Robert Williamson

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Lezanne Ooi, Mirella Dottori, Anthony L Cook, Martin Engel, Vini Gautam, Alexandra Grubman, Damian Hernandez, Anna E King, Simon Maksour, Helena Targa Dias Anastacio, Rachelle Balez, Alice Pebay, Colin Pouton, Michael Valenzuela, Anthony White, Robert Williamson

Journal article  |  2020  |  The Neuroscientist

Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a publ..

Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing

Misha Angrist, Rodolphe Barrangou, Francoise Baylis, Carolyn Brokowski, Gaetan Burgio, Arthur Caplan, Carolyn Riley Chapman, George M Church, Robert Cook-Deegan, Bryan Cwik, Jennifer A Doudna, John H Evans, Henry T Greely, Laura Hercher, J Benjamin Hurlbut, Richard O Hynes, Tetsuya Ishii, Samira Kiani, LaTasha Hoskins Lee, Guillaume Levrier, et al.

Journal article  |  2020  |  CRISPR JOURNAL

In September 2020, a detailed report on Heritable Human Genome Editing was published. The report offers a translational pathway fo..

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease

Xavier Hadoux, Flora Hui, Jeremiah KH Lim, Colin L Masters, Alice Pebay, Sophie Chevalier, Jason Ha, Samantha Loi, Christopher J Fowler, Christopher Rowe, Victor L Villemagne, Edward N Taylor, Christopher Fluke, Jean-Paul Soucy, Frederic Lesage, Jean-Philippe Sylvestre, Pedro Rosa-Neto, Sulantha Mathotaarachchi, Serge Gauthier, Ziad S Nasreddine, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

Studies of rodent models of Alzheimer's disease (AD) and of human tissues suggest that the retinal changes that occur in AD, inclu..

Effect of APOE Genotype on Amyloid Deposition, Brain Volume, and Memory in Cognitively Normal Older Individuals

Yen Ying Lim, Robert Williamson, Simon M Laws, Victor L Villemagne, Pierrick Bourgeat, Christopher Fowler, Stephanie Rainey-Smith, Olivier Salvado, Ralph N Martins, Christopher C Rowe, Colin L Masters, Paul Maruff

Journal article  |  2017  |  JOURNAL OF ALZHEIMERS DISEASE

BACKGROUND: The association between the apolipoprotein E (APOE) ɛ4 allele and high risk of developing Alzheimer's disease (AD) dem..

Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients

Jun Liu, Paul J Verma, Marguerite V Evans-Galea, Martin B Delatycki, Anna Michalska, Jessie Leung, Duncan Crombie, Joseph P Sarsero, Robert Williamson, Mirella Dottori, Alice Pebay

Journal article  |  2011  |  STEM CELL REVIEWS AND REPORTS

Friedreich ataxia (FRDA) is an autosomal recessive disorder characterised by neurodegeneration and cardiomyopathy. It is caused by..

Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells

Caitlin E Filby, Robert Williamson, Peter van Kooy, Alice Pebay, Mirella Dottori, Ngaire J Elwood, Faten Zaibak

Journal article  |  2011  |  STEM CELL RESEARCH & THERAPY

INTRODUCTION: Unrestricted somatic stem cells (USSC) derived from umbilical cord blood are an attractive alternative to human embr..

The challenge of developmentally appropriate care: predictive genetic testing in young people for familial adenomatous polyposis

Rony E Duncan, Lynn Gillam, Julian Savulescu, Robert Williamson, John G Rogers, Martin B Delatycki

Journal article  |  2010  |  FAMILIAL CANCER

Predictive genetic tests for familial adenomatous polyposis (FAP) are routinely offered to young people during early adolescence. ..

Unrestricted somatic stem cells from human umbilical cord blood grow in serum-free medium as spheres

Faten Zaibak, Paul Bello, Jennifer Kozlovski, Duncan Crombie, Haozhi Ang, Mirella Dottori, Robert Williamson

Journal article  |  2009  |  BMC BIOTECHNOLOGY

BACKGROUND: Human umbilical cord blood-derived unrestricted somatic stem cells (USSCs), which are capable of multilineage differen..

Site-specific, Rep-mediated integration of the intact beta-globin locus in the human erythroleukaemic cell line K562

SE Howden, L Voullaire, H Wardan, R Williamson, J Vadolas

Journal article  |  2008  |  GENE THERAPY

The stable, regulated and tissue-specific expression of a therapeutic transgene can be best achieved by the transfer of a complete..

Cell-mediated rejection results in allograft loss after liver cell transplantation

Katrina J Allen, Nicole A Mifsud, Robert Williamson, Patrick Bertolino, Winita Hardikar

Journal article  |  2008  |  LIVER TRANSPLANTATION

Liver cell transplantation in humans has been impeded by invariable loss of the graft. It is unclear whether graft loss is due to ..