Jamie Rossjohn

Collision-Induced Affinity Selection Mass Spectrometry for Identification of Ligands

Tin Mak, Jamie Rossjohn, Dene R Littler, Miaomiao Liu, Ronald J Quinn

Journal article  |  2022  |  ACS Bio & Med Chem Au

SARS-CoV-2-specific T cell memory with common TCR alpha beta motifs is established in unvaccinated children who seroconvert after infection

Louise C Rowntree, Thi HO Nguyen, Lukasz Kedzierski, Melanie R Neeland, Jan Petersen, Jeremy Chase Crawford, Lilith F Allen, E Bridie Clemens, Brendon Chua, Hayley A McQuilten, Anastasia A Minervina, Mikhail Pogorelyy, Priyanka Chaurasia, Hyon-Xhi Tan, Adam K Wheatley, Xiaoxiao Jia, Fatima Amanat, Florian Krammer, E Kaitlynn Allen, Sabrina Sonda, et al.

Journal article  |  2022  |  IMMUNITY

As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains la..

Overcoming the LAG3 phase problem

Jan Petersen, Jamie Rossjohn

Journal article  |  2022  |  NATURE IMMUNOLOGY

Lymphocyte activation gene 3 (LAG3) is an important checkpoint inhibitor molecule of immunotherapeutic interest. New crystal struc..

Structural bases of T cell antigen receptor recognition in celiac disease.

Laura Ciacchi, Hugh H Reid, Jamie Rossjohn

Journal article  |  2022  |  Curr Opin Struct Biol

Celiac disease (CeD) is a human leukocyte antigen (HLA)-linked autoimmune-like disorder that is triggered by the ingestion of glut..

Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program.

Jack L McMurray, Anouk von Borstel, Taher E Taher, Eleni Syrimi, Graham S Taylor, Maria Sharif, Jamie Rossjohn, Ester BM Remmerswaal, Frederike J Bemelman, Felipe A Vieira Braga, Xi Chen, Sarah A Teichmann, Fiyaz Mohammed, Andrea A Berry, Kirsten E Lyke, Kim C Williamson, Michael JT Stubbington, Martin S Davey, Carrie R Willcox, Benjamin E Willcox

Journal article  |  2022  |  Cell Rep

γδ T cells are generally considered innate-like lymphocytes, however, an "adaptive-like" γδ compartment has now emerged. To unders..

Crystal structures of pertussis toxin with NAD and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity.

Moona Sakari, Mai T Tran, Jamie Rossjohn, Arto T Pulliainen, Travis Beddoe, Dene R Littler

Journal article  |  2022  |  J Biol Chem

Bordetella pertussis is the causative agent of whooping cough, a highly contagious respiratory disease. Pertussis toxin (PT), a ma..

Cutting Edge: Unconventional CD8 T Cell Recognition of a Naturally Occurring HLA-A*02:01-Restricted 20mer Epitope.

Miranda H Meeuwsen, Anne K Wouters, Renate S Hagedoorn, Michel GD Kester, Dennis FG Remst, Dirk M van der Steen, Arnoud de Ru, Peter A van Veelen, Jamie Rossjohn, Stephanie Gras, JH Frederik Falkenburg, Mirjam HM Heemskerk

Journal article  |  2022  |  J Immunol

Unconventional HLA class I-restricted CD8+ T cell epitopes, longer than 10 aa, have been implicated to play a role in human immuni..

Dual TCR-alpha Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation

Sara Suliman, Lars Kjer-Nielsen, Sarah K Iwany, Kattya Lopez Tamara, Liyen Loh, Ludivine Grzelak, Katherine Kedzierska, Tonatiuh A Ocampo, Alexandra J Corbett, James McCluskey, Jamie Rossjohn, Segundo R Leon, Roger Calderon, Leonid Lecca-Garcia, Megan B Murray, D Branch Moody, Ildiko Van Rhijn

Journal article  |  2022  |  JOURNAL OF IMMUNOLOGY

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT..

Binding Studies of the Prodrug HAO472 to SARS-Cov-2 Nsp9 and Variants.

Miaomiao Liu, Dene R Littler, Jamie Rossjohn, Ronald J Quinn

Journal article  |  2022  |  ACS Omega

SARS-CoV-2 (COVID-19) has infected over 219 million people and caused the death of over 4.55 million worldwide. In a previous scre..

Structural basis of T cell receptor specificity and cross-reactivity of two HLA-DQ2.5-restricted gluten epitopes in celiac disease.

Laura Ciacchi, Carine Farenc, Shiva Dahal-Koirala, Jan Petersen, Ludvig M Sollid, Hugh H Reid, Jamie Rossjohn

Journal article  |  2022  |  J Biol Chem

Celiac disease is a T cell-mediated chronic inflammatory condition often characterized by human leukocyte antigen (HLA)-DQ2.5 mole..