Stuart Mazzone

Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses.

Woo-Jung Song, Christopher KM Hui, James H Hull, Surinder S Birring, Lorcan McGarvey, Stuart B Mazzone, Kian Fan Chung

Journal article  |  2021  |  The Lancet Respiratory Medicine

Cough is one of the most common presenting symptoms of COVID-19, along with fever and loss of taste and smell. Cough can persist f..

Global physiology and pathophysiology of cough: Part 2. Demographic and clinical considerations: CHEST Expert Panel report.

Lorcan McGarvey, Bruce K Rubin, Satoru Ebihara, Karen Hegland, Alycia Rivet, Richard S Irwin, Donald C Bolser, Anne B Chang, Peter G Gibson, Stuart B Mazzone, undefined CHEST Expert Cough Panel

Journal article  |  2021  |  CHEST Journal

BACKGROUND: Cough characteristics vary between patients and this can impact clinical diagnosis and care. The purpose of Part 2 of ..

Jugular vagal ganglia neurons and airway nociception: A target for treating chronic cough.

Aung Aung Kywe Moe, Alice E McGovern, Stuart B Mazzone

Journal article  |  2021  |  The International Journal of Biochemistry & Cell Biology

The airways receive a dense supply of sensory nerve fibers that are responsive to damaging or potentially injurious stimuli. These..

Reciprocal connectivity of the periaqueductal gray with the ponto-medullary respiratory network in rat

Pedro Trevizan-Bau, Werner Furuya, Stuart B Mazzone, Davor Stanic, Rishi R Dhingra, Mathias Dutschmann

Journal article  |  2021  |  Brain Research

Synaptic activities of the periaqueductal gray (PAG) can modulate or appropriate the respiratory motor activities in the context o..

Behavioral and Regional Brain Responses to Inhalation of Capsaicin Modified by Painful Conditioning in Humans

Abubakar B Abubakar, Tara G Bautista, Matthew R Dimmock, Stuart B Mazzone, Michael J Farrell

Journal article  |  2021  |  CHEST Journal

BACKGROUND: Cough is a defense mechanism that protects the airways and lungs in response to airway irritation. The sensory neurons..

The impact of influenza pulmonary infection and inflammation on vagal bronchopulmonary sensory neurons

Nathalie AJ Verzele, Brendon Y Chua, Charity W Law, Albert Zhang, Matthew E Ritchie, Oliver Wightman, Isaac N Edwards, Katina D Hulme, Conor J Bloxham, Helle Bielefeldt-Ohmann, Matthew W Trewella, Aung Aung Kywe Moe, Keng Yih Chew, Stuart B Mazzone, Kirsty R Short, Alice E McGovern

Journal article  |  2021  |  The FASEB Journal

Influenza A virus (IAV) is rapidly detected in the airways by the immune system, with resident parenchymal cells and leukocytes or..

Mini Review: Central Organization of Airway Afferent Nerve Circuits

Robert Behrens, Alice E McGovern, Michael J Farrell, Aung Aung Kywe Moe, Stuart B Mazzone

Journal article  |  2021  |  Neuroscience Letters

Airway afferents monitor the local chemical and physical micro-environments in the airway wall and lungs and send this information..

Forebrain projection neurons target functionally diverse respiratory control areas in the midbrain, pons, and medulla oblongata

Pedro Trevizan-Bau, Rishi R Dhingra, Werner I Furuya, Davor Stanic, Stuart B Mazzone, Mathias Dutschmann

Journal article  |  2021  |  The Journal of Comparative Neurology

Eupnea is generated by neural circuits located in the ponto-medullary brainstem, but can be modulated by higher brain inputs which..

Global Physiology and Pathophysiology of Cough Part 1: Cough Phenomenology - CHEST Guideline and Expert Panel Report

Kai K Lee, Paul W Davenport, Jaclyn A Smith, Richard S Irwin, Lorcan McGarvey, Stuart B Mazzone, Surinder S Birring

Journal article  |  2021  |  CHEST Journal

The purpose of this state-of-the-art review is to update the American College of Chest Physicians 2006 guideline on global physiol..

Descending Modulation of Laryngeal Vagal Sensory Processing in the Brainstem Orchestrated by the Submedius Thalamic Nucleus

Stuart B Mazzone, Tara G Bautista, Anthony JM Verberne, Matthew W Trewella, Michael J Farrell, Alice E McGovern

Journal article  |  2020  |  Journal of Neuroscience

The nodose and jugular vagal ganglia supply sensory innervation to the airways and lungs. Jugular vagal airway sensory neurons wir..