Andrew Webb

A de novo MS1 feature detector for the Bruker timsTOF Pro

Daryl Wilding-McBride, Andrew I Webb

Journal article  |  2022  |  PLOS ONE

Identification of peptides by analysis of data acquired by the two established methods for bottom-up proteomics, DDA and DIA, reli..

New participants and pathways in immune receptor trafficking

Justine Mintern, Haiyin Liu, Andrew Webb, Angus Johnston, Jose Villadangos

Journal article  |  2022  |  Molecular Immunology

Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death

Lin Liu, Jarrod J Sandow, Deena M Leslie Pedrioli, Andre L Samson, Natasha Silke, Tobias Kratina, Rebecca L Ambrose, Marcel Doerflinger, Zhaoqing Hu, Emma Morrish, Diep Chau, Andrew J Kueh, Cheree Fitzibbon, Marc Pellegrini, Jaclyn S Pearson, Michael O Hottiger, Andrew Webb, Najoua Lalaoui, John Silke

Journal article  |  2022  |  SCIENCE ADVANCES

Tumor necrosis factor (TNF) is a key component of the innate immune response. Upon binding to its receptor, TNFR1, it promotes pro..

SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia

Lauren M Brown, Soroor Hediyeh-Zadeh, Teresa Sadras, Hannah Huckstep, Jarrod J Sandow, Ray C Bartolo, Hansen J Kosasih, Nadia M Davidson, Breon Schmidt, Stefan Bjelosevic, Ricky Johnstone, Andrew Webb, Seong L Khaw, Alicia Oshlack, Melissa J Davis, Paul G Ekert

Journal article  |  2022  |  BLOOD ADVANCES

Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL characterized by a gene expres..

Combining deep learning and 3D contrast source inversion in MR-based electrical properties tomography.

Reijer Leijsen, Cornelis van den Berg, Andrew Webb, Rob Remis, Stefano Mandija

Journal article  |  2022  |  NMR Biomed

Magnetic resonance electrical properties tomography (MR-EPT) is a technique used to estimate the conductivity and permittivity of ..

K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis

Ammara Usman Farooq, Kelly Gembus, Jarrod J Sandow, Andrew Webb, Suresh Mathivanan, Jantina A Manning, Sonia S Shah, Natalie J Foot, Sharad Kumar

Journal article  |  2022  |  JOURNAL OF EXTRACELLULAR VESICLES

Extracellular vesicles (EVs) are important mediators of intercellular communication. However, EV biogenesis remains poorly underst..

Simplifying MS1 and MS2 spectra to achieve lower mass error, more dynamic range, and higher peptide identification confidence on the Bruker timsTOF Pro.

Daryl Wilding-McBride, Laura F Dagley, Sukhdeep K Spall, Giuseppe Infusini, Andrew I Webb

Journal article  |  2022  |  PLoS One

For bottom-up proteomic analysis, the goal of analytical pipelines that process the raw output of mass spectrometers is to detect,..

Oligomerization-driven MLKL ubiquitylation antagonizes necroptosis

Zikou Liu, Laura F Dagley, Kristy Shield-Artin, Samuel N Young, Aleksandra Bankovacki, Xiangyi Wang, Michelle Tang, Jason Howitt, Che A Stafford, Ueli Nachbur, Cheree Fitzgibbon, Sarah E Garnish, Andrew Webb, David Komander, James M Murphy, Joanne M Hildebrand, John Silke

Journal article  |  2021  |  EMBO JOURNAL

Mixed lineage kinase domain-like (MLKL) is the executioner in the caspase-independent form of programmed cell death called necropt..

Mass Dynamics 1.0: A Streamlined, Web-Based Environment for Analyzing, Sharing, and Integrating Label-Free Data

Joseph Bloom, Aaron Triantafyllidis, Anna Quaglieri, Paula Burton Ngov, Giuseppe Infusini, Andrew Webb

Journal article  |  2021  |  JOURNAL OF PROTEOME RESEARCH

Label-free quantification (LFQ) of shotgun proteomics data is a popular and robust method for the characterization of relative pro..

Dynamic reconfiguration of pro-apoptotic BAK on membranes

Jarrod J Sandow, Iris Kl Tan, Alan S Huang, Shashank Masaldan, Jonathan P Bernardini, Ahmad Z Wardak, Richard W Birkinshaw, Robert L Ninnis, Ziyan Liu, Destiny Dalseno, Daisy Lio, Giuseppi Infusini, Peter E Czabotar, Andrew Webb, Grant Dewson

Journal article  |  2021  |  EMBO JOURNAL

BAK and BAX, the effectors of intrinsic apoptosis, each undergo major reconfiguration to an activated conformer that self-associat..