Elizabeth Christie

The evolutionary history of 2,658 cancers

Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C Dentro, Santiago Gonzalez, Daniel Rosebrock, Thomas J Mitchell, Yulia Rubanova, Pavana Anur, Kaixian Yu, Maxime Tarabichi, Amit Deshwar, Jeff Wintersinger, Kortine Kleinheinz, Ignacio Vazquez-Garcia, Kerstin Haase, Lara Jerman, Subhajit Sengupta, Geoff Macintyre, Salem Malikic, et al.

Journal article  |  2020  |  Nature

Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this proce..

Pan-cancer analysis of whole genomes

Peter J Campbell, Gad Getz, Jan O Korbel, Joshua M Stuart, Jennifer L Jennings, Lincoln D Stein, Marc D Perry, Hardeep K Nahal-Bose, BF Francis Ouellette, Constance H Li, Esther Rheinbay, G Petur Nielsen, Dennis C Sgroi, Chin-Lee Wu, William C Faquin, Vikram Deshpande, Paul C Boutros, Alexander J Lazar, Katherine A Hoadley, David N Louis, et al.

Journal article  |  2020  |  Nature

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this v..

Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.

Yulia Rubanova, Ruian Shi, Caitlin F Harrigan, Roujia Li, Jeff Wintersinger, Nil Sahin, Amit Deshwar, undefined PCAWG Evolution and Heterogeneity Working Group, Quaid Morris, undefined PCAWG Consortium

Journal article  |  2020  |  Nature Communications

The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures tha..

Inferring structural variant cancer cell fraction.

Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, undefined PCAWG Evolution and Heterogeneity Working Group, Niall M Corcoran, Tony Papenfuss, Christopher M Hovens, Florian Markowetz, Geoff Macintyre, undefined PCAWG Consortium

Journal article  |  2020  |  Nature Communications

We present SVclone, a computational method for inferring the cancer cell fraction of structural variant (SV) breakpoints from whol..

Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

Elizabeth H Stover, Maria B Baco, Ofir Cohen, Yvonne Y Li, Elizabeth L Christie, Mukta Bagul, Amy Goodale, Yenarae Lee, Sasha Pantel, Matthew G Rees, Guo Wei, Adam G Presser, Maya K Gelbard, Weiqun Zhang, Ioannis K Zervantonakis, Patrick D Bhola, Jeremy Ryan, Jennifer L Guerriero, Joan Montero, Felice J Liang, et al.

Journal article  |  2019  |  Molecular Cancer Research

High-grade serous ovarian cancer (HGSOC) is often sensitive to initial treatment with platinum and taxane combination chemotherapy..

POOLED GENOMIC SCREENS IDENTIFY ANTI-APOPTOTIC GENES AS MEDIATORS OF CHEMOTHERAPY RESISTANCE IN OVARIAN CANCER

Elizabeth H Stover, Maria B Baco, Ofir Cohen, Yvonne Li, Elizabeth Christie, Mukta Bagul, Amy Goodale, Yenarae Lee, Sasha Pantel, Matthew Rees, Guo Wei, Adam Presser, Ioannis Zervantonakis, Patrick Bhola, Jeremy Ryan, Jennifer Guerriero, Felice Liang, Andrew Cherniack, Federica Piccioni, Ursula A Matulonis, et al.

Conference Proceedings  |  2019  |  CLINICAL CANCER RESEARCH

Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer

Elizabeth L Christie, Swetansu Pattnaik, Jessica Beach, Anthony Copeland, Nineveh Rashoo, Sian Fereday, Joy Hendley, Kathryn Alsop, Samuel L Brady, Greg Lamb, Ahwan Pandey, Anna deFazio, Heather Thorne, Andrea Bild, David DL Bowtell

Journal article  |  2019  |  Nature Communications

Ovarian Carcinoma-Associated Mesenchymal Stem Cells Arise from Tissue-Specific Normal Stroma

Lan G Coffman, Alexander T Pearson, Leonard G Frisbie, Zachary Freeman, Elizabeth Christie, David D Bowtell, Ronald J Buckanovich

Journal article  |  2019  |  STEM CELLS

Mechanisms of Drug Resistance in High-Grade Serous Ovarian Cancer

Alison E Freimund, Jessica A Beach, Elizabeth L Christie, David DL Bowtell

Journal article  |  2018  |  Hematology/Oncology Clinics of North America

Acquired chemotherapy resistance in high-grade serous ovarian cancer patients.

Elizabeth L Christie, Jessica Beach, Dariush Etemadmoghadam, Dale Garsed, Ann-Marie Patch, Sian Fereday, Swetansu Pattnaik, Samuel Brady, Andrea Bild, David DL Bowtell

Conference Proceedings  |  2018  |  CLINICAL CANCER RESEARCH

Characterizing recurrent high-grade serous ovarian cancer through wholegenome sequencing

Elizabeth L Christie, Swetansu Pattnaik, Sian Fereday, Heather Thorne, Andrea Bild, David D Bowtell

Conference Proceedings  |  2018  |  Molecular and Cellular Biology / Genetics

Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer

Dale W Garsed, Kathryn Alsop, Sian Fereday, Catherine Emmanuel, Catherine J Kennedy, Dariush Etemadmoghadam, Bo Gao, Val Gebski, Valerie Gares, Elizabeth L Christie, Maartje CA Wouters, Katy Milne, Joshy George, Ann-Marie Patch, Jason Li, Gisela Mir Arnau, Timothy Semple, Sreeja R Gadipally, Yoke-Eng Chiew, Joy Hendley, et al.

Journal article  |  2018  |  Clinical Cancer Research

Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

Timothy O'Donnell, Elizabeth L Christie, Arun Ahuja, Jacqueline Buros, B Arman Aksoy, David DL Bowtell, Alexandra Snyder, Jeff Hammerbacher

Journal article  |  2018  |  BMC Cancer

Acquired chemotherapy resistance in ovarian cancer

EL Christie, DDL Bowtell

Journal article  |  2017  |  Annals of Oncology

EIF1AX and NRAS Mutations Co-occur and Cooperate in Low-Grade Serous Ovarian Carcinomas

Dariush Etemadmoghadam, Walid J Azar, Ying Lei, Tania Moujaber, Dale W Garsed, Catherine J Kennedy, Sian Fereday, Chris Mitchell, Yoke-Eng Chiew, Joy Hendley, Raghwa Sharma, Paul R Harnett, Jason Li, Elizabeth L Christie, Ann-Marie Patch, Joshy George, George Au-Yeung, Gisela Mir Arnau, Timothy P Holloway, Timothy Semple, et al.

Journal article  |  2017  |  Cancer Research

Reversion of BRCA1/2 Germline Mutations Detected in Circulating Tumor DNA From Patients With High-Grade Serous Ovarian Cancer

Elizabeth L Christie, Sian Fereday, Ken Doig, Swetansu Pattnaik, Sarah-Jane Dawson, David DL Bowtell

Journal article  |  2017  |  Journal of Clinical Oncology

Blood Worth Bottling: Circulating Tumor DNA as a Cancer Biomarker

Elizabeth L Christie, Sarah-Jane Dawson, David DL Bowtell

Journal article  |  2016  |  Cancer Research

A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff, Elizabeth Christie, Odette Spruyt, Scott Williams, Orla McNally, Linda Mileshkin, Sumitra Ananda, Julene Hallo, Sherene Loi, Clare Scott, Peter Savas, Lisa Devereux, Patricia O'Brien, Sameera Gunawardena, Clare Hampson, Kate Strachan, et al.

Journal article  |  2016  |  Nature Biotechnology

Whole-genome characterization of chemoresistant ovarian cancer

Ann-Marie Patch, Elizabeth L Christie, Dariush Etemadmoghadam, Dale W Garsed, Joshy George, Sian Fereday, Katia Nones, Prue Cowin, Kathryn Alsop, Peter J Bailey, Karin S Kassahn, Felicity Newell, Michael CJ Quinn, Stephen Kazakoff, Kelly Quek, Charlotte Wilhelm-Benartzi, Ed Curry, Huei San Leong, Anne Hamilton, Linda Mileshkin, et al.

Journal article  |  2015  |  Nature

LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

Prue A Cowin, Joshy George, Sian Fereday, Elizabeth Loehrer, Peter Van Loo, Carleen Cullinane, Dariush Etemadmoghadam, Sarah Ftouni, Laura Galletta, Michael S Anglesio, Joy Hendley, Leanne Bowes, Karen E Sheppard, Elizabeth L Christie, Richard B Pearson, Paul R Harnett, Viola Heinzelmann-Schwarz, Michael Friedlander, Orla McNally, Michael Quinn, et al.

Journal article  |  2012  |  CANCER RESEARCH