Bridgette Semple

White matter changes following experimental pediatric traumatic brain injury: an advanced diffusion-weighted imaging investigation

Akram Zamani, Terence J O'Brien, Jeff Kershaw, Leigh A Johnston, Bridgette D Semple, David K Wright

Journal article  |  2021  |  Brain Imaging and Behavior: an international journal

Pediatric traumatic brain injury (pTBI) is a major community health concern. Due to ongoing maturation, injury to the brain at a y..

Catastrophic consequences: can the feline parasiteToxoplasma gondiiprompt the purrfect neuroinflammatory storm following traumatic brain injury?

Tamara L Baker, Mujun Sun, Bridgette D Semple, Shiraz Tyebji, Christopher J Tonkin, Richelle Mychasiuk, Sandy R Shultz

Journal article  |  2020  |  Journal of Neuroinflammation

Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is ..

Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model

Akram Zamani, Kim L Powell, Ashleigh May, Bridgette D Semple

Journal article  |  2020  |  Brain Research Bulletin

Quantitative polymerase chain reaction (qPCR) is the gold standard method in targeted analysis of messenger RNA (mRNA) levels in a..

The Impact of Traumatic Injury to the Immature Human Brain: A Scoping Review with Insights from Advanced Structural Neuroimaging

Akram Zamani, Nicholas P Ryan, David K Wright, Karen Caeyenberghs, Bridgette D Semple

Journal article  |  2020  |  Journal of Neurotrauma

Traumatic brain injury (TBI) during critical periods of early-life brain development can affect the normal formation of brain netw..

Potential Neuroprotective Effect of the HMGB1 Inhibitor Glycyrrhizin in Neurological Disorders.

Yam Nath Paudel, Efthalia Angelopoulou, Bridgette Semple, Christina Piperi, Iekhsan Othman, Mohd Farooq Shaikh

Journal article  |  2020  |  ACS Chemical Neuroscience

Glycyrrhizin (glycyrrhizic acid), a bioactive triterpenoid saponin constituent of Glycyrrhiza glabra, is a traditional medicine po..

Immune Challenges and Seizures: How Do Early Life Insults Influence Epileptogenesis?

Bridgette D Semple, Larissa K Dill, Terence J O'Brien

Journal article  |  2020  |  Frontiers in Pharmacology

The development of epilepsy, a process known as epileptogenesis, often occurs later in life following a prenatal or early postnata..

High mobility group box 1 (HMGB1) as a novel frontier in epileptogenesis: from pathogenesis to therapeutic approaches

Yam Nath Paudel, Bridgette D Semple, Nigel C Jones, Iekhsan Othman, Mohd Farooq Shaikh

Journal article  |  2019  |  Journal of Neurochemistry

Epilepsy is a serious neurological condition exhibiting complex pathology and deserving of more serious attention. More than 30% o..

Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets

Rishabh Sharma, Wai Lam Leung, Akram Zamani, Terence J O'Brien, Pablo M Casillas Espinosa, Bridgette D Semple

Journal article  |  2019  |  Brain Sciences

Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to increased morbidity and mortality for su..

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Kyria M Webster, Sandy R Shultz, Ezgi Ozturk, Larissa K Dill, Mujun Sun, Pablo Casillas-Espinosa, Nigel C Jones, Peter J Crack, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Experimental Neurology

High mobility group box protein-1 (HMGB1) has been implicated as a key mediator of neuroinflammation and neurodegeneration in a ra..

An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats

Wai Lam Leung, Pablo Casillas-Espinosa, Pragati Sharma, Piero Perucca, Kim Powell, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Epilepsia