Timothy Ryan

Polysaccharide conformations measured by solution state X-ray scattering

BW Mansel, TM Ryan, HL Chen, L Lundin, MAK Williams

Journal article  |  2020  |  Chemical Physics Letters

Changes in the orientations of cellulose microfibrils during the development of collenchyma cell walls of celery (Apium graveolens L.).

Da Chen, Laurence D Melton, Duncan J McGillivray, Timothy M Ryan, Philip J Harris

Journal article  |  2019  |  Planta

MAIN CONCLUSION: During development, cellulose microfibrils in collenchyma walls become increasingly longitudinal, as determined b..

Solution structure of linear battacin lipopeptides - the effect of lengthening fatty acid chain.

Shinji Kihara, Gayan Heruka De Zoysa, Rayomand Shahlori, Praveen G Vadakkedath, Timothy M Ryan, Jitendra P Mata, Vijayalekshmi Sarojini, Duncan J McGillivray

Journal article  |  2019  |  Soft Matter

In recent years, lipopeptides have received attention for their enhanced antimicrobial activity, especially against multi-drug res..

Lipid-apolipoprotein interactions in amyloid fibril formation and relevance to atherosclerosis

Geoffrey J Howlett, Timothy M Ryan, Michael DW Griffin

Journal article  |  2019  |  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Resolving solution conformations of the model semi-flexible polyelectrolyte homogalacturonan using molecular dynamics simulations and small-angle x-ray scattering.

Bradley W Mansel, Amir Hossein Irani, Timothy M Ryan, Duncan J McGillivray, Hsin-Lung Chen, Martin AK Williams

Journal article  |  2019  |  The European Physical Journal E

The conformation of polyelectrolytes in the solution state has long been of interest in polymer science. Herein we utilize all ato..

Nanostructure of electrospun collagen: Do electrospun collagen fibers form native structures?

KH Sizeland, KA Hofman, IC Hallett, DE Martin, J Potgieter, NM Kirby, A Hawley, ST Mudie, TM Ryan, RG Haverkamp, MH Cumming

Journal article  |  2018  |  Materialia

Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase subclass.

Oliver W Sterritt, Eric JM Lang, Sarah A Kessans, Timothy M Ryan, Borries Demeler, Geoffrey B Jameson, Emily J Parker

Journal article  |  2018  |  Bioscience Reports

In Pseudomonas aeruginosa (Pae), the shikimate pathway end product, chorismate, serves as the last common precursor for the biosyn..

Artificially modified collagen fibril orientation affects leather tear strength.

Susyn J Kelly, Hannah C Wells, Katie H Sizeland, Nigel Kirby, Richard L Edmonds, Tim Ryan, Adrian Hawley, Stephen Mudie, Richard G Haverkamp

Journal article  |  2018  |  Journal of the Science of Food and Agriculture

BACKGROUND: Ovine leather has around half the tear strength of bovine leather and is therefore not suitable for high-value applica..

Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim.

Suresh Banjara, Jiahao Mao, Timothy M Ryan, Sofia Caria, Marc Kvansakul

Journal article  |  2018  |  Journal of Biological Chemistry

Programmed cell death or apoptosis is a critical mechanism for the controlled removal of damaged or infected cells, and proteins o..

Effects of polysaccharide charge pattern on the microstructures of β-lactoglobulin-pectin complex coacervates, studied by SAXS and SANS

AY Xu, LD Melton, TM Ryan, JP Mata, A Rekas, MAK Williams, DJ McGillivray

Journal article  |  2018  |  Food Hydrocolloids

An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis

Timothy M Ryan, Jill Trewhella, James M Murphy, Jeremy R Keown, Lachlan Casey, F Grant Pearce, David C Goldstone, Kelan Chen, Zhenyao Luo, Bostjan Kobe, Christopher A McDevitt, Serena A Watkin, Adrian M Hawley, Stephen T Mudie, Vesna Samardzic Boban, Nigel Kirby

Journal article  |  2018  |  Journal of Applied Crystallography

Mapping tear strength and collagen fibril orientation in bovine, ovine and cervine hides and skins

SJ Kelly, RL Edmonds, S Cooper, KH Sizeland, HC Wells, T Ryan, N Kirby, A Hawley, S Mudie, RG Haverkamp

Journal article  |  2018  |  Journal of the American Leather Chemists Association

Collagen Fibril Response to Strain in Scaffolds from Ovine Forestomach for Tissue Engineering

KH Sizeland, HC Wells, SJR Kelly, KE Nesdale, BCH May, SG Dempsey, CH Miller, N Kirby, A Hawley, S Mudie, T Ryan, D Cookson, RG Haverkamp

Journal article  |  2017  |  ACS Biomaterials Science & Engineering

2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update.

Jill Trewhella, Anthony P Duff, Dominique Durand, Frank Gabel, J Mitchell Guss, Wayne A Hendrickson, Greg L Hura, David A Jacques, Nigel M Kirby, Ann H Kwan, Javier Pérez, Lois Pollack, Timothy M Ryan, Andrej Sali, Dina Schneidman-Duhovny, Torsten Schwede, Dmitri I Svergun, Masaaki Sugiyama, John A Tainer, Patrice Vachette, et al.

Journal article  |  2017  |  Acta Crystallographica Section D Structural Biology

In 2012, preliminary guidelines were published addressing sample quality, data acquisition and reduction, presentation of scatteri..

Biochemically-defined pools of amyloid-beta in sporadic Alzheimer's disease: correlation with amyloid PET

Blaine R Roberts, Monica Lind, Aaron Z Wagen, Alan Rembach, Tony Frugier, Qiao-Xin Li, Timothy M Ryan, Catriona A McLean, James D Doecke, Christopher C Rowe, Victor L Villemagne, Colin L Masters

Journal article  |  2017  |  Brain

Sugar-coated proteins: the importance of degree of polymerisation of oligo-galacturonic acid on protein binding and aggregation.

Amy Y Xu, Laurence D Melton, Timothy M Ryan, Jitendra P Mata, Geoffrey B Jameson, Agata Rekas, Martin AK Williams, Duncan J McGillivray

Journal article  |  2017  |  Soft Matter

We have simplified the structural heterogeneity of protein-polysaccharide binding by investigating protein binding to oligosacchar..

The influence of water, lanolin, urea, proline, paraffin and fatliquor on collagen: D -spacing in leather

KH Sizeland, HC Wells, SJR Kelly, RL Edmonds, NM Kirby, A Hawley, ST Mudie, TM Ryan, RG Haverkamp

Journal article  |  2017  |  RSC Advances

Water, lanolin and Lipsol interact with collagen to alter the structure at the fibrillar scale.

Improved radiation dose efficiency in solution SAXS using a sheath flow sample environment.

Nigel Kirby, Nathan Cowieson, Adrian M Hawley, Stephen T Mudie, Duncan J McGillivray, Michael Kusel, Vesna Samardzic-Boban, Timothy M Ryan

Journal article  |  2016  |  Acta Crystallographica Section D Structural Biology

Radiation damage is a major limitation to synchrotron small-angle X-ray scattering analysis of biomacromolecules. Flowing the samp..

Combined pressure and temperature denaturation of ribonuclease A produces alternate denatured states.

Timothy M Ryan, Yun Xun, Nathan P Cowieson, Jitendra P Mata, Andrew Jackson, Brian R Pauw, Andrew J Smith, Nigel Kirby, Duncan McGillivray

Journal article  |  2016  |  Biochemical and Biophysical Research Communications

Protein folding, unfolding and misfolding have become critically important to a range of health and industry applications. Increas..

Apolipoprotein C-II Adopts Distinct Structures in Complex with Micellar and Submicellar Forms of the Amyloid-Inhibiting Lipid-Mimetic Dodecylphosphocholine

Timothy M Ryan, Michael DW Griffin, Duncan J McGillivray, Robert B Knott, Kathleen Wood, Colin L Masters, Nigel Kirby, Cyril C Curtain

Journal article  |  2016  |  BIOPHYSICAL JOURNAL

Fluphenazine center dot HCl and Epigallocatechin Gal late Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

Courtney O Zlatic, Yu Mao, Timothy M Ryan, Yee-Foong Mok, Blaine R Roberts, Geoffrey J Howlett, Michael DW Griffin

Journal article  |  2015  |  Biochemistry

The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro

Steven J Collins, Carolin Tumpach, Qiao-Xin Li, Victoria Lewis, Timothy M Ryan, Blaine Roberts, Simon C Drew, Victoria A Lawson, Cathryn L Haigh

Journal article  |  2015  |  STEM CELL RESEARCH & THERAPY

Stabilization of Nontoxic A beta-Oligomers: Insights into the Mechanism of Action of Hydroxyquinolines in Alzheimer's Disease

Timothy M Ryan, Blaine R Roberts, Gawain McColl, Dominic J Hare, Philip A Doble, Qiao-Xin Li, Monica Lind, Anne M Roberts, Haydyn DT Mertens, Nigel Kirby, Chi LL Pham, Mark G Hinds, Paul A Adlard, Kevin J Barnham, Cyril C Curtain, Colin L Masters

Journal article  |  2015  |  JOURNAL OF NEUROSCIENCE

The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II

Timothy M Ryan, Yee-Foong Mok, Geoffrey J Howlett, Michael DW Griffin

Book Chapter  |  2015  |  Advances in Experimental Medicine and Biology

Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study

Cyril C Curtain, Nigel M Kirby, Haydyn DT Mertens, Kevin J Barnham, Robert B Knott, Colin L Masters, Roberto Cappai, Agata Rekas, Vijaya B Kenche, Timothy Ryan

Journal article  |  2015  |  MOLECULAR BIOSYSTEMS

Small angle X-ray scattering analysis of Cu2 -induced oligomers of the Alzheimer's amyloid beta peptide

Timothy M Ryan, Nigel Kirby, Haydyn DT Mertens, Blaine Roberts, Kevin J Barnham, Roberto Cappai, Chi Le Lan Pham, Colin L Masters, Cyril C Curtain

Journal article  |  2015  |  METALLOMICS

Bayesian Graphical Network Analyses Reveal Complex Biological Interactions Specific to Alzheimer's Disease

Alan Rembach, Francesco C Stingo, Christine Peterson, Marina Vannucci, Kim-Anh Do, William J Wilson, S Lance Macaulay, Timothy M Ryan, Ralph N Martins, David Ames, Colin L Masters, James D Doecke

Journal article  |  2015  |  JOURNAL OF ALZHEIMERS DISEASE

The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue

Dominic J Hare, Jessica L George, Lisa Bray, Irene Volitakis, Angela Vais, Timothy M Ryan, Robert A Cherny, Ashley I Bush, Colin L Masters, Paul A Adlard, Philip A Doble, David I Finkelstein

Journal article  |  2014  |  JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid beta

Mingfeng Yu, Timothy M Ryan, Samantha Ellis, Ashley I Bush, James A Triccas, Peter J Rutledge, Matthew H Todd

Journal article  |  2014  |  METALLOMICS

Guanidine hydrochloride denaturation of dopamine-induced alpha-synuclein oligomers: A small-angle X-ray scattering study

Chi LL Pham, Nigel Kirby, Kathleen Wood, Timothy Ryan, Blaine Roberts, Anna Sokolova, Kevin J Barnham, Colin L Masters, Robert B Knott, Roberto Cappai, Cyril C Curtain, Agata Rekas

Journal article  |  2014  |  PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Progress towards a consensus on biomarkers for Alzheimer's disease: a review of peripheral analytes

Alan Rembach, Tim M Ryan, Blaine R Roberts, James D Doecke, William J Wilson, Andrew D Watt, Kevin J Barnham, Colin L Masters

Journal article  |  2013  |  Biomarkers in Medicine

Metalloproteomics: principles, challenges, and applications to neurodegeneration

Amber Lothian, Dominic J Hare, Rudolf Grimm, Timothy M Ryan, Colin L Masters, Blaine R Roberts

Journal article  |  2013  |  FRONTIERS IN AGING NEUROSCIENCE

Ammonium hydroxide treatment of A beta produces an aggregate free solution suitable for biophysical and cell culture characterization

Timothy M Ryan, Joanne Caine, Haydyn DT Mertens, Nigel Kirby, Julie Nigro, Kerry Breheney, Lynne J Waddington, Victor A Streltsov, Cyril Curtain, Colin L Masters, Blaine R Roberts

Journal article  |  2013  |  PEERJ

The Role of Aβ in Alzheimer's Disease

TM Ryan, BR Roberts, VA Streltsov, SD Nuttall, CL Masters

Book Chapter  |  2013

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

Dominic J Hare, Alexandra Grubman, Timothy M Ryan, Amber Lothian, Jeffrey R Liddell, Rudolf Grimm, Toshiaki Matsuda, Philip A Doble, Robert A Cherny, Ashley I Bush, Anthony R White, Colin L Masters, Blaine R Roberts

Journal article  |  2013  |  METALLOMICS

Utility of an improved model of amyloid-beta (A beta(1-42)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease

Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny

Journal article  |  2012  |  MOLECULAR NEURODEGENERATION

Structural determination of the phosphorylation domain of the ryanodine receptor.

Parveen Sharma, Noboru Ishiyama, Usha Nair, Wenping Li, Aiping Dong, Tetsuaki Miyake, Aaron Wilson, Tim Ryan, David H MacLennan, Thomas Kislinger, Mitsuhiko Ikura, Sirano Dhe-Paganon, Anthony O Gramolini

Journal article  |  2012  |  FEBS Journal

The ryanodine receptor (RyR) is a large, homotetrameric sarcoplasmic reticulum membrane protein that is essential for Ca(2+) cycli..

Small Amphipathic Molecules Modulate Secondary Structure and Amyloid Fibril-forming Kinetics of Alzheimer Disease Peptide A beta(1-42)

TM Ryan, AM Friedhuber, M Lind, GJ Howlett, C Masters, BR Roberts

Journal article  |  2012  |  Journal of Biological Chemistry

Bovine serum albumin unfolds in Couette flow

Innocent B Bekard, Peter Asimakis, Chai L Teoh, Tim Ryan, Geoffrey J Howlett, Joseph Bertolini, Dave E Dunstan

Journal article  |  2012  |  Soft Matter

NBD-Labeled Phospholipid Accelerates Apolipoprotein C-II Amyloid Fibril Formation but Is Not Incorporated into Mature Fibrils

Timothy M Ryan, Michael DW Griffin, Michael F Bailey, Peter Schuck, Geoffrey J Howlett

Journal article  |  2011  |  Biochemistry

Shear Flow Induced Changes in Apolipoprotein C-II Conformation and Amyloid Fibril Formation

Chai Lean Teoh, Innocent B Bekard, Peter Asimakis, Michael DW Griffin, Timothy M Ryan, Dave E Dunstan, Geoffrey J Howlett

Journal article  |  2011  |  Biochemistry

Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP).

Timothy Ryan, Parveen Sharma, Alex Ignatchenko, David H MacLennan, Thomas Kislinger, Anthony O Gramolini

Journal article  |  2011  |  Journal of Biological Chemistry

The ryanodine receptor type 1 (RyR1) is a homotetrameric Ca(2+) release channel located in the sarcoplasmic reticulum of skeletal ..

Sedimentation velocity analysis of amyloid oligomers and fibrils using fluorescence detection

Yee-Foong Mok, Timothy M Ryan, Shuo Yang, Danny M Hatters, Geoffrey J Howlett, Michael DW Griffin

Journal article  |  2011  |  METHODS

High-Affinity Amphipathic Modulators of Amyloid Fibril Nucleation and Elongation

Timothy M Ryan, Michael DW Griffin, Chai Lean Teoh, Jingkai Ooi, Geoffrey J Howlett

Journal article  |  2011  |  Journal of Molecular Biology

Phospholipids Enhance Nucleation but Not Elongation of Apolipoprotein C-II Amyloid Fibrils

Timothy M Ryan, Chai L Teoh, Michael DW Griffin, Michael F Bailey, Peter Schuck, Geoffrey J Howlett

Journal article  |  2010  |  Journal of Molecular Biology

Domain Organization of the Monomeric Form of the Tom70 Mitochondrial Import Receptor (vol 388, pg 1043, 2009)

Ryan D Mills, Jill Trewhella, Theresa Wenli Qiu, Thomas Welte, Timothy M Ryan, Tracey Hanley, Robert B Knott, Trevor Lithgow, Terrence D Mulhern

Journal article  |  2009  |  Journal of Molecular Biology

Domain Organization of the Monomeric Form of the Tom70 Mitochondrial Import Receptor

Ryan D Mills, Jill Trewhella, Theresa Wenli Qiu, Thomas Welte, Timothy M Ryan, Tracey Hanley, Robert B Knott, Trevor Lithgow, Terrence D Mulhern

Journal article  |  2009  |  Journal of Molecular Biology

Molar Mass Determination of Water-Soluble Light-Emitting Conjugated Polymers by Fluorescence-Based Analytical Ultracentrifugation

Xiao-Tao Hao, Tim Ryan, Michael F Bailey, Trevor A Smith

Journal article  |  2009  |  Macromolecules

Fluorescence Detection of a Lipid-induced Tetrameric Intermediate in Amyloid Fibril Formation by Apolipoprotein C-II

Timothy M Ryan, Geoffrey J Howlett, Michael F Bailey

Journal article  |  2008  |  Journal of Biological Chemistry