Jamie Rossjohn

Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2-Bl/HLA-G

Mayumi Ishikawa, Andrew J Brooks, Manuel A Fernandez-Rojo, Johan Medina, Yash Chhabra, Shiro Minami, Kathryn A Tunny, Robert G Parton, Julian P Vivian, Jamie Rossjohn, Viral Chikani, Grant A Ramm, Ken KY Ho, Michael J Waters

Journal article  |  2020  |  Hepatology

Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 m..

Cytomegalovirus replication is associated with enrichment of distinct g 8 T cell subsets following lung transplantation: A novel therapeutic approach?

Sanda Stankovic, Martin S Davey, Evangeline M Shaw, Anouk von Borstel, Yvonne Cristiano, Bronwyn J Levvey, Jamie Rossjohn, Glen P Westall, Gregory I Snell, Andrew G Brooks, Lucy C Sullivan

Journal article  |  2020  |  Journal of Heart and Lung Transplantation

BACKGROUND: Anti-viral treatments to control cytomegalovirus (CMV) after lung transplantation (LTx) are associated with toxicity a..

A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

Roeland Lameris, Adam Shahine, Daniel G Pellicci, Adam P Uldrich, Stephanie Gras, Jerome Le Nours, Richard WJ Groen, Jana Vree, Scott JJ Reddiex, Sergio M Quinones-Parra, Stewart K Richardson, Amy R Howell, Sonja Zweegman, Dale I Godfrey, Tanja D de Gruijl, Jamie Rossjohn, Hans J van der Vliet

Journal article  |  2020  |  Nature Cancer

Atypical TRAV1-2(-) T cell receptor recognition of the antigen-presenting molecule MR1

Wael Awad, Erin W Meermeier, Maria L Sandoval-Romero, Jerome Le Nours, Aneta H Worley, Megan D Null, Ligong Liu, James McCluskey, David P Fairlie, David M Lewinsohn, Jamie Rossjohn

Journal article  |  2020  |  Journal of Biological Chemistry

MR1 presents vitamin B-related metabolites to mucosal associated invariant T (MAIT) cells, which are characterized, in part, by th..

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

Hamish EG McWilliam, Jeffrey YW Mak, Wael Awad, Matthew Zorkau, Sebastian Cruz-Gomez, Hui Jing Lim, Yuting Yan, Sam Wormald, Laura F Dagley, Sidonia BG Eckle, Alexandra J Corbett, Haiyin Liu, Shihan Li, Scott JJ Reddiex, Justine D Mintern, Ligong Liu, James McCluskey, Jamie Rossjohn, David P Fairlie, Jose A Villadangos

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of the United States of America

The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2..

Overlapping Peptides Elicit Distinct CD8( ) T Cell Responses following Influenza A Virus Infection

Lisa M Assmus, Jing Guan, Ting Wu, Carine Farenc, Xavier YX Sng, Pirooz Zareie, Angela Nguyen, Andrea T Nguyen, David C Tscharke, Paul G Thomas, Jamie Rossjohn, Stephanie Gras, Nathan P Croft, Anthony W Purcell, Nicole L La Gruta

Journal article  |  2020  |  The Journal of Immunology

The presentation of pathogen-derived peptides on MHC class I molecules is essential for the initiation of adaptive CD8+ T cell imm..

A Shared TCR Bias toward an Immunogenic EBV Epitope Dominates in HLA-B*07:02-Expressing Individuals

Louise C Rowntree, Thi HO Nguyen, Carine Farenc, Hanim Halim, Luca Hensen, Jamie Rossjohn, Tom C Kotsimbos, Anthony W Purcell, Katherine Kedzierska, Stephanie Gras, Nicole A Mifsud

Journal article  |  2020  |  The Journal of Immunology

EBV is one of the most common viruses found in humans and is prototypic of a persistent viral infection characterized by periods o..

Peripheral Blood Mucosal-Associated Invariant T Cells in Tuberculosis Patients and Healthy Mycobacterium tuberculosis-Exposed Controls

Sara Suliman, Anele Gela, Simon C Mendelsohn, Sarah K Iwany, Kattya Lopez Tamara, Simbarashe Mabwe, Nicole Bilek, Fatoumatta Darboe, Michelle Fisher, Alexandra J Corbett, Lars Kjer-Nielsen, Sidonia BG Eckle, Chuan-Chin Huang, Zibiao Zhang, David M Lewinsohn, James McCluskey, Jamie Rossjohn, Mark Hatherill, Segundo R Leon, Roger Calderon, et al.

Journal article  |  2020  |  The Journal of Infectious Diseases

BACKGROUND: In human blood, mucosal-associated invariant T (MAIT) cells are abundant T cells that recognize antigens presented on ..

Tetramer Immunization and Selection Followed by CELLISA Screening to Generate Monoclonal Antibodies against the Mouse Cytomegalovirus m12 Immunoevasin

Oscar A Aguilar, Miho Tanaka, Gautham R Balaji, Richard Berry, Jamie Rossjohn, Lewis L Lanier, James R Carlyle

Journal article  |  2020  |  Journal of Immunology

The generation of reliable mAb of unique and desired specificities serves as a valuable technology to study protein expression and..

Human gamma delta T cells recognize CD1b by two distinct mechanisms

Josephine F Reijneveld, Tonatiuh A Ocampo, Adam Shahine, Benjamin S Gully, Pierre Vantourout, Adrian C Hayday, Jamie Rossjohn, D Branch Moody, Ildiko Van Rhijn

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of USA

γδ T cells form an abundant part of the human cellular immune system, where they respond to tissue damage, infection, and cancer. ..