Jamie Rossjohn

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8 T cells.

Sneha Sant, Sergio M Quiñones-Parra, Marios Koutsakos, Emma J Grant, Thomas Loudovaris, Stuart I Mannering, Jane Crowe, Carolien E van de Sandt, Guus F Rimmelzwaan, Jamie Rossjohn, Stephanie Gras, Liyen Loh, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2020  |  PLOS Pathogens

Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell ..

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.

Amine Toubal, Badr Kiaf, Lucie Beaudoin, Lucie Cagninacci, Moez Rhimi, Blandine Fruchet, Jennifer da Silva, Alexandra J Corbett, Yannick Simoni, Olivier Lantz, Jamie Rossjohn, James McCluskey, Philippe Lesnik, Emmanuelle Maguin, Agnès Lehuen

Journal article  |  2020  |  Nature Communications

Obesity is associated with low-grade chronic inflammation promoting insulin-resistance and diabetes. Gut microbiota dysbiosis is a..

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1.

Lauren J Howson, Wael Awad, Anouk von Borstel, Hui Jing Lim, Hamish EG McWilliam, Maria L Sandoval-Romero, Shamik Majumdar, Abdul Rezzak Hamzeh, Thomas D Andrews, David H McDermott, Philip M Murphy, Jérôme Le Nours, Jeffrey YW Mak, Ligong Liu, David P Fairlie, James McCluskey, Jose A Villadangos, Matthew C Cook, Stephen J Turner, Martin S Davey, et al.

Journal article  |  2020  |  Science Immunology

The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are ..

A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction.

Shutao Mei, Fuyi Li, André Leier, Tatiana T Marquez-Lago, Kailin Giam, Nathan P Croft, Tatsuya Akutsu, A Ian Smith, Jian Li, Jamie Rossjohn, Anthony W Purcell, Jiangning Song

Journal article  |  2020  |  Briefings in Bioinformatics

Human leukocyte antigen class I (HLA-I) molecules are encoded by major histocompatibility complex (MHC) class I loci in humans. Th..

Effects of a local auxiliary protein on the two-dimensional affinity of a TCR-peptide MHC interaction.

Victoria Junghans, Manto Chouliara, Ana Mafalda Santos, Deborah Hatherley, Jan Petersen, Tommy Dam, Lena M Svensson, Jamie Rossjohn, Simon J Davis, Peter Jönsson

Journal article  |  2020  |  Journal of Cell Science

The affinity of T-cell receptors (TCRs) for major histocompatibility complex molecules (MHCs) presenting cognate antigens likely d..

Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.

Dene R Littler, Benjamin S Gully, Rhys N Colson, Jamie Rossjohn

Journal article  |  2020  |  iScience

Many of the SARS-CoV-2 proteins have related counterparts across the Severe Acute Respiratory Syndrome (SARS-CoV) family. One such..

The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function

Philippa M Saunders, Bruce J MacLachlan, Phillip Pymm, Patricia T Illing, Yuanchen Deng, Shu Cheng Wong, Clare VL Oates, Anthony W Purcell, Jamie Rossjohn, Julian P Vivian, Andrew G Brooks

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

Micropolymorphisms within human leukocyte antigen (HLA) class I molecules can change the architecture of the peptide-binding cleft..

Ligand-dependent downregulation of MR1 cell surface expression

Mariolina Salio, Wael Awad, Natacha Veerapen, Claudia Gonzalez-Lopez, Corinna Kulicke, Dominic Waithe, Anne WJ Martens, David M Lewinsohn, Judith V Hobrath, Liam R Cox, Jamie Rossjohn, Gurdyal S Besra, Vincenzo Cerundolo

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

The antigen-presenting molecule MR1 presents riboflavin-based metabolites to Mucosal-Associated Invariant T (MAIT) cells. While MR..

Growth hormone stops excessive inflammation after partial hepatectomy allowing liver regeneration and survival via induction of H2-Bl/HLA-G.

Mayumi Ishikawa, Andrew J Brooks, Manuel A Fernández-Rojo, Johan Medina, Yash Chhabra, Shiro Minami, Kathryn A Tunny, Robert G Parton, Julian P Vivian, Jamie Rossjohn, Viral Chikani, Grant A Ramm, Ken KY Ho, Michael J Waters

Journal article  |  2020  |  Hepatology

Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 m..

Peripheral blood mucosal-associated invariant T (MAIT) cells in tuberculosis patients and healthy Mycobacterium tuberculosis-exposed controls.

Sara Suliman, Anele Gela, Simon C Mendelsohn, Sarah K Iwany, Kattya Lopez Tamara, Simbarashe Mabwe, Nicole Bilek, Fatoumatta Darboe, Michelle Fisher, Alexandra J Corbett, Lars Kjer-Nielsen, Sidonia BG Eckle, Chuan-Chin Huang, Zibiao Zhang, David M Lewinsohn, James McCluskey, Jamie Rossjohn, Mark Hatherill, Segundo R León, Roger I Calderon, et al.

Journal article  |  2020  |  The Journal of Infectious Diseases

BACKGROUND: In human blood, mucosal-associated invariant T (MAIT) cells are abundant T cells, which recognize antigens presented o..

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

Lars Fugger, Lise Torp Jensen, Jamie Rossjohn

Journal article  |  2020  |  Cell

Autoimmune diseases are a result of the immune system being misdirected toward its host and have major and increasing unmet clinic..

Virus-Mediated Suppression of the Antigen Presentation Molecule MR1

Brian P McSharry, Carolyn Samer, Hamish EG McWilliam, Caroline L Ashley, Michael B Yee, Megan Steain, Ligong Liu, David P Fairlie, Paul R Kinchington, James McCluskey, Allison Abendroth, Jose A Villadangos, Jamie Rossjohn, Barry Slobedman

Journal article  |  2020  |  Cell Reports

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCR alpha beta Clonotypes with Potent Antimicrobial Responses

Liyen Loh, Nicholas A Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L Bird, Hui-Fern Koay, Carolien E van de Sandt, Marcela L Moreira, Martha Lappas, E Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L Flanagan, Kylie M Quinn, Jamie Rossjohn, Paul G Thomas, Sidonia BG Eckle, James McCluskey, Dale I Godfrey, et al.

Journal article  |  2020  |  The Journal of Immunology

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to und..

Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8( ) T Cell Receptors

Louise C Rowntree, Heleen van den Heuvel, Jessica Sun, Lloyd J D'Orsogna, Thi HO Nguyen, Frans HJ Claas, Jamie Rossjohn, Tom C Kotsimbos, Anthony W Purcell, Nicole A Mifsud

Journal article  |  2020  |  Frontiers in Immunology

T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unw..

A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease

Yi Tian Ting, Shiva Dahal-Koirala, Hui Shi Keshia Kim, Shuo-Wang Qiao, Ralf S Neumann, Knut EA Lundin, Jan Petersen, Hugh H Reid, Ludvig M Sollid, Jamie Rossjohn

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

The highly homologous human leukocyte antigen (HLA)-DQ2 molecules, HLA-DQ2.5 and HLA-DQ2.2, are implicated in the pathogenesis of ..

Modulation of innate and adaptive immunity by cytomegaloviruses

Richard Berry, Gabrielle M Watson, Stipan Jonjic, Mariapia A Degli-Esposti, Jamie Rossjohn

Journal article  |  2020  |  Nature Reviews Immunology

The coordinated activities of innate and adaptive immunity are critical for effective protection against viruses. To counter this,..

Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Michael D Crowther, Garry Dotlon, Mateusz Legut, Marine E Caillaud, Angharad Lloyd, Meriem Attaf, Sarah AE Galloway, Cristina Rius, Colin P Farrell, Barbara Szomolay, Ann Ager, Alan L Parker, Anna Fuller, Marco Donia, James McCluskey, Jamie Rossjohn, Inge Marie Svane, John D Phillips, Andrew K Sewell

Journal article  |  2020  |  Nature Immunology

Human leukocyte antigen (HLA)-independent, T cell-mediated targeting of cancer cells would allow immune destruction of malignancie..

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products

Sarah Nicolai, Marcin Wegrecki, Tan-Yun Cheng, Elvire A Bourgeois, Rachel N Cotton, Jacob A Mayfield, Gwennaelle C Monnot, Jerome Le Nours, Ildiko Van Rhijn, Jamie Rossjohn, D Branch Moody, Annemieke de Jong

Journal article  |  2020  |  Science Immunology

During industrialization, humans have been exposed to increasing numbers of foreign chemicals. Failure of the immune system to tol..

Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation

Terry CC Lim Kam Sian, Saranjah Indumathy, Hanim Halim, Anja Greule, Max J Cryle, Paul Bowness, Jamie Rossjohn, Stephanie Gras, Anthony W Purcell, Ralf B Schittenhelm

Journal article  |  2019  |  Journal of Biological Chemistry

Expression of human leukocyte antigen (HLA)-B27 is strongly associated with predisposition toward ankylosing spondylitis (AS) and ..

Cross-Reactive Donor-Specific CD8( ) Tregs Efficiently Prevent Transplant Rejection

Elodie Picarda, Severine Bezie, Lorena Usero, Jason Ossart, Marine Besnard, Hanim Halim, Klara Echasserieau, Claire Usal, Jamie Rossjohn, Karine Bernardeau, Stephanie Gras, Carole Guillonneau

Journal article  |  2019  |  Cell Reports

To reduce the use of non-specific immunosuppressive drugs detrimental to transplant patient health, therapies in development aim t..

A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1

Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett, et al.

Journal article  |  2019  |  Science

T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..

A TCR beta-Chain Motif Biases toward Recognition of Human CD1 Proteins

Peter Reinink, Adam Shahine, Stephanie Gras, Tan-Yun Cheng, Rachel Farquhar, Kattya Lopez, Sara A Suliman, Josephine F Reijneveld, Jerome Le Nours, Li Lynn Tan, Segundo R Leon, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B Murray, Jamie Rossjohn, D Branch Moody, Ildiko Van Rhijn

Journal article  |  2019  |  The Journal of Immunology

High-throughput TCR sequencing allows interrogation of the human TCR repertoire, potentially connecting TCR sequences to antigenic..

Challenging immunodominance of influenza-specific CD8( ) T cell responses restricted by the risk-associated HLA-A*68:01 allomorph

CE van de Sandt, EB Clemens, EJ Grant, LC Rowntree, S Sant, H Halim, J Crowe, AC Cheng, TC Kotsimbos, M Richards, A Miller, SYC Tong, J Rossjohn, THO Nguyen, S Gras, W Chen, K Kedzierska

Journal article  |  2019  |  Nature Communications

Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease ar..

Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells.

Zhenjun Chen, Huimeng Wang, Criselle D'Souza, Hui-Fern Koay, Bronwyn Meehan, Zhe Zhao, Troi Pediongco, Mai Shi, Tianyuan Zhu, Bingjie Wang, Lars Kjer-Nielsen, Sidonia BG Eckle, Jamie Rossjohn, David P Fairlie, Dale I Godfrey, Richard A Strugnell, James McCluskey, Alexandra J Corbett

Journal article  |  2019  |  Current Protocols in Immunology

This unit describes the utility of various mouse models of infection and immunization for studying mucosal-associated invariant T ..

Characterization of Human Mucosal-associated Invariant T (MAIT) Cells.

Michael NT Souter, Liyen Loh, Shihan Li, Bronwyn S Meehan, Nicholas A Gherardin, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, Katherine Kedzierska, Daniel G Pellicci, Zhenjun Chen, Lars Kjer-Nielsen, Alexandra J Corbett, James McCluskey, Sidonia BG Eckle

Journal article  |  2019  |  Current Protocols in Immunology

Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells restricted by the major histocompatibility comp..

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Catarina F Almeida, Srinivasan Sundararaj, Jerome Le Nours, T Praveena, Benjamin Cao, Satvika Burugupalli, Dylan GM Smith, Onisha Patel, Manfred Brigl, Daniel G Pellicci, Spencer J Williams, Adam P Uldrich, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2019  |  Nature Communications

Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an und..

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

Huimeng Wang, Lars Kjer-Nielsen, Mai Shi, Criselle D'Souza, Troi J Pediongco, Hanwei Cao, Lyudmila Kostenko, Xin Yi Lim, Sidonia BG Eckle, Bronwyn S Meehan, Tianyuan Zhu, Bingjie Wang, Zhe Zhao, Jeffrey YW Mak, David P Fairlie, Michele WL Teng, Jamie Rossjohn, Di Yu, Barbara Fazekas de St Groth, George Lovrecz, et al.

Journal article  |  2019  |  Science Immunology

Mucosal-associated invariant T (MAIT) cells are activated in a TCR-dependent manner by antigens derived from the riboflavin synthe..

IL-23 co-stimulation drives antigen-specific MAIT cell activation and enables vaccination against bacterial infection

H Wang, L Kjer-Nielsen, M Shi, DC Souza, T Pediongco, H Cao, L Kostenko, X Lim, S Eckle, B Meeha, B Wang, T Zhu, J Mak, D Fairlie, M Teng, J Rossjohn, D Yu, B Groth, J McCluskey, R Strugnell, et al.

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

PD-L1-and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease

Ryan Galea, Hendrik J Nel, Meghna Talekar, Xiao Liu, Joshua D Ooi, Megan Huynh, Sara Hadjigol, Kate J Robson, Yi Tian Ting, Suzanne Cole, Karyn Cochlin, Shannon Hitchcock, Bijun Zeng, Suman Yekollu, Martine Boks, Natalie Goh, Helen Roberts, Jamie Rossjohn, Hugh H Reid, Ben J Boyd, et al.

Journal article  |  2019  |  JCI Insight

A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44

Annika Niehrs, Wilfredo F Garcia-Beltran, Paul J Norman, Gabrielle M Watson, Angelique Hoelzemer, Anais Chapel, Laura Richert, Andreas Pommerening-Roeser, Christian Koerner, Mikki Ozawa, Gloria Martrus, Jamie Rossjohn, Jar-How Lee, Richard Berry, Mary Carrington, Marcus Altfeld

Journal article  |  2019  |  Nature Immunology

Natural killer (NK) cells can recognize virus-infected and stressed cells1 using activating and inhibitory receptors, many of whic..

Structural basis for the recognition of nectin-like protein-5 by the human-activating immune receptor, DNAM-1

Felix A Deuss, Gabrielle M Watson, Katharine J Goodall, Isobel Leece, Sayantani Chatterjee, Zhihui Fu, Morten Thaysen-Andersen, Daniel M Andrews, Jamie Rossjohn, Richard Berry

Journal article  |  2019  |  Journal of Biological Chemistry

Nectin and nectin-like (NECL) adhesion molecules are broadly overexpressed in a wide range of cancers. By binding to these adhesio..

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Joshua D Ooi, Jhih-Hang Jiang, Peter J Eggenhuizen, Ling L Chua, Mirjan van Timmeren, Khai L Loh, Kim M O'Sullivan, Poh Y Gan, Yong Zhong, Kirill Tsyganov, Lani R Shochet, Jessica Ryan, Coen A Stegeman, Lars Fugger, Hugh H Reid, Jamie Rossjohn, Peter Heeringa, Stephen R Holdsworth, Anton Y Peleg, A Richard Kitching

Journal article  |  2019  |  Nature Communications

Autoreactivity to myeloperoxidase (MPO) causes anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), with rapid..

H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4 T cells can be readily detected in narcolepsy type 1 patients and healthy controls.

MS Schinkelshoek, R Fronczek, EMC Kooy-Winkelaar, J Petersen, HH Reid, A van der Heide, JW Drijfhout, J Rossjohn, GJ Lammers, F Koning

Journal article  |  2019  |  Journal of Neuroimmunology

Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglu..

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Marios Koutsakos, Hamish EG McWilliam, Turgut E Aktepe, Svenja Fritzlar, Patricia T Illing, Nicole A Mifsud, Anthony W Purcell, Steve Rockman, Patrick C Reading, Julian P Vivian, Jamie Rossjohn, Andrew G Brooks, Jason M Mackenzie, Justine D Mintern, Jose A Villadangos, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2019  |  Frontiers in Immunology

Human CD8( ) T cell cross-reactivity across influenza A, B and C viruses

Marios Koutsakos, Patricia T Illing, Thi HO Nguyen, Nicole A Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A Eltahla, E Bridie Clemens, Sneha Sant, Brendon Y Chua, Chinn Yi Wong, E Kaitlynn Allen, Don Teng, Pradyot Dash, David F Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C Hurt, Ian Barr, Steve Rockman, et al.

Journal article  |  2019  |  Nature Immunology

A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells

Shuvashis Dey, Ramanathan Vaidyanathan, K Kamil Reza, Jing Wang, Yuling Wang, Hendrik J Nel, Soi-Cheng Law, Jennifer Tyler, Jamie Rossjohn, Hugh H Reid, Abu Ali Ibn Sina, Ranjeny Thomas, Matt Trau

Journal article  |  2019  |  Sensors and Actuators B: Chemical

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

Toufic Mayassi, Kristin Ladell, Herman Gudjonson, James E McLaren, Dustin G Shaw, Mai T Tran, Jagoda J Rokicka, Ian Lawrence, Jean-Christophe Grenier, Vincent van Unen, Cezary Ciszewski, Matthew Dimaano, Hoda E Sayegh, Vinod Kumar, Cisca Wijmenga, Peter HR Green, Ranjana Gokhale, Hilary Jericho, Carol E Semrad, Stefano Guandalini, et al.

Journal article  |  2019  |  Cell

Structural Basis for CD96 Immune Receptor Recognition of Nectin-like Protein-5, CD155

Felix A Deuss, Gabrielle M Watson, Zhihui Fu, Jamie Rossjohn, Richard Berry

Journal article  |  2019  |  Structure

The early proximal alpha beta TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network

Steven C Neier, Alejandro Ferrer, Katelynn M Wilton, Stephen EP Smith, April MH Kelcher, Kevin D Pavelko, Jenna M Canfield, Tessa R Davis, Robert J Stiles, Zhenjun Chen, James McCluskey, Scott R Burrows, Jamie Rossjohn, Deanne M Hebrink, Eva M Carmona, Andrew H Limper, Dietmar J Kappes, Peter J Wettstein, Aaron J Johnson, Larry R Pease, et al.

Journal article  |  2019  |  Science Immunology

Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes

Shiva Dahal-Koirala, Laura Ciacchi, Jan Petersen, Louise Fremgaard Risnes, Ralf Stefan Neumann, Asbjorn Christophersen, Knut EA Lundin, Hugh H Reid, Shuo-Wang Qiao, Jamie Rossjohn, Ludvig M Sollid

Journal article  |  2019  |  Journal of Biological Chemistry

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

Adam Shahine, Peter Reinink, Josephine F Reijneveld, Stephanie Gras, Mira Holzheimer, Tan-Yun Cheng, Adriaan J Minnaard, John D Altman, Steffi Lenz, Jacques Prandi, Joanna Kubler-Kielb, D Branch Moody, Jamie Rossjohn, Ildiko Van Rhijn

Journal article  |  2019  |  Nature Communications

Broad CD8( ) T cell cross-recognition of distinct influenza A strains in humans

Emma J Grant, Tracy M Josephs, Liyen Loh, E Bridie Clemens, Sneha Sant, Mandvi Bharadwaj, Weisan Chen, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska

Journal article  |  2018  |  NATURE COMMUNICATIONS

Editorial.

Jamie Rossjohn, Dale I Godfrey

Journal article  |  2018  |  Seminars in Cell & Developmental Biology

The Diverse Family of MR1-Restricted T Cells

Nicholas A Gherardin, James McCluskey, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2018  |  The Journal of Immunology

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Patricia T Illing, Phillip Pymm, Nathan P Croft, Hugo G Hilton, Vladimir Jojic, Alex S Han, Juan L Mendoza, Nicole A Mifsud, Nadine L Dudek, James McCluskey, Peter Parham, Jamie Rossjohn, Julian P Vivian, Anthony W Purcell

Journal article  |  2018  |  NATURE COMMUNICATIONS

Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition

Gautham R Balaji, Oscar A Aguilar, Miho Tanaka, Miguel A Shingu-Vazquez, Zhihui Fu, Benjamin S Gully, Lewis L Lanier, James R Carlyle, Jamie Rossjohn, Richard Berry

Journal article  |  2018  |  Nature Communications

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Pouya Faridi, Chen Li, Sri H Ramarathinam, Julian P Vivian, Patricia T Filing, Nicole A Mifsud, Rochelle Ayala, Jiangning Song, Linden J Gearing, Paul J Hertzog, Nicola Ternette, Jamie Rossjohn, Nathan P Croft, Anthony W Purcell

Journal article  |  2018  |  Science Immunology

HLA and kidney disease: from associations to mechanisms

Kate J Robson, Joshua D Ooi, Stephen R Holdsworth, Jamie Rossjohn, A Richard Kitching

Journal article  |  2018  |  Nature Reviews Nephrology

Pre-Clinical Clonally-Expanded aggrecan89-103-Specific CD4 T Cells Are a Target for Autoimmune Arthritis Prevention

Pascale Wehr, Hendrik Nel, Soi Cheng Law, Diahann Jansen, Nicole La Gruta, Hugh Reid, Jamie Rossjohn, Ranjeny Thomas

Conference Proceedings  |  2018  |  ARTHRITIS & RHEUMATOLOGY

MAIT cells protect against pulmonary Legionella longbeachae infection

Huimeng Wang, Criselle D'Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J Pediongco, Sidonia BG Eckle, Bronwyn S Meehan, Mai Shi, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey YW Mak, David P Fairlie, Yoichiro Iwakura, Jennifer M Gunnersen, Andrew W Stent, Dale I Godfrey, Jamie Rossjohn, Glen P Westall, Lars Kjer-Nielsen, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

Phospholipid signaling in innate immune cells

Valerie B O'Donnell, Jamie Rossjohn, Michael JO Wakelam

Journal article  |  2018  |  Journal of Clinical Investigation

Understanding the drivers of MHC restriction of T cell receptors

Nicole L La Gruta, Stephanie Gras, Stephen R Daley, Paul G Thomas, Jamie Rossjohn

Journal article  |  2018  |  Nature Reviews Immunology

An overview on the identification of MAIT cell antigens

Lars Kjer-Nielsen, Alexandra J Corbett, Zhenjun Chen, Ligong Liu, Jeffrey YW Mak, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, James McCluskey, Sidonia BG Eckle

Journal article  |  2018  |  Immunology and Cell Biology

Mucosal-associated invariant T cell receptor recognition of small molecules presented by MR1

Wael Awad, Jerome Le Nours, Lars Kjer-Nielsen, James McCluskey, Jamie Rossjohn

Journal article  |  2018  |  Immunology and Cell Biology

Single-Cell Approach to Influenza Specific CD8( ) T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection

Sneha Sant, Ludiyine Grzelak, Zhongfang Wang, Angela Pizzollal, Manbs Koutsakos, Jane Crowe, Thomas Loudoyaris, Stuart I Mannering, Glen P Westall, Linda M Wakiml, Jamie Rossjohn, Stephanie Gras, Michael Richards, Jianqing Xu, Paul G Thomas, Liyen Loh, Thi H Nguyen, Katherine Kedzierska

Journal article  |  2018  |  Frontiers in Immunology

Inability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses

Louise C Rowntree, Thi HO Nguyen, Hanim Halim, Anthony W Purcell, Jamie Rossjohn, Stephanie Gras, Tom C Kotsimbos, Nicole A Mifsud

Journal article  |  2018  |  The Journal of Immunology

Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics

Sri H Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda WS Yeung, Nicole A Mifsud, Secondo Sonza, Patricia T Illing, Elias N Glaros, Robert J Center, Shane R Thomas, Stephen J Kent, Nicola Ternette, Damian FJ Purcell, Jamie Rossjohn, Anthony W Purcell

Journal article  |  2018  |  PROTEOMICS

Lipids hide or step aside for CD1-autoreactive T cell receptors

Rachel N Cotton, Adam Shahine, Jamie Rossjohn, D Branch Moody

Journal article  |  2018  |  Current Opinion in Immunology

CD4( ) T cell-mediated HLA class II cross-restriction in HIV controllers

Moran Galperin, Carine Farenc, Madhura Mukhopadhyay, Dhilshan Jayasinghe, Amandine Decroos, Daniela Benati, Li Lynn Tan, Lisa Ciacchi, Hugh H Reid, Jamie Rossjohn, Lisa A Chakrabarti, Stephanie Gras

Journal article  |  2018  |  Science Immunology

Dual Modifications of alpha-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity

Divya Chennamadhavuni, Noemi Alejandra Saavedra-Avila, Leandro J Carreno, Matthew J Guberman-Pfeffer, Pooja Arora, Yongqing Tang, Hui-Fern Koay, Dale I Godfrey, Santosh Keshipeddy, Stewart K Richardson, Srinivasan Sundararaj, Jae Ho Lo, Xiangshu Wen, Jose A Gascon, Weiming Yuan, Jamie Rossjohn, Jerome Le Nours, Steven A Porcelli, Amy R Howell

Journal article  |  2018  |  Cell Chemical Biology

Reply to Roudier et al.: HLA-DRB1 polymorphism, anti-citrullinated protein antibodies, and rheumatoid arthritis

Yi Tian Ting, Anthony W Purcell, Hugh H Reid, Jamie Rossjohn

Journal article  |  2018  |  Journal of Biological Chemistry

Recipient mucosal-associated invariant T cells control GVHD within the colon

Antiopi Varelias, Mark D Bunting, Kate L Ormerod, Motoko Koyama, Stuart D Olver, Jasmin Straube, Rachel D Kuns, Renee J Robb, Andrea S Henden, Leanne Cooper, Nancy Lachner, Kate H Gartlan, Olivier Lantz, Lars Kjer-Nielsen, Jeffrey YW Mak, David P Fairlie, Andrew D Clouston, James McCluskey, Jamie Rossjohn, Steven W Lane, et al.

Journal article  |  2018  |  Journal of Clinical Investigation

HLA variation and disease

Calliope A Dendrou, Jan Petersen, Jamie Rossjohn, Lars Fugger

Journal article  |  2018  |  Nature Reviews Immunology

Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon

Antiopi Varelias, Mark Bunting, Kate Ormerod, Motoko Koyama, Stuart Olver, Jasmin Straube, Rachel Kuns, Renee Robb, Andrea Henden, Leanne Cooper, Nancy Lachner, Kate Gartlan, Olivier J Lantz, Lars Kjer-Nielsen, Jeffrey Mak, David Fairlie, Andrew Clouston, James McCluskey, Jamie Rossjohn, Steven Lane, et al.

Conference Proceedings  |  2018  |  JOURNAL OF IMMUNOLOGY

THE ALLOTYPIC ARCHITECTURE OF HLA-B57 ALLOTYPES ALTERS PEPTIDE CONFORMATION TO REGULATE INHIBITION OF NK CELL ACTIVATION THROUGH KIR3DL1

Andrew G Brooks, Philippa M Saunders, Philip Pymm, Jacqueline ML Widjaja, Jie Lin, Jamie Rossjohn, Julian P Vivian

Conference Proceedings  |  2018  |  HLA

Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

Maureen P Martin, Vivek Naranbhai, Patrick R Shea, Ying Qi, Veron Ramsuran, Nicolas Vince, Xiaojiang Gao, Rasmi Thomas, Zabrina L Brumme, Jonathan M Carlson, Steven M Wolinsky, James J Goedert, Bruce D Walker, Florencia P Segal, Steven G Deeks, David W Haas, Stephen A Migueles, Mark Connors, Nelson Michael, Jacques Fellay, et al.

Journal article  |  2018  |  Journal of Clinical Investigation

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry

John J Miles, Mai Ping Tan, Garry Dolton, Emily SJ Edwards, Sarah AE Galloway, Bruno Laugel, Mathew Clement, Julia Makinde, Kristin Ladell, Katherine K Matthews, Thomas S Watkins, Katie Tungatt, Yide Wong, Han Siean Lee, Richard J Clark, Johanne M Pentier, Meriem Attaf, Anya Lissina, Ann Ager, Awen Gallimore, et al.

Journal article  |  2018  |  Journal of Clinical Investigation

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids

Kwok S Wun, Josephine F Reijneveld, Tan-Yun Cheng, Kristin Ladell, Adam P Uldrich, Jerome Le Nours, Kelly L Miners, James E McLaren, Emma J Grant, Oscar L Haigh, Thomas S Watkins, Sara Suliman, Sarah Iwany, Judith Jimenez, Roger Calderon, Kattya L Tamara, Segundo R Leon, Megan B Murray, Jacob A Mayfield, John D Altman, et al.

Journal article  |  2018  |  Nature Immunology

Unconventional T Cell Targets for Cancer Immunotherapy

Dale I Godfrey, Jerome Le Nours, Daniel M Andrews, Adam P Uldrich, Jamie Rossjohn

Journal article  |  2018  |  Immunity

Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide

Kok Fei Chan, Benjamin S Gully, Stephanie Gras, Dennis X Beringer, Lars Kjer-Nielsen, Jonathan Cebon, James McCluskey, Weisan Chen, Jamie Rossjohn

Journal article  |  2018  |  NATURE COMMUNICATIONS

The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis

Yi Tian Ting, Jan Petersen, Sri H Ramarathinam, Stephen W Scally, Khai L Loh, Ranjeny Thomas, Anish Suri, Daniel G Baker, Anthony W Purcell, Hugh H Reid, Jamie Rossjohn

Journal article  |  2018  |  Journal of Biological Chemistry

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection

Criselle D'Souza, Troi Pediongco, Huimeng Wang, Jean-Pierre Y Scheerlinck, Lyudmila Kostenko, Robyn Esterbauer, Andrew W Stent, Sidonia BG Eckle, Bronwyn S Meehan, Richard A Strugnell, Hanwei Cao, Ligong Liu, Jeffrey YW Mak, George Lovrecz, Louis Lu, David P Fairlie, Jamie Rossjohn, James McCluskey, Alison L Every, Zhenjun Chen, et al.

Journal article  |  2018  |  The Journal of Immunology

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function

Srinivasan Sundararaj, Jingjing Zhang, S Harsha Krovi, Romain Bedel, Kathryn D Tuttle, Natacha Veerapen, Gurdyal S Besra, Yogesh Khandokar, T Praveenaa, Jerome Le Nours, Jennifer L Matsuda, Jamie Rossjohn, Laurent Gapin

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Flow Cytometric Clinical Immunomonitoring Using Peptide-MHC Class II Tetramers: Optimization of Methods and Protocol Development

Diahann TSL Jansen, Nishta Ramnoruth, Khai L Loh, Jamie Rossjohn, Hugh H Reid, Hendrik J Nel, Ranjeny Thomas

Journal article  |  2018  |  Frontiers in Immunology

A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct alpha beta T cell receptors

Lucy C Sullivan, Nicholas G Walpole, Carine Farenc, Gabriella Pietra, Matthew JW Sum, Craig S Clements, Eleanor J Lee, Travis Beddoe, Michela Falco, Maria Cristina Mingari, Lorenzo Moretta, Stephanie Gras, Jamie Rossjohn, Andrew G Brooks

Journal article  |  2017  |  Journal of Biological Chemistry

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes

Ophelie Rouxel, Jennifer Da Silva, Lucie Beaudoin, Isabelle Nel, Celine Tard, Lucie Cagninacci, Badr Kiaf, Masaya Oshima, Marc Diedisheim, Marion Salou, Alexandra Corbett, Jamie Rossjohn, James McCluskey, Raphael Scharfmann, Manuela Battaglia, Michel Polak, Olivier Lantz, Jacques Beltrand, Agnes Lehuen

Journal article  |  2017  |  Nature Immunology

A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene

Natalija Van Braeckel-Budimir, Stephanie Gras, Kristin Ladell, Tracy M Josephs, Lecia Pewe, Stina L Urban, Kelly L Miners, Carine Farenc, David A Price, Jamie Rossjohn, John T Harty

Journal article  |  2017  |  Immunity

Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis

Stephen W Scally, Soi-Cheng Law, Yi Tian Ting, Jurgen van Heemst, Jeremy Sokolove, Aaron J Deutsch, E Bridie Clemens, Antonis K Moustakas, George K Papadopoulos, Diane van der Woude, Irene Smolik, Carol A Hitchon, David B Robinson, Elizabeth D Ferucci, Charles N Bernstein, Xiaobo Meng, Vidyanand Anaparti, Tom Huizinga, Katherine Kedzierska, Hugh H Reid, et al.

Journal article  |  2017  |  Annals of the Rheumatic Diseases

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8( ) T cell response

Abigail Culshaw, Kristin Ladell, Stephanie Gras, James E McLaren, Kelly L Miners, Carine Farenc, Heleen van den Heuvel, Emma Gostick, Wanwisa Dejnirattisai, Apirath Wangteeraprasert, Thaneeya Duangchinda, Pojchong Chotiyarnwong, Wannee Limpitikul, Sirijitt Vasanawathana, Prida Malasit, Tao Dong, Jamie Rossjohn, Juthathip Mongkolsapaya, David A Price, Gavin R Screaton

Journal article  |  2017  |  Nature Immunology

The molecular basis for peptide repertoire selection in the human leukocyte antigen (HLA) C*06:02 molecule

Jesse I Mobbs, Patricia T Illing, Nadine L Dudek, Andrew G Brooks, Daniel G Baker, Anthony W Purcell, Jamie Rossjohn, Julian P Vivian

Journal article  |  2017  |  Journal of Biological Chemistry

A molecular basis of human T cell receptor autoreactivity toward self-phospholipids

Adam Shahine, Ildiko Van Rhijn, Tan-Yun Cheng, Sarah Iwany, Stephanie Gras, D Branch Moody, Jamie Rossjohn

Journal article  |  2017  |  Science Immunology

Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins

Dene R Littler, Sheng Y Ang, Danilo G Moriel, Martina Kocan, Oded Kleifeld, Matthew D Johnson, Mai T Tran, Adrienne W Paton, James C Paton, Roger J Summers, Mark A Schembri, Jamie Rossjohn, Travis Beddoe

Journal article  |  2017  |  Journal of Biological Chemistry

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface

Patrick J Brennan, Tan-Yun Cheng, Daniel G Pellicci, Gerald FM Watts, Natacha Veerapen, David C Young, Jamie Rossjohn, Gurdyal S Besra, Dale I Godfrey, Michael B Brenner, D Branch Moody

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT)

Felix A Deuss, Benjamin S Gully, Jamie Rossjohn, Richard Berry

Journal article  |  2017  |  Journal of Biological Chemistry

Structural and regulatory diversity shape HLA-C protein expression levels

Gurman Kaur, Stephanie Gras, Jesse I Mobbs, Julian P Vivian, Adrian Cortes, Thomas Barber, Subita Balaram Kuttikkatte, Lise Torp Jensen, Kathrine E Attfield, Calliope A Dendrou, Mary Carrington, Gil McVean, Anthony W Purcell, Jamie Rossjohn, Lars Fugger

Journal article  |  2017  |  Nature Communications

MAIT cells and MR1-antigen recognition

Andrew N Keller, Alexandra J Corbett, Jacinta M Wubben, James McCluskey, Jamie Rossjohn

Journal article  |  2017  |  Current Opinion in Immunology

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression

Christopher R Shaler, Joshua Choi, Patrick T Rudak, Arash Memarnejadian, Peter A Szabo, Mauro E Tun-Abraham, Jamie Rossjohn, Alexandra J Corbett, James McCluskey, John K McCormick, Olivier Lantz, Roberto Hernandez-Alejandro, SM Mansour Haeryfar

Journal article  |  2017  |  PLOS BIOLOGY

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Joshua D Ooi, Jan Petersen, Yu H Tan, Megan Huynh, Zoe J Willett, Sri H Ramarathinam, Peter J Eggenhuizen, Khai L Loh, Katherine A Watson, Poh Y Gan, Maliha AA Likhan, Nadine L Dudek, Andreas Handel, Billy G Hudson, Lars Fugger, David A Power, Stephen G Holt, P Toby Coates, Jon W Gregersen, Anthony W Purcell, et al.

Journal article  |  2017  |  Nature

A hot spot on interferon alpha/beta receptor subunit 1 (IFNAR1) underpins its interaction with interferon-beta and dictates signaling

Nicole A de Weerd, Antony Y Matthews, Phillip R Pattie, Nollaig M Bourke, San S Lim, Julian P Vivian, Jamie Rossjohn, Paul J Hertzog

Journal article  |  2017  |  Journal of Biological Chemistry

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

Phillip Pymm, Patricia T Illing, Sri H Ramarathinam, Geraldine M O'Connor, Victoria A Hughes, Corinne Hitchen, David A Price, Bosco K Ho, Daniel W McVicar, Andrew G Brooks, Anthony W Purcell, Jamie Rossjohn, Julian P Vivian

Journal article  |  2017  |  Nature Structural & Molecular Biology

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells

Andrew N Keller, Sidonia BG Eckle, Weijun Xu, Ligong Liu, Victoria A Hughes, Jeffrey YW Mak, Bronwyn S Meehan, Troi Pediongco, Richard W Birkinshaw, Zhenjun Chen, Huimeng Wang, Criselle D'Souza, Lars Kjer-Nielsen, Nicholas A Gherardin, Dale I Godfrey, Lyudmila Kostenko, Alexandra J Corbett, Anthony W Purcell, David P Fairlie, James McCluskey, et al.

Journal article  |  2017  |  Nature Immunology

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family

Oscar A Aguilar, Richard Berry, Mir Munir A Rahim, Johanna J Reichel, Branka Popovic, Miho Tanaka, Zhihui Fu, Gautham R Balaji, Timothy NH Lau, Megan M Tu, Christina L Kirkham, Ahmad Bakur Mahmoud, Aruz Mesci, Astrid Krmpotic, David SJ Allan, Andrew P Makrigiannis, Stipan Jonjic, Jamie Rossjohn, James R Carlyle

Journal article  |  2017  |  Cell

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

Jeffrey YW Mak, Weijun Xu, Robert C Reid, Alexandra J Corbett, Bronwyn S Meehan, Huimeng Wang, Zhenjun Chen, Jamie Rossjohn, James McCluskey, Ligong Liu, David P Fairlie

Journal article  |  2017  |  NATURE COMMUNICATIONS

Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit

Dene R Littler, Hayley E Bullen, Katherine L Harvey, Travis Beddoe, Brendan S Crabb, Jamie Rossjohn, Paul R Gilson

Journal article  |  2016  |  Journal of Biological Chemistry

Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct alpha beta T Cell Receptor Signatures

Emma J Grant, Tracy M Josephs, Sophie A Valkenburg, Linda Wooldridge, Margaret Hellard, Jamie Rossjohn, Mandvi Bharadwaj, Katherine Kedzierska, Stephanie Gras

Journal article  |  2016  |  Journal of Biological Chemistry

Crystal structure of fuculose aldolase from the Antarctic psychrophilic yeast Glaciozyma antarctica PI12

Nardiah Rizwana Jaafar, Dene Littler, Travis Beddoe, Jamie Rossjohn, Rosli Md Illias, Nor Muhammad Mahadi, Mukram Mohamed Mackeen, Abdul Munir Abdul Murad, Farah Diba Abu Bakar

Journal article  |  2016  |  Acta Crystallographica Section F Structural Biology Communications

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination (vol 113, pg E5454, 2016)

Sophie V Pageon, Thibault Tabarin, Yui Yamamoto, Yuanqing Ma, Philip R Nicovich, John S Bridgeman, Andre Cohnen, Carola Benzing, Yijun Gao, Michael D Crowther, Katie Tungatt, Garry Dolton, Andrew K Sewell, David A Price, Oreste Acuto, Robert G Parton, J Justin Gooding, Jeremie Rossy, Jamie Rossjohn, Katharina Gaus

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

Stephanie Gras, Ildiko Van Rhijn, Adam Shahine, Tan-Yun Cheng, Mugdha Bhati, Li Lynn Tan, Hanim Halim, Kathryn D Tuttle, Laurent Gapin, Jerome Le Nours, D Branch Moody, Jamie Rossjohn

Journal article  |  2016  |  Nature Communications

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response

Stephanie Gras, Jesseka Chadderton, Claudia M Del Campo, Carine Farenc, Florian Wiede, Tracy M Josephs, Xavier YX Sng, Michiko Mirams, Katherine A Watson, Tony Tiganis, Kylie M Quinn, Jamie Rossjohn, Nicole L La Gruta

Journal article  |  2016  |  Immunity

Targeted suppression of autoreactive CD8( ) T-cell activation using blocking anti-CD8 antibodies

Mathew Clement, James A Pearson, Stephanie Gras, Hugo A van den Berg, Anya Lissina, Sian Llewellyn-Lacey, Mark D Willis, Tamsin Dockree, James E McLaren, Julia Ekeruche-Makinde, Emma Gostick, Neil P Robertson, Jamie Rossjohn, Scott R Burrows, David A Price, F Susan Wong, Mark Peakman, Ania Skowera, Linda Wooldridge

Journal article  |  2016  |  Scientific Reports

Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution

Jan Petersen, Yvonne Kooy-Winkelaar, Khai Lee Loh, Tran Mai, Jeroen Van Bergen, Frits Koning, Jamie Rossjohn, Hugh H Reid

Journal article  |  2016  |  Structure

CD1a on Langerhans cells controls inflammatory skin disease

Ji Hyung Kim, Yu Hu, Yongqing Tang, Jessica Kim, Victoria A Hughes, Jerome Le Nours, Elsa A Marquez, Anthony W Purcell, Qi Wan, Masahiko Sugita, Jamie Rossjohn, Florian Winau

Journal article  |  2016  |  Nature Immunology

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation

Liyen Loh, Zhongfang Wang, Sneha Sant, Marios Koutsakos, Sinthujan Jegaskanda, Alexandra J Corbett, Ligong Liu, David P Fairlie, Jane Crowe, Jamie Rossjohn, Jianqing Xu, Peter C Doherty, James McCluskey, Katherine Kedzierska

Journal article  |  2016  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human TRAV1-2-negative MR1-restricted T cells detect S-pyogenes and alternatives to MAIT riboflavin-based antigens

Erin W Meermeier, Bruno F Laugel, Andrew K Sewell, Alexandra J Corbett, Jamie Rossjohn, James McCluskey, Melanie J Harriff, Tamera Franks, Marielle C Gold, David M Lewinsohn

Journal article  |  2016  |  NATURE COMMUNICATIONS

Public T cell receptors confer high-avidity CD4 responses to HIV controllers

Daniela Benati, Moran Galperin, Olivier Lambotte, Stephanie Gras, Annick Lim, Madhura Mukhopadhyay, Alexandre Nouel, Kristy-Anne Campbell, Brigitte Lemercier, Mathieu Claireaux, Samia Hendou, Pierre Lechat, Pierre de Truchis, Faroudy Boufassa, Jamie Rossjohn, Jean-Francois Delfraissy, Fernando Arenzana-Seisdedos, Lisa A Chakrabarti

Journal article  |  2016  |  Journal of Clinical Investigation

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

David K Cole, Anna M Bulek, Garry Dolton, Andrea J Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John J Miles, Mark Peakman, Linda Wooldridge, Pierre J Rizkallah, Andrew K Sewell

Journal article  |  2016  |  Journal of Clinical Investigation

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions

Peter Jonsson, Jennifer H Southcombe, Ana Mafalda Santos, Jiandong Huo, Ricardo A Fernandes, James McColl, Melissa Lever, Edward J Evans, Alexander Hudson, Veronica T Chang, Tomas Hanke, Andrew Godkin, Paul D Dunne, Mathew H Horrocks, Matthieu Palayret, Gavin R Screaton, Jan Petersen, Jamie Rossjohn, Lars Fugger, Omer Dushek, et al.

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition

Philippa M Saunders, Phillip Pymm, Gabriella Pietra, Victoria A Hughes, Corinne Hitchen, Geraldine M O'Connor, Fabrizio Loiacono, Jacqueline Widjaja, David A Price, Michela Falco, Maria Cristina Mingari, Lorenzo Moretta, Daniel W McVicar, Jamie Rossjohn, Andrew G Brooks, Julian P Vivian

Journal article  |  2016  |  Journal of Experimental Medicine

Mucosa-Associated Invariant T Cells Are Systemically Depleted in Simian Immunodeficiency Virus-Infected Rhesus Macaques

Carol Vinton, Fan Wu, Jamie Rossjohn, Kenta Matsuda, James McCluskey, Vanessa Hirsch, David A Price, Jason M Brenchley

Journal article  |  2016  |  Journal of Virology

A biased view toward celiac disease

J Rossjohn, F Koning

Journal article  |  2016  |  Mucosal Immunology

The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1

Hamish EG McWilliam, Sidonia BG Eckle, Alex Theodossis, Ligong Liu, Zhenjun Chen, Jacinta M Wubben, David P Fairlie, Richard A Strugnell, Justine D Mintern, James McCluskey, Jamie Rossjohn, Jose A Villadangos

Journal article  |  2016  |  Nature Immunology

Molecular basis for universal HLA-A(star)0201-restricted CD8( ) T-cell immunity against influenza viruses

Sophie A Valkenburg, Tracy M Josephs, E Bridie Clemens, Emma J Grant, Thi HO Nguyen, George C Wang, David A Price, Adrian Miller, Steven YC Tong, Paul G Thomas, Peter C Doherty, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection

Victor Y Du, Anju Bansal, Jonathan Carlson, Jesus F Salazar-Gonzalez, Maria G Salazar, Kristin Ladell, Stephanie Gras, Tracy M Josephs, Sonya L Heath, David A Price, Jamie Rossjohn, Eric Hunter, Paul A Goepfert

Journal article  |  2016  |  The Journal of Immunology

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens

Jerome Le Nours, T Praveena, Daniel G Pellicci, Nicholas A Gherardin, Fiona J Ross, Ricky T Lim, Gurdyal S Besra, Santosh Keshipeddy, Stewart K Richardson, Amy R Howell, Stephanie Gras, Dale I Godfrey, Jamie Rossjohn, Adam P Uldrich

Journal article  |  2016  |  Nature Communications

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

Nicholas A Gherardin, Andrew N Keller, Rachel E Woolley, Jerome Le Nours, David S Ritchie, Paul J Neeson, Richard W Birkinshaw, Sidonia BG Eckle, John N Waddington, Ligong Liu, David P Fairlie, Adam P Uldrich, Daniel G Pellicci, James McCluskey, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2016  |  Immunity

Human autoreactive T cells recognize CD1b and phospholipids

Ildiko Van Rhijn, Twan van Berlo, Tamara Hilmenyuk, Tan-Yun Cheng, Benjamin J Wolf, Raju VV Tatituri, Adam P Uldrich, Giorgio Napolitani, Vincenzo Cerundolo, John D Altman, Peter Willemsen, Shouxiong Huang, Jamie Rossjohn, Gurdyal S Besra, Michael B Brenner, Dale I Godfrey, D Branch Moody

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells

Sidonia BG Eckle, Alexandra J Corbett, Andrew N Keller, Zhenjun Chen, Dale I Godfrey, Ligong Liu, Jeffrey YW Mak, David P Fairlie, Jamie Rossjohn, James McCluskey

Journal article  |  2015  |  Journal of Biological Chemistry

Antigen Specificity of Type I NKT Cells Is Governed by TCR beta-Chain Diversity

Garth Cameron, Daniel G Pellicci, Adam P Uldrich, Gurdyal S Besra, Petr Illarionov, Spencer J Williams, Nicole L La Gruta, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2015  |  JOURNAL OF IMMUNOLOGY

The burgeoning family of unconventional T cells

Dale I Godfrey, Adam P Uldrich, James McCluskey, Jamie Rossjohn, D Branch Moody

Journal article  |  2015  |  Nature Immunology

Understanding the complexity and malleability of T-cell recognition

John J Miles, James McCluskey, Jamie Rossjohn, Stephanie Gras

Journal article  |  2015  |  Immunology & Cell Biology

The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4

Shoeib Moradi, Richard Berry, Phillip Pymm, Corinne Hitchen, Simone A Beckham, Matthew CJ Wilce, Nicholas G Walpole, Craig S Clements, Hugh H Reid, Matthew A Perugini, Andrew G Brooks, Jamie Rossjohn, Julian P Vivian

Journal article  |  2015  |  Journal of Biological Chemistry

Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients

Isabelle Magalhaes, Karine Pingris, Christine Poitou, Stephanie Bessoles, Nicolas Venteclef, Badr Kiaf, Lucie Beaudoin, Jennifer Da Silva, Omran Allatif, Jamie Rossjohn, Lars Kjer-Nielsen, James McCluskey, Severine Ledoux, Laurent Genser, Adriana Torcivia, Claire Soudais, Olivier Lantz, Christian Boitard, Judith Aron-Wisnewsky, Etienne Larger, et al.

Journal article  |  2015  |  JOURNAL OF CLINICAL INVESTIGATION

MAIT cells are depleted early but retain functional cytokine expression in HIV infection

Caroline S Fernandez, Thakshila Amarasena, Anthony D Kelleher, Jamie Rossjohn, James McCluskey, Dale I Godfrey, Stephen J Kent

Journal article  |  2015  |  Immunology & Cell Biology

Identification of Self-antigen-specific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis

Soi-Cheng Law, Helen Benham, Hugh H Reid, Jamie Rossjohn, Ranjeny Thomas

Journal article  |  2014  |  Rheumatic Disease Clinics of North America

The Cellular Redox Environment Alters Antigen Presentation

Jonathan A Trujillo, Nathan P Croft, Nadine L Dudek, Rudragouda Channappanavar, Alex Theodossis, Andrew I Webb, Michelle A Dunstone, Patricia T Illing, Noah S Butler, Craig Fett, David C Tscharke, Jamie Rossjohn, Stanley Perlman, Anthony W Purcell

Journal article  |  2014  |  Journal of Biological Chemistry

HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants

Graham A Heap, Michael N Weedon, Claire M Bewshea, Abhey Singh, Mian Chen, Jack B Satchwel, Julian P Vivian, Kenji So, Patrick C Dubois, Jane M Andrews, Vito Annese, Peter Bampton, Martin Barnardo, Sally Bell, Andy Cole, Susan J Connor, Tom Creed, Fraser R Cummings, Mauro D'Amato, Tawfique K Daneshmend, et al.

Journal article  |  2014  |  Nature Genetics

A structural and functional investigation of a novel protein from Mycobacterium smegmatis implicated in mycobacterial macrophage survivability

Adam Shahine, Dene Littler, Rajini Brammananath, Phooi Y Chan, Paul K Crellin, Ross L Coppel, Jamie Rossjohn, Travis Beddoe

Journal article  |  2014  |  Acta Crystallographica Section D Biological Crystallography

Missense single nucleotide polymorphisms in the human T cell receptor loci control variable gene usage in the T cell repertoire

Rebekah M Brennan, Jacqueline M Burrows, Thomas Elliott, Michelle A Neller, Stephanie Gras, Jamie Rossjohn, John J Miles, Scott R Burrows

Journal article  |  2014  |  British Journal of Haematology

A mortise-tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes

Denisse L Leyton, Matthew D Johnson, Rajiv Thapa, Gerard HM Huysmans, Rhys A Dunstan, Nermin Celik, Hsin-Hui Shen, Dorothy Loo, Matthew J Belousoff, Anthony W Purcell, Ian R Henderson, Travis Beddoe, Jamie Rossjohn, Lisandra L Martin, Richard A Strugnell, Trevor Lithgow

Journal article  |  2014  |  Nature Communications

Structural and Functional Correlates of Enhanced Antiviral Immunity Generated by Heteroclitic CD8 T Cell Epitopes

Jonathan A Trujillo, Stephanie Gras, Kelly-Anne Twist, Nathan P Croft, Rudragouda Channappanavar, Jamie Rossjohn, Anthony W Purcell, Stanley Perlman

Journal article  |  2014  |  The Journal of Immunology

A structural characterization of the isoniazid Mycobacterium tuberculosis drug target, Rv2971, in its unliganded form

Adam Shahine, Anggia Prasetyoputri, Jamie Rossjohn, Travis Beddoe

Journal article  |  2014  |  Acta Crystallographica Section F Structural Biology Communications

The Ly49 natural killer cell receptors: a versatile tool for viral self-discrimination

Richard Berry, Jamie Rossjohn, Andrew G Brooks

Journal article  |  2014  |  Immunology & Cell Biology

Purification and biological characterization of soluble, recombinant mouse IFN beta expressed in insect cells

Sebastian A Stifter, Jodee A Gould, Niamh E Mangan, Hugh H Reid, Jamie Rossjohn, Paul J Hertzog, Nicole A de Weerd

Journal article  |  2014  |  Protein Expression and Purification

CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens

Annemieke de Jong, Tan-Yun Cheng, Shouxiong Huang, Stephanie Gras, Richard W Birkinshaw, Anne G Kasmar, Ildiko Van Rhijn, Victor Pena-Cruz, Daniel T Ruan, John D Altman, Jamie Rossjohn, D Branch Moody

Journal article  |  2014  |  Nature Immunology

Preexisting CD8 T-cell immunity to the H7N9 influenza a virus varies across ethnicities

S Quiñones-Parra, E Grant, L Loh, THO Nguyen, KA Campbell, SYC Tong, A Miller, PC Doherty, D Vijaykrishna, J Rossjohn, S Gras, K Kedzierska

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity

Romain Bedel, Richard Berry, Thierry Mallevaey, Jennifer L Matsuda, Jingjing Zhang, Dale I Godfrey, Jamie Rossjohn, John W Kappler, Philippa Marrack, Laurent Gapin

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Alloreactivity

SBG Eckle, J Rossjohn, J McCluskey

Book Chapter  |  2013  |  Methods in Molecular Biology

The alloimmune response between individuals genetically disparate for antigens encoded within the major histocompatibility complex..

Targeting of a natural killer cell receptor family by a viral immunoevasin

Richard Berry, Natasha Ng, Philippa M Saunders, Julian P Vivian, Jie Lin, Felix A Deuss, Alexandra J Corbett, Catherine A Forbes, Jacqueline M Widjaja, Lucy C Sullivan, Adrian D McAlister, Matthew A Perugini, Melissa J Call, Anthony A Scalzo, Mariapia A Degli-Esposti, Jerome D Coudert, Travis Beddoe, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2013  |  Nature Immunology

Beta-testing NKT cell self-reactivity

Dale I Godfrey, Daniel G Pellicci, Jamie Rossjohn

Journal article  |  2011  |  Nature Immunology

V beta 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen

Onisha Patel, Daniel G Pellicci, Adam P Uldrich, Lucy C Sullivan, Mugdha Bhati, Melissa McKnight, Stewart K Richardson, Amy R Howell, Thierry Mallevaey, Jingjing Zhang, Romain Bedel, Gurdyal S Besra, Andrew G Brooks, Lars Kjer-Nielsen, James McCluskey, Steven A Porcelli, Laurent Gapin, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2011  |  Proceedings of the National Academy of Sciences

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B

Julian P Vivian, Renee C Duncan, Richard Berry, Geraldine M O'Connor, Hugh H Reid, Travis Beddoe, Stephanie Gras, Philippa M Saunders, Maya A Olshina, Jacqueline ML Widjaja, Christopher M Harpur, Jie Lin, Sebastien M Maloveste, David A Price, Bernard AP Lafont, Daniel W McVicar, Craig S Clements, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2011  |  Nature

Recognition of beta-linked self glycolipids mediated by natural killer T cell antigen receptors

Daniel G Pellicci, Andrew J Clarke, Onisha Patel, Thierry Mallevaey, Travis Beddoe, Jerome Le Nours, Adam P Uldrich, James McCluskey, Gurdyal S Besra, Steven A Porcelli, Laurent Gapin, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2011  |  Nature Immunology

New ways to turn on NKT cells

Dale Ian Godfrey, Jamie Rossjohn

Journal article  |  2011  |  Journal of Experimental Medicine

Insight into the basis of autonomous immunoreceptor activation

Richard Berry, Zhenjun Chen, James McCluskey, Jamie Rossjohn

Journal article  |  2011  |  Trends in Immunology

The Shaping of T Cell Receptor Recognition by Self-Tolerance

Stephanie Gras, Scott R Burrows, Lars Kjer-Nielsen, Craig S Clements, Yu Chih Liu, Lucy C Sullivan, Melissa J Bell, Andrew G Brooks, Anthony W Purcell, James McCluskey, Jamie Rossjohn

Journal article  |  2009  |  Immunity

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

Julia K Archbold, Whitney A Macdonald, Stephanie Gras, Lauren K Ely, John J Miles, Melissa J Bell, Rebekah M Brennan, Travis Beddoe, Matthew CJ Wilce, Craig S Clements, Anthony W Purcell, James McCluskey, Scott R Burrows, Jamie Rossjohn

Journal article  |  2009  |  Journal of Experimental Medicine

More than one reason to rethink the use of peptides in vaccine design

Anthony W Purcell, James McCluskey, Jamie Rossjohn

Journal article  |  2007  |  Nature Reviews Drug Discovery

Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction

LK Ely, T Beddoe, CS Clements, JM Matthews, AW Purcell, L Kjer-Nielsen, J McCluskey, J Rossjohn

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America