Ruth MacKinnon

Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability

Ruth N MacKinnon, Joanne Peverall, Lynda J Campbell, Meaghan Wall

Journal article  |  2020  |  MOLECULAR CYTOGENETICS

BACKGROUND: The U937 cell line is widely employed as a research tool. It has a complex karyotype. A PICALM-MLLT10 fusion gene form..

BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus-associated T/NK-cell lymphoma

Nenad Sejic, Lindsay C George, Rosemary J Tierney, Catherine Chang, Olga Kondrashova, Ruth N MacKinnon, Ping Lan, Andrew Bell, Guillaume Lessene, Heather M Long, Andreas Strasser, Claire Shannon-Lowe, Gemma L Kelly

Journal article  |  2020  |  BLOOD ADVANCES

Epstein-Barr virus (EBV)-associated T- and natural killer (NK)-cell malignancies, such as extranodal NK-/T-cell lymphoma (ENKTL), ..

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Matthew Ku, Ruth N MacKinnon, Meaghan Wall, Nisha Narayan, Carl Walkley, Heung-Chin Cheng, Lynda J Campbell, Louise E Purton, Harshal Nandurkar

Journal article  |  2019  |  SCIENTIFIC REPORTS

Deletion of long arm of chromosome 20 [del(20q)] is the second most frequent recurrent chromosomal abnormality in hematological ma..

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

Anuratha Sakthianandeswaren, Marie J Parsons, Dmitri Mouradov, Ruth N MacKinnon, Bruno Catimel, Sheng Liu, Michelle Palmieri, Christopher Love, Robert N Jorissen, Shan Li, Lachlan Whitehead, Tracy L Putoczki, Adele Preaudet, Cary Tsui, Cameron J Nowell, Robyn L Ward, Nicholas J Hawkins, Jayesh Desai, Peter Gibbs, Matthias Ernst, et al.

Journal article  |  2018  |  CANCER DISCOVERY

ADP-ribosylation is an important posttranslational protein modification that regulates diverse biological processes, controlled by..

Analysis of Chromothripsis by Combined FISH and Microarray Analysis

Ruth N MacKinnon

Journal article  |  2018  |  CHROMOTHRIPSIS: METHODS AND PROTOCOLS

Fluorescence in situ hybridization (FISH) to metaphase chromosomes, in conjunction with SNP array, array CGH, or whole genome sequ..

Active centromere and chromosome identification in fixed cell lines

Thian T Beh, Ruth N MacKinnon, Paul Kalitsis

Journal article  |  2016  |  MOLECULAR CYTOGENETICS

BACKGROUND: The centromere plays a crucial role in ensuring the fidelity of chromosome segregation during cell divisions. However,..

The Dicentric Chromosome dic(20;22) Is a Recurrent Abnormality in Myelodysplastic Syndromes and Is a Product of Telomere Fusion

Ruth N MacKinnon, Hendrika M Duivenvoorden, Lynda J Campbell, Meaghan Wall

Journal article  |  2016  |  CYTOGENETIC AND GENOME RESEARCH

We describe a recurrent dicentric chromosome formed by telomere fusion between chromosome 20 and chromosome 22 in 4 cases of myelo..

Src family kinases and their role in hematological malignancies

Matthew Ku, Meaghan Wall, Ruth N MacKinnon, Carl R Walkley, Louise E Purton, Constantine Tam, David Izon, Lynda Campbell, Heung-Chin Cheng, Harshal Nandurkar

Journal article  |  2015  |  LEUKEMIA & LYMPHOMA

The Src family protein tyrosine kinases (SFKs) are non-receptor intracellular kinases that have important roles in both hematopoie..

Chromothripsis under the microscope: a cytogenetic perspective of two cases of AML with catastrophic chromosome rearrangement

Ruth N MacKinnon, Lynda J Campbell

Journal article  |  2013  |  CANCER GENETICS

Chromothripsis is a recently described phenomenon identified in cancer cells that produces catastrophic chromosome reorganization ..

Genome organization and the role of centromeres in evolution of the erythroleukaemia cell line HEL.

Ruth N Mackinnon, Meaghan Wall, Adrian Zordan, Srilakshmi Nutalapati, Bruce Mercer, Joanne Peverall, Lynda J Campbell

Journal article  |  2013  |  Evol Med Public Health

BACKGROUND AND OBJECTIVES: The human erythroleukaemia (HEL) cell line has a highly rearranged genome. We matched whole chromosome ..