Find out more about Timothy Ryan's experience
Timothy Ryan's highlights
Timothy Ryan's selected work
Changes in the orientations of cellulose microfibrils during the development of collenchym..
Solution structure of linear battacin lipopeptides - the effect of lengthening fatty acid ..
Lipid-apolipoprotein interactions in amyloid fibril formation and relevance to atheroscler..
Resolving solution conformations of the model semi-flexible polyelectrolyte homogalacturon..
Nanostructure of electrospun collagen: Do electrospun collagen fibers form native structur..
Displaying the 49 most recent scholarly works by Timothy Ryan.
Changes in the orientations of cellulose microfibrils during the development of collenchyma cell walls of celery (Apium graveolens L.).
Da Chen, Laurence D Melton, Duncan J McGillivray, Timothy M Ryan, Philip J Harris
Journal article | 2019 | Planta
MAIN CONCLUSION: During development, cellulose microfibrils in collenchyma walls become increasingly longitudinal, as determined b..
Solution structure of linear battacin lipopeptides - the effect of lengthening fatty acid chain.
Shinji Kihara, Gayan Heruka De Zoysa, Rayomand Shahlori, Praveen G Vadakkedath, Timothy M Ryan, Jitendra P Mata, Vijayalekshmi Sarojini, Duncan J McGillivray
Journal article | 2019 | Soft Matter
In recent years, lipopeptides have received attention for their enhanced antimicrobial activity, especially against multi-drug res..
Resolving solution conformations of the model semi-flexible polyelectrolyte homogalacturonan using molecular dynamics simulations and small-angle x-ray scattering.
Bradley W Mansel, Amir Hossein Irani, Timothy M Ryan, Duncan J McGillivray, Hsin-Lung Chen, Martin AK Williams
Journal article | 2019 | The European Physical Journal E
The conformation of polyelectrolytes in the solution state has long been of interest in polymer science. Herein we utilize all ato..
Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase subclass.
Oliver W Sterritt, Eric JM Lang, Sarah A Kessans, Timothy M Ryan, Borries Demeler, Geoffrey B Jameson, Emily J Parker
Journal article | 2018 | Bioscience Reports
In Pseudomonas aeruginosa (Pae), the shikimate pathway end product, chorismate, serves as the last common precursor for the biosyn..
Artificially modified collagen fibril orientation affects leather tear strength.
Susyn J Kelly, Hannah C Wells, Katie H Sizeland, Nigel Kirby, Richard L Edmonds, Tim Ryan, Adrian Hawley, Stephen Mudie, Richard G Haverkamp
Journal article | 2018 | Journal of the Science of Food and Agriculture
BACKGROUND: Ovine leather has around half the tear strength of bovine leather and is therefore not suitable for high-value applica..
Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim.
Suresh Banjara, Jiahao Mao, Timothy M Ryan, Sofia Caria, Marc Kvansakul
Journal article | 2018 | Journal of Biological Chemistry
Programmed cell death or apoptosis is a critical mechanism for the controlled removal of damaged or infected cells, and proteins o..
An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis
Timothy M Ryan, Jill Trewhella, James M Murphy, Jeremy R Keown, Lachlan Casey, F Grant Pearce, David C Goldstone, Kelan Chen, Zhenyao Luo, Bostjan Kobe, Christopher A McDevitt, Serena A Watkin, Adrian M Hawley, Stephen T Mudie, Vesna Samardzic Boban, Nigel Kirby
Journal article | 2018 | Journal of Applied Crystallography
2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update.
Jill Trewhella, Anthony P Duff, Dominique Durand, Frank Gabel, J Mitchell Guss, Wayne A Hendrickson, Greg L Hura, David A Jacques, Nigel M Kirby, Ann H Kwan, Javier Pérez, Lois Pollack, Timothy M Ryan, Andrej Sali, Dina Schneidman-Duhovny, Torsten Schwede, Dmitri I Svergun, Masaaki Sugiyama, John A Tainer, Patrice Vachette, et al.
Journal article | 2017 | Acta Crystallographica Section D Structural Biology
In 2012, preliminary guidelines were published addressing sample quality, data acquisition and reduction, presentation of scatteri..
Biochemically-defined pools of amyloid-beta in sporadic Alzheimer's disease: correlation with amyloid PET
Blaine R Roberts, Monica Lind, Aaron Z Wagen, Alan Rembach, Tony Frugier, Qiao-Xin Li, Timothy M Ryan, Catriona A McLean, James D Doecke, Christopher C Rowe, Victor L Villemagne, Colin L Masters
Journal article | 2017 | Brain
Sugar-coated proteins: the importance of degree of polymerisation of oligo-galacturonic acid on protein binding and aggregation.
Amy Y Xu, Laurence D Melton, Timothy M Ryan, Jitendra P Mata, Geoffrey B Jameson, Agata Rekas, Martin AK Williams, Duncan J McGillivray
Journal article | 2017 | Soft Matter
We have simplified the structural heterogeneity of protein-polysaccharide binding by investigating protein binding to oligosacchar..
The influence of water, lanolin, urea, proline, paraffin and fatliquor on collagen: D -spacing in leather
KH Sizeland, HC Wells, SJR Kelly, RL Edmonds, NM Kirby, A Hawley, ST Mudie, TM Ryan, RG Haverkamp
Journal article | 2017 | RSC Advances
Water, lanolin and Lipsol interact with collagen to alter the structure at the fibrillar scale.
Improved radiation dose efficiency in solution SAXS using a sheath flow sample environment.
Nigel Kirby, Nathan Cowieson, Adrian M Hawley, Stephen T Mudie, Duncan J McGillivray, Michael Kusel, Vesna Samardzic-Boban, Timothy M Ryan
Journal article | 2016 | Acta Crystallographica Section D Structural Biology
Radiation damage is a major limitation to synchrotron small-angle X-ray scattering analysis of biomacromolecules. Flowing the samp..
Combined pressure and temperature denaturation of ribonuclease A produces alternate denatured states.
Timothy M Ryan, Yun Xun, Nathan P Cowieson, Jitendra P Mata, Andrew Jackson, Brian R Pauw, Andrew J Smith, Nigel Kirby, Duncan McGillivray
Journal article | 2016 | Biochemical and Biophysical Research Communications
Protein folding, unfolding and misfolding have become critically important to a range of health and industry applications. Increas..
Apolipoprotein C-II Adopts Distinct Structures in Complex with Micellar and Submicellar Forms of the Amyloid-Inhibiting Lipid-Mimetic Dodecylphosphocholine
Timothy M Ryan, Michael DW Griffin, Duncan J McGillivray, Robert B Knott, Kathleen Wood, Colin L Masters, Nigel Kirby, Cyril C Curtain
Journal article | 2016 | BIOPHYSICAL JOURNAL
Fluphenazine center dot HCl and Epigallocatechin Gal late Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils
Courtney O Zlatic, Yu Mao, Timothy M Ryan, Yee-Foong Mok, Blaine R Roberts, Geoffrey J Howlett, Michael DW Griffin
Journal article | 2015 | Biochemistry
Stabilization of Nontoxic A beta-Oligomers: Insights into the Mechanism of Action of Hydroxyquinolines in Alzheimer's Disease
Timothy M Ryan, Blaine R Roberts, Gawain McColl, Dominic J Hare, Philip A Doble, Qiao-Xin Li, Monica Lind, Anne M Roberts, Haydyn DT Mertens, Nigel Kirby, Chi LL Pham, Mark G Hinds, Paul A Adlard, Kevin J Barnham, Cyril C Curtain, Colin L Masters
Journal article | 2015 | JOURNAL OF NEUROSCIENCE
Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study
Cyril C Curtain, Nigel M Kirby, Haydyn DT Mertens, Kevin J Barnham, Robert B Knott, Colin L Masters, Roberto Cappai, Agata Rekas, Vijaya B Kenche, Timothy Ryan
Journal article | 2015 | MOLECULAR BIOSYSTEMS
Bayesian Graphical Network Analyses Reveal Complex Biological Interactions Specific to Alzheimer's Disease
Alan Rembach, Francesco C Stingo, Christine Peterson, Marina Vannucci, Kim-Anh Do, William J Wilson, S Lance Macaulay, Timothy M Ryan, Ralph N Martins, David Ames, Colin L Masters, James D Doecke
Journal article | 2015 | JOURNAL OF ALZHEIMERS DISEASE
The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue
Dominic J Hare, Jessica L George, Lisa Bray, Irene Volitakis, Angela Vais, Timothy M Ryan, Robert A Cherny, Ashley I Bush, Colin L Masters, Paul A Adlard, Philip A Doble, David I Finkelstein
Journal article | 2014 | JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
Guanidine hydrochloride denaturation of dopamine-induced alpha-synuclein oligomers: A small-angle X-ray scattering study
Chi LL Pham, Nigel Kirby, Kathleen Wood, Timothy Ryan, Blaine Roberts, Anna Sokolova, Kevin J Barnham, Colin L Masters, Robert B Knott, Roberto Cappai, Cyril C Curtain, Agata Rekas
Journal article | 2014 | PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Ammonium hydroxide treatment of A beta produces an aggregate free solution suitable for biophysical and cell culture characterization
Timothy M Ryan, Joanne Caine, Haydyn DT Mertens, Nigel Kirby, Julie Nigro, Kerry Breheney, Lynne J Waddington, Victor A Streltsov, Cyril Curtain, Colin L Masters, Blaine R Roberts
Journal article | 2013 | PEERJ
Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry
Dominic J Hare, Alexandra Grubman, Timothy M Ryan, Amber Lothian, Jeffrey R Liddell, Rudolf Grimm, Toshiaki Matsuda, Philip A Doble, Robert A Cherny, Ashley I Bush, Anthony R White, Colin L Masters, Blaine R Roberts
Journal article | 2013 | METALLOMICS
Utility of an improved model of amyloid-beta (A beta(1-42)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease
Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny
Journal article | 2012 | MOLECULAR NEURODEGENERATION
Structural determination of the phosphorylation domain of the ryanodine receptor.
Parveen Sharma, Noboru Ishiyama, Usha Nair, Wenping Li, Aiping Dong, Tetsuaki Miyake, Aaron Wilson, Tim Ryan, David H MacLennan, Thomas Kislinger, Mitsuhiko Ikura, Sirano Dhe-Paganon, Anthony O Gramolini
Journal article | 2012 | FEBS Journal
The ryanodine receptor (RyR) is a large, homotetrameric sarcoplasmic reticulum membrane protein that is essential for Ca(2+) cycli..
Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP).
Timothy Ryan, Parveen Sharma, Alex Ignatchenko, David H MacLennan, Thomas Kislinger, Anthony O Gramolini
Journal article | 2011 | Journal of Biological Chemistry
The ryanodine receptor type 1 (RyR1) is a homotetrameric Ca(2+) release channel located in the sarcoplasmic reticulum of skeletal ..
Domain Organization of the Monomeric Form of the Tom70 Mitochondrial Import Receptor (vol 388, pg 1043, 2009)
Ryan D Mills, Jill Trewhella, Theresa Wenli Qiu, Thomas Welte, Timothy M Ryan, Tracey Hanley, Robert B Knott, Trevor Lithgow, Terrence D Mulhern
Journal article | 2009 | Journal of Molecular Biology
Biochemistry And Molecular Biology
Florey Department Of Neuroscience And Mental Health
University of Melbourne
University of Melbourne