Bridgette Semple

Pediatric traumatic brain injury and a subsequent transient immune challenge independently influenced chronic outcomes in male mice

R Sharma, PM Casillas-Espinosa, LK Dill, SSJ Rewell, MR Hudson, TJ O'Brien, SR Shultz, BD Semple

Journal article  |  2022  |  Brain, Behavior, and Immunity

Traumatic brain injury (TBI) is a major contributor to death and disability worldwide. Children are at particularly high risk of b..

Incidence of post-traumatic epilepsy following paediatric traumatic brain injury: protocol for systematic review and meta-analysis

Frederick P Mariajoseph, Sarah S Rewell, Terence J O'Brien, Bridgette D Semple, Ana Antonic-Baker

Journal article  |  2021  |  BMJ OPEN

INTRODUCTION: Post-traumatic epilepsy (PTE) is a recognised complication of traumatic brain injury (TBI), and is associated with h..

Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury (vol 339, 113652, 2021)

Jessica L Fletcher, Larissa K Dill, Rhiannon J Wood, Sharon Wang, Kate Robertson, Simon S Murray, Akram Zamani, Bridgette D Semple

Journal article  |  2021  |  EXPERIMENTAL NEUROLOGY

The authors regret the inclusion of a calculation error, in results section 3.6 (Fig. 5a and b), regarding cortical and hippocampa..

Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury

Jessica L Fletcher, Larissa K Dill, Rhiannon J Wood, Sharon Wang, Kate Robertson, Simon S Murray, Akram Zamani, Bridgette D Semple

Journal article  |  2021  |  EXPERIMENTAL NEUROLOGY

Young children have a high risk of sustaining a traumatic brain injury (TBI), which can have debilitating life-long consequences. ..

A systemic immune challenge to model hospital-acquired infections independently regulates immune responses after pediatric traumatic brain injury

Rishabh Sharma, Akram Zamani, Larissa K Dill, Mujun Sun, Erskine Chu, Marcus J Robinson, Terence J O'Brien, Sandy R Shultz, Bridgette D Semple

Journal article  |  2021  |  JOURNAL OF NEUROINFLAMMATION

BACKGROUND: Traumatic brain injury (TBI) is a major cause of disability in young children, yet the factors contributing to poor ou..

White matter changes following experimental pediatric traumatic brain injury: an advanced diffusion-weighted imaging investigation

Akram Zamani, Terence J O'Brien, Jeff Kershaw, Leigh A Johnston, Bridgette D Semple, David K Wright

Journal article  |  2021  |  Brain Imaging and Behavior: an international journal

Pediatric traumatic brain injury (pTBI) is a major community health concern. Due to ongoing maturation, injury to the brain at a y..

A Pro-social Pill? The Potential of Pharmacological Treatments to Improve Social Outcomes After Pediatric Traumatic Brain Injury.

Bridgette D Semple, Ramesh Raghupathi

Journal article  |  2021  |  Front Neurol

Traumatic brain injury (TBI) is a leading cause of injury-induced disability in young children worldwide, and social behavior impa..

Catastrophic consequences: can the feline parasiteToxoplasma gondiiprompt the purrfect neuroinflammatory storm following traumatic brain injury?

Tamara L Baker, Mujun Sun, Bridgette D Semple, Shiraz Tyebji, Christopher J Tonkin, Richelle Mychasiuk, Sandy R Shultz

Journal article  |  2020  |  JOURNAL OF NEUROINFLAMMATION

Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is ..

Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model

Akram Zamani, Kim L Powell, Ashleigh May, Bridgette D Semple

Journal article  |  2020  |  BRAIN RESEARCH BULLETIN

Quantitative polymerase chain reaction (qPCR) is the gold standard method in targeted analysis of messenger RNA (mRNA) levels in a..

The Impact of Traumatic Injury to the Immature Human Brain: A Scoping Review with Insights from Advanced Structural Neuroimaging

Akram Zamani, Nicholas P Ryan, David K Wright, Karen Caeyenberghs, Bridgette D Semple

Journal article  |  2020  |  JOURNAL OF NEUROTRAUMA

Traumatic brain injury (TBI) during critical periods of early-life brain development can affect the normal formation of brain netw..