Adam Uldrich

alpha-Glucuronosyl and alpha-glucosyl diacylglycerides, natural killer T cell-activating lipids from bacteria and fungi

Satvika Burugupalli, Catarina F Almeida, Dylan GM Smith, Sayali Shah, Onisha Patel, Jamie Rossjohn, Adam P Uldrich, Dale I Godfrey, Spencer J Williams

Journal article  |  2020  |  Chemical Science

Microbial α-glycosyl diacylglycerides when presented by the antigen presenting molecule CD1d are recognized by both classical type..

Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells

Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Zheng Ruan, Hamish EG McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Nash, Andrew Hammet, Anne M Verhagen, Gino Vairo, et al.

Journal article  |  2020  |  Science

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..

A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1

Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett, et al.

Journal article  |  2019  |  Science

T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Catarina F Almeida, Srinivasan Sundararaj, Jerome Le Nours, T Praveena, Benjamin Cao, Satvika Burugupalli, Dylan GM Smith, Onisha Patel, Manfred Brigl, Daniel G Pellicci, Spencer J Williams, Adam P Uldrich, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2019  |  Nature Communications

Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an und..

α-Glucuronosyl and α-Glucosyl Diacylglycerides, Natural Killer T Cell-Activating Lipids from Bacteria and Fungi

SATVIKA BURUGUPALLI, CATARINA DOS SANTOS SA E ALMEIDA, Dylan GM Smith, SAYALI SHAH, ONISHA PATEL, Jamie Rossjohn, ADAM ULDRICH, DALE GODFREY, Spencer Williams

Journal article  |  2019

Natural killer T cells express T cell receptors (TCRs) that recognize glycolipid antigens in association with the antigen-presenti..

Diverse MR1-restricted T cells in mice and humans.

Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

Journal article  |  2019  |  Nature Communications

Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..

gamma delta T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis (vol 19, pg 464, 2018)

Ayano C Kohlgruber, Shani T Gal-Oz, Nelson M LaMarche, Moto Shimazaki, Danielle Duquette, Hui-Fern Koay, Hung N Nguyen, Amir I Mina, Tyler Paras, Ali Tavakkoli, Ulrich von Andrian, Adam P Uldrich, Dale I Godfrey, Alexander S Banks, Tal Shay, Michael B Brenner, Lydia Lynch

Journal article  |  2019  |  Nature Immunology

More Than a BTK Inhibitor; Ibrutinib Profoundly Impacts the Function of Cell Mediated Immunity

Chia Sharpe, Joanne Davis, Kylie D Mason, Dale I Godfrey, Adam Uldrich, Constantine S Tam, Rachel Koldej, David Ritchie

Conference Proceedings  |  2018  |  Blood

Human blood MAIT cell subsets defined using MR1 tetramers

Nicholas A Gherardin, Michael NT Souter, Hui-Fern Koay, Kirstie M Mangas, Torsten Seemann, Timothy P Stinear, Sidonia BG Eckle, Stuart P Berzins, Yves d'Udekem, Igor E Konstantinov, David P Fairlie, David S Ritchie, Paul J Neeson, Daniel G Pellicci, Adam P Uldrich, James McCluskey, Dale I Godfrey

Journal article  |  2018  |  IMMUNOLOGY AND CELL BIOLOGY

gamma delta T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

Ayano C Kohlgruber, Shani T Gal-Oz, Nelson M LaMarche, Moto Shimazaki, Danielle Duquette, Hung N Nguyen, Amir I Mina, Tyler Paras, Ali Tavakkoli, Ulrich von Andrian, Alexander S Banks, Tal Shay, Michael B Brenner, Lydia Lynch

Journal article  |  2018  |  Nature Immunology

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids

Kwok S Wun, Josephine F Reijneveld, Tan-Yun Cheng, Kristin Ladell, Adam P Uldrich, Jerome Le Nours, Kelly L Miners, James E McLaren, Emma J Grant, Oscar L Haigh, Thomas S Watkins, Sara Suliman, Sarah Iwany, Judith Jimenez, Roger Calderon, Kattya L Tamara, Segundo R Leon, Megan B Murray, Jacob A Mayfield, John D Altman, et al.

Journal article  |  2018  |  Nature Immunology

Unconventional T Cell Targets for Cancer Immunotherapy

Dale I Godfrey, Jerome Le Nours, Daniel M Andrews, Adam P Uldrich, Jamie Rossjohn

Journal article  |  2018  |  Immunity

Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma

Nicholas A Gherardin, Liyen Loh, Lorenztino Admojo, Alexander J Davenport, Kelden Richardson, Amy Rogers, Phillip K Darcy, Misty R Jenkins, H Miles Prince, Simon J Harrison, Hang Quach, David P Fairlie, Katherine Kedzierska, James McCluskey, Adam P Uldrich, Paul J Neeson, David S Ritchie, Dale I Godfrey

Journal article  |  2018  |  SCIENTIFIC REPORTS

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

Hui-Fern Koay, Nicholas A Gherardin, Anselm Enders, Liyen Loh, Laura K Mackay, Catarina F Almeida, Brendan E Russ, Claudia A Nold-Petry, Marcel F Nold, Sammy Bedoui, Zhenjun Chen, Alexandra J Corbett, Sidonia BG Eckle, Bronwyn Meehan, Yves d'Udekem, Igor E Konstantinov, Martha Lappas, Ligong Liu, Chris C Goodnow, David P Fairlie, et al.

Journal article  |  2016  |  NATURE IMMUNOLOGY

All work and no Id2 makes a dull NKT cell

Daniel G Pellicci, Adam P Uldrich

Journal article  |  2016  |  Immunology & Cell Biology

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens

Jerome Le Nours, T Praveena, Daniel G Pellicci, Nicholas A Gherardin, Fiona J Ross, Ricky T Lim, Gurdyal S Besra, Santosh Keshipeddy, Stewart K Richardson, Amy R Howell, Stephanie Gras, Dale I Godfrey, Jamie Rossjohn, Adam P Uldrich

Journal article  |  2016  |  Nature Communications

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

Nicholas A Gherardin, Andrew N Keller, Rachel E Woolley, Jerome Le Nours, David S Ritchie, Paul J Neeson, Richard W Birkinshaw, Sidonia BG Eckle, John N Waddington, Ligong Liu, David P Fairlie, Adam P Uldrich, Daniel G Pellicci, James McCluskey, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2016  |  Immunity

Human autoreactive T cells recognize CD1b and phospholipids

Ildiko Van Rhijn, Twan van Berlo, Tamara Hilmenyuk, Tan-Yun Cheng, Benjamin J Wolf, Raju VV Tatituri, Adam P Uldrich, Giorgio Napolitani, Vincenzo Cerundolo, John D Altman, Peter Willemsen, Shouxiong Huang, Jamie Rossjohn, Gurdyal S Besra, Michael B Brenner, Dale I Godfrey, D Branch Moody

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

Antigen Specificity of Type I NKT Cells Is Governed by TCR beta-Chain Diversity

Garth Cameron, Daniel G Pellicci, Adam P Uldrich, Gurdyal S Besra, Petr Illarionov, Spencer J Williams, Nicole L La Gruta, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2015  |  JOURNAL OF IMMUNOLOGY

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

Dennis X Beringer, Fleur S Kleijwegt, Florian Wiede, Arno R van der Slik, Khai Lee Loh, Jan Petersen, Nadine L Dudek, Gaby Duinkerken, Sandra Laban, Antoinette Joosten, Julian P Vivian, Zhenjun Chen, Adam P Uldrich, Dale I Godfrey, James McCluskey, David A Price, Kristen J Radford, Anthony W Purcell, Tatjana Nikolic, Hugh H Reid, et al.

Journal article  |  2015  |  Nature Immunology

The burgeoning family of unconventional T cells

Dale I Godfrey, Adam P Uldrich, James McCluskey, Jamie Rossjohn, D Branch Moody

Journal article  |  2015  |  Nature Immunology

Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells

Benjamin J Wolf, Raju VV Tatituri, Catarina F Almeida, Jerome Le Nours, Veemal Bhowruth, Darryl Johnson, Adam P Uldrich, Fong-Fu Hsu, Manfred Brigl, Gurdyal S Besra, Jamie Rossjohn, Dale I Godfrey, Michael B Brenner

Journal article  |  2015  |  JOURNAL OF IMMUNOLOGY

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

Azad Rahimpour, Hui Fern Koay, Anselm Enders, Rhiannon Clanchy, Sidonia BG Eckle, Bronwyn Meehan, Zhenjun Chen, Belinda Whittle, Ligong Liu, David P Fairlie, Chris C Goodnow, James McCluskey, Jamie Rossjohn, Adam P Uldrich, Daniel G Pellicci, Dale I Godfrey

Journal article  |  2015  |  JOURNAL OF EXPERIMENTAL MEDICINE

alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands

Richard W Birkinshaw, Daniel G Pellicci, Tan-Yun Cheng, Andrew N Keller, Maria Sandoval-Romero, Stephanie Gras, Annemieke de Jong, Adam P Uldrich, D Branch Moody, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2015  |  Nature Immunology

CD3(bright) signals on gamma delta T cells identify IL-17A-producing V gamma 6V delta 1( ) T cells

C Paget, MT Chow, NA Gherardin, PA Beavis, AP Uldrich, H Duret, M Hassane, F Souza-Fonseca-Guimaraes, DA Mogilenko, D Staumont-Salle, NK Escalante, GR Hill, P Neeson, DS Ritchie, D Dombrowicz, T Mallevaey, F Trottein, GT Belz, DI Godfrey, MJ Smyth

Journal article  |  2015  |  Immunology & Cell Biology

The molecular bases of delta/alpha beta T cell-mediated antigen recognition

Daniel G Pellicci, Adam P Uldrich, Jerome Le Nours, Fiona Ross, Eric Chabrol, Sidonia BG Eckle, Renate de Boer, Ricky T Lim, Kirsty McPherson, Gurdyal Besra, Amy R Howell, Lorenzo Moretta, James McCluskey, Mirjam HM Heemskerk, Stephanie Gras, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2014  |  JOURNAL OF EXPERIMENTAL MEDICINE

IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival

KE Webster, H-O Kim, K Kyparissoudis, TM Corpuz, GV Pinget, AP Uldrich, R Brink, GT Belz, J-H Cho, DI Godfrey, J Sprent

Journal article  |  2014  |  Mucosal Immunology

CD1d-lipid antigen recognition by the gamma delta TCR

Adam P Uldrich, Jerome Le Nours, Daniel G Pellicci, Nicholas A Gherardin, Kirsty G McPherson, Ricky T Lim, Onisha Patel, Travis Beddoe, Stephanie Gras, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2013  |  Nature Immunology

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

Rangsima Reantragoon, Alexandra J Corbett, Isaac G Sakala, Nicholas A Gherardin, John B Furness, Zhenjun Chen, Sidonia BG Eckle, Adam P Uldrich, Richard W Birkinshaw, Onisha Patel, Lyudmila Kostenko, Bronwyn Meehan, Katherine Kedzierska, Ligong Liu, David P Fairlie, Ted H Hansen, Dale I Godfrey, Jamie Rossjohn, James McCluskey, Lars Kjer-Nielsen

Journal article  |  2013  |  Journal of Experimental Medicine

ZBTB7B (Th-POK) Regulates the Development of IL-17-Producing CD1d-Restricted Mouse NKT Cells

Anselm Enders, Sanda Stankovic, Charis Teh, Adam P Uldrich, Mehmet Yabas, Torsten Juelich, John A Altin, Sandra Frankenreiter, Hannes Bergmann, Carla M Roots, Konstantinos Kyparissoudis, Chris C Goodnow, Dale I Godfrey

Journal article  |  2012  |  Journal of Immunology

Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

Onisha Patel, Daniel G Pellicci, Stephanie Gras, Maria L Sandoval-Romero, Adam P Uldrich, Thierry Mallevaey, Andrew J Clarke, Jerome Le Nours, Alex Theodossis, Susanna L Cardell, Laurent Gapin, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2012  |  NATURE IMMUNOLOGY

NKT cells-an early warning system for HBV infection

Dale I Godfrey, Adam P Uldrich, Alan G Baxter

Journal article  |  2012  |  Nature Medicine

V beta 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen

Onisha Patel, Daniel G Pellicci, Adam P Uldrich, Lucy C Sullivan, Mugdha Bhati, Melissa McKnight, Stewart K Richardson, Amy R Howell, Thierry Mallevaey, Jingjing Zhang, Romain Bedel, Gurdyal S Besra, Andrew G Brooks, Lars Kjer-Nielsen, James McCluskey, Steven A Porcelli, Laurent Gapin, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2011  |  Proceedings of the National Academy of Sciences

Recognition of beta-linked self glycolipids mediated by natural killer T cell antigen receptors

Daniel G Pellicci, Andrew J Clarke, Onisha Patel, Thierry Mallevaey, Travis Beddoe, Jerome Le Nours, Adam P Uldrich, James McCluskey, Gurdyal S Besra, Steven A Porcelli, Laurent Gapin, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2011  |  Nature Immunology

A semi-invariant V(alpha)10( ) T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

Adam P Uldrich, Onisha Patel, Garth Cameron, Daniel G Pellicci, E Bridie Day, Lucy C Sullivan, Konstantinos Kyparissoudis, Lars Kjer-Nielsen, Julian P Vivian, Benjamin Cao, Andrew G Brooks, Spencer J Williams, Petr Illarionov, Gurdyal S Besra, Stephen J Turner, Steven A Porcelli, James McCluskey, Mark J Smyth, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2011  |  Nature Immunology

A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells

Kwok S Wun, Garth Cameron, Onisha Patel, Siew Siew Pang, Daniel G Pellicci, Lucy C Sullivan, Santosh Keshipeddy, Mary H Young, Adam P Uldrich, Meena S Thakur, Stewart K Richardson, Amy R Howell, Petr A Illarionov, Andrew G Brooks, Gurdyal S Besra, James McCluskey, Laurent Gapin, Steven A Porcelli, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2011  |  Immunity

SOCS-1 Binding to Tyrosine 441 of IFN-gamma Receptor Subunit 1 Contributes to the Attenuation of IFN-gamma Signaling In Vivo

Robyn Starr, Martina Fuchsberger, Lei Shong Lau, Adam P Uldrich, Ankita Goradia, Tracy A Willson, Anne M Verhagen, Warren S Alexander, Mark J Smyth

Journal article  |  2009  |  The Journal of Immunology

Antigen challenge inhibits thymic emigration

AP Uldrich, SP Berzins, MA Malin, P Bouillet, A Strasser, MJ Smyth, RL Boyd, DI Godfrey

Journal article  |  2006  |  Journal of Immunology

NKT cell stimulation with glycolipid antigen in vivo: Costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge

AP Uldrich, NY Crowe, K Kyparissoudis, DG Pellicci, YF Zhan, AM Lew, P Bouillet, A Strasser, MJ Smyth, DI Godfrey

Journal article  |  2005  |  Journal of Immunology

Functional analysis of granzyme M and its role in immunity to infection

LI Pao, N Sumaria, JM Kelly, S van Dommelen, E Cretney, ME Wallace, DA Anthony, AP Uldrich, DI Godfrey, JM Papadimitriou, A Mullbacher, MA Degli-Esposti, MJ Smyth

Journal article  |  2005  |  Journal of Immunology

Are we really on the right TRAIL?

E Cretney, AP Uldrich, SP Berzins, A Strasser, DI Godfrey, MJ Smyth

Journal article  |  2005  |  Immunologic Research

Normal thymocyte negative selection in TRAIL-deficient mice

E Cretney, AP Uldrich, SP Berzins, A Strasser, DI Godfrey, MJ Smyth

Journal article  |  2003  |  Journal of Experimental Medicine

Thymic regeneration: teaching an old immune system new tricks

SP Berzins, AP Uldrich, JS Sutherland, J Gill, JFAP Miller, DI Godfrey, RL Boyd

Journal article  |  2002  |  Trends in Molecular Medicine

A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1.1(-) CD4( ) CD1d-dependent precursor stage

DG Pellicci, KJL Hammond, AP Uldrich, AG Baxter, MJ Smyth, DI Godfrey

Journal article  |  2002  |  Journal of Experimental Medicine