier, Alan Lai, Yu Chen, Karen J McLean, Amy J Halliday, Yi Sui, Simon Moulton, Gordon G Wallace, Mark J Cook
Journal article | 2015 | Restorative Neurology and Neuroscience
Capture of Somatic mtDNA Point Mutations with Severe Effects on Oxidative Phosphorylation in Synaptosome Cybrid Clones from Human Brain
Matthew McKenzie, Maria Chiotis, Jana Hroudova, Maria IG Lopez Sanchez, Sze Chern Lim, Mark J Cook, Penny McKelvie, Richard GH Cotton, Michael Murphy, Justin C St John, Ian A Trounce
Journal article | 2014 | Human Mutation
A community survey of cardiovascular risk factors in an urban population in Botswana exploring potential for telemedicine
J Joubert, O Nkomazana, K Mompati, L Joubert, PM Preux, P La Croix, J Laing, S Korn, B Mbogwe, B Tsima, M Cook
Journal article | 2014 | European Research in Telemedicine / La Recherche Européenne en Télémédecine
Long memory processes are revealed in the dynamics of the epileptic brain
MJ Cook, A Varsavsky, D Himes, K Leyde, S Berkovic, T O'Brien, I Mareels
Journal article | 2014 | Frontiers in Neurology
The pattern of epileptic seizures is often considered unpredictable, and the interval between events without correlation. A number..
Exercise-induced seizures and lateral asymmetry in patients with temporal lobe epilepsy.
Jordan T Kamel, Radwa AB Badawy, Mark J Cook
Journal article | 2014 | Epilepsy & Behavior Case Reports
OBJECTIVE: The objective of this case report is to better characterize the clinical features and potential pathophysiological mech..
White Matter Changes in Patients with Parkinson's Disease Carrying Small CGG Expansion FMR1 Alleles: A Pilot Study
Nicholas Trost, Mark Cook, Eleanor Hammersley, Minh Q Bui, Peter Brotchie, Trent Burgess, Howard Slater, Elsdon Storey, Danuta Z Loesch
Journal article | 2014 | Neurodegenerative Diseases
F-18-Flumazenil: A gamma-Aminobutyric Acid A-Specific PET Radiotracer for the Localization of Drug-Resistant Temporal Lobe Epilepsy
Lucy Vivash, Marie-Claude Gregoire, Eddie W Lau, Robert E Ware, David Binns, Peter Roselt, Viviane Bouilleret, Damian E Myers, Mark J Cook, Rodney J Hicks, Terence J O'Brien
Journal article | 2013 | Journal of Nuclear Medicine
Prediction of seizure likelihood with a long-term, implanted seizure advisory system in patients with drug-resistant epilepsy: a first-in-man study
Mark J Cook, Terence J O'Brien, Samuel F Berkovic, Michael Murphy, Andrew Morokoff, Gavin Fabinyi, Wendyl D'Souza, Raju Yerra, John Archer, Lucas Litewka, Sean Hosking, Paul Lightfoot, Vanessa Ruedebusch, W Douglas Sheffield, David Snyder, Kent Leyde, David Himes
Journal article | 2013 | Lancet Neurology
Engineering a multimodal nerve conduit for repair of injured peripheral nerve
AF Quigley, KJ Bulluss, ILB Kyratzis, K Gilmore, T Mysore, KSU Schirmer, EL Kennedy, M O'Shea, YB Truong, SL Edwards, G Peeters, P Herwig, JM Razal, TE Campbell, KN Lowes, MJ Higgins, SE Moulton, MA Murphy, MJ Cook, GM Clark, et al.
Journal article | 2013 | Journal of Neural Engineering
A Neural Mass Model of Spontaneous Burst Suppression and Epileptic Seizures
Dean R Freestone, Dragan Nesic, Amirhossein Jafarian, Mark J Cook, David B Grayden
Conference Proceedings | 2013 | Proceedings of the 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
A Method for Actively Tracking Excitability of Brain Networks using a Fully Implantable Monitoring System
Dean R Freestone, Sam N Long, Stephen Frey, Paul H Stypulkowski, Jonathon E Giftakis, Mark J Cook
Conference Proceedings | 2013 | Proceedings of the 35th Annual International Conference of the IEEE EMBS
In vivo biocompatibility and in vitro characterization of poly-lactide-co-glycolide structures containing levetiracetam, for the treatment of epilepsy
Amy J Halliday, Toni E Campbell, Joselito M Razal, Karen J McLean, Timothy S Nelson, Mark J Cook, Gordon G Wallace
Journal article | 2012 | Journal of Biomedical Materials Research Part A
Electrical probing of cortical excitability in patients with epilepsy
Dean R Freestone, Levin Kuhlmann, David B Grayden, Anthony N Burkitt, Alan Lai, Timothy S Nelson, Simon Vogrin, Michael Murphy, Wendyl D'Souza, Radwa Badawy, Dragan Nesic, Mark J Cook
Journal article | 2011 | Epilepsy and Behavior
PRELIMINARY OBSERVATIONS ON AN AMBULATORY INTRACRANIAL EEG (IEEG) EPILEPSY MANAGEMENT SYSTEM
M Cook, W D'Souza, M Murphy, L Litewka, T O'Brien, R Yerra, A Morokoff, S Hosking, D Germaine, S Berkovic, P Lightfoot, G Fabinyi, W Boling, J Archer, D Himes, V Ruedebusch, D Sheffield
Conference Proceedings | 2011 | EPILEPSIA
CLOSED-LOOP SEIZURE CONTROL WITH VERY HIGH FREQUENCY ELECTRICAL STIMULATION AT SEIZURE ONSET IN THE GAERS MODEL OF ABSENCE EPILEPSY
Timothy S Nelson, Courtney L Suhr, Dean R Freestone, Alan Lai, Amy J Halliday, Karen J Mclean, Anthony N Burkitt, Mark J Cook
Journal article | 2011 | International Journal of Neural Systems
Novel single base pair COX III subunit deletion of mitochondrial DNA associated with rhabdomyolysis
Rosetta Marotta, Judy Chin, Denise M Kirby, Maria Chiotis, Mark Cook, Steven J Collins
Journal article | 2011 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance
Douglas E Crompton, Ingrid E Scheffer, Isabella Taylor, Mark J Cook, Penelope A McKelvie, Danya F Vears, Kate M Lawrence, Jacinta M McMahon, Bronwyn E Grinton, Anne M McIntosh, Samuel F Berkovic
Journal article | 2010 | Brain
Association of the MELAS m.3243A > G mutation with myositis and the superiority of urine over muscle, blood and hair for mutation detection
Rosetta Marotta, Katrina Reardon, Penny A McKelvie, Maria Chiotis, Judy Chin, Mark Cook, Steven J Collins
Journal article | 2009 | Journal of Clinical Neuroscience
TARGETED CORRECTIVE GENE CONVERSION (TCGC): MOLECULAR SYSTEMS FOR IMPROVED CORRECTION OF GENE MUTATIONS IN MUSCLE
Robert Kapsa, Joe Razal, Anita Quigley, Magdalena Kita, Marian Todaro, Luveen Bissonauth, Rod Shepherd, Simon Moulton, Mark J Cook, Leone Spiccia, David Officer, Graeme M Clark, Gordon G Wallace
Conference Proceedings | 2009 | JOURNAL OF GENE MEDICINE
The Thalamocortical Circuit and the Generation of Epileptic Spikes in Rat Models of Focal Epilepsy
Dean R Freestone, David B Grayden, Alan Lai, Timothy S Nelson, Amy Halliday, Anthony N Burkitt, Mark J Cook
Conference Proceedings | 2009 | Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2009
The thalamocortical circuit and the generation of epileptic spikes in rat models of focal epilepsy.
DR Freestone, DB Grayden, A Lai, TS Nelson, A Halliday, AN Burkitt, MJ Cook
Journal article | 2009 | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
The spectrum of SCNIA-related infantile epileptic encephalopathies
Louise A Harkin, Jacinta M McMahon, Xenia Iona, Leanne Dibbens, James T Pelekanos, Sameer M Zuberi, Lynette G Sadleir, Eva Andermann, Deepak Gill, Kevin Farrell, Mary Connolly, Thorsten Stanley, Michael Harbord, Frederick Andermann, Jing Wang, Sat Dev Batish, Jeffrey G Jones, William K Seltzer, Alison Gardner, Grant Sutherland, et al.
Journal article | 2007 | Brain
The spectrum of SCN1A-related infantile epileptic encephalopathies
LA Harkin, JM McMahon, X Iona, L Dibbens, JT Pelekanos, SM Zuberi, LG Sadleir, E Andermann, D Gill, K Farrell, M Connolly, T Stanley, M Harbord, F Andermann, J Wang, SD Batish, JG Jones, WK Seltzer, A Gardner, G Sutherland, et al.
Journal article | 2007 | Brain
'MRI negative PET positive temporal lobe epilepsy' shows quantitative structural and functional brain differences from mesial temporal lobe epilepsy
RP Carne, TJ O'Brien, CJ Kilpatrick, LR MacGregor, L Litewka, RJ Hicks, MA Murphy, AH Kaye, MJ Cook
Conference Proceedings | 2005 | JOURNAL OF THE NEUROLOGICAL SCIENCES
Hippocampal volume in first-episode psychoses and chronic schizophrenia - A high-resolution magnetic resonance imaging study
D Velakoulis, C Pantelis, PD McGorry, P Dudgeon, W Brewer, M Cook, P Desmond, N Bridle, P Tierney, V Murrie, B Singh, D Copolov
Journal article | 1999 | Archives of General Psychiatry
Surgical treatment of patients with single and dual pathology: Relevance of lesion and of hippocampal atrophy to seizure outcome
LM Li, F Cendes, C Watson, F Andermann, DR Fish, F Dubeau, S Free, A Olivier, W Harkness, DGT Thomas, JS Duncan, JWAS Sander, SD Shorvon, MJ Cook, DL Arnold
Journal article | 1997 | Neurology
Displaying the 4 most recent news articles by Mark Cook.
Honours, Awards and Fellowships
FAHMS - Fellow of the Australian Academy of Health and Medical Sciences
FRCP - Fellow of the Royal College of Physicians of London
FRACP - Fellow of the Royal Australasian College of Physicians
Chair Of Medicine (St Vincent'S Hospital)
Medicine - St Vincent'S Hospital
State Chair, Victoria
Australian and New Zealand Association of Neurologists
Royal Australian College of Physicians
Doctor of Medicine
University of Melbourne
Bachelor of Medicine, Surgery
University of Melbourne