Bridgette Semple

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?

Tamara L Baker, Mujun Sun, Bridgette D Semple, Shiraz Tyebji, Christopher J Tonkin, Richelle Mychasiuk, Sandy R Shultz

Journal article  |  2020  |  Journal of Neuroinflammation

Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is ..

Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model

Akram Zamani, Kim L Powell, Ashleigh May, Bridgette D Semple

Journal article  |  2020  |  Brain Research Bulletin

Quantitative polymerase chain reaction (qPCR) is the gold standard method in targeted analysis of messenger RNA (mRNA) levels in a..

The Impact of Traumatic Injury to the Immature Human Brain: A Scoping Review with Insights from Advanced Structural Neuroimaging.

Akram Zamani, Nicholas P Ryan, David K Wright, Karen Caeyenberghs, Bridgette D Semple

Journal article  |  2020  |  Journal of Neurotrauma

Traumatic brain injury (TBI) during critical periods of early-life brain development can affect the normal formation of brain netw..

Potential Neuroprotective Effect of the HMGB1 Inhibitor Glycyrrhizin in Neurological Disorders.

Yam Nath Paudel, Efthalia Angelopoulou, Bridgette Semple, Christina Piperi, Iekhsan Othman, Mohd Farooq Shaikh

Journal article  |  2020  |  ACS Chemical Neuroscience

Glycyrrhizin (glycyrrhizic acid), a bioactive triterpenoid saponin constituent of Glycyrrhiza glabra, is a traditional medicine po..

Immune Challenges and Seizures: How Do Early Life Insults Influence Epileptogenesis?

Bridgette D Semple, Larissa K Dill, Terence J O'Brien

Journal article  |  2020  |  Frontiers in Pharmacology

The development of epilepsy, a process known as epileptogenesis, often occurs later in life following a prenatal or early postnata..

High mobility group box 1 (HMGB1) as a novel frontier in epileptogenesis: from pathogenesis to therapeutic approaches

Yam Nath Paudel, Bridgette D Semple, Nigel C Jones, Iekhsan Othman, Mohd Farooq Shaikh

Journal article  |  2019  |  Journal of Neurochemistry

Epilepsy is a serious neurological condition exhibiting complex pathology and deserving of more serious attention. More than 30% o..

Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets

Rishabh Sharma, Wai Lam Leung, Akram Zamani, Terence J O'Brien, Pablo M Casillas Espinosa, Bridgette D Semple

Journal article  |  2019  |  Brain Sciences

Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to increased morbidity and mortality for su..

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Kyria M Webster, Sandy R Shultz, Ezgi Ozturk, Larissa K Dill, Mujun Sun, Pablo Casillas-Espinosa, Nigel C Jones, Peter J Crack, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Experimental Neurology

High mobility group box protein-1 (HMGB1) has been implicated as a key mediator of neuroinflammation and neurodegeneration in a ra..

An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats

Wai Lam Leung, Pablo Casillas-Espinosa, Pragati Sharma, Piero Perucca, Kim Powell, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Epilepsia

Aged rats have an altered immune response and worse outcomes after traumatic brain injury

Mujun Sun, Rhys D Brady, Pablo M Casillas-Espinosa, David K Wright, Bridgette D Semple, Hyun Ah Kim, Richelle Mychasiuk, Christopher G Sobey, Terence J O'Brien, Antony Vinh, Stuart J McDonald, Sandy R Shultz

Journal article  |  2019  |  Brain, Behavior, and Immunity

Infections after a traumatic brain injury: The complex interplay between the immune and neurological systems

Rishabh Sharma, Sandy R Shultz, Marcus J Robinson, Antonio Belli, Margaret L Hibbs, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Brain, Behavior, and Immunity

The Clinical Relevance of Behavior Testing in Animal Models of Traumatic Brain Injury

Sandy R Shultz, Stuart J McDonald, Frances Corrigan, Bridgette D Semple, Sabrina Salberg, Akram Zamani, Nigel C Jones, Richelle Mychasiuk

Journal article  |  2019  |  Journal of Neurotrauma

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments.

Maria Cristina Morganti-Kossmann, Bridgette D Semple, Sarah C Hellewell, Nicole Bye, Jenna M Ziebell

Journal article  |  2019  |  Acta Neuropathologica

This review recounts the definitions and research evidence supporting the multifaceted roles of neuroinflammation in the injured b..

Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice

Kyria M Webster, Mujun Sun, Peter J Crack, Terence J O'Brien, Sandy R Shultz, Bridgette D Semple

Journal article  |  2019  |  Journal of Comparative Neurology

Determinants of social behavior deficits and recovery after pediatric traumatic brain injury

Akram Zamani, Richelle Mychasiuk, Bridgette D Semple

Journal article  |  2019  |  Experimental Neurology

Modelling traumatic brain injury and posttraumatic epilepsy in rodents

Rhys D Brady, Pablo M Casillas-Espinosa, Denes V Agoston, Edward H Bertram, Alaa Kamnaksh, Bridgette D Semple, Sandy R Shultz

Journal article  |  2019  |  Neurobiology of Disease

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

Bridgette D Semple, Akram Zamani, Genevieve Rayner, Sandy R Shultz, Nigel C Jones

Journal article  |  2019  |  Neurobiology of Disease

In search of antiepileptogenic treatments for post-traumatic epilepsy

Patricia G Saletti, Idrish Ali, Pablo M Casillas-Espinosa, Bridgette D Semple, Christos Panagiotis Lisgaras, Solomon L Moshe, Aristea S Galanopoulou

Journal article  |  2019  |  Neurobiology of Disease

A Concomitant Muscle Injury Does Not Worsen Traumatic Brain Injury Outcomes in Mice

Mujun Sun, Rhys D Brady, Chris van der Poel, Danielle Apted, Bridgette D Semple, Jarrod E Church, Terence J O'Brien, Stuart J McDonald, Sandy R Shultz

Journal article  |  2018  |  Frontiers in Neurology

Mild Traumatic Brain Injury in Adolescent Mice Alters Skull Bone Properties to Influence a Subsequent Brain Impact at Adulthood: A Pilot Study

Thomas J McColl, Rhys D Brady, Sandy R Shultz, Lauren Lovick, Kyria M Webster, Mujun Sun, Stuart J McDonald, Terence J O'Brien, Bridgette D Semple

Journal article  |  2018  |  Frontiers in Neurology

Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion

Meaghan Clough, Steven Mutimer, David K Wright, Adrian Tsang, Daniel M Costello, Andrew J Gardner, Peter Stanwell, Richelle Mychasiuk, Mujun Sun, Rhys D Brady, Stuart J McDonald, Kyria M Webster, Maddison R Johnstone, Bridgette D Semple, Denes V Agoston, Owen B White, Richard Frayne, Joanne Fielding, Terence J O'Brien, Sandy R Shultz

Journal article  |  2018  |  Journal of Neurotrauma

The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury

Thomas M Woodcock, Tony Frugier, Thanh Nguyen Tan, Bridgette Deanne Semple, Nicole Bye, Matteo Massara, Benedetta Savino, Roberta Besio, Cristina Sobacchi, Massimo Locati, Maria Cristina Morganti-Kossmann

Journal article  |  2017  |  PLOS ONE

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Mujun Sun, Rhys D Brady, David K Wright, Hyun Ah Kim, Shenpeng R Zhang, Christopher G Sobey, Maddison R Johnstone, Terence J O'Brien, Bridgette D Semple, Stuart J McDonald, Sandy R Shultz

Journal article  |  2017  |  Brain, Behavior, and Immunity

Interleukin-1 Receptor in Seizure Susceptibility after Traumatic Injury to the Pediatric Brain

Bridgette D Semple, Terence J O'Brien, Kayleen Gimlin, David K Wright, Shi Eun Kim, Pablo M Casillas-Espinosa, Kyria M Webster, Steven Petrou, Linda J Noble-Haeusslein

Journal article  |  2017  |  The Journal of Neuroscience

Sex-dependent changes in neuronal morphology and psychosocial behaviors after pediatric brain injury

Bridgette D Semple, Shilpi Dixit, Sandy R Shultz, Wah Chin Boon, Terence J O'Brien

Journal article  |  2017  |  Behavioural Brain Research

Inflammation in epileptogenesis after traumatic brain injury

Kyria M Webster, Mujun Sun, Peter Crack, Terence J O'Brien, Sandy R Shultz, Bridgette D Semple

Journal article  |  2017  |  Journal of Neuroinflammation

Challenging the dogma that 'rest is best' after concussion (Commentary on Mychasiuk et al.).

Bridgette D Semple

Journal article  |  2016  |  European Journal of Neuroscience

Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury

David K Wright, Jack Trezise, Alaa Kamnaksh, Ramsey Bekdash, Leigh A Johnston, Roger Ordidge, Bridgette D Semple, Andrew J Gardner, Peter Stanwell, Terence J O'Brien, Denes V Agoston, Sandy R Shultz

Journal article  |  2016  |  SCIENTIFIC REPORTS

Therapies negating neuroinflammation after brain trauma.

Sarah Hellewell, Bridgette D Semple, Maria Cristina Morganti-Kossmann

Journal article  |  2016  |  Brain Research

Traumatic brain injury (TBI) elicits a complex secondary injury response, with neuroinflammation as a crucial central component. L..

Social dysfunction after pediatric traumatic brain injury: A translational perspective

Nicholas P Ryan, Cathy Catroppa, Celia Godfrey, Linda J Noble-Haeusslein, Sandy R Shultz, Terence J O'Brien, Vicki Anderson, Bridgette D Semple

Journal article  |  2016  |  Neuroscience & Biobehavioral Reviews

Behavioral testing after experimental traumatic brain injury

BD Semple, LJ Noble-Haeusslein

Book Chapter  |  2016

Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice.

Nikita M Bajwa, Shina Halavi, Mary Hamer, Bridgette D Semple, Linda J Noble-Haeusslein, Mohsen Baghchechi, Alex Hiroto, Richard E Hartman, André Obenaus

Journal article  |  2016  |  PLOS ONE

Mild traumatic brain injuries can lead to long-lasting cognitive and motor deficits, increasing the risk of future behavioral, neu..

Pediatric Rodent Models of Traumatic Brain Injury.

Bridgette D Semple, Jaclyn Carlson, Linda J Noble-Haeusslein

Journal article  |  2016  |  Methods in molecular biology (Clifton, N.J.)

Due to a high incidence of traumatic brain injury (TBI) in children and adolescents, age-specific studies are necessary to fully u..

Long-Term Anesthetic-Dependent Hypoactivity after Repetitive Mild Traumatic Brain Injuries in Adolescent Mice.

Bridgette D Semple, Raha Sadjadi, Jaclyn Carlson, Yiran Chen, Duan Xu, Donna M Ferriero, Linda J Noble-Haeusslein

Journal article  |  2016  |  Developmental Neuroscience

Recent evidence supports the hypothesis that repetitive mild traumatic brain injuries (rmTBIs) culminate in neurological impairmen..

Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

Kyria M Webster, David K Wright, Mujun Sun, Bridgette D Semple, Ezgi Ozturk, Donald G Stein, Terence J O'Brien, Sandy R Shultz

Journal article  |  2015  |  JOURNAL OF NEUROINFLAMMATION

Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse

Bridgette D Semple, Linda J Noble-Haeusslein, Major Gooyit, Kayleen G Tercovich, Zhihong Peng, Trung T Nguyen, Valerie A Schroeder, Mark A Suckow, Mayland Chang, Jacob Raber, Alpa Trivedi

Journal article  |  2015  |  PLOS ONE

Found in translation: Understanding the biology and behavior of experimental traumatic brain injury.

Corina O Bondi, Bridgette D Semple, Linda J Noble-Haeusslein, Nicole D Osier, Shaun W Carlson, C Edward Dixon, Christopher C Giza, Anthony E Kline

Journal article  |  2015  |  Neuroscience & Biobehavioral Reviews

The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled "Traumatic brain injury..

Repetitive concussions in adolescent athletes - translating clinical and experimental research into perspectives on rehabilitation strategies

Bridgette D Semple, Sangmi Lee, Raha Sadjadi, Nora Fritz, Jaclyn Carlson, Carrie Griep, Vanessa Ho, Patrice Jang, Annick Lamb, Beth Popolizio, Sonia Saini, Jeffrey J Bazarian, Mayumi L Prins, Donna M Ferriero, D Michele Basso, Linda J Noble-Haeusslein

Journal article  |  2015  |  Frontiers in Neurology

Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain

Bridgette D Semple, Alpa Trivedi, Kayleen Gimlin, Linda J Noble-Haeusslein

Journal article  |  2015  |  Neurobiology of Disease

Early preservation of mitochondrial bioenergetics supports both structural and functional recovery after neurotrauma.

Bridgette D Semple

Journal article  |  2014  |  Experimental Neurology

N-acetylcysteine, a precursor to the potent antioxidant glutathione, has been investigated as a potential therapeutic agent for se..

Sociosexual and Communication Deficits after Traumatic Injury to the Developing Murine Brain

Bridgette D Semple, Linda J Noble-Haeusslein, Yong Jun Kwon, Pingdewinde N Sam, A Matt Gibson, Sarah Grissom, Sienna Brown, Zahra Adahman, Christopher A Hollingsworth, Alexander Kwakye, Kayleen Gimlin, Elisabeth A Wilde, Gerri Hanten, Harvey S Levin, A Katrin Schenk

Journal article  |  2014  |  PLOS ONE

Granulocyte-Macrophage Colony-Stimulating Factor Is Neuroprotective in Experimental Traumatic Brain Injury

Sandy R Shultz, Xin L Tan, David K Wright, Shijie J Liu, Bridgette D Semple, Leigh Johnston, Nigel C Jones, Andrew D Cook, John A Hamilton, Terence J O'Brien

Journal article  |  2014  |  Journal of Neurotrauma

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species.

Bridgette D Semple, Klas Blomgren, Kayleen Gimlin, Donna M Ferriero, Linda J Noble-Haeusslein

Journal article  |  2013  |  Progress in Neurobiology

Hypoxic-ischemic and traumatic brain injuries are leading causes of long-term mortality and disability in infants and children. Al..

Traumatic Injury to the Immature Frontal Lobe: A New Murine Model of Long-Term Motor Impairment in the Absence of Psychosocial or Cognitive Deficits

Chien-Yi Chen, Linda J Noble-Haeusslein, Donna Ferriero, Bridgette D Semple

Journal article  |  2013  |  Developmental Neuroscience

Deficits in social behavior emerge during development after pediatric traumatic brain injury in mice.

Bridgette D Semple, Sandra A Canchola, Linda J Noble-Haeusslein

Journal article  |  2012  |  Journal of Neurotrauma

The pediatric brain may be particularly vulnerable to social deficits after traumatic brain injury (TBI) due to the protracted nat..

Attenuation of microglial activation with minocycline is not associated with changes in neurogenesis after focal traumatic brain injury in adult mice.

Si Yun Ng, Bridgette D Semple, M Cristina Morganti-Kossmann, Nicole Bye

Journal article  |  2012  |  Journal of Neurotrauma

Neurogenesis is stimulated following injury to the adult brain and could potentially contribute to tissue repair. However, evidenc..

Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury.

Jenna M Ziebell, Nicole Bye, Bridgette D Semple, Thomas Kossmann, Maria Cristina Morganti-Kossmann

Journal article  |  2011  |  Brain Research

Progressive neurodegeneration following traumatic brain injury (TBI) involves the Fas and TNF-receptor1 protein systems which have..

Broad-spectrum neuroprotection against traumatic brain injury by agonism of peroxisome proliferator-activated receptors.

Bridgette D Semple, Linda J Noble-Haeusslein

Journal article  |  2011  |  Experimental Neurology

In a recent issue of Experimental Neurology, Sauerbeck and colleagues demonstrated that treatment with the peroxisome proliferator..

Modulation of Immune Response by Head Injury

C Morganti-Kossmann, B Semple, J Ziebell, E Yan, N Bye, T Kossmann

Book Chapter  |  2010

Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury.

Bridgette D Semple, Nicole Bye, Jenna M Ziebell, M Cristina Morganti-Kossmann

Journal article  |  2010  |  Neurobiology of Disease

The contribution of infiltrated neutrophils to secondary damage following traumatic brain injury remains controversial. Chemokines..

CCL2 modulates cytokine production in cultured mouse astrocytes

Bridgette D Semple, Tony Frugier, M Cristina Morganti-Kossmann

Journal article  |  2010  |  Journal of neuroinflammation

Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice.

Bridgette D Semple, Nicole Bye, Mario Rancan, Jenna M Ziebell, M Cristina Morganti-Kossmann

Journal article  |  2010  |  Journal of Cerebral Blood Flow & Metabolism

Cerebral inflammation involves molecular cascades contributing to progressive damage after traumatic brain injury (TBI). The chemo..

Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks.

Bridgette D Semple, Thomas Kossmann, Maria Cristina Morganti-Kossmann

Journal article  |  2010  |  Journal of Cerebral Blood Flow & Metabolism

Chemokines and their receptors have crucial roles in the trafficking of leukocytes, and are of particular interest in the context ..

MCP-1 KNOCKOUT MICE EXHIBIT IMPROVED NEUROLOGICAL OUTCOME, ALTERED CYTOKINE PRODUCTION, REDUCED MACROPHAGE INFILTRATION AND REDUCED LESION VOLUME FOLLOWING FOCAL TRAUMATIC BRAIN INJURY

Bridgette Semple, Nicole Bye, Nakisa Malakooti, Jenna Ziebell, Cristina Morganti-Kossmann

Conference Proceedings  |  2009  |  JOURNAL OF NEUROTRAUMA

LACK OF FUNCTIONAL FAS IN TBI MICE ATTENUATES NEUROLOGICAL DEFICIT, CELL DEATH AND LESION VOLUME AND IS ASSOCIATED WITH ALTERED CYTOKINE

Jenna M Ziebell, Nicole Bye, Bridgette Semple, Thomas Kossmann, Cristina M Morganti-Kossmann

Conference Proceedings  |  2009  |  JOURNAL OF NEUROTRAUMA

DEFICIENCY OF THE CHEMOKINE RECEPTOR CXCR2 ATTENUATES NEUTROPHIL INFILTRATION BUT HAS NO EFFECT ON NEUROLOGICAL RECOVERY FOLLOWING CLOSED HEAD INJURY

Cristina Morganti-Kossmann, Bridgette Semple, Nicole Bye, Nakisa Malakooti, Jenna Ziebell

Conference Proceedings  |  2009  |  JOURNAL OF NEUROTRAUMA