Bhupinder Pal

Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression

Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G Williams, Anthony J Costello, Paul J Neeson, Bhupinder Pal, Nicholas D Huntington, et al.

Journal article  |  2021  |  BMC CANCER

BACKGROUND: Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings ..

The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile

Jean Berthelet, Verena C Wimmer, Holly J Whitfield, Antonin Serrano, Thomas Boudier, Stefano Mangiola, Michal Merdas, Farrah El-Saafin, David Baloyan, Jordan Wilcox, Steven Wilcox, Adam C Parslow, Anthony T Papenfuss, Belinda Yeo, Matthias Ernst, Bhupinder Pal, Robin L Anderson, Melissa J Davis, Kelly L Rogers, Frederic Hollande, et al.

Journal article  |  2021  |  SCIENCE ADVANCES

Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network involved in ..

Single cell transcriptome atlas of mouse mammary epithelial cells across development

Bhupinder Pal, Yunshun Chen, Michael JG Milevskiy, Francois Vaillant, Lexie Prokopuk, Caleb A Dawson, Bianca D Capaldo, Xiaoyu Song, Felicity Jackling, Paul Timpson, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2021  |  BREAST CANCER RESEARCH

BACKGROUND: Heterogeneity within the mouse mammary epithelium and potential lineage relationships have been recently explored by s..

A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast

Bhupinder Pal, Yunshun Chen, Francois Vaillant, Bianca D Capaldo, Rachel Joyce, Xiaoyu Song, Vanessa L Bryant, Jocelyn S Penington, Leon Di Stefano, Nina Tubau Ribera, Stephen Wilcox, Gregory B Mann, Anthony T Papenfuss, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2021  |  EMBO JOURNAL

To examine global changes in breast heterogeneity across different states, we determined the single-cell transcriptomes of > 340,0..

Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB

Holly Holliday, Daniel Roden, Simon Junankar, Sunny Z Wu, Laura A Baker, Christoph Krisp, Chia-Ling Chan, Andrea McFarland, Joanna N Skhinas, Thomas R Cox, Bhupinder Pal, Nicholas D Huntington, Christopher J Ormandy, Jason S Carroll, Jane Visvader, Mark P Molloy, Alexander Swarbrick

Journal article  |  2021  |  ISCIENCE

Inhibitor of differentiation (ID) proteins dimerize with basic HLH (bHLH) transcription factors, repressing transcription of linea..

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling

Caleb A Dawson, Bhupinder Pal, Francois Vaillant, Luke C Gandolfo, Zhaoyuan Liu, Camille Bleriot, Florent Ginhoux, Gordon K Smyth, Geoffrey J Lindeman, Scott N Mueller, Anne C Rios, Jane E Visvader

Journal article  |  2020  |  NATURE CELL BIOLOGY

Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland functi..

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

Najoua Lalaoui, Delphine Merino, Goknur Giner, Francois Vaillant, Diep Chau, Lin Liu, Tobias Kratina, Bhupinder Pal, James R Whittle, Nima Etemadi, Jean Berthelet, Julius Grasel, Cathrine Hall, Matthew E Ritchie, Matthias Ernst, Gordon K Smyth, David L Vaux, Jane E Visvader, Geoffrey J Lindeman, John Silke

Journal article  |  2020  |  Cell Death and Differentiation

Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function to facilitate tumor cell death. Her..

Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells

Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Zheng Ruan, Hamish EG McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Nash, Andrew Hammet, Anne M Verhagen, Gino Vairo, et al.

Journal article  |  2020  |  Science

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..

MicroRNA-Related Genetic Variants Are Associated With Diabetic Retinopathy in Type 1 Diabetes Mellitus

Ebony Liu, Georgia Kaidonis, Bennet J McComish, Mark C Gillies, Sotoodeh Abhary, Rohan W Essex, John H Chang, Bishwanath Pal, Mark Daniell, Stewart Lake, Nikolai Petrovsky, Alex W Hewitt, Alicia Jenkins, Ecosse L Lamoureux, Jonathan M Gleadle, Jamie E Craig, Kathryn P Burdon

Journal article  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Purpose: Few studies have explored the association of genetic variants in microRNA genes and binding sites with diabetic retinopat..

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging.

Anne C Rios, Bianca D Capaldo, François Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, undefined 3DTCLSM Group, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2019  |  Cancer Cell

(Cancer Cell 35, 618–632.e1–e6; April 15, 2019) In the STAR Methods section of the originally published version of this article, t..