Adam Uldrich

A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

Roeland Lameris, Adam Shahine, Daniel G Pellicci, Adam P Uldrich, Stephanie Gras, Jerome Le Nours, Richard WJ Groen, Jana Vree, Scott JJ Reddiex, Sergio M Quinones-Parra, Stewart K Richardson, Amy R Howell, Sonja Zweegman, Dale I Godfrey, Tanja D de Gruijl, Jamie Rossjohn, Hans J van der Vliet

Journal article  |  2020  |  Nature Cancer

Immune recognition of phosphoantigen-butyrophilin molecular complexes by gamma delta T cells

Adam P Uldrich, Marc Rigau, Dale I Godfrey

Journal article  |  2020  |  Immunological Reviews

Gamma-delta (γδ) T cells are an important component of the immune system. They are often enriched in non-lymphoid tissues and exhi..

Butyrophilin molecules govern gamma delta T cell reactivity against phosphoantigens

Marc Rigau, Simone Ostrouska, Tom Fulford, Darryl Neil Johnson, Katherine Woods, Zheng Ruan, Hamish McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Hammet, Anne M Verhagen, Gino Vairo, Eugene Maraskovsky, et al.

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

alpha-Glucuronosyl and alpha-glucosyl diacylglycerides, natural killer T cell-activating lipids from bacteria and fungi

Satvika Burugupalli, Catarina F Almeida, Dylan GM Smith, Sayali Shah, Onisha Patel, Jamie Rossjohn, Adam P Uldrich, Dale I Godfrey, Spencer J Williams

Journal article  |  2020  |  Chemical Science

Microbial α-glycosyl diacylglycerides when presented by the antigen presenting molecule CD1d are recognized by both classical type..

Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells

Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Zheng Ruan, Hamish EG McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Nash, Andrew Hammet, Anne M Verhagen, Gino Vairo, et al.

Journal article  |  2020  |  Science

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..

A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1

Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett, et al.

Journal article  |  2019  |  Science

T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Catarina F Almeida, Srinivasan Sundararaj, Jerome Le Nours, T Praveena, Benjamin Cao, Satvika Burugupalli, Dylan GM Smith, Onisha Patel, Manfred Brigl, Daniel G Pellicci, Spencer J Williams, Adam P Uldrich, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2019  |  Nature Communications

Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an und..

α-Glucuronosyl and α-Glucosyl Diacylglycerides, Natural Killer T Cell-Activating Lipids from Bacteria and Fungi

SATVIKA BURUGUPALLI, CATARINA DOS SANTOS SA E ALMEIDA, Dylan GM Smith, SAYALI SHAH, ONISHA PATEL, Jamie Rossjohn, ADAM ULDRICH, DALE GODFREY, Spencer Williams

Journal article  |  2019

Natural killer T cells express T cell receptors (TCRs) that recognize glycolipid antigens in association with the antigen-presenti..

Diverse MR1-restricted T cells in mice and humans.

Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

Journal article  |  2019  |  Nature Communications

Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..

gamma delta T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis (vol 19, pg 464, 2018)

Ayano C Kohlgruber, Shani T Gal-Oz, Nelson M LaMarche, Moto Shimazaki, Danielle Duquette, Hui-Fern Koay, Hung N Nguyen, Amir I Mina, Tyler Paras, Ali Tavakkoli, Ulrich von Andrian, Adam P Uldrich, Dale I Godfrey, Alexander S Banks, Tal Shay, Michael B Brenner, Lydia Lynch

Journal article  |  2019  |  Nature Immunology