Angus Stock

Mechanistic Target of Rapamycin Inhibition Prevents Coronary Artery Remodeling in a Murine Model of Kawasaki Disease.

Angus T Stock, Sarah Parsons, Damian B D'Silva, Jacinta A Hansen, Varun J Sharma, Fiona James, Graham Starkey, Rohit D'Costa, Claire L Gordon, Ian P Wicks

Journal article  |  2023  |  Arthritis Rheumatol

OBJECTIVE: Remodeling of the coronary arteries is a common feature in severe cases of Kawasaki disease (KD). This pathology is dri..

Intimal macrophages develop from circulating monocytes during vasculitis.

Angus T Stock, Sarah Parsons, Varun J Sharma, Fiona James, Graham Starkey, Rohit D'Costa, Claire L Gordon, Ian P Wicks

Journal article  |  2022  |  Clin Transl Immunology

OBJECTIVE: Vasculitis is characterised by inflammation of the blood vessels. While all layers of the vessel can be affected, infla..

The Selective Expansion and Targeted Accumulation of Bone Marrow-Derived Macrophages Drive Cardiac Vasculitis

Angus T Stock, Nicholas Collins, Gordon K Smyth, Yifang Hu, Jacinta A Hansen, Damian B D'Silva, Hamdi A Jama, Andrew M Lew, Thomas Gebhardt, Catriona A McLean, Ian P Wicks

Journal article  |  2019  |  JOURNAL OF IMMUNOLOGY

The adult heart contains macrophages derived from both embryonic and adult bone marrow (BM)-derived precursors. This population di..

TNF and IL-1 Play Essential but Temporally Distinct Roles in Driving Cardiac Inflammation in a Murine Model of Kawasaki Disease

Angus T Stock, Hamdi A Jama, Jacinta A Hansen, Ian P Wicks

Journal article  |  2019  |  JOURNAL OF IMMUNOLOGY

Kawasaki disease (KD) is a leading cause of pediatric heart disease, characterized by the emergence of life-threatening coronary v..

GM-CSF primes cardiac inflammation in a mouse model of Kawasaki disease

Angus T Stock, Jacinta A Hansen, Matthew A Sleeman, Brent S McKenzie, Ian P Wicks

Journal article  |  2016  |  JOURNAL OF EXPERIMENTAL MEDICINE

Kawasaki disease (KD) is the leading cause of pediatric heart disease in developed countries. KD patients develop cardiac inflamma..

T Cell Help Amplifies Innate Signals in CD8( ) DCs for Optimal CD8( ) T Cell Priming

Marie Greyer, Paul G Whitney, Angus T Stock, Gayle M Davey, Christina Tebartz, Annabell Bachem, Justine D Mintern, Richard A Strugnell, Stephen J Turner, Thomas Gebhardt, Meredith O'Keeffe, William R Heath, Sammy Bedoui

Journal article  |  2016  |  CELL REPORTS

DCs often require stimulation from CD4(+) T cells to propagate CD8(+) T cell responses, but precisely how T cell help optimizes th..

Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8( ) T Cell Differentiation

Brendan E Russ, Moshe Olshanksy, Heather S Smallwood, Jasmine Li, Alice E Denton, Julia E Prier, Angus T Stock, Hayley A Croom, Jolie G Cullen, Michelle LT Nguyen, Stephanie Rowe, Matthew R Olson, David B Finkelstein, Anne Kelso, Paul G Thomas, Terry P Speed, Sudha Rao, Stephen J Turner

Journal article  |  2014  |  IMMUNITY

The molecular mechanisms that regulate the rapid transcriptional changes that occur during cytotoxic T lymphocyte (CTL) proliferat..

Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection

Angus T Stock, Jeffrey M Smith, Francis R Carbone

Journal article  |  2014  |  JOURNAL OF EXPERIMENTAL MEDICINE

Infection induces the expression of inflammatory chemokines that recruit immune cells to the site of inflammation. Whereas tissues..

The developmental pathway for CD103( )CD8( ) tissue-resident memory T cells of skin

Laura K Mackay, Azad Rahimpour, Joel Z Ma, Nicholas Collins, Angus T Stock, Ming-Li Hafon, Javier Vega-Ramos, Pilar Lauzurica, Scott N Mueller, Tijana Stefanovic, David C Tscharke, William R Heath, Michael Inouye, Francis R Carbone, Thomas Gebhardt

Journal article  |  2013  |  NATURE IMMUNOLOGY

Tissue-resident memory T cells (T(RM) cells) provide superior protection against infection in extralymphoid tissues. Here we found..

Vitamin A notches up CD11b(hi) DC development

Angus T Stock, Sammy Bedoui

Journal article  |  2013  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Vitamin A and its metabolite retinoic acid influence various aspects of immunity. Although the capacity of vitamin A to condition ..