Elizabeth Christie

Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models

Emma Morrish, Anthony Copeland, Donia M Moujalled, Jason A Powell, Natasha Silke, Ann Lin, Kate E Jarman, Jarrod J Sandow, Gregor Ebert, Liana Mackiewicz, Jessica A Beach, Elizabeth L Christie, Alexander C Lewis, Giovanna Pomilio, Karla C Fischer, Laura MacPherson, David DL Bowtell, Andrew Webb, Marc Pellegrini, Mark A Dawson, et al.

Journal article  |  2020  |  Blood Advances

The specific targeting of inhibitor of apoptosis (IAP) proteins by Smac-mimetic (SM) drugs, such as birinapant, has been tested in..

Sex differences in oncogenic mutational processes.

Constance H Li, Stephenie D Prokopec, Ren X Sun, Fouad Yousif, Nathaniel Schmitz, undefined PCAWG Tumour Subtypes and Clinical Translation, Paul C Boutros, undefined PCAWG Consortium

Journal article  |  2020  |  Nature Communications

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside t..

Drug resistance in end-stage high-grade serous ovarian cancer.

Elizabeth L Christie, Kathryn Alsop, George Au-Yeung, Ahwan Pandey, David DL Bowtell

Conference Proceedings  |  2020  |  CLINICAL CANCER RESEARCH

ROR1 is associated with ovarian cancer progression and chemoresistance.

Dongli Liu, Miya John, Claire E Henry, Elizabeth L Christie, David DL Bowtell, Kristina Tang, Viola Heinzelmann-Schwarz, Catherine Kennedy, Jessica Boros, Anna DeFazio, Caroline E Ford

Conference Proceedings  |  2020  |  CLINICAL CANCER RESEARCH

Phenotypic and genomic characterization of intratumoral heterogeneity in high-grade serous ovarian cancer.

Paula Cunnea, Ed Curry, Katherine Nixon, Ratri Wulandari, Kerstin Thol, Chun Hei Kwok, Jennifer Ploski, Iain McNeish, Elizabeth Christie, David Bowtell, Christina Fotopoulou

Conference Proceedings  |  2020  |  CLINICAL CANCER RESEARCH

Spatial characterization of drug resistance in ovarian cancer.

Kathleen I Pishas, Elizabeth L Christie, Jessica A Beach, Kathryn Alsop, Alison Freimund, Nidhi Vashistha, Niyati Jhaveri, Emerald Doolittle, Wei Wei, Bingqing Zhang, Xiao-Jun Ma, David DL Bowtell

Conference Proceedings  |  2020  |  CLINICAL CANCER RESEARCH

The evolutionary history of 2,658 cancers

Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C Dentro, Santiago Gonzalez, Daniel Rosebrock, Thomas J Mitchell, Yulia Rubanova, Pavana Anur, Kaixian Yu, Maxime Tarabichi, Amit Deshwar, Jeff Wintersinger, Kortine Kleinheinz, Ignacio Vazquez-Garcia, Kerstin Haase, Lara Jerman, Subhajit Sengupta, Geoff Macintyre, Salem Malikic, et al.

Journal article  |  2020  |  Nature

Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this proce..

Pan-cancer analysis of whole genomes

Peter J Campbell, Gad Getz, Jan O Korbel, Joshua M Stuart, Jennifer L Jennings, Lincoln D Stein, Marc D Perry, Hardeep K Nahal-Bose, BF Francis Ouellette, Constance H Li, Esther Rheinbay, G Petur Nielsen, Dennis C Sgroi, Chin-Lee Wu, William C Faquin, Vikram Deshpande, Paul C Boutros, Alexander J Lazar, Katherine A Hoadley, David N Louis, et al.

Journal article  |  2020  |  Nature

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this v..

Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.

Yulia Rubanova, Ruian Shi, Caitlin F Harrigan, Roujia Li, Jeff Wintersinger, Nil Sahin, Amit Deshwar, undefined PCAWG Evolution and Heterogeneity Working Group, Quaid Morris, undefined PCAWG Consortium

Journal article  |  2020  |  Nature Communications

The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures tha..

Inferring structural variant cancer cell fraction

Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schröder, undefined PCAWG Evolution and Heterogeneity Working Group, Niall M Corcoran, Tony Papenfuss, Christopher M Hovens, Florian Markowetz, Geoff Macintyre, undefined PCAWG Consortium

Journal article  |  2020  |  Nature Communications

We present SVclone, a computational method for inferring the cancer cell fraction of structural variant (SV) breakpoints from whol..